PHARVARIS N V

Institution	Shares	Value ($000)
HighVista Strategies LLC	162,370	$4,506
Eversept Partners, LP	439,177	$12,187
STEMPOINT CAPITAL LP	58,389	$1,620
ORBIMED ADVISORS LLC	205,400	$5,700
Trexquant Investment LP	84,353	$2,341
OCCUDO QUANTITATIVE STRATEGIES LP	12,349	$343
SummitTX Capital, L.P.	22,859	$634
ALPS ADVISORS INC	52,592	$1,459
Quadrature Capital Ltd	28,920	$803
Jump Financial, LLC	26,300	$730
TWO SIGMA ADVISERS, LP	89,600	$2,486
Squarepoint Ops LLC	100,359	$2,785
UBS ASSET MANAGEMENT AMERICAS INC	83,947	$2,330
Verition Fund Management LLC	17,898	$497
SUSQUEHANNA INTERNATIONAL GROUP, LLP	61,624	$1,710
Quantbot Technologies LP	4,260	$118
Qube Research & Technologies Ltd	14,706	$408
TEACHER RETIREMENT SYSTEM OF TEXAS	8,911	$247
Zurcher Kantonalbank (Zurich Cantonalbank)	3,979	$110
Mirae Asset Global Investments Co., Ltd.	3,113	$86

Increased Positions (41)

Saturn V Capital Management LP

Value ($000) $31,636 (+43.1%) Shares 1,140,033 (+28.6%)

Patient Square Capital LP

Value ($000) $15,060 (+74.8%) Shares 542,696 (+57.1%)

Ikarian Capital, LLC

Value ($000) $13,510 (+157.7%) Shares 486,856 (+131.7%)

DEERFIELD MANAGEMENT COMPANY, L.P.

Value ($000) $86,748 (+42.4%) Shares 3,126,042 (+28.0%)

Birchview Capital, LP

Value ($000) $828 (+123.6%) Shares 29,847 (+101.0%)

Soleus Capital Management, L.P.

Value ($000) $19,482 (+20.7%) Shares 702,052 (+8.5%)

ADAR1 Capital Management, LLC

Value ($000) $2,373 (+178.8%) Shares 85,528 (+150.6%)

Virtus Investment Advisers, LLC

Value ($000) $306 (+85.4%) Shares 11,011 (+66.7%)

Palumbo Wealth Management LLC

Value ($000) $560 (+34.9%) Shares 20,182 (+21.3%)

TWO SIGMA INVESTMENTS, LP

Value ($000) $5,971 (+2156.4%) Shares 215,188 (+1928.7%)

China Universal Asset Management Co., Ltd.

Value ($000) $290 (+287.0%) Shares 10,438 (+247.9%)

Point72 Asset Management, L.P.

Value ($000) $19,748 (+52.4%) Shares 711,625 (+37.0%)

BOOTHBAY FUND MANAGEMENT, LLC

Value ($000) $4,360 (+29.3%) Shares 157,117 (+16.2%)

D. E. Shaw & Co., Inc.

Value ($000) $7,231 (+1166.3%) Shares 260,572 (+1038.6%)

XTX Topco Ltd

Value ($000) $515 (+151.5%) Shares 18,568 (+126.1%)

SCHRODER INVESTMENT MANAGEMENT GROUP

Value ($000) $4,148 (+1316.2%) Shares 158,019 (+1208.9%)

MILLENNIUM MANAGEMENT LLC

Value ($000) $6,906 (+159.8%) Shares 248,858 (+133.6%)

WELLINGTON MANAGEMENT GROUP LLP

Value ($000) $52,886 (+22.2%) Shares 1,905,793 (+9.9%)

BlackRock, Inc.

Value ($000) $19,662 (+90.2%) Shares 708,558 (+71.0%)

MORGAN STANLEY

Value ($000) $6,891 (+374.1%) Shares 248,334 (+326.2%)

Institution	Prev Shares	Curr Shares	Change
Saturn V Capital Management LP	886,332	1,140,033	+253,701 (+28.6%)
Patient Square Capital LP	345,381	542,696	+197,315 (+57.1%)
Ikarian Capital, LLC	210,165	486,856	+276,691 (+131.7%)
DEERFIELD MANAGEMENT COMPANY, L.P.	2,442,464	3,126,042	+683,578 (+28.0%)
Birchview Capital, LP	14,847	29,847	+15,000 (+101.0%)
Soleus Capital Management, L.P.	647,052	702,052	+55,000 (+8.5%)
ADAR1 Capital Management, LLC	34,124	85,528	+51,404 (+150.6%)
Virtus Investment Advisers, LLC	6,604	11,011	+4,407 (+66.7%)
Palumbo Wealth Management LLC	16,641	20,182	+3,541 (+21.3%)
TWO SIGMA INVESTMENTS, LP	10,607	215,188	+204,581 (+1928.7%)
China Universal Asset Management Co., Ltd.	3,000	10,438	+7,438 (+247.9%)
Point72 Asset Management, L.P.	519,381	711,625	+192,244 (+37.0%)
BOOTHBAY FUND MANAGEMENT, LLC	135,181	157,117	+21,936 (+16.2%)
D. E. Shaw & Co., Inc.	22,886	260,572	+237,686 (+1038.6%)
XTX Topco Ltd	8,213	18,568	+10,355 (+126.1%)
SCHRODER INVESTMENT MANAGEMENT GROUP	12,073	158,019	+145,946 (+1208.9%)
MILLENNIUM MANAGEMENT LLC	106,548	248,858	+142,310 (+133.6%)
WELLINGTON MANAGEMENT GROUP LLP	1,734,743	1,905,793	+171,050 (+9.9%)
BlackRock, Inc.	414,417	708,558	+294,141 (+71.0%)
MORGAN STANLEY	58,263	248,334	+190,071 (+326.2%)

