Location: New York, NY
CIK: 0001224962 · Show all filings
Period: Q1 2026 (← Previous) (Next →)
Filing Date: May 29, 2026
Total Value: $5.118B (99.7% shares, 0.3% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| PRAX | PRAXIS PRECISION MEDICINES I | 2,035,986 | $656M | 12.8% | $322.19 * | $83.83 | +272.0% | COM NEW | 74006W207 |
| CELC | CELCUITY INC | 3,127,200 | $357M | 7.0% | $114.14 * | $29.05 | +269.9% | COM | 15102K100 |
| ASND | ASCENDIS PHARMA A/S | 1,531,421 | $350M | 6.8% | $228.73 | $191.21 | — | SPONSORED ADR | 04351P101 |
| ROIV | ROIVANT SCIENCES LTD | 8,285,461 | $230M | 4.5% | $27.70 * | $12.73 | +89.8% | SHS | G76279101 |
| CNTA | CENTESSA PHARMACEUTICALS PLC | 5,258,903 | $209M | 4.1% | $39.72 | $28.79 | — | SPONSORED ADS | 152309100 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 2,373,795 | $206M | 4.0% | $86.97 * | $92.51 | +11.2% | COM | 76243J105 |
| SYRE | SPYRE THERAPEUTICS INC | 3,783,225 | $191M | 3.7% | $50.44 * | $24.71 | +39.7% | COM NEW | 00773J202 |
| NUVL | NUVALENT INC | 1,580,505 | $162M | 3.2% | $102.45 | $46.66 | +122.1% | COM | 670703107 |
| EWTX | EDGEWISE THERAPEUTICS INC | 4,423,974 | $139M | 2.7% | $31.50 * | $22.18 | +27.1% | COM | 28036F105 |
| PTGX | PROTAGONIST THERAPEUTICS INC | 1,230,879 | $130M | 2.5% | $105.40 * | $39.65 | +110.1% | COM | 74366E102 |
| APGE | APOGEE THERAPEUTICS INC | 1,540,384 | $130M | 2.5% | $84.17 * | $42.68 | +69.2% | COM | 03770N101 |
| TVTX | TRAVERE THERAPEUTICS INC | 4,142,551 | $123M | 2.4% | $29.71 * | $19.92 | +55.8% | COM | 89422G107 |
| AMLX | AMYLYX PHARMACEUTICALS INC | 8,284,882 | $115M | 2.3% | $13.90 | $4.53 | +208.8% | COM | 03237H101 |
| IMTX | IMMATICS N.V | 10,383,456 | $102M | 2.0% | $9.84 | $10.60 | -7.4% | SHS | N44445109 |
| RLAY | RELAY THERAPEUTICS INC | 9,751,141 | $97.02M | 1.9% | $9.95 * | $8.07 | +2.8% | COM | 75943R102 |
| INBX | INHIBRX BIOSCIENCES INC | 1,442,707 | $96.99M | 1.9% | $67.23 * | $22.31 | +248.5% | COM | 45720N103 |
| MGTX | MEIRAGTX HLDGS PLC | 10,326,103 | $89.31M | 1.7% | $8.65 * | $10.52 | -27.6% | COM | G59665102 |
| ZYME | ZYMEWORKS INC | 3,510,078 | $87.89M | 1.7% | $25.04 * | $15.32 | +52.5% | COM | 98985Y108 |
| SLDB | SOLID BIOSCIENCES INC | 11,906,646 | $85.73M | 1.7% | $7.20 * | $6.40 | -5.5% | COM NEW | 83422E204 |
| DYN | DYNE THERAPEUTICS INC | 4,668,839 | $84.65M | 1.7% | $18.13 * | $18.63 | -8.1% | COM | 26818M108 |
| BCRX | BIOCRYST PHARMACEUTICALS INC | 7,434,033 | $70.77M | 1.4% | $9.52 * | $7.10 | -1.4% | COM | 09058V103 |
| ORKA | ORUKA THERAPEUTICS INC | 1,395,501 | $68.45M | 1.3% | $49.05 * | $16.66 | +94.8% | COM | 687604108 |
