RA CAPITAL MANAGEMENT, L.P. Diversified Active

Location: Boston, MA

CIK: 0001346824 · Show all filings

Period: Q4 2019 (← Previous) (Next →)

Filing Date: Feb 14, 2020

Total Value: $3.298B (100.0% shares, 0.0% debt)

Holdings (34)

— SYNTHORX INC 20.6%

Value $680M Shares 9,724,598 Share Price $69.89 Est. Cost/Share $17.38 Unrealized @ Report Date —

ASND ASCENDIS PHARMA A S 17.7%

Value $582M Shares 4,185,342 Share Price $139.12 Est. Cost/Share $19.49 Unrealized @ Report Date —

— RA PHARMACEUTICALS INC 6.9%

Value $228M Shares 4,858,260 Share Price $46.93 Est. Cost/Share $8.41 Unrealized @ Report Date —

ARVN ARVINAS INC 4.6%

Value $151M Shares 3,672,872 Share Price $41.09 * Est. Cost/Share $23.47 Unrealized @ Report Date +24.7%

— CHEMOCENTRYX INC 3.8%

Value $127M Shares 3,199,389