Decreased Positions (16)

Commodore Capital LP

Value ($000) $52,432 (-13.1%) Shares 1,889,445 (-21.9%)

Bain Capital Life Sciences Investors, LLC

Value ($000) $77,758 (-2.0%) Shares 2,802,081 (-11.9%)

Cormorant Asset Management, LP

Value ($000) $30,053 (-11.6%) Shares 1,083,000 (-20.6%)

GREAT POINT PARTNERS LLC

Value ($000) $2,298 (-40.6%) Shares 82,800 (-46.6%)

Octagon Capital Advisors LP

Value ($000) $18,633 (+3.4%) Shares 671,465 (-7.1%)

SPHERA FUNDS MANAGEMENT LTD.

Value ($000) $1,775 (-40.4%) Shares 63,953 (-46.4%)

Kynam Capital Management, LP

Value ($000) $17,771 (+5.5%) Shares 640,395 (-5.1%)

Logos Global Management LP

Value ($000) $2,775 (-25.9%) Shares 100,000 (-33.3%)

BALYASNY ASSET MANAGEMENT L.P.

Value ($000) $13,771 (-11.8%) Shares 496,259 (-20.7%)

Polar Capital Holdings Plc

Value ($000) $6,603 (-0.0%) Shares 237,962 (-10.1%)

TUDOR INVESTMENT CORP ET AL

Value ($000) $889 (-54.3%) Shares 32,028 (-58.9%)

Amundi

Value ($000) $767 (-20.5%) Shares 27,640 (-33.4%)

JPMORGAN CHASE & CO

Value ($000) $609 (-9.9%) Shares 21,942 (-19.0%)

BARCLAYS PLC

Value ($000) $77 (-27.1%) Shares 2,775 (-51.3%)

HRT FINANCIAL LP

Value ($000) $0 (-37.4%) Shares 14,764 (-43.7%)

SBI Securities Co., Ltd.

Value ($000) $0 (-62.7%) Shares 1 (-66.7%)

Institution	Prev Shares	Curr Shares	Change
Commodore Capital LP	2,418,476	1,889,445	-529,031 (-21.9%)
Bain Capital Life Sciences Investors, LLC	3,181,275	2,802,081	-379,194 (-11.9%)
Cormorant Asset Management, LP	1,363,200	1,083,000	-280,200 (-20.6%)
GREAT POINT PARTNERS LLC	155,105	82,800	-72,305 (-46.6%)
Octagon Capital Advisors LP	722,595	671,465	-51,130 (-7.1%)
SPHERA FUNDS MANAGEMENT LTD.	119,406	63,953	-55,453 (-46.4%)
Kynam Capital Management, LP	675,000	640,395	-34,605 (-5.1%)
Logos Global Management LP	150,000	100,000	-50,000 (-33.3%)
BALYASNY ASSET MANAGEMENT L.P.	625,758	496,259	-129,499 (-20.7%)
Polar Capital Holdings Plc	264,693	237,962	-26,731 (-10.1%)
TUDOR INVESTMENT CORP ET AL	77,891	32,028	-45,863 (-58.9%)
Amundi	41,517	27,640	-13,877 (-33.4%)
JPMORGAN CHASE & CO	27,085	21,942	-5,143 (-19.0%)
BARCLAYS PLC	5,700	2,775	-2,925 (-51.3%)
HRT FINANCIAL LP	26,202	14,764	-11,438 (-43.7%)
SBI Securities Co., Ltd.	3	1	-2 (-66.7%)

Exited Positions (6)

Paradigm Biocapital Advisors LP

Value ($000) $45,796 Shares 1,835,494

VR Adviser, LLC

Value ($000) $16,831 Shares 674,599

SILVERARC CAPITAL MANAGEMENT, LLC

Value ($000) $4,588 Shares 183,903

Integral Health Asset Management, LLC

Value ($000) $4,990 Shares 200,000

Woodline Partners LP

Value ($000) $2,495 Shares 100,000

Quarry LP

Value ($000) $11 Shares 442

Institution	Prev Shares	Prev Value ($000)
Paradigm Biocapital Advisors LP	1,835,494	$45,796
VR Adviser, LLC	674,599	$16,831
SILVERARC CAPITAL MANAGEMENT, LLC	183,903	$4,588
Integral Health Asset Management, LLC	200,000	$4,990
Woodline Partners LP	100,000	$2,495
Quarry LP	442	$11