| AORT | ARTIVION INC | 1,637,290 | $59.96M | 1.2% | $36.62 * | $19.16 | +114.9% | COM | 228903100 |
| NRIX | NURIX THERAPEUTICS INC | 3,710,877 | $57.52M | 1.1% | $15.50 * | $14.07 | +23.2% | COM | 67080M103 |
| MRNA | MODERNA INC | 1,000,000 | $50.8M | 1.0% | $50.80 | — | — | Put | 60770K107 |
| NAUT | NAUTILUS BIOTECHNOLOGY INC | 12,594,211 | $48.87M | 1.0% | $3.88 * | $8.54 | -74.1% | COM | 63909J108 |
| CTMX | CYTOMX THERAPEUTICS INC. | 10,098,824 | $47.46M | 0.9% | $4.70 * | $1.93 | +170.5% | COM | 23284F105 |
| ANRO | ALTO NEUROSCIENCE INC | 2,009,893 | $45.18M | 0.9% | $22.48 * | $12.34 | +35.8% | COM SHS | 02157Q109 |
| ENGN | ENGENE HOLDINGS INC | 5,827,506 | $39.69M | 0.8% | $6.81 * | $6.78 | +42.5% | COM | 29286M105 |
| IMVT | IMMUNOVANT INC | 1,597,383 | $39.68M | 0.8% | $24.84 * | $23.20 | +13.2% | COM | 45258J102 |
| ISRG | INTUITIVE SURGICAL INC | 85,419 | $39.38M | 0.8% | $460.99 * | $443.22 | +17.5% | COM NEW | 46120E602 |
| IONS | IONIS PHARMACEUTICALS INC | 504,000 | $37.85M | 0.7% | $75.09 * | $81.81 | 0.0% | COM | 462222100 |
| DAWN | DAY ONE BIOPHARMACEUTICALS I | 1,755,799 | $37.64M | 0.7% | $21.44 * | $11.02 | 0.0% | COM | 23954D109 |
| ABVX | ABIVAX SA | 328,884 | $36.62M | 0.7% | $111.35 | $92.50 | — | SPONSORED ADS | 00370M103 |
| CRVS | CORVUS PHARMACEUTICALS INC | 2,292,441 | $33.54M | 0.7% | $14.63 * | $12.47 | +30.6% | COM | 221015100 |
| RGEN | REPLIGEN CORP | 280,541 | $33.05M | 0.6% | $117.82 * | $140.51 | +8.5% | COM | 759916109 |
| JAZZ | JAZZ PHARMACEUTICALS PLC | 170,000 | $32.14M | 0.6% | $189.05 * | $153.31 | +10.3% | SHS USD | G50871105 |
| GLTO | DAMORA THERAPEUTICS INC | 1,223,000 | $31.68M | 0.6% | $25.90 | $25.80 | 0.0% | COM NEW | 36322Q206 |
| XFOR | X4 PHARMACEUTICALS INC | 6,737,648 | $27.83M | 0.5% | $4.13 * | $3.63 | +0.1% | COM NEW | 98420X202 |
| GH | GUARDANT HEALTH INC | 300,000 | $27.71M | 0.5% | $92.37 * | $97.86 | +9.8% | COM | 40131M109 |
| DRUG | BRIGHT MINDS BIOSCIENCES INC | 377,544 | $27.55M | 0.5% | $72.97 * | $35.55 | +136.3% | COM NEW | 10919W405 |
| IVVD | INVIVYD INC | 20,859,303 | $27.12M | 0.5% | $1.30 * | $2.08 | -4.9% | COM | 00534A102 |
| SION | SIONNA THERAPEUTICS INC | 658,439 | $26.4M | 0.5% | $40.09 * | $16.34 | +140.2% | COM | 829401108 |
| AXSM | AXSOME THERAPEUTICS INC. | 149,950 | $25.34M | 0.5% | $169.02 * | $77.79 | +131.7% | COM | 05464T104 |
| RVMD | REVOLUTION MEDICINES INC | 258,600 | $25.15M | 0.5% | $97.25 * | $103.02 | 0.0% | COM | 76155X100 |
