LEXICON PHARMACEUTICALS INC

Ticker: LXRX CUSIP: 528872302 Class: COM NEW

Note: Option positions (PUT/CALL) are excluded.

InstitutionSharesValue ($000)
Artal Group S.A.136,180,481$156,608
Siren, L.L.C.38,918,903$44,757
FMR LLC37,834,207$43,509
VANGUARD GROUP INC9,606,549$11,048
MILLENNIUM MANAGEMENT LLC4,821,733$5,545
BlackRock, Inc.3,192,448$3,671
UBS Group AG3,007,237$3,458
Sessa Capital IM, L.P.3,000,000$3,450
GEODE CAPITAL MANAGEMENT, LLC2,500,022$2,876
CIBC Private Wealth Group, LLC1,950,000$2,243
JANE STREET GROUP, LLC1,724,304$1,983
CITADEL ADVISORS LLC1,710,975$1,968
MARSHALL WACE, LLP1,262,367$1,452
SUSQUEHANNA INTERNATIONAL GROUP, LLP1,207,242$1,388
CHARLES SCHWAB INVESTMENT MANAGEMENT INC1,055,123$1,213
GSA CAPITAL PARTNERS LLP996,235$1
GOLDMAN SACHS GROUP INC921,204$1,059
Hennion & Walsh Asset Management, Inc.901,222$1,036
STATE STREET CORP884,738$1,017
Ishara Investments LP880,000$1,012
ACADIAN ASSET MANAGEMENT LLC640,130$1
TWO SIGMA INVESTMENTS, LP637,308$733
Invesco Ltd.594,883$684
NORTHERN TRUST CORP412,164$474
Compagnie Lombard Odier SCmA410,000$472
Point72 Asset Management, L.P.284,025$327
OMERS ADMINISTRATION Corp273,800$315
ExodusPoint Capital Management, LP268,433$309
RENAISSANCE TECHNOLOGIES LLC263,254$303
GROUP ONE TRADING, L.P.224,308$258
BARCLAYS PLC194,743$224
MORGAN STANLEY193,035$222
TWO SIGMA ADVISERS, LP180,977$208
Ikarian Capital, LLC164,674$189
Cerity Partners LLC144,944$167
AQR CAPITAL MANAGEMENT LLC144,800$167
Headlands Technologies LLC136,113$157
Lighthouse Investment Partners, LLC126,600$146
HRT FINANCIAL LP117,549$0
Monaco Asset Management SAM117,188$135
TWO SIGMA SECURITIES, LLC114,632$132
Graham Capital Management, L.P.109,900$126
BANK OF AMERICA CORP /DE/102,097$117
Hudson Bay Capital Management LP100,532$116
XTX Topco Ltd96,090$111
Jefferies Financial Group Inc.92,530$106
CITIGROUP INC91,670$105
Quarry LP88,000$101
LPL Financial LLC87,057$100
CAXTON ASSOCIATES LLP71,027$82
BANK OF MONTREAL /CAN/70,000$81
Vanguard Personalized Indexing Management, LLC66,567$77
Straight Path Wealth Management62,666$72
State of Wyoming60,571$70
Squarepoint Ops LLC60,472$70
Optiver Holding B.V.52,595$60
Fortis Group Advisors, LLC50,000$58
R Squared Ltd46,579$54
BOOTHBAY FUND MANAGEMENT, LLC44,315$51
WEDBUSH SECURITIES INC40,850$0
KWB Wealth40,640$47
Catalyst Funds Management Pty Ltd40,300$46
CIBC Asset Management Inc39,520$45
Virtu Financial LLC36,468$0
UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO35,714$41
PRUDENTIAL FINANCIAL INC33,800$39
EntryPoint Capital, LLC33,618$39
Vermillion & White Wealth Management Group, LLC32,000$37
Leonteq Securities AG30,000$35
Pathstone Holdings, LLC29,969$34
Tower Research Capital LLC (TRC)29,093$33
PINNACLE ASSOCIATES LTD29,015$33
SECURITY NATIONAL BANK OF SIOUX CITY IOWA /IA/26,650$31
OPPENHEIMER & CO INC23,500$27
Cambridge Investment Research Advisors, Inc.21,505$0
VICTORY CAPITAL MANAGEMENT INC21,191$24
Invera Wealth Advisors, LLC20,000$23
TIAA TRUST, NATIONAL ASSOCIATION20,000$23
Bank of New York Mellon Corp19,124$22
CREDIT AGRICOLE S A18,975$22
Quadrature Capital Ltd18,414$21
StoneX Group Inc.16,234$19
SIMPLEX TRADING, LLC14,758$17
Cetera Investment Advisers14,188$16
LAZARD ASSET MANAGEMENT LLC14,090$16
Callan Family Office, LLC14,090$16
TRUIST FINANCIAL CORP14,000$16
WEALTH ENHANCEMENT ADVISORY SERVICES, LLC13,520$15
CWM, LLC13,179$0
Schonfeld Strategic Advisors LLC13,108$15
Chemistry Wealth Management LLC12,000$14
HBK Sorce Advisory LLC11,786$14
CAPTRUST FINANCIAL ADVISORS11,735$13
Fortress Wealth Group, LLC11,350$13
Perennial Investment Advisors, LLC10,990$13
NBT BANK N A /NY10,000$12
Berger Financial Group, Inc10,000$12
ROYAL BANK OF CANADA6,768$7
Golden State Wealth Management, LLC3,700$4
SBI Securities Co., Ltd.3,018$3
24 other institutions16,707$17
Total (124 institutions)260,426,785$297,347