| GENERAL ATLANTIC, L.P. | 8,031,252 | $222,867 |
| FMR LLC | 6,399,158 | $177,577 |
| Foresite Capital Management IV, LLC | 4,778,581 | $132,606 |
| venBio Partners LLC | 4,639,304 | $128,741 |
| VIKING GLOBAL INVESTORS LP | 3,653,310 | $101,379 |
| EQT Fund Management S.a r.l. | 3,424,609 | $95,033 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,126,042 | $86,748 |
| Bain Capital Life Sciences Investors, LLC | 2,802,081 | $77,758 |
| WELLINGTON MANAGEMENT GROUP LLP | 1,905,793 | $52,886 |
| Commodore Capital LP | 1,889,445 | $52,432 |
| Novo Holdings A/S | 1,750,000 | $48,563 |
| Saturn V Capital Management LP | 1,140,033 | $31,636 |
| Cormorant Asset Management, LP | 1,083,000 | $30,053 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 941,605 | $26 |
| 5AM Venture Management, LLC | 797,600 | $22,133 |
| Sofinnova Investments, Inc. | 745,169 | $20,678 |
| Point72 Asset Management, L.P. | 711,625 | $19,748 |
| BlackRock, Inc. | 708,558 | $19,662 |
| Soleus Capital Management, L.P. | 702,052 | $19,482 |
| Octagon Capital Advisors LP | 671,465 | $18,633 |
| Kynam Capital Management, LP | 640,395 | $17,771 |
| Rock Springs Capital Management LP | 623,402 | $17,299 |
| Patient Square Capital LP | 542,696 | $15,060 |
| BALYASNY ASSET MANAGEMENT L.P. | 496,259 | $13,771 |
| Ikarian Capital, LLC | 486,856 | $13,510 |
| Elmind Capital, LP | 475,750 | $13,202 |
| Eversept Partners, LP | 439,177 | $12,187 |
| BAKER BROS. ADVISORS LP | 375,000 | $10,406 |
| D. E. Shaw & Co., Inc. | 260,572 | $7,231 |
| MILLENNIUM MANAGEMENT LLC | 248,858 | $6,906 |
| MORGAN STANLEY | 248,334 | $6,891 |
| Polar Capital Holdings Plc | 237,962 | $6,603 |
| TWO SIGMA INVESTMENTS, LP | 215,188 | $5,971 |
| ORBIMED ADVISORS LLC | 205,400 | $5,700 |
| Kalehua Capital Management LLC | 198,772 | $5,516 |
| Tetragon Partners GP Ltd | 194,612 | $5,400 |
| HighVista Strategies LLC | 162,370 | $4,506 |
| STATE STREET CORP | 161,499 | $4,482 |
| GOLDMAN SACHS GROUP INC | 160,910 | $4,465 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 158,019 | $4,148 |
| BOOTHBAY FUND MANAGEMENT, LLC | 157,117 | $4,360 |
| UBS Group AG | 137,734 | $3,822 |
| CITADEL ADVISORS LLC | 135,069 | $3,748 |
| Alyeska Investment Group, L.P. | 125,000 | $3,469 |
| TD Asset Management Inc | 120,248 | $3,337 |
| Squarepoint Ops LLC | 100,359 | $2,785 |
| Logos Global Management LP | 100,000 | $2,775 |
| TWO SIGMA ADVISERS, LP | 89,600 | $2,486 |
| GEODE CAPITAL MANAGEMENT, LLC | 86,801 | $2,408 |
| ADAR1 Capital Management, LLC | 85,528 | $2,373 |
| Trexquant Investment LP | 84,353 | $2,341 |
| UBS ASSET MANAGEMENT AMERICAS INC | 83,947 | $2,330 |
| GREAT POINT PARTNERS LLC | 82,800 | $2,298 |
| NORTHERN TRUST CORP | 81,035 | $2,249 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 79,890 | $2,097 |
| JANE STREET GROUP, LLC | 73,111 | $2,029 |
| SPHERA FUNDS MANAGEMENT LTD. | 63,953 | $1,775 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 61,624 | $1,710 |
| BNP PARIBAS ARBITRAGE, SA | 59,037 | $1,638 |
| STEMPOINT CAPITAL LP | 58,389 | $1,620 |
| DEUTSCHE BANK AG\ | 56,388 | $1,565 |
| Seven Fleet Capital Management LP | 55,342 | $1,536 |
| ALPS ADVISORS INC | 52,592 | $1,459 |
| Swiss National Bank | 44,757 | $1,242 |
| TUDOR INVESTMENT CORP ET AL | 32,028 | $889 |
| MARSHALL WACE, LLP | 31,832 | $883 |
| Birchview Capital, LP | 29,847 | $828 |
| Quadrature Capital Ltd | 28,920 | $803 |
| Amundi | 27,640 | $767 |
| Jump Financial, LLC | 26,300 | $730 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 23,982 | $666 |
| SummitTX Capital, L.P. | 22,859 | $634 |
| Legal & General Group Plc | 22,666 | $629 |
| JPMORGAN CHASE & CO | 21,942 | $609 |
| PSP Research LLC | 20,511 | $569 |
| Palumbo Wealth Management LLC | 20,182 | $560 |
| BANK OF AMERICA CORP /DE/ | 19,557 | $543 |
| VANGUARD GROUP INC | 19,310 | $536 |
| XTX Topco Ltd | 18,568 | $515 |
| Verition Fund Management LLC | 17,898 | $497 |
| Nuveen, LLC | 17,007 | $472 |
| HRT FINANCIAL LP | 14,764 | $0 |
| Qube Research & Technologies Ltd | 14,706 | $408 |
| OCCUDO QUANTITATIVE STRATEGIES LP | 12,349 | $343 |
| Virtus Investment Advisers, LLC | 11,011 | $306 |
| China Universal Asset Management Co., Ltd. | 10,438 | $290 |
| ALLIANCEBERNSTEIN L.P. | 8,980 | $249 |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 8,911 | $247 |
| Police & Firemen's Retirement System of New Jersey | 8,239 | $229 |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 7,569 | $210 |
| KLP KAPITALFORVALTNING AS | 5,800 | $161 |
| BNP Paribas Investment Partners S.A. | 5,510 | $0 |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P | 5,000 | $139 |
| Quantbot Technologies LP | 4,260 | $118 |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 3,979 | $110 |
| Mirae Asset Global Investments Co., Ltd. | 3,113 | $86 |
| BARCLAYS PLC | 2,775 | $77 |
| CITIGROUP INC | 1,787 | $50 |
| GF FUND MANAGEMENT CO. LTD. | 1,258 | $35 |
| Tower Research Capital LLC (TRC) | 471 | $13 |
| 6 other institutions | 850 | $15 |