| SABS | SAB BIOTHERAPEUTICS INC | 6,431,743 | $24.63M | 0.5% | $3.83 * | $3.91 | +2.3% | COM NEW | 78397T202 |
| BLTE | BELITE BIO INC | 151,979 | $24.23M | 0.5% | $159.44 | $149.63 | — | SPONSORED ADS | 07782B104 |
| TENX | TENAX THERAPEUTICS INC | 1,447,782 | $23.15M | 0.5% | $15.99 * | $12.04 | +12.1% | COM NEW | 88032L605 |
| AXGN | AXOGEN INC | 697,312 | $23.1M | 0.5% | $33.13 | $24.59 | +35.4% | COM | 05463X106 |
| VRDN | VIRIDIAN THERAPEUTICS INC | 1,170,829 | $22.9M | 0.4% | $19.56 * | $22.91 | +34.6% | COM | 92790C104 |
| OBIO | ORCHESTRA BIOMED HLDGS INC | 5,037,906 | $21.41M | 0.4% | $4.25 * | $8.01 | -48.5% | COM | 68572M106 |
| RAPP | RAPPORT THERAPEUTICS INC | 673,923 | $21.09M | 0.4% | $31.29 * | $21.78 | +27.8% | COM | 75383L102 |
| DBVT | DBV TECHNOLOGIES S A | 964,391 | $20.15M | 0.4% | $20.89 | $20.89 | — | SPONSORED ADS | 23306J309 |
| LONA | LEONABIO INC | 1,859,322 | $19.11M | 0.4% | $10.28 * | $4.39 | +28.1% | COM | 04746L203 |
| AVR | ANTERIS TECHNOLOGIES GLOBAL | 3,425,476 | $19.01M | 0.4% | $5.55 | $5.59 | -0.1% | COM | 03675P102 |
| STRO | SUTRO BIOPHARMA INC | 715,307 | $17.82M | 0.3% | $24.91 * | $15.08 | 0.0% | COM SHS | 869367201 |
| TNGX | TANGO THERAPEUTICS INC | 808,153 | $16.91M | 0.3% | $20.92 * | $9.82 | +21.3% | COM | 87583X109 |
| CTNM | CONTINEUM THERAPEUTICS INC | 1,255,592 | $16.4M | 0.3% | $13.06 * | $13.62 | -1.9% | CL A | 21217B100 |
| — | CELCUITY INC | 6,500,000 | $15.88M | 0.3% | $2.44 | $1.34 | — | NOTE 2.750% 8/0 | 15102KAA8 |
| PALI | PALISADE BIO INC | 8,928,149 | $15.62M | 0.3% | $1.75 | $1.92 | -7.2% | COM | 696389402 |
| OCS | OCULIS HOLDING AG | 493,827 | $13.13M | 0.3% | $26.59 | $20.00 | +32.4% | ORDINARY SHARES | H5870P102 |
| IRTC | IRHYTHM HOLDINGS INC | 105,026 | $12.4M | 0.2% | $118.02 * | $158.94 | -0.2% | COM | 450056106 |
| ADGM | ADAGIO MED HLDGS INC | 9,876,576 | $11.01M | 0.2% | $1.11 * | $4.76 | -79.4% | COM | 00534B100 |
| EVMN | EVOMMUNE INC | 448,350 | $10.31M | 0.2% | $22.99 * | $21.99 | 0.0% | COM SHS | 30054Y107 |
| PHAT | PHATHOM PHARMACEUTICALS INC | 925,000 | $10.28M | 0.2% | $11.11 * | $13.69 | 0.0% | COM | 71722W107 |
| NMRA | NEUMORA THERAPEUTICS INC. | 5,104,097 | $9.953M | 0.2% | $1.95 * | $2.46 | 0.0% | COM | 640979100 |
| OMDA | OMADA HEALTH INC | 786,330 | $9.884M | 0.2% | $12.57 * | $17.31 | -19.3% | COM | 68170A108 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 65,050 | $8.57M | 0.2% | $131.74 | $124.99 | +7.5% | COM | 64125C109 |
| BBNX | BETA BIONICS INC | 842,944 | $8.446M | 0.2% | $10.02 * | $21.31 | -19.8% | COM | 08659B102 |
| IRD | OPUS GENETICS INC | 1,835,842 | $8.353M | 0.2% | $4.55 * | $1.12 | +145.5% | COM | 67577R102 |
