GREAT POINT PARTNERS LLC Quant / Systematic

CIK: 0001281446 · Show all filings

Period: Q2 2019 (← Previous) (Next →)

Filing Date: Aug 14, 2019

Total Value ($000): $900,806,000 (100.0% shares, 0.0% debt)

Holdings (30)

IOVA IOVANCE BIOTHERAPEUTICS, INC. 14.3%

Value ($000) $128,995,000 Shares 5,260,803 Est. Cost $9.91 Unrealized +52.0%

PTCT PTC THERAPEUTICS, INC. 9.9%

Value ($000) $88,847,000 Shares 1,974,385 Est. Cost $28.46 Unrealized +38.7%

— ZOGENIX, INC. 8.5%

Value ($000) $76,132,000 Shares 1,593,396 Est. Cost $11839.82 Unrealized —

— AUDENTES THERAPEUTICS, INC. 8.1%

Value ($000) $72,802,000 Shares 1,922,937 Est. Cost $6914.70 Unrealized —

KURA KURA ONCOLOGY, INC. 6.7%

Value ($000) $60,011,000 Shares 3,047,800 Est. Cost $12.67 Unrealized +31.0%

— ACCELERON PHARMA INC 6.6%

Value ($000) $59,537,000 Shares 1,449,300 Est. Cost $18289.17 Unrealized —

ASND ASCENDIS PHARMA AS 6.4%

Value ($000) $57,575,000 Shares 500,000 Est. Cost $19673.19 Unrealized —

— TRICIDA, INC. 6.2%

Value ($000) $56,191,000 Shares 1,423,998 Est. Cost $39460.03 Unrealized —

ACAD ACADIA PHARMACEUTICALS, INC. 4.5%

Value ($000) $40,095,000 Shares 1,500,000 Est. Cost $18.73 Unrealized +36.4%

— MIRATI THERAPEUTICS INC. 3.4%

Value ($000) $30,900,000 Shares 300,000 Est. Cost $103000.00 Unrealized —

— MIRATI THERAPEUTICS INC. 3.4%

Value ($000) $30,900,000 Shares 300,000 Est. Cost $103000.00 Unrealized —

— ZYMEWORKS INC. 2.6%

Value ($000) $23,409,000 Shares 1,064,041 Est. Cost $21698.24 Unrealized —

— RETROPHIN INC. 2.2%

Value ($000) $20,162,000 Shares 1,003,600 Est. Cost $20089.68 Unrealized —

— MIRATII THERAPEUTICS INC. 2.0%

Value ($000) $18,025,000 Shares 175,000 Est. Cost $103000.00 Unrealized —

PRTA PROTHENA CORPORATION PLC 2.0%

Value ($000) $17,718,000 Shares 1,676,250 Est. Cost $10.27 Unrealized 0.0%

— BIOHAVEN PHARMACEUTICAL HOLDING CO LTD. 1.7%

Value ($000) $15,327,000 Shares 350,000 Est. Cost $43791.43 Unrealized —

— MILLENDO THERAPEUTICS, INC. 1.7%

Value ($000) $14,891,000 Shares 1,288,093 Est. Cost $7.95 Unrealized —

— DERMIRA INC. 1.6%

Value ($000) $14,846,000 Shares 1,552,900 Est. Cost $338.76 Unrealized —

— ZOGENIX, INC. 1.6%

Value ($000) $14,334,000 Shares 300,000 Est. Cost $11839.82 Unrealized —

GNFTY GENFIT 1.5%

Value ($000) $13,711,000 Shares 694,253 Est. Cost $24.00 Unrealized —

— MENLO THERAPEUTICS INC. 1.2%

Value ($000) $10,386,000 Shares 1,733,882 Est. Cost $7.51 Unrealized —

— BIOHAVEN PHARMACEUTICAL HOLDING CO. LTD. 1.0%

Value ($000) $8,758,000 Shares 200,000 Est. Cost $43791.43 Unrealized —

— FOAMIX PHARMACEUTICALS LTD 0.6%

Value ($000) $5,022,000 Shares 2,110,071 Est. Cost $7.50 Unrealized —

IOVA IOVANCE BIOTHERAPETUICS, INC. 0.5%

Value ($000) $4,904,000 Shares 200,000 Est. Cost $9.91 Unrealized +52.0%

— MOMENTA PHARMACEUTICALS, INC. 0.5%

Value ($000) $4,259,000 Shares 342,064 Est. Cost $1196.13 Unrealized —

