Location: New York, NY
CIK: 0001224962 · Show all filings
Period: Q4 2025 (← Previous) (Next →)
Filing Date: Feb 17, 2026
Total Value: $5.61B (99.7% shares, 0.3% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| PRAX | PRAXIS PRECISION MEDICINES I | 1,995,986 | $588M | 10.5% | $294.74 * | $79.26 | +135.0% | COM NEW | 74006W207 |
| CELC | CELCUITY INC | 3,160,200 | $315M | 5.6% | $99.74 * | $29.05 | +183.0% | COM | 15102K100 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 2,546,391 | $273M | 4.9% | $107.04 | $92.51 | +14.7% | COM | 76243J105 |
| ASND | ASCENDIS PHARMA A/S | 1,081,421 | $231M | 4.1% | $213.24 | $175.60 | — | SPONSORED ADR | 04351P101 |
| APGE | APOGEE THERAPEUTICS INC | 2,330,651 | $176M | 3.1% | $75.48 * | $42.68 | +47.6% | COM | 03770N101 |
| ROIV | ROIVANT SCIENCES LTD | 7,985,461 | $173M | 3.1% | $21.70 * | $12.30 | +60.3% | SHS | G76279101 |
| NUVL | NUVALENT INC | 1,665,105 | $167M | 3.0% | $100.59 | $46.66 | +111.3% | COM | 670703107 |
| TVTX | TRAVERE THERAPEUTICS INC | 4,278,180 | $163M | 2.9% | $38.21 * | $19.92 | +63.3% | COM | 89422G107 |
| XBI | SPDR SERIES TRUST | 1,100,000 | $134M | 2.4% | $121.93 | — | — | Put | 78464A870 |
| EXAS | EXACT SCIENCES CORP | 1,200,487 | $122M | 2.2% | $101.56 * | $68.54 | +17.2% | COM | 30063P105 |
| PTGX | PROTAGONIST THERAPEUTICS INC | 1,350,425 | $118M | 2.1% | $87.34 * | $39.65 | +106.5% | COM | 74366E102 |
| INBX | INHIBRX BIOSCIENCES INC | 1,452,707 | $115M | 2.0% | $79.00 * | $22.31 | +205.4% | COM | 45720N103 |
| EWTX | EDGEWISE THERAPEUTICS | 4,457,974 | $111M | 2.0% | $24.82 * | $22.18 | -9.5% | COM | 28036F105 |
| IMTX | IMMATICS N.V | 10,383,456 | $109M | 1.9% | $10.50 * | $10.60 | -4.8% | SHS | N44445109 |
| SYRE | SPYRE THERAPEUTICS INC | 3,069,225 | $101M | 1.8% | $32.76 * | $22.43 | +16.5% | COM NEW | 00773J202 |
| AMLX | AMYLYX PHARMACEUTICALS INC | 8,284,882 | $100M | 1.8% | $12.08 * | $4.53 | +199.8% | COM | 03237H101 |
| ACLX | ARCELLX INC | 1,466,071 | $95.59M | 1.7% | $65.20 * | $24.76 | +222.2% | COMMON STOCK | 03940C100 |
| VRDN | VIRIDIAN THERAPEUTICS INC | 3,042,703 | $94.69M | 1.7% | $31.12 * | $22.91 | +19.7% | COM | 92790C104 |
| BSX | BOSTON SCIENTIFIC CORP | 979,000 | $93.35M | 1.7% | $95.35 * | $99.04 | -1.0% | COM | 101137107 |
| FOLD | AMICUS THERAPEUTICS INC | 6,370,851 | $90.72M | 1.6% | $14.24 * | $7.36 | +33.4% | COM | 03152W109 |
| ZYME | ZYMEWORKS INC | 3,261,850 | $85.88M | 1.5% | $26.33 * | $14.71 | +48.3% | COM | 98985Y108 |
