| FMR LLC | 15,380,675 | $677,519 |
| Siren, L.L.C. | 10,825,013 | $476,842 |
| BlackRock, Inc. | 7,217,034 | $317,910 |
| Samsara BioCapital, LLC | 6,897,652 | $303,842 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,402,437 | $282 |
| WELLINGTON MANAGEMENT GROUP LLP | 5,759,428 | $253,703 |
| Redmile Group, LLC | 5,220,846 | $229,978 |
| VANGUARD GROUP INC | 5,195,465 | $228,860 |
| Bellevue Group AG | 4,056,592 | $178,693 |
| STATE STREET CORP | 4,034,434 | $177,717 |
| Orbis Allan Gray Ltd | 3,428,929 | $151,044 |
| Paradigm Biocapital Advisors LP | 3,062,157 | $134,888 |
| JENNISON ASSOCIATES LLC | 2,795,188 | $123,128 |
| EVENTIDE ASSET MANAGEMENT, LLC | 2,431,333 | $107,093 |
| NORGES BANK | 2,079,515 | $91,603 |
| GEODE CAPITAL MANAGEMENT, LLC | 2,034,024 | $89,616 |
| Hood River Capital Management LLC | 2,026,758 | $89,279 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,952,877 | $86,024 |
| JANUS HENDERSON GROUP PLC | 1,774,168 | $78,222 |
| Holocene Advisors, LP | 1,387,120 | $61,103 |
| GOLDMAN SACHS GROUP INC | 1,324,213 | $58,332 |
| Polar Capital Holdings Plc | 1,322,011 | $58,235 |
| Woodline Partners LP | 1,211,088 | $53,348 |
| Pictet Asset Management Holding SA | 1,195,967 | $52,682 |
| Capital World Investors | 1,128,752 | $49,722 |
| BANK OF AMERICA CORP /DE/ | 1,050,506 | $46,275 |
| UBS Group AG | 905,432 | $39,884 |
| STEMPOINT CAPITAL LP | 886,893 | $39,068 |
| Ensign Peak Advisors, Inc | 835,851 | $36,819 |
| BNP Paribas Investment Partners S.A. | 829,422 | $37 |
| FEDERATED HERMES, INC. | 797,913 | $35,148 |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 769,442 | $33,894 |
| Rock Springs Capital Management LP | 733,477 | $32,310 |
| NORTHERN TRUST CORP | 721,062 | $31,763 |
| AMERICAN CENTURY COMPANIES INC | 708,253 | $31,199 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 702,095 | $30,927 |
| Vestal Point Capital, LP | 700,000 | $30,835 |
| LOOMIS SAYLES & CO L P | 691,913 | $30,479 |
| Nuveen, LLC | 604,417 | $26,625 |
| BNP PARIBAS ARBITRAGE, SA | 554,602 | $24,430 |
| Fisher Asset Management, LLC | 531,439 | $23,410 |
| Voya Investment Management LLC | 514,224 | $22,652 |
| CITADEL ADVISORS LLC | 495,946 | $21,846 |
| First Turn Management, LLC | 459,727 | $20,251 |
| TWO SIGMA INVESTMENTS, LP | 405,523 | $17,863 |
| MORGAN STANLEY | 372,731 | $16,419 |
| MARSHALL WACE, LLP | 368,037 | $16,212 |
| Eagle Health Investments LP | 363,300 | $16,003 |
| Integral Health Asset Management, LLC | 300,000 | $13,215 |
| Clearbridge Investments, LLC | 295,475 | $13,016 |
| TD Asset Management Inc | 281,444 | $12,398 |
| AQR CAPITAL MANAGEMENT LLC | 280,324 | $12,348 |
| NAN FUNG TRINITY (HK) LTD | 263,245 | $11,596 |
| Casdin Capital, LLC | 260,000 | $11,453 |
| BARCLAYS PLC | 251,913 | $11,097 |
| RAYMOND JAMES FINANCIAL INC | 245,387 | $10,809 |
| Bank of New York Mellon Corp | 232,018 | $10,220 |
| DEUTSCHE BANK AG\ | 226,168 | $9,963 |
| ARMISTICE CAPITAL, LLC | 200,000 | $8,810 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 186,926 | $8,170 |
| Man Group plc | 182,024 | $8,018 |
| JPMORGAN CHASE & CO | 170,773 | $7,523 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 168,547 | $7,424 |
| SPHERA FUNDS MANAGEMENT LTD. | 158,265 | $6,972 |
| Granahan Investment Management, LLC | 153,769 | $6,774 |
| PEREGRINE CAPITAL MANAGEMENT LLC | 152,854 | $6,733 |
| Candriam S.C.A. | 145,633 | $6,415 |
| Rafferty Asset Management, LLC | 129,132 | $5,688 |
| iA Global Asset Management Inc. | 123,272 | $5 |
| Swiss National Bank | 123,200 | $5,427 |
| SEI INVESTMENTS CO | 120,527 | $5,309 |
| EFG International AG | 118,824 | $5,243 |
| RHUMBLINE ADVISERS | 108,864 | $4,795 |
| UBS ASSET MANAGEMENT AMERICAS INC | 107,183 | $4,721 |
| ExodusPoint Capital Management, LP | 106,228 | $4,679 |
| FIDEURAM - INTESA SANPAOLO PRIVATE BANKING S.P.A. | 103,191 | $4,546 |
| Hudson Bay Capital Management LP | 100,000 | $4,405 |
| Artia Global Partners LP | 96,285 | $4,241 |
| WELLS FARGO & COMPANY/MN | 90,553 | $3,989 |
| JANE STREET GROUP, LLC | 88,530 | $3,900 |
| Moody Aldrich Partners LLC | 85,293 | $3,757 |
| SG Americas Securities, LLC | 84,349 | $4 |
| Invesco Ltd. | 82,462 | $3,632 |
| ALLIANCEBERNSTEIN L.P. | 82,110 | $3,617 |
| PICTON MAHONEY ASSET MANAGEMENT | 78,046 | $3,438 |
| Aisling Capital Management LP | 77,031 | $3,393 |
| ADAR1 Capital Management, LLC | 69,589 | $3,065 |
| DARK FOREST CAPITAL MANAGEMENT LP | 64,534 | $2,843 |
| Legal & General Group Plc | 63,336 | $2,790 |
| KENNEDY CAPITAL MANAGEMENT LLC | 62,678 | $2,761 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 60,815 | $2,679 |
| StoneCrest Wealth Management, Inc. | 59,003 | $2,494 |
| TUDOR INVESTMENT CORP ET AL | 55,117 | $2,428 |
| MILLENNIUM MANAGEMENT LLC | 50,418 | $2,221 |
| Trexquant Investment LP | 48,927 | $2,155 |
| PROFUND ADVISORS LLC | 48,152 | $2,121 |
| MetLife Investment Management, LLC | 46,657 | $2,055 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 45,798 | $2,014 |
| KVP Capital Advisors, LP | 45,000 | $1,982 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 42,672 | $1,880 |
| 171 other institutions | 1,518,976 | $59,903 |