GREAT POINT PARTNERS LLC Quant / Systematic

CIK: 0001281446 · Show all filings

Period: Q3 2019 (← Previous) (Next →)

Filing Date: Nov 15, 2019

Total Value ($000): $1,088,642 (100.0% shares, 0.0% debt)

Holdings (41)

IOVA IOVANCE BIOTHERAPEUTICS, INC 8.8%

Value ($000) $95,747 Shares 5,260,803 Est. Cost $9.91 Unrealized +123.2%

— ZOGENIX, INC. 7.4%

Value ($000) $80,080 Shares 2,000,000 Est. Cost $9440.90 Unrealized —

ACAD ACADIA PHARMACEUTICALS, INC. 7.2%

Value ($000) $78,845 Shares 2,190,742 Est. Cost $22.38 Unrealized +35.5%

— AUDENTES THERAPEUTICS, INC. 6.4%

Value ($000) $69,804 Shares 2,485,000 Est. Cost $5357.07 Unrealized —

PTCT PTC THERAPEUTICS, INC. 6.2%

Value ($000) $67,640 Shares 2,000,000 Est. Cost $28.65 Unrealized +51.9%

— ZYMEWORKS INC 5.6%

Value ($000) $61,175 Shares 2,466,744 Est. Cost $9373.73 Unrealized —

— ACCELERON PHARMA INC 5.3%

Value ($000) $57,475 Shares 1,454,700 Est. Cost $18289.17 Unrealized —

— The Medicines Company 4.6%

Value ($000) $50,000 Shares 1,000,000 Est. Cost — Unrealized —

KURA KURA ONCOLOGY, INC 4.3%

Value ($000) $46,815 Shares 3,086,053 Est. Cost $12.73 Unrealized +39.8%

PEN PENUMBRA INC 3.7%

Value ($000) $40,347 Shares 300,000 Est. Cost $154.70 Unrealized 0.0%

— NEKTAR THERAPEUTICS 3.6%

Value ($000) $38,707 Shares 2,125,000 Est. Cost $18.22 Unrealized —

ASND ASCENDIS PHARMA AS 3.5%

Value ($000) $38,528 Shares 400,000 Est. Cost $19673.19 Unrealized —

UTHR UNITED THERAPEUTICS CORP 3.4%

Value ($000) $37,483 Shares 470,000 Est. Cost $80.53 Unrealized 0.0%

ASND ASCENDIS PHARMA AS 2.7%

Value ($000) $28,896 Shares 300,000 Est. Cost $19673.19 Unrealized —

— Mirati Therapeutics, Inc. 2.1%

Value ($000) $23,373 Shares 300,000 Est. Cost $103000.00 Unrealized —

— MIRATI THERAPEUTICS INC 2.1%

Value ($000) $23,373 Shares 300,000 Est. Cost $103000.00 Unrealized —

DXCM DEXCOM, INC 2.1%

Value ($000) $22,575 Shares 151,264 Est. Cost $38.85 Unrealized 0.0%

— RETROPHIN INC 1.9%

Value ($000) $20,167 Shares 1,740,000 Est. Cost $11592.26 Unrealized —

— TRICIDA, INC. 1.7%

Value ($000) $18,118 Shares 586,929 Est. Cost $39460.03 Unrealized —

— DERMIRA INC 1.5%

Value ($000) $16,750 Shares 2,621,333 Est. Cost $203.29 Unrealized —

PRTA PROTHENA CORPORATION PLC 1.5%

Value ($000) $16,198 Shares 2,066,041 Est. Cost $10.01 Unrealized -11.2%

IONS IONIS PHARMACEUTICALS, INC. 1.5%

Value ($000) $16,176 Shares 270,000 Est. Cost $65.17 Unrealized 0.0%