| — | ASTRIA THERAPEUTICS INC | 6,485,420 | $84.89M | 1.5% | $13.09 | $11.36 | — | COM | 04635X102 |
| MGTX | MEIRAGTX HLDGS PLC | 10,326,103 | $82.09M | 1.5% | $7.95 * | $10.52 | -21.0% | COM | G59665102 |
| AORT | ARTIVION INC | 1,722,290 | $78.55M | 1.4% | $45.61 * | $19.16 | +132.5% | COM | 228903100 |
| CNTA | CENTESSA PHARMACEUTICALS PLC | 2,917,634 | $72.97M | 1.3% | $25.01 | $20.01 | — | SPONSORED ADS | 152309100 |
| DYN | DYNE THERAPEUTICS INC | 3,478,944 | $68.05M | 1.2% | $19.56 * | $19.15 | -1.1% | COM | 26818M108 |
| NRIX | NURIX THERAPEUTICS INC | 3,555,877 | $67.45M | 1.2% | $18.97 * | $13.92 | +3.2% | COM | 67080M103 |
| SLDB | SOLID BIOSCIENCES INC | 11,833,539 | $66.74M | 1.2% | $5.64 * | $6.40 | -15.4% | COM NEW | 83422E204 |
| BLTE | BELITE BIO INC | 414,239 | $66.26M | 1.2% | $159.96 | $149.63 | — | SPONSORED ADS | 07782B104 |
| ABVX | ABIVAX SA | 458,343 | $61.81M | 1.1% | $134.85 | $92.50 | — | SPONSORED ADS | 00370M103 |
| IVVD | INVIVYD INC | 21,785,166 | $53.81M | 1.0% | $2.47 * | $2.08 | 0.0% | COM | 00534A102 |
| ENGN | ENGENE HOLDINGS INC | 5,869,076 | $53M | 0.9% | $9.03 * | $6.78 | +18.2% | COM | 29286M105 |
| RGEN | REPLIGEN CORP | 315,541 | $51.7M | 0.9% | $163.86 * | $140.51 | +11.5% | COM | 759916109 |
| IMVT | IMMUNOVANT INC | 1,994,890 | $50.71M | 0.9% | $25.42 * | $23.20 | -3.9% | COM | 45258J102 |
| ISRG | INTUITIVE SURGICAL INC | 87,919 | $49.79M | 0.9% | $566.36 * | $443.22 | +20.1% | COM NEW | 46120E602 |
| SION | SIONNA THERAPEUTICS INC | 1,179,098 | $48.51M | 0.9% | $41.14 * | $16.34 | +132.1% | COM | 829401108 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 331,050 | $46.95M | 0.8% | $141.83 * | $124.99 | +15.9% | COM | 64125C109 |
| DHR | DANAHER CORPORATION | 200,000 | $45.78M | 0.8% | $228.92 * | $219.54 | 0.0% | COM | 235851102 |
| ORKA | ORUKA THERAPEUTICS INC | 1,476,501 | $44.75M | 0.8% | $30.31 * | $16.66 | +67.2% | COM | 687604108 |
| CTMX | CYTOMX THERAPEUTICS INC | 9,680,185 | $41.24M | 0.7% | $4.26 * | $1.79 | +112.3% | COM | 23284F105 |
| OMDA | OMADA HEALTH INC | 2,396,330 | $37.81M | 0.7% | $15.78 * | $17.31 | +17.2% | COM | 68170A108 |
| — | CIDARA THERAPEUTICS INC | 165,131 | $36.48M | 0.7% | $220.89 | $220.89 | — | COM NEW | 171757206 |
| IRON | DISC MEDICINE INC | 450,743 | $35.79M | 0.6% | $79.41 * | $84.50 | 0.0% | COM | 254604101 |
| DRUG | BRIGHT MINDS BIOSCIENCES INC | 449,290 | $35.06M | 0.6% | $78.04 * | $35.55 | +88.0% | COM NEW | 10919W405 |
| PEN | PENUMBRA INC | 110,529 | $34.36M | 0.6% | $310.91 * | $255.20 | +8.2% | COM | 70975L107 |
