| PERCEPTIVE ADVISORS LLC | 1,452,707 | $114,764 |
| VIKING GLOBAL INVESTORS LP | 1,437,705 | $113,579 |
| MORGAN STANLEY | 1,167,728 | $92,251 |
| Sanofi | 1,157,926 | $91,476 |
| HighTower Advisors, LLC | 870,507 | $68,770 |
| BlackRock, Inc. | 777,383 | $61,413 |
| VANGUARD GROUP INC | 623,084 | $49,224 |
| Sofinnova Investments, Inc. | 454,657 | $35,918 |
| Capital Research Global Investors | 421,575 | $33,304 |
| STATE STREET CORP | 374,961 | $29,622 |
| Caligan Partners LP | 323,565 | $25,562 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 297,116 | $23,472 |
| MILLENNIUM MANAGEMENT LLC | 275,917 | $21,797 |
| PFM Health Sciences, LP | 265,517 | $20,976 |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 264,000 | $20,856 |
| GEODE CAPITAL MANAGEMENT, LLC | 226,009 | $17,859 |
| Schonfeld Strategic Advisors LLC | 214,725 | $16,963 |
| Woodline Partners LP | 139,479 | $11,019 |
| NORGES BANK | 133,300 | $10,531 |
| D. E. Shaw & Co., Inc. | 122,101 | $9,646 |
| Invesco Ltd. | 112,396 | $8,879 |
| CDC Financial, Inc. | 110,810 | $8,754 |
| GOLDMAN SACHS GROUP INC | 100,617 | $7,949 |
| BOOTHBAY FUND MANAGEMENT, LLC | 92,009 | $7,269 |
| NORTHERN TRUST CORP | 88,509 | $6,992 |
| SummitTX Capital, L.P. | 82,885 | $6,548 |
| UBS Group AG | 73,699 | $5,822 |
| KENNEDY CAPITAL MANAGEMENT LLC | 71,488 | $5,648 |
| BANK OF AMERICA CORP /DE/ | 69,119 | $5,460 |
| CITIGROUP INC | 55,759 | $4,405 |
| RENAISSANCE TECHNOLOGIES LLC | 52,600 | $4,155 |
| FMR LLC | 46,269 | $3,655 |
| Laird Norton Wetherby Trust Company, LLC | 40,382 | $3,190 |
| ArrowMark Colorado Holdings LLC | 35,176 | $2,779 |
| JANE STREET GROUP, LLC | 33,019 | $2,609 |
| MARSHALL WACE, LLP | 29,310 | $2,315 |
| FRANKLIN RESOURCES INC | 29,308 | $2,315 |
| WELLINGTON MANAGEMENT GROUP LLP | 28,393 | $2,243 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 27,341 | $2,160 |
| CITADEL ADVISORS LLC | 26,900 | $2,125 |
| Bank of New York Mellon Corp | 26,748 | $2,113 |
| ACADIAN ASSET MANAGEMENT LLC | 25,390 | $2 |
| Soleus Capital Management, L.P. | 25,000 | $1,975 |
| Empirical Financial Services, LLC d.b.a. Empirical Wealth Management | 22,883 | $1,808 |
| BARCLAYS PLC | 21,879 | $1,728 |
| Russell Investments Group, Ltd. | 20,778 | $1,641 |
| Corient Private Wealth LLC | 20,443 | $1,615 |
| Nuveen, LLC | 17,090 | $1,350 |
| JPMORGAN CHASE & CO | 17,059 | $1,348 |
| ACUTA CAPITAL PARTNERS, LLC | 16,377 | $1,294 |
| SG Americas Securities, LLC | 16,088 | $1 |
| Groupe la Francaise | 15,636 | $1,235 |
| Voleon Capital Management LP | 15,008 | $1,186 |
| BNP PARIBAS ARBITRAGE, SA | 14,850 | $1,173 |
| Ethic Inc. | 12,971 | $1,025 |
| Mariner, LLC | 12,746 | $1,008 |
| Jain Global LLC | 12,098 | $956 |
| VICTORY CAPITAL MANAGEMENT INC | 11,963 | $945 |
| RHUMBLINE ADVISERS | 11,435 | $903 |
| WELLS FARGO & COMPANY/MN | 10,813 | $854 |
| Meridian Wealth Advisors, LLC | 10,500 | $830 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 10,141 | $801 |
| Quantinno Capital Management LP | 10,038 | $793 |
| XTX Topco Ltd | 9,021 | $713 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 9,000 | $711 |
| ALLIANCEBERNSTEIN L.P. | 8,950 | $707 |
| Jefferies Financial Group Inc. | 8,901 | $703 |
| CREDIT INDUSTRIEL ET COMMERCIAL | 8,656 | $684 |
| Rafferty Asset Management, LLC | 8,582 | $678 |
| AQR CAPITAL MANAGEMENT LLC | 7,501 | $593 |
| Belvedere Trading LLC | 7,402 | $585 |
| DEUTSCHE BANK AG\ | 6,638 | $524 |
| PSP Research LLC | 6,389 | $505 |
| Creative Planning | 5,708 | $451 |
| Voya Investment Management LLC | 5,564 | $440 |
| Janney Montgomery Scott LLC | 5,495 | $0 |
| GROUP ONE TRADING, L.P. | 5,358 | $423 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,334 | $0 |
| MetLife Investment Management, LLC | 5,320 | $420 |
| Harvest Investment Services, LLC | 5,049 | $399 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 4,712 | $372 |
| TUDOR INVESTMENT CORP ET AL | 4,642 | $367 |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 3,800 | $300 |
| Birchview Capital, LP | 3,698 | $292 |
| Jump Financial, LLC | 3,504 | $277 |
| NEW YORK STATE COMMON RETIREMENT FUND | 3,472 | $274 |
| Squarepoint Ops LLC | 3,398 | $268 |
| Presidio Capital Management, LLC | 3,394 | $268 |
| Virtus Investment Advisers, LLC | 3,343 | $264 |
| PROFUND ADVISORS LLC | 3,271 | $258 |
| INTECH INVESTMENT MANAGEMENT LLC | 3,242 | $256 |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 3,101 | $233 |
| AMERIPRISE FINANCIAL INC | 3,051 | $241 |
| NBC SECURITIES, INC. | 3,000 | $237 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 2,785 | $220 |
| Police & Firemen's Retirement System of New Jersey | 2,660 | $210 |
| China Universal Asset Management Co., Ltd. | 2,370 | $187 |
| AlphaQuest LLC | 2,192 | $173 |
| Hurley Capital, LLC | 1,660 | $131 |
| DIADEMA PARTNERS LP | 1,299 | $103 |
| 37 other institutions | 12,487 | $866 |