TNDM TANDEM DIABETES CARE, INC. 1.4%

Value ($000) $14,745 Shares 250,000 Est. Cost $63.83 Unrealized 0.0%

— Mirati Therapeutics, Inc. 1.3%

Value ($000) $13,634 Shares 175,000 Est. Cost $103000.00 Unrealized —

— MOMENTA PHARMACEUTICALS, INC. 1.2%

Value ($000) $12,960 Shares 1,000,000 Est. Cost $417.68 Unrealized —

GNFTY GENFIT ADR 1.1%

Value ($000) $11,935 Shares 685,553 Est. Cost $24.00 Unrealized —

— ZOGENIX, INC. 0.9%

Value ($000) $10,010 Shares 250,000 Est. Cost $9440.90 Unrealized —

— ALLAKOS, INC. 0.9%

Value ($000) $9,829 Shares 125,000 Est. Cost $78.63 Unrealized —

— SILK ROAD MEDICAL INC 0.9%

Value ($000) $9,823 Shares 301,979 Est. Cost $32.53 Unrealized —

— MILLENDO THERAPEUTICS, INC 0.8%

Value ($000) $9,158 Shares 1,288,093 Est. Cost $7.95 Unrealized —

— TURNING POINT THERAPEUTICS, INC. 0.8%

Value ($000) $8,356 Shares 222,222 Est. Cost $37.60 Unrealized —

— MENLO THERAPEUTICS INC. 0.7%

Value ($000) $7,401 Shares 1,652,013 Est. Cost $7.51 Unrealized —

— ABEONA THERAPEUTICS INC 0.7%

Value ($000) $7,312 Shares 3,235,601 Est. Cost $2.26 Unrealized —

— ATARA BIOTHERAP 0.6%

Value ($000) $7,060 Shares 500,000 Est. Cost $14.12 Unrealized —

EXEL EXELIXIS, INC 0.5%

Value ($000) $5,477 Shares 309,700 Est. Cost $20.24 Unrealized 0.0%

AXSM Axsome Therapeutics, Inc 0.4%

Value ($000) $4,048 Shares 200,000 Est. Cost — Unrealized —

IOVA IOVANCE BIOTHERAPEUTICS, INC 0.3%

Value ($000) $3,640 Shares 200,000 Est. Cost $9.91 Unrealized +123.2%

— PROTEOSTASIS THERAPEUTICS INC. 0.3%

Value ($000) $2,958 Shares 3,500,000 Est. Cost $2.98 Unrealized —

— MYOVANT SCIENCES LTD 0.2%

Value ($000) $1,690 Shares 325,000 Est. Cost $5.20 Unrealized —

OPK OPKO HEALTH INC 0.0%

Value ($000) $193 Shares 92,140 Est. Cost $2.04 Unrealized 0.0%

— STREAMLINE HEALTH SOLUTNS, INC 0.0%

Value ($000) $141 Shares 130,137 Est. Cost $6.45 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
IOVA	IOVANCE BIOTHERAPEUTICS, INC	5,260,803	$95,747	8.8%	$9.91	+123.2%	COM	462260100
—	ZOGENIX, INC.	2,000,000	$80,080	7.4%	$9440.90	—	COM	98978L204
ACAD	ACADIA PHARMACEUTICALS, INC.	2,190,742	$78,845	7.2%	$22.38	+35.5%	COM	004225108
—	AUDENTES THERAPEUTICS, INC.	2,485,000	$69,804	6.4%	$5357.07	—	COM	05070R104
PTCT	PTC THERAPEUTICS, INC.	2,000,000	$67,640	6.2%	$28.65	+51.9%	COM	69366J200
—	ZYMEWORKS INC	2,466,744	$61,175	5.6%	$9373.73	—	COM	98985W102
—	ACCELERON PHARMA INC	1,454,700	$57,475	5.3%	$18289.17	—	COM	00434H108