| ANRO | ALTO NEUROSCIENCE INC | 1,784,393 | $31.76M | 0.6% | $17.80 * | $11.78 | +6.9% | COM SHS | 02157Q109 |
| CAI | CARIS LIFE SCIENCES INC | 1,136,206 | $30.65M | 0.5% | $26.98 * | $26.99 | +4.3% | COM | 142152107 |
| JAZZ | JAZZ PHARMACEUTICALS PLC | 170,000 | $28.9M | 0.5% | $170.00 * | $153.31 | 0.0% | SHS USD | G50871105 |
| PALI | PALISADE BIO INC | 12,050,000 | $28.32M | 0.5% | $2.35 * | $1.92 | 0.0% | COM | 696389402 |
| RAPT | RAPT THERAPEUTICS INC | 825,890 | $27.97M | 0.5% | $33.87 * | $25.84 | +20.2% | COM NEW | 75382E208 |
| PVLA | PALVELLA THERAPEUTICS INC NE | 266,287 | $27.87M | 0.5% | $104.67 * | $44.59 | +91.3% | COM | 697947109 |
| AXSM | AXSOME THERAPEUTICS INC | 148,900 | $27.2M | 0.5% | $182.64 * | $77.79 | +79.5% | COM | 05464T104 |
| AXGN | AXOGEN INC | 784,140 | $25.66M | 0.5% | $32.73 * | $24.59 | 0.0% | COM | 05463X106 |
| XFOR | X4 PHARMACEUTICALS INC | 6,314,452 | $25.26M | 0.5% | $4.00 * | $3.63 | 0.0% | COM NEW | 98420X202 |
| BCRX | BIOCRYST PHARMACEUTICALS INC | 3,162,529 | $24.67M | 0.4% | $7.80 * | $7.23 | 0.0% | COM | 09058V103 |
| NAUT | NAUTILUS BIOTECHNOLOGY INC | 12,594,211 | $24.56M | 0.4% | $1.95 * | $8.54 | -80.8% | COM | 63909J108 |
| KOD | KODIAK SCIENCES INC | 848,900 | $23.74M | 0.4% | $27.96 * | $11.61 | +76.4% | COM | 50015M109 |
| BIIB | BIOGEN INC | 124,000 | $21.82M | 0.4% | $175.99 * | $163.37 | 0.0% | COM | 09062X103 |
| ALDX | ALDEYRA THERAPEUTICS INC | 4,185,632 | $21.68M | 0.4% | $5.18 | $7.22 | -28.9% | COM | 01438T106 |
| OBIO | ORCHESTRA BIOMED HLDGS INC | 5,127,256 | $21.28M | 0.4% | $4.15 * | $8.01 | -49.6% | COM | 68572M106 |
| MIRM | MIRUM PHARMACEUTICALS INC | 259,545 | $20.5M | 0.4% | $78.99 * | $71.78 | 0.0% | COM | 604749101 |
| RAPP | RAPPORT THERAPEUTICS INC | 673,923 | $20.45M | 0.4% | $30.34 * | $21.78 | +27.1% | COM | 75383L102 |
| GRAL | GRAIL INC | 237,342 | $20.31M | 0.4% | $85.59 | $86.40 | 0.0% | COM | 384747101 |
| IRTC | IRHYTHM TECHNOLOGIES INC | 108,000 | $19.16M | 0.3% | $177.44 | $158.94 | +11.5% | COM | 450056106 |
| BBNX | BETA BIONICS INC | 602,944 | $18.37M | 0.3% | $30.47 * | $22.99 | +16.2% | COM | 08659B102 |
| CVS | CVS HEALTH CORP | 220,000 | $17.46M | 0.3% | $79.36 | $78.67 | 0.0% | COM | 126650100 |
| CTNM | CONTINEUM THERAPEUTICS INC | 1,464,592 | $16.74M | 0.3% | $11.43 | $13.62 | -16.2% | CL A | 21217B100 |
| GH | GUARDANT HEALTH INC | 160,000 | $16.34M | 0.3% | $102.14 * | $89.46 | 0.0% | COM | 40131M109 |
