| Lynx1 Capital Management LP | 10,406,575 | $132,164 |
| BVF INC/IL | 8,827,712 | $112,112 |
| RA CAPITAL MANAGEMENT, L.P. | 7,676,697 | $97,494 |
| RTW INVESTMENTS, LP | 5,933,815 | $75,359 |
| FMR LLC | 5,136,045 | $65,228 |
| Avoro Capital Advisors LLC | 1,800,000 | $22,860 |
| Cormorant Asset Management, LP | 1,300,000 | $16,510 |
| Jefferies Financial Group Inc. | 712,300 | $9,046 |
| Verition Fund Management LLC | 673,735 | $8,556 |
| 5AM Venture Management, LLC | 572,665 | $7,273 |
| BlackRock, Inc. | 434,401 | $5,517 |
| Troluce Capital Advisors LLC | 373,212 | $4,740 |
| UBS Group AG | 363,381 | $4,615 |
| Squadron Capital Management LLC | 315,000 | $4,001 |
| MILLENNIUM MANAGEMENT LLC | 295,926 | $3,758 |
| CenterBook Partners LP | 283,441 | $3,600 |
| MARSHALL WACE, LLP | 240,764 | $3,058 |
| HighVista Strategies LLC | 240,524 | $3,055 |
| Alyeska Investment Group, L.P. | 204,975 | $2,603 |
| BOOTHBAY FUND MANAGEMENT, LLC | 112,184 | $1,425 |
| GOLDMAN SACHS GROUP INC | 80,986 | $1,029 |
| AdvisorShares Investments LLC | 67,112 | $852 |
| Trexquant Investment LP | 54,776 | $696 |
| MORGAN STANLEY | 51,404 | $653 |
| JANE STREET GROUP, LLC | 50,005 | $635 |
| BIT Capital GmbH | 50,000 | $635 |
| XTX Topco Ltd | 44,446 | $564 |
| GEODE CAPITAL MANAGEMENT, LLC | 35,645 | $453 |
| NORTHERN TRUST CORP | 32,828 | $417 |
| CITADEL ADVISORS LLC | 26,258 | $333 |
| Virtus Investment Advisers, LLC | 20,408 | $259 |
| JPMORGAN CHASE & CO | 18,881 | $240 |
| GSA CAPITAL PARTNERS LLP | 18,565 | $0 |
| HRT FINANCIAL LP | 15,936 | $0 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 15,877 | $202 |
| HighTower Advisors, LLC | 15,600 | $198 |
| STATE STREET CORP | 10,821 | $137 |
| Lion Point Capital, LP | 10,200 | $130 |
| China Universal Asset Management Co., Ltd. | 10,107 | $128 |
| OSAIC HOLDINGS, INC. | 10,025 | $127 |
| BANK OF AMERICA CORP /DE/ | 4,450 | $57 |
| CITIGROUP INC | 4,404 | $56 |
| Mirae Asset Global Investments Co., Ltd. | 3,014 | $38 |
| BARCLAYS PLC | 2,118 | $27 |
| ROYAL BANK OF CANADA | 1,810 | $23 |
| BNP PARIBAS ARBITRAGE, SA | 1,337 | $17 |
| WELLS FARGO & COMPANY/MN | 1,250 | $16 |
| GF FUND MANAGEMENT CO. LTD. | 1,218 | $15 |
| Tower Research Capital LLC (TRC) | 770 | $10 |
| Global Retirement Partners, LLC | 400 | $5 |
| Daiwa Securities Group Inc. | 207 | $0 |
| SIMPLEX TRADING, LLC | 48 | $1 |
| SBI Securities Co., Ltd. | 20 | $0 |