| BLLN | BILLIONTOONE INC | 91,812 | $7.248M | 0.1% | $78.94 * | $98.39 | -11.7% | CL A | 090168105 |
| TWST | TWIST BIOSCIENCE CORP | 150,000 | $7.128M | 0.1% | $47.52 * | $44.18 | 0.0% | COM | 90184D100 |
| SRZN | SURROZEN INC | 229,393 | $6.682M | 0.1% | $29.13 * | $22.23 | 0.0% | COM NEW | 86889P208 |
| AGMB | AGOMAB THERAPEUTICS NV | 600,000 | $6.294M | 0.1% | $10.49 | $10.49 | — | SPONSORED ADS | 00860C102 |
| EOLS | EVOLUS INC | 1,286,862 | $5.289M | 0.1% | $4.11 * | $4.90 | 0.0% | COM | 30052C107 |
| COGT | COGENT BIOSCIENCES INC | 121,082 | $4.66M | 0.1% | $38.49 * | $28.11 | +32.9% | COM | 19240Q201 |
| OCUL | OCULAR THERAPEUTIX INC | 500,000 | $4.235M | 0.1% | $8.47 | — | — | Call | 67576A100 |
| ADMA | ADMA BIOLOGICS INC | 467,233 | $4.21M | 0.1% | $9.01 * | $8.62 | +96.6% | COM | 000899104 |
| IKT | INHIBIKASE THERAPEUTICS INC | 2,315,000 | $3.889M | 0.1% | $1.68 * | $2.49 | -30.5% | COM NEW | 45719W205 |
| CBIO | CRESCENT BIOPHARMA INC. | 206,942 | $3.802M | 0.1% | $18.37 * | $21.15 | -47.7% | COM | G2545C104 |
| APLS | APELLIS PHARMACEUTICALS INC | 80,956 | $3.257M | 0.1% | $40.23 * | $22.69 | 0.0% | COM | 03753U106 |
| OM | OUTSET MED INC | 833,333 | $3.2M | 0.1% | $3.84 * | $11.92 | -62.3% | COM NEW | 690145206 |
| EDSA | EDESA BIOTECH INC | 563,239 | $2.946M | 0.1% | $5.23 * | $1.28 | 0.0% | COM NEW | 27966L306 |
| ADPT | ADAPTIVE BIOTECHNOLOGIES COR | 152,500 | $2.117M | 0.0% | $13.88 * | $16.99 | 0.0% | COM | 00650F109 |
| AVTX | AVALO THERAPEUTICS INC | 139,667 | $2.085M | 0.0% | $14.93 * | $7.58 | +104.5% | COM NEW | 05338F306 |
| CNTB | CONNECT BIOPHARMA HLDGS LTD | 792,696 | $2.077M | 0.0% | $2.62 * | $2.13 | +16.2% | SHS | G23549101 |
| CORT | CORCEPT THERAPEUTICS INC | 50,000 | $2.015M | 0.0% | $40.31 * | $38.80 | 0.0% | COM | 218352102 |
| MDLN | MEDLINE INC | 28,000 | $1.246M | 0.0% | $44.50 | $42.23 | +6.2% | COM CL A | 58507V107 |
| PTN | PALATIN TECHNOLOGIES INC | 61,945 | $1.079M | 0.0% | $17.42 | $13.14 | +32.8% | COM NEW | 696077601 |
| CPIX | CUMBERLAND PHARMACEUTICALS I | 196,978 | $640K | 0.0% | $3.25 * | $2.96 | +39.5% | COM | 230770109 |
| RVMDW | REVOLUTION MEDICINES INC | 250,000 | $448K | 0.0% | $1.79 | $0.33 | — | *W EXP 12/17/202 | 76155X118 |
| XGN | EXAGEN INC | 114,893 | $345K | 0.0% | $3.00 * | $4.33 | 0.0% | COM | 30068X103 |
| ENSC | ENSYSCE BIOSCIENCES INC | 86,666 | $46,670 | 0.0% | $0.54 * | $6.89 | -89.9% | COM NEW | 293602504 |
| SRZNW | SURROZEN INC | 166,666 | $2,667 | 0.0% | $0.02 | $1.14 | — | *W EXP 08/01/203 | 86889P117 |