| FMR LLC | 65,779,464 | $1,427,414 |
| MORGAN STANLEY | 58,359,553 | $1,266,402 |
| VANGUARD GROUP INC | 42,059,041 | $912,681 |
| BlackRock, Inc. | 41,170,475 | $893,399 |
| QVT Financial LP | 26,387,021 | $572,598 |
| UBS Group AG | 18,390,792 | $399,080 |
| STATE STREET CORP | 17,361,465 | $376,744 |
| SB INVESTMENT ADVISERS (UK) LTD | 16,413,603 | $356,175 |
| GOLDMAN SACHS GROUP INC | 10,982,683 | $238,324 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 10,677,894 | $231,710 |
| Two Seas Capital LP | 9,791,891 | $212,484 |
| DIMENSIONAL FUND ADVISORS LP | 9,247,468 | $200,666 |
| Rubric Capital Management LP | 9,000,000 | $195,300 |
| Patient Square Capital LP | 8,166,047 | $177,203 |
| GEODE CAPITAL MANAGEMENT, LLC | 8,153,546 | $176,972 |
| PERCEPTIVE ADVISORS LLC | 7,985,461 | $173,285 |
| Assenagon Asset Management S.A. | 6,937,112 | $150,535 |
| VIKING GLOBAL INVESTORS LP | 6,443,191 | $139,817 |
| BAKER BROS. ADVISORS LP | 5,555,017 | $120,544 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,335,125 | $116 |
| NORGES BANK | 5,195,859 | $112,750 |
| Jefferies Financial Group Inc. | 3,514,833 | $76,272 |
| MARSHALL WACE, LLP | 3,458,926 | $75,059 |
| ADAR1 Capital Management, LLC | 3,428,962 | $74,408 |
| NORTHERN TRUST CORP | 3,285,928 | $71,305 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 3,239,696 | $70,301 |
| BlackBarn Capital Partners LP | 3,084,300 | $66,929 |
| BANK OF AMERICA CORP /DE/ | 2,928,328 | $63,545 |
| JANUS HENDERSON GROUP PLC | 2,918,109 | $63,279 |
| Bank of New York Mellon Corp | 2,903,129 | $62,998 |
| Polar Capital Holdings Plc | 2,690,124 | $58,376 |
| Candriam S.C.A. | 2,490,426 | $54,045 |
| JENNISON ASSOCIATES LLC | 2,353,386 | $51,068 |
| Pictet Asset Management Holding SA | 2,312,436 | $50,180 |
| BNP PARIBAS ARBITRAGE, SA | 2,294,506 | $49,791 |
| CITADEL ADVISORS LLC | 2,286,001 | $49,606 |
| Invesco Ltd. | 2,281,487 | $49,508 |
| Nuveen, LLC | 2,249,867 | $48,822 |
| ORBIMED ADVISORS LLC | 2,190,907 | $47,543 |
| Whitefort Capital Management, LP | 2,120,000 | $46,004 |
| UBS ASSET MANAGEMENT AMERICAS INC | 2,084,609 | $45,236 |
| DME Capital Management, LP | 2,069,309 | $44,904 |
| NATIONAL BANK OF CANADA /FI/ | 2,040,000 | $44,268 |
| Clearbridge Investments, LLC | 1,972,921 | $42,812 |
| PENN DAVIS MCFARLAND INC | 1,858,289 | $40,325 |
| Woodline Partners LP | 1,750,017 | $37,975 |
| CITIGROUP INC | 1,711,744 | $37,145 |
| Affinity Asset Advisors, LLC | 1,700,000 | $36,890 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 1,672,720 | $36,298 |
| Man Group plc | 1,457,127 | $31,620 |
| BANK OF NOVA SCOTIA | 1,423,000 | $30,879 |
| JANE STREET GROUP, LLC | 1,311,585 | $28,461 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,286,197 | $27,910 |
| MILLENNIUM MANAGEMENT LLC | 1,197,592 | $25,988 |
| First Turn Management, LLC | 1,186,817 | $25,754 |
| Parkside Financial Bank & Trust | 1,166,756 | $25,319 |
| Amundi | 1,043,464 | $22,643 |
| RHUMBLINE ADVISERS | 1,037,631 | $22,517 |
| Davern Capital Partners, LP | 1,028,298 | $22,314 |
| STEMPOINT CAPITAL LP | 966,698 | $20,977 |
| PRINCIPAL FINANCIAL GROUP INC | 941,222 | $20,425 |
| JPMORGAN CHASE & CO | 934,533 | $20,279 |
| Gotham Asset Management, LLC | 925,193 | $20,077 |
| AQR CAPITAL MANAGEMENT LLC | 880,773 | $18,989 |
| Integral Health Asset Management, LLC | 850,000 | $18,445 |
| BARCLAYS PLC | 839,279 | $18,212 |
| Qube Research & Technologies Ltd | 759,219 | $16,475 |
| Swiss National Bank | 740,646 | $16,072 |
| Sofinnova Investments, Inc. | 734,582 | $15,940 |
| Verition Fund Management LLC | 728,997 | $15,819 |
| ALGERT GLOBAL LLC | 706,554 | $15 |
| AMERIPRISE FINANCIAL INC | 645,448 | $14,006 |
| ENVESTNET ASSET MANAGEMENT INC | 641,461 | $13,920 |
| TORONTO DOMINION BANK | 631,004 | $13,693 |
| Prosight Management, LP | 627,162 | $13,609 |
| ROYAL BANK OF CANADA | 613,609 | $13,315 |
| CenterBook Partners LP | 611,833 | $13,277 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 598,515 | $12,967 |
| Legal & General Group Plc | 589,673 | $12,796 |
| ING GROEP NV | 588,400 | $12,768 |
| TD Asset Management Inc | 551,376 | $11,965 |
| Impax Asset Management Group plc | 550,000 | $11,935 |
| ALLIANCEBERNSTEIN L.P. | 542,047 | $11,762 |
| Retirement Systems of Alabama | 525,863 | $11,411 |
| Squarepoint Ops LLC | 516,955 | $11,218 |
| MUFG Securities EMEA plc | 492,000 | $10,676 |
| GILDER GAGNON HOWE & CO LLC | 483,117 | $10,484 |
| PDT Partners, LLC | 464,944 | $10,089 |
| Capricorn Fund Managers Ltd | 445,500 | $9,667 |
| Weiss Asset Management LP | 425,565 | $9,235 |
| D. E. Shaw & Co., Inc. | 395,404 | $8,580 |
| Pier Capital, LLC | 391,061 | $8,486 |
| Dorsey Wright & Associates | 376,106 | $8,162 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 358,559 | $7,781 |
| LPL Financial LLC | 351,467 | $7,627 |
| DekaBank Deutsche Girozentrale | 350,000 | $4 |
| Voleon Capital Management LP | 342,421 | $7,431 |
| Neo Ivy Capital Management | 341,354 | $7,407 |
| WINTON GROUP Ltd | 326,362 | $7,082 |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 325,757 | $7,069 |
| 295 other institutions | 14,220,321 | $275,837 |