GREAT POINT PARTNERS LLC Quant / Systematic

Location: Greenwich, CT

CIK: 0001281446 · Show all filings

Period: Q1 2019 (← Previous) (Next →)

Filing Date: May 14, 2019

Total Value: $1.01B (100.0% shares, 0.0% debt)

Holdings (40)

PTCT PTC THERAPEUTICS INC 6.8%

Value $68.29M Shares 1,814,260 Est. Cost $27.49 Unrealized +22.1%

— ZOGENIX INC 6.5%

Value $65.99M Shares 1,199,545 Est. Cost $39.55 Unrealized —

— GLOBAL BLOOD THERAPEUTICS INC 6.2%

Value $62.46M Shares 1,180,000 Est. Cost $41.05 Unrealized —

— AUDENTES THERAPEUTICS INC 6.1%

Value $61.36M Shares 1,572,618 Est. Cost $21.32 Unrealized —

ACAD ACADIA PHARMACEUTICALS INC 5.3%

Value $53.7M Shares 2,000,000 Est. Cost $18.73 Unrealized +24.7%

IOVA IOVANCE BIOTHERAPEUTICS INC 5.2%

Value $52.95M Shares 5,567,348 Est. Cost $9.91 Unrealized -2.0%

— ACCELERON PHARMA INC 5.0%

Value $50.3M Shares 1,080,113 Est. Cost $10499.23 Unrealized —

ASND ASCENDIS PHARMA AS 4.8%

Value $48.85M Shares 415,000 Est. Cost $117.70 Unrealized —

BCRX BIOCRYST PHARMACEUTICALS 4.8%

Value $48.48M Shares 5,955,762 Est. Cost $5.12 Unrealized +67.3%

— INTERCEPT PHARMACEUTICALS INC 4.4%

Value $44.74M Shares 400,000 Est. Cost — Unrealized —

UTHR UNITED THERAPEUTICS CORP DEL 4.4%

Value $44.58M Shares 379,832 Est. Cost $115.96 Unrealized +0.5%

— ARRAY BIOPHARMA INC 4.3%

Value $43.88M Shares 1,800,000 Est. Cost $14.25 Unrealized —

KURA KURA ONCOLOGY INC 4.3%

Value $43.88M Shares 2,645,100 Est. Cost $12.07 Unrealized +27.7%

PBYI PUMA BIOTECHNOLOGY INC 3.5%

Value $34.91M Shares 900,000 Est. Cost $30.01 Unrealized +1.8%

— FIVE PRIME THERAPEUTICS INC 3.2%

Value $32.14M Shares 2,398,409 Est. Cost $6226.03 Unrealized —

GNFTY GENFIT SA 2.9%

Value $29.53M Shares 1,230,314 Est. Cost $24.00 Unrealized —

— EPIZYME INC 2.7%

Value $26.93M Shares 2,173,913 Est. Cost $12.39 Unrealized —

ASND ASCENDIS PHARMA AS 2.3%

Value $23.54M Shares 200,000 Est. Cost $117.70 Unrealized —

— DERMIRA INC 2.0%

Value $20.32M Shares 1,500,000 Est. Cost $13.55 Unrealized —

— MILLENDO THERAPEUTICS INC 1.9%

Value $19.32M Shares 1,288,093 Est. Cost $7.95 Unrealized —

KRYS KRYSTAL BIOTECH INC 1.6%

Value $16.19M Shares 492,100 Est. Cost $20.94 Unrealized +12.6%

— MENLO THERAPEUTICS INC 1.6%

Value $16.15M Shares 2,057,027 Est. Cost $7.51 Unrealized —

— CYMABAY THERAPEUTICS INC 1.3%

Value $13.27M Shares 998,841 Est. Cost $7.87 Unrealized —

— FIBROGEN INC 1.1%

Value $10.87M Shares 200,000 Est. Cost — Unrealized —

CTMX CYTOMX THERAPEUTICS INC 1.0%

Value $10.31M Shares 959,077 Est. Cost $14.78 Unrealized 0.0%

— BIOHAVEN PHARMACTL HLDG CO 1.0%

Value $10.29M Shares 200,000 Est. Cost — Unrealized —

— FOAMIX PHARMACEUTICALS LTD 1.0%

Value $10.11M Shares 2,697,133 Est. Cost $7.50 Unrealized —

— ZAFGEN INC 0.8%

Value $8.524M Shares 3,110,874 Est. Cost $9.93 Unrealized —

— DERMIRA INC 0.7%

Value $7.524M Shares 555,300 Est. Cost $13.55 Unrealized —

RVLPQ OSMOTICA PHARMACEUTICALS PLC 0.5%

Value $5.4M Shares 1,500,000 Est. Cost $8.00 Unrealized -8.0%

— ARRAY BIOPHARMA INC 0.5%

Value $4.876M Shares 200,000 Est. Cost $14.25 Unrealized —

SVRA SAVARA INC 0.5%

Value $4.867M Shares 660,366 Est. Cost $11.29 Unrealized -33.2%

— MOMENTA PHARMACEUTICALS INC 0.4%

Value $4.498M Shares 309,564 Est. Cost $14.53 Unrealized —

— PROTEOSTASIS THERAPEUTICS INC 0.4%

Value $4.41M Shares 3,500,000 Est. Cost $2.98 Unrealized —