RVLPQ OSMOTICA PHARMACEUTICALS PLC 0.4%

Value ($000) $3,522,000 Shares 926,933 Est. Cost $8.00 Unrealized -58.5%

— PROTEOSTASIS THERAPEUTICS INC. 0.4%

Value ($000) $3,416,000 Shares 3,500,000 Est. Cost $2.98 Unrealized —

— FIVE PRIME THERAPEUTICS, INC. 0.4%

Value ($000) $3,303,000 Shares 547,712 Est. Cost $6226.03 Unrealized —

— ZAFGEN INC. 0.3%

Value ($000) $2,631,000 Shares 2,211,194 Est. Cost $9.93 Unrealized —

— STREAMLINE HEALTH SOLUTNS, INC. 0.0%

Value ($000) $197,000 Shares 130,137 Est. Cost $6.45 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
IOVA	IOVANCE BIOTHERAPEUTICS, INC.	5,260,803	$128,995,000	14.3%	$9.91	+52.0%	COM	462260100
PTCT	PTC THERAPEUTICS, INC.	1,974,385	$88,847,000	9.9%	$28.46	+38.7%	COM	69366J200
—	ZOGENIX, INC.	1,593,396	$76,132,000	8.5%	$11839.82	—	COM	98978L204
—	AUDENTES THERAPEUTICS, INC.	1,922,937	$72,802,000	8.1%	$6914.70	—	COM	05070R104
KURA	KURA ONCOLOGY, INC.	3,047,800	$60,011,000	6.7%	$12.67	+31.0%	COM	50127T109
—	ACCELERON PHARMA INC	1,449,300	$59,537,000	6.6%	$18289.17	—	COM	00434H108
ASND	ASCENDIS PHARMA AS	500,000	$57,575,000	6.4%	$19673.19	—	SPOSORED ADR	04351P101
—	TRICIDA, INC.	1,423,998	$56,191,000	6.2%	$39460.03	—	COM	89610F101
ACAD	ACADIA PHARMACEUTICALS, INC.	1,500,000	$40,095,000	4.5%	$18.73	+36.4%	COM	004225108
—	MIRATI THERAPEUTICS INC.	300,000	$30,900,000	3.4%	$103000.00	—	Put	60468T105
—	MIRATI THERAPEUTICS INC.	300,000	$30,900,000	3.4%	$103000.00	—	COM	60468T105
—	ZYMEWORKS INC.	1,064,041	$23,409,000	2.6%	$21698.24	—	COM	98985W102
—	RETROPHIN INC.	1,003,600	$20,162,000	2.2%	$20089.68	—	COM	761299106
—	MIRATII THERAPEUTICS INC.	175,000	$18,025,000	2.0%	$103000.00	—	Call	60468T105
PRTA	PROTHENA CORPORATION PLC	1,676,250	$17,718,000	2.0%	$10.27	0.0%	COM	G72800108
—	BIOHAVEN PHARMACEUTICAL HOLDING CO LTD.	350,000	$15,327,000	1.7%	$43791.43	—	COM	G11196105
—	MILLENDO THERAPEUTICS, INC.	1,288,093	$14,891,000	1.7%	$7.95	—	COM	60040X103
—	DERMIRA INC.	1,552,900	$14,846,000	1.6%	$338.76	—	COM	24983L104
—	ZOGENIX, INC.	300,000	$14,334,000	1.6%	$11839.82	—	Put	98978L204
GNFTY	GENFIT	694,253	$13,711,000	1.5%	$24.00	—	ADS	372279109
—	MENLO THERAPEUTICS INC.	1,733,882	$10,386,000	1.2%	$7.51	—	COM	586858102
—	BIOHAVEN PHARMACEUTICAL HOLDING CO. LTD.	200,000	$8,758,000	1.0%	$43791.43	—	Put	G11196105
—	FOAMIX PHARMACEUTICALS LTD	2,110,071	$5,022,000	0.6%	$7.50	—	COM	M46135105
IOVA	IOVANCE BIOTHERAPETUICS, INC.	200,000	$4,904,000	0.5%	$9.91	+52.0%	Call	462260100
—	MOMENTA PHARMACEUTICALS, INC.	342,064	$4,259,000	0.5%	$1196.13	—	COM	60877T100
RVLPQ	OSMOTICA PHARMACEUTICALS PLC	926,933	$3,522,000	0.4%	$8.00	-58.5%	COM	G6S41R101
—	PROTEOSTASIS THERAPEUTICS INC.	3,500,000	$3,416,000	0.4%	$2.98	—	COM	74373B109
—	FIVE PRIME THERAPEUTICS, INC.	547,712	$3,303,000	0.4%	$6226.03	—	COM	33830X104
—	ZAFGEN INC.	2,211,194	$2,631,000	0.3%	$9.93	—	COM	98885E103
—	STREAMLINE HEALTH SOLUTNS, INC.	130,137	$197,000	0.0%	$6.45	—	COM	86323X106