| Avoro Capital Advisors LLC | 5,888,888 | $298,213 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,461,976 | $277 |
| BlackRock, Inc. | 4,825,519 | $244,364 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 4,059,695 | $205,583 |
| VANGUARD GROUP INC | 3,570,401 | $180,805 |
| Kynam Capital Management, LP | 3,433,051 | $173,850 |
| Eversept Partners, LP | 3,072,304 | $155,581 |
| FMR LLC | 2,885,853 | $146,140 |
| Deep Track Capital, LP | 2,821,135 | $142,862 |
| Sofinnova Investments, Inc. | 2,793,987 | $141,488 |
| STATE STREET CORP | 2,676,600 | $135,543 |
| Integral Health Asset Management, LLC | 1,800,000 | $91,152 |
| Point72 Asset Management, L.P. | 1,738,385 | $88,032 |
| Bellevue Group AG | 1,698,152 | $85,994 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,444,925 | $73,185 |
| Pictet Asset Management Holding SA | 1,392,421 | $70,512 |
| Holocene Advisors, LP | 1,307,393 | $66,206 |
| ALLIANCEBERNSTEIN L.P. | 1,218,657 | $61,713 |
| GOLDMAN SACHS GROUP INC | 1,120,780 | $56,756 |
| Woodline Partners LP | 1,000,279 | $50,654 |
| First Light Asset Management, LLC | 869,676 | $44,040 |
| Tri Locum Partners LP | 805,689 | $40,800 |
| BRAIDWELL LP | 784,742 | $39,739 |
| CITADEL ADVISORS LLC | 777,488 | $39,372 |
| AMERICAN CENTURY COMPANIES INC | 732,699 | $37,104 |
| BANK OF AMERICA CORP /DE/ | 694,319 | $35,160 |
| ARMISTICE CAPITAL, LLC | 653,796 | $33,108 |
| First Turn Management, LLC | 601,774 | $30,474 |
| Rock Springs Capital Management LP | 568,579 | $28,793 |
| Vestal Point Capital, LP | 550,000 | $27,852 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 518,858 | $26,275 |
| MORGAN STANLEY | 499,665 | $25,303 |
| Elmind Capital, LP | 482,500 | $24,434 |
| BNP PARIBAS ARBITRAGE, SA | 474,668 | $24,037 |
| NORTHERN TRUST CORP | 473,219 | $23,964 |
| Candriam S.C.A. | 449,554 | $22,766 |
| Rhenman & Partners Asset Management AB | 420,000 | $21,269 |
| Voya Investment Management LLC | 418,963 | $21,216 |
| Qube Research & Technologies Ltd | 378,055 | $19,145 |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 371,151 | $18,795 |
| ORBIMED ADVISORS LLC | 353,500 | $17,901 |
| DIMENSIONAL FUND ADVISORS LP | 351,886 | $17,820 |
| DEUTSCHE BANK AG\ | 347,426 | $17,594 |
| TD Asset Management Inc | 325,564 | $16,487 |
| BARCLAYS PLC | 253,716 | $12,848 |
| TimesSquare Capital Management, LLC | 252,462 | $12,785 |
| Affinity Asset Advisors, LLC | 250,000 | $12,660 |
| Alphabet Inc. | 241,264 | $12,218 |
| Nuveen, LLC | 227,081 | $11,499 |
| TWO SIGMA INVESTMENTS, LP | 209,951 | $10,632 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 207,968 | $10,627 |
| UBS Group AG | 207,289 | $10,497 |
| UBS ASSET MANAGEMENT AMERICAS INC | 202,953 | $10,278 |
| MILLENNIUM MANAGEMENT LLC | 199,723 | $10,114 |
| RENAISSANCE TECHNOLOGIES LLC | 193,400 | $9,794 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 176,684 | $8,947 |
| CITIGROUP INC | 174,255 | $8,824 |
| Bank of New York Mellon Corp | 169,734 | $8,595 |
| BNP Paribas Investment Partners S.A. | 154,553 | $8 |
| WELLS FARGO & COMPANY/MN | 145,205 | $7,353 |
| Nicholas Investment Partners, LP | 144,810 | $7,333 |
| Russell Investments Group, Ltd. | 124,866 | $6,323 |
| Exome Asset Management LLC | 124,391 | $6,299 |
| Swedbank AB | 121,200 | $6,138 |
| CANADA PENSION PLAN INVESTMENT BOARD | 120,600 | $6,107 |
| PLATINUM INVESTMENT MANAGEMENT LTD | 119,384 | $6,046 |
| GW&K Investment Management, LLC | 113,753 | $6 |
| PFM Health Sciences, LP | 107,690 | $5,453 |
| Parkman Healthcare Partners LLC | 100,564 | $5,093 |
| Invesco Ltd. | 89,851 | $4,550 |
| Rafferty Asset Management, LLC | 85,836 | $4,347 |
| Soviero Asset Management, LP | 85,000 | $4,304 |
| Swiss National Bank | 75,600 | $3,828 |
| ExodusPoint Capital Management, LP | 72,741 | $3,684 |
| RHUMBLINE ADVISERS | 66,511 | $3,368 |
| RAYMOND JAMES FINANCIAL INC | 64,875 | $3,285 |
| ALGERT GLOBAL LLC | 64,868 | $3 |
| Cinctive Capital Management LP | 64,617 | $3,272 |
| JPMORGAN CHASE & CO | 64,107 | $3,246 |
| EASTERN BANK | 56,050 | $2,838 |
| BALYASNY ASSET MANAGEMENT L.P. | 54,327 | $2,751 |
| ALPS ADVISORS INC | 52,392 | $2,653 |
| J. Safra Sarasin Holding AG | 52,327 | $2,650 |
| Trexquant Investment LP | 50,055 | $2,535 |
| Legal & General Group Plc | 46,426 | $2,351 |
| Birchview Capital, LP | 44,000 | $2,228 |
| Headlands Technologies LLC | 42,825 | $2,169 |
| Hennion & Walsh Asset Management, Inc. | 42,374 | $2,146 |
| E. Ohman J:or Asset Management AB | 39,500 | $2,000 |
| NEW YORK STATE COMMON RETIREMENT FUND | 38,021 | $1,925 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 37,830 | $1,916 |
| SECTORAL ASSET MANAGEMENT INC | 36,858 | $1,866 |
| KVP Capital Advisors, LP | 32,700 | $1,656 |
| Schonfeld Strategic Advisors LLC | 32,402 | $1,641 |
| Man Group plc | 32,364 | $1,639 |
| PROFUND ADVISORS LLC | 32,024 | $1,622 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 31,779 | $1,626 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 30,797 | $1,562 |
| DARK FOREST CAPITAL MANAGEMENT LP | 30,682 | $1,554 |
| MetLife Investment Management, LLC | 30,463 | $1,543 |
| 111 other institutions | 916,480 | $43,212 |