—	The Medicines Company	1,000,000	$50,000	4.6%	—	—	Call	584688105
KURA	KURA ONCOLOGY, INC	3,086,053	$46,815	4.3%	$12.73	+39.8%	COM	50127T109
PEN	PENUMBRA INC	300,000	$40,347	3.7%	$154.70	0.0%	COM	70975L107
—	NEKTAR THERAPEUTICS	2,125,000	$38,707	3.6%	$18.22	—	COM	640268108
ASND	ASCENDIS PHARMA AS	400,000	$38,528	3.5%	$19673.19	—	Call	04351P101
UTHR	UNITED THERAPEUTICS CORP	470,000	$37,483	3.4%	$80.53	0.0%	COM	91307C102
ASND	ASCENDIS PHARMA AS	300,000	$28,896	2.7%	$19673.19	—	SPONSORED ADR	04351P101
—	Mirati Therapeutics, Inc.	300,000	$23,373	2.1%	$103000.00	—	Put	60468T105
—	MIRATI THERAPEUTICS INC	300,000	$23,373	2.1%	$103000.00	—	COM	60468T105
DXCM	DEXCOM, INC	151,264	$22,575	2.1%	$38.85	0.0%	COM	252131107
—	RETROPHIN INC	1,740,000	$20,167	1.9%	$11592.26	—	COM	761299106
—	TRICIDA, INC.	586,929	$18,118	1.7%	$39460.03	—	COM	89610F101
—	DERMIRA INC	2,621,333	$16,750	1.5%	$203.29	—	COM	24983L104
PRTA	PROTHENA CORPORATION PLC	2,066,041	$16,198	1.5%	$10.01	-11.2%	COM	G72800108
IONS	IONIS PHARMACEUTICALS, INC.	270,000	$16,176	1.5%	$65.17	0.0%	COM	462222100
TNDM	TANDEM DIABETES CARE, INC.	250,000	$14,745	1.4%	$63.83	0.0%	COM	875372203
—	Mirati Therapeutics, Inc.	175,000	$13,634	1.3%	$103000.00	—	Call	60468T105
—	MOMENTA PHARMACEUTICALS, INC.	1,000,000	$12,960	1.2%	$417.68	—	COM	60877T100
GNFTY	GENFIT ADR	685,553	$11,935	1.1%	$24.00	—	COM	372279109
—	ZOGENIX, INC.	250,000	$10,010	0.9%	$9440.90	—	Call	98978L204
—	ALLAKOS, INC.	125,000	$9,829	0.9%	$78.63	—	COM	01671P100
—	SILK ROAD MEDICAL INC	301,979	$9,823	0.9%	$32.53	—	COM	82710M100
—	MILLENDO THERAPEUTICS, INC	1,288,093	$9,158	0.8%	$7.95	—	COM	60040X103
—	TURNING POINT THERAPEUTICS, INC.	222,222	$8,356	0.8%	$37.60	—	COM	90041T108
—	MENLO THERAPEUTICS INC.	1,652,013	$7,401	0.7%	$7.51	—	COM	586858102
—	ABEONA THERAPEUTICS INC	3,235,601	$7,312	0.7%	$2.26	—	COM	00289Y107
—	ATARA BIOTHERAP	500,000	$7,060	0.6%	$14.12	—	COM	046513107
EXEL	EXELIXIS, INC	309,700	$5,477	0.5%	$20.24	0.0%	COM	30161Q104
AXSM	Axsome Therapeutics, Inc	200,000	$4,048	0.4%	—	—	Call	05464T104
IOVA	IOVANCE BIOTHERAPEUTICS, INC	200,000	$3,640	0.3%	$9.91	+123.2%	Call	462260100
—	PROTEOSTASIS THERAPEUTICS INC.	3,500,000	$2,958	0.3%	$2.98	—	COM	74373B109
—	MYOVANT SCIENCES LTD	325,000	$1,690	0.2%	$5.20	—	COM	G637AM102
OPK	OPKO HEALTH INC	92,140	$193	0.0%	$2.04	0.0%	COM	68375N103
—	STREAMLINE HEALTH SOLUTNS, INC	130,137	$141	0.0%	$6.45	—	COM	86323X106