— NOVAVAX INC 0.2%

Value $2.479M Shares 4,500,000 Est. Cost — Unrealized —

— SOLID BIOSCIENCES INC 0.2%

Value $1.84M Shares 200,000 Est. Cost — Unrealized —

— NOVAVAX INC 0.1%

Value $1.102M Shares 2,000,000 Est. Cost — Unrealized —

AKBA AKEBIA THERAPEUTICS INC 0.1%

Value $1.077M Shares 131,531 Est. Cost $6.86 Unrealized 0.0%

— ZYMEWORKS INC 0.0%

Value $236K Shares 14,610 Est. Cost $16.15 Unrealized —

— STREAMLINE HEALTH SOLUTIONS 0.0%

Value $137K Shares 130,137 Est. Cost $6.45 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
PTCT	PTC THERAPEUTICS INC	1,814,260	$68.29M	6.8%	$27.49	+22.1%	COM	69366J200
—	ZOGENIX INC	1,199,545	$65.99M	6.5%	$39.55	—	COM	98978L204
—	GLOBAL BLOOD THERAPEUTICS INC	1,180,000	$62.46M	6.2%	$41.05	—	COM	37890U108
—	AUDENTES THERAPEUTICS INC	1,572,618	$61.36M	6.1%	$21.32	—	COM	05070R104
ACAD	ACADIA PHARMACEUTICALS INC	2,000,000	$53.7M	5.3%	$18.73	+24.7%	COM	004225108
IOVA	IOVANCE BIOTHERAPEUTICS INC	5,567,348	$52.95M	5.2%	$9.91	-2.0%	COM	462260100
—	ACCELERON PHARMA INC	1,080,113	$50.3M	5.0%	$10499.23	—	COM	00434H108
ASND	ASCENDIS PHARMA AS	415,000	$48.85M	4.8%	$117.70	—	SPONSORED ADR	04351P101
BCRX	BIOCRYST PHARMACEUTICALS	5,955,762	$48.48M	4.8%	$5.12	+67.3%	COM	09058V103
—	INTERCEPT PHARMACEUTICALS INC	400,000	$44.74M	4.4%	—	—	Put	45845P108
UTHR	UNITED THERAPEUTICS CORP DEL	379,832	$44.58M	4.4%	$115.96	+0.5%	COM	91307C102
—	ARRAY BIOPHARMA INC	1,800,000	$43.88M	4.3%	$14.25	—	COM	04269X105
KURA	KURA ONCOLOGY INC	2,645,100	$43.88M	4.3%	$12.07	+27.7%	COM	50127T109
PBYI	PUMA BIOTECHNOLOGY INC	900,000	$34.91M	3.5%	$30.01	+1.8%	COM	74587V107
—	FIVE PRIME THERAPEUTICS INC	2,398,409	$32.14M	3.2%	$6226.03	—	COM	33830X104
GNFTY	GENFIT SA	1,230,314	$29.53M	2.9%	$24.00	—	ADS	372279109
—	EPIZYME INC	2,173,913	$26.93M	2.7%	$12.39	—	COM	29428V104
ASND	ASCENDIS PHARMA AS	200,000	$23.54M	2.3%	$117.70	—	Put	04351P101
—	DERMIRA INC	1,500,000	$20.32M	2.0%	$13.55	—	COM	24983L104
—	MILLENDO THERAPEUTICS INC	1,288,093	$19.32M	1.9%	$7.95	—	COM	60040X103
KRYS	KRYSTAL BIOTECH INC	492,100	$16.19M	1.6%	$20.94	+12.6%	COM	501147102
—	MENLO THERAPEUTICS INC	2,057,027	$16.15M	1.6%	$7.51	—	COM	586858102
—	CYMABAY THERAPEUTICS INC	998,841	$13.27M	1.3%	$7.87	—	COM	23257D103
—	FIBROGEN INC	200,000	$10.87M	1.1%	—	—	Put	31572Q808
CTMX	CYTOMX THERAPEUTICS INC	959,077	$10.31M	1.0%	$14.78	0.0%	COM	23284F105
—	BIOHAVEN PHARMACTL HLDG CO	200,000	$10.29M	1.0%	—	—	Put	G11196105
—	FOAMIX PHARMACEUTICALS LTD	2,697,133	$10.11M	1.0%	$7.50	—	SHS	M46135105
—	ZAFGEN INC	3,110,874	$8.524M	0.8%	$9.93	—	COM	98885E103
—	DERMIRA INC	555,300	$7.524M	0.7%	$13.55	—	Put	24983L104
RVLPQ	OSMOTICA PHARMACEUTICALS PLC	1,500,000	$5.4M	0.5%	$8.00	-8.0%	SHS	G6S41R101
—	ARRAY BIOPHARMA INC	200,000	$4.876M	0.5%	$14.25	—	Call	04269X105
SVRA	SAVARA INC	660,366	$4.867M	0.5%	$11.29	-33.2%	COM	805111101
—	MOMENTA PHARMACEUTICALS INC	309,564	$4.498M	0.4%	$14.53	—	COM	60877T100
—	PROTEOSTASIS THERAPEUTICS INC	3,500,000	$4.41M	0.4%	$2.98	—	COM	74373B109
—	NOVAVAX INC	4,500,000	$2.479M	0.2%	—	—	Call	670002104
—	SOLID BIOSCIENCES INC	200,000	$1.84M	0.2%	—	—	Call	83422E105
—	NOVAVAX INC	2,000,000	$1.102M	0.1%	—	—	Put	670002104
AKBA	AKEBIA THERAPEUTICS INC	131,531	$1.077M	0.1%	$6.86	0.0%	COM	00972D105
—	ZYMEWORKS INC	14,610	$236K	0.0%	$16.15	—	COM	98985W102
—	STREAMLINE HEALTH SOLUTIONS	130,137	$137K	0.0%	$6.45	—	COM	86323X106