| ADMA | ADMA BIOLOGICS INC | 883,468 | $16.11M | 0.3% | $18.24 * | $8.62 | +95.4% | COM | 000899104 |
| RLAY | RELAY THERAPEUTICS INC | 1,903,245 | $16.1M | 0.3% | $8.46 * | $7.14 | 0.0% | COM | 75943R102 |
| GKOS | GLAUKOS CORP | 140,000 | $15.81M | 0.3% | $112.91 * | $95.54 | 0.0% | COM | 377322102 |
| DXCM | DEXCOM INC | 225,758 | $14.98M | 0.3% | $66.37 * | $64.65 | 0.0% | COM | 252131107 |
| SVRA | SAVARA INC | 2,400,000 | $14.47M | 0.3% | $6.03 * | $4.90 | 0.0% | COM | 805111101 |
| — | CELCUITY INC | 6,500,000 | $14.1M | 0.3% | $2.17 | $1.34 | — | NOTE 2.750% 8/0 | 15102KAA8 |
| LONA | ATHIRA PHARMA INC | 1,859,322 | $14.08M | 0.3% | $7.57 * | $4.39 | +4.3% | COM | 04746L203 |
| SEPN | SEPTERNA INC | 433,160 | $12.08M | 0.2% | $27.88 * | $8.24 | +190.0% | COM | 81734D104 |
| IKT | INHIBIKASE THERAPEUTICS INC | 5,421,568 | $11.11M | 0.2% | $2.05 * | $2.49 | -36.2% | COM NEW | 45719W205 |
| ADGM | ADAGIO MED HLDGS INC | 9,876,576 | $10.27M | 0.2% | $1.04 * | $4.76 | -75.1% | COM | 00534B100 |
| OCS | OCULIS HOLDING AG | 493,827 | $9.862M | 0.2% | $19.97 | $20.00 | 0.0% | ORDINARY SHARES | H5870P102 |
| GOSS | GOSSAMER BIO INC | 3,139,669 | $9.733M | 0.2% | $3.10 * | $2.20 | +29.5% | COM | 38341P102 |
| MPLT | MAPLIGHT THERAPEUTICS INC | 550,000 | $9.661M | 0.2% | $17.57 * | $16.75 | 0.0% | COM | 56565P103 |
| XENE | XENON PHARMACEUTICALS INC | 200,791 | $8.999M | 0.2% | $44.82 * | $26.63 | +57.7% | COM | 98420N105 |
| IRD | OPUS GENETICS INC | 4,325,000 | $8.693M | 0.2% | $2.01 | $1.12 | +81.8% | COM | 67577R102 |
| AVR | ANTERIS TECHNOLOGIES GLOBAL | 1,675,476 | $8.361M | 0.1% | $4.99 * | $5.59 | -18.0% | COM | 03675P102 |
| KMTS | KESTRA MED TECHNOLOGIES LTD | 285,000 | $7.558M | 0.1% | $26.52 * | $25.75 | 0.0% | SHS | G52441105 |
| CAPR | CAPRICOR THERAPEUTICS INC | 242,100 | $6.987M | 0.1% | $28.86 | — | — | Call | 14070B309 |
| BLLN | BILLIONTOONE INC | 72,812 | $5.959M | 0.1% | $81.84 * | $101.40 | 0.0% | CL A | 090168105 |
| BHVN | BIOHAVEN LTD | 500,000 | $5.645M | 0.1% | $11.29 | — | — | Call | G1110E107 |
| KYMR | KYMERA THERAPEUTICS INC | 69,935 | $5.442M | 0.1% | $77.81 * | $34.43 | +96.1% | COM | 501575104 |
| PEPG | PEPGEN INC | 829,870 | $5.402M | 0.1% | $6.51 * | $1.61 | +222.0% | COM | 713317105 |
| CBIO | CRESCENT BIOPHARMA INC. | 453,686 | $5.381M | 0.1% | $11.86 * | $21.15 | -39.8% | COM | G2545C104 |
| TENX | TENAX THERAPEUTICS INC | 439,142 | $5.353M | 0.1% | $12.19 * | $8.70 | 0.0% | COM NEW | 88032L605 |
