| FMR LLC | 2,807,442 | $58,563 |
| abrdn plc | 1,141,824 | $23,818 |
| BRAIDWELL LP | 927,524 | $19,348 |
| BAKER BROS. ADVISORS LP | 903,400 | $18,845 |
| BlackRock, Inc. | 854,363 | $17,822 |
| 5AM Venture Management, LLC | 606,660 | $12,655 |
| VANGUARD GROUP INC | 599,898 | $12,514 |
| ORBIMED ADVISORS LLC | 574,600 | $11,986 |
| Point72 Asset Management, L.P. | 492,332 | $10,270 |
| Vestal Point Capital, LP | 328,000 | $6,842 |
| CITADEL ADVISORS LLC | 317,617 | $6,625 |
| Bollard Group LLC | 302,953 | $6 |
| MILLENNIUM MANAGEMENT LLC | 300,820 | $6,275 |
| GEODE CAPITAL MANAGEMENT, LLC | 263,560 | $5,499 |
| Pale Fire Capital SE | 261,026 | $5,445 |
| Prosight Management, LP | 235,000 | $4,902 |
| Opaleye Management Inc. | 214,747 | $4,480 |
| KENNEDY CAPITAL MANAGEMENT LLC | 209,225 | $4,364 |
| STATE STREET CORP | 209,125 | $4,362 |
| Woodline Partners LP | 200,000 | $4,172 |
| Squarepoint Ops LLC | 199,646 | $4,165 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 151,713 | $3,165 |
| WELLS FARGO & COMPANY/MN | 120,411 | $2,512 |
| D. E. Shaw & Co., Inc. | 120,250 | $2,508 |
| ExodusPoint Capital Management, LP | 111,188 | $2,319 |
| MORGAN STANLEY | 94,435 | $1,970 |
| GOLDMAN SACHS GROUP INC | 92,703 | $1,934 |
| KOTLER KEVIN | 80,000 | $1,669 |
| Knott David M Jr | 74,000 | $1,544 |
| NORTHERN TRUST CORP | 72,255 | $1,507 |
| Connor, Clark & Lunn Investment Management Ltd. | 71,657 | $1,495 |
| GSA CAPITAL PARTNERS LLP | 63,276 | $1 |
| RAYMOND JAMES FINANCIAL INC | 54,601 | $1,139 |
| PFM Health Sciences, LP | 42,724 | $891 |
| SECTORAL ASSET MANAGEMENT INC | 42,255 | $881 |
| Jump Financial, LLC | 39,500 | $824 |
| Schonfeld Strategic Advisors LLC | 39,109 | $816 |
| WELLINGTON MANAGEMENT GROUP LLP | 37,379 | $780 |
| Aldebaran Capital, LLC | 37,353 | $779 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 32,461 | $677 |
| UBS Group AG | 31,215 | $651 |
| MARSHALL WACE, LLP | 30,918 | $645 |
| ADAR1 Capital Management, LLC | 30,007 | $626 |
| BIT Capital GmbH | 30,000 | $626 |
| MONIMUS CAPITAL MANAGEMENT, LP | 26,594 | $555 |
| Bank of New York Mellon Corp | 25,858 | $539 |
| BARCLAYS PLC | 22,443 | $468 |
| Aquatic Capital Management LLC | 22,262 | $464 |
| JANE STREET GROUP, LLC | 19,321 | $403 |
| AlphaQuest LLC | 18,187 | $379 |
| ALPS ADVISORS INC | 15,369 | $321 |
| SEI INVESTMENTS CO | 15,251 | $318 |
| Nuveen, LLC | 14,304 | $298 |
| RHUMBLINE ADVISERS | 14,196 | $296 |
| Virtus Investment Advisers, LLC | 13,462 | $281 |
| Palumbo Wealth Management LLC | 13,046 | $272 |
| Marex Group plc | 12,501 | $261 |
| Clarius Group, LLC | 10,130 | $211 |
| DIMENSIONAL FUND ADVISORS LP | 10,075 | $210 |
| Quadrature Capital Ltd | 10,014 | $209 |
| BANK OF AMERICA CORP /DE/ | 9,225 | $192 |
| SIMPLEX TRADING, LLC | 9,142 | $191 |
| DEUTSCHE BANK AG\ | 7,589 | $158 |
| MetLife Investment Management, LLC | 6,724 | $140 |
| Clearstead Advisors, LLC | 6,500 | $136 |
| AlphaCentric Advisors LLC | 6,476 | $135 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 6,410 | $113 |
| CANADA PENSION PLAN INVESTMENT BOARD | 6,300 | $131 |
| China Universal Asset Management Co., Ltd. | 6,050 | $126 |
| JPMORGAN CHASE & CO | 5,779 | $121 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 5,079 | $106 |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,000 | $104 |
| NISA INVESTMENT ADVISORS, LLC | 5,000 | $104 |
| BNP PARIBAS ARBITRAGE, SA | 2,819 | $59 |
| Police & Firemen's Retirement System of New Jersey | 2,638 | $55 |
| Ameritas Investment Partners, Inc. | 1,122 | $23 |
| Legal & General Group Plc | 1,050 | $22 |
| CITIGROUP INC | 1,033 | $22 |
| Russell Investments Group, Ltd. | 929 | $19 |
| Mirae Asset Global Investments Co., Ltd. | 909 | $19 |
| Tower Research Capital LLC (TRC) | 752 | $16 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 676 | $14 |
| HighMark Wealth Management LLC | 587 | $12 |
| GROUP ONE TRADING, L.P. | 541 | $11 |
| Sterling Capital Management LLC | 537 | $11 |
| ROYAL BANK OF CANADA | 521 | $10 |
| Federation des caisses Desjardins du Quebec | 500 | $10 |
| CWM, LLC | 466 | $0 |
| Farther Finance Advisors, LLC | 373 | $8 |
| GF FUND MANAGEMENT CO. LTD. | 367 | $8 |
| AMALGAMATED BANK | 345 | $0 |
| UBS ASSET MANAGEMENT AMERICAS INC | 173 | $4 |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 164 | $3 |
| Vermillion & White Wealth Management Group, LLC | 107 | $2 |
| Daiwa Securities Group Inc. | 80 | $0 |
| Allworth Financial LP | 62 | $1 |
| US BANCORP \DE\ | 37 | $1 |
| OPTIMA CAPITAL LLC | 31 | $1 |
| GAMMA Investing LLC | 29 | $1 |
| Caldwell Trust Co | 20 | $0 |
| 5 other institutions | 31 | $1 |