| CRVS | CORVUS PHARMACEUTICALS INC | 692,441 | $5.332M | 0.1% | $7.70 * | $3.64 | +116.7% | COM | 221015100 |
| TECX | TECTONIC THERAPEUTIC INC | 250,000 | $5.215M | 0.1% | $20.86 | — | — | Call | 878972108 |
| AQST | AQUESTIVE THERAPEUTICS INC | 747,193 | $4.827M | 0.1% | $6.46 * | $3.57 | +74.6% | COM | 03843E104 |
| TNGX | TANGO THERAPEUTICS INC | 513,035 | $4.545M | 0.1% | $8.86 * | $8.62 | 0.0% | COM | 87583X109 |
| KRYS | KRYSTAL BIOTECH INC | 17,500 | $4.314M | 0.1% | $246.54 * | $149.68 | +40.6% | COM | 501147102 |
| COGT | COGENT BIOSCIENCES INC | 121,082 | $4.301M | 0.1% | $35.52 * | $28.11 | 0.0% | COM | 19240Q201 |
| OLMA | OLEMA PHARMACEUTICALS INC | 165,713 | $4.143M | 0.1% | $25.00 * | $17.79 | 0.0% | COM | 68062P106 |
| SDGR | SCHRODINGER INC | 202,400 | $3.619M | 0.1% | $17.88 * | $18.96 | 0.0% | COM | 80810D103 |
| OM | OUTSET MED INC | 833,333 | $3.092M | 0.1% | $3.71 * | $11.92 | -28.1% | COM NEW | 690145206 |
| SABS | SAB BIOTHERAPEUTICS INC | 803,210 | $3.004M | 0.1% | $3.74 * | $3.29 | 0.0% | COM NEW | 78397T202 |
| AVTX | AVALO THERAPEUTICS INC | 139,667 | $2.536M | 0.0% | $18.16 * | $7.58 | +122.8% | COM NEW | 05338F306 |
| CNTB | CONNECT BIOPHARMA HLDGS LTD | 792,696 | $2.235M | 0.0% | $2.82 * | $2.13 | 0.0% | SHS | G23549101 |
| IMMX | IMMIX BIOPHARMA INC | 338,941 | $1.773M | 0.0% | $5.23 * | $4.12 | 0.0% | COM | 45258H106 |
| LXEO | LEXEO THERAPEUTICS INC | 139,835 | $1.389M | 0.0% | $9.93 * | $11.93 | -23.5% | COM | 52886X107 |
| CPIX | CUMBERLAND PHARMACEUTICALS I | 341,087 | $1.358M | 0.0% | $3.98 * | $2.96 | 0.0% | COM | 230770109 |
| MDLN | MEDLINE INC | 28,000 | $1.176M | 0.0% | $42.00 | $42.23 | 0.0% | COM CL A | 58507V107 |
| PTN | PALATIN TECHNOLOGIES INC | 70,000 | $1.077M | 0.0% | $15.38 * | $13.14 | 0.0% | COM NEW | 696077601 |
| LENZ | LENZ THERAPEUTICS INC | 50,000 | $800K | 0.0% | $16.00 * | $29.15 | 0.0% | COM | 52635N103 |
| BDSX | BIODESIX | 108,694 | $739K | 0.0% | $6.80 * | $7.69 | -4.3% | COM | 09075X207 |
| — | ENVVENO MEDICAL CORPORATION | 1,759,035 | $564K | 0.0% | $0.32 | $3.16 | — | COM | 29415J106 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 152,714 | $417K | 0.0% | $2.73 * | $2.31 | 0.0% | COM | 462260100 |
| RVMDW | REVOLUTION MEDICINES INC | 250,000 | $235K | 0.0% | $0.94 | $0.33 | — | *W EXP 12/17/202 | 76155X118 |
| ENSC | ENSYSCE BIOSCIENCES INC | 86,666 | $79,733 | 0.0% | $0.92 * | $6.89 | -73.1% | COM NEW | 293602504 |
| SRZNW | SURROZEN INC | 166,666 | $3,333 | 0.0% | $0.02 | $1.14 | — | *W EXP 08/01/203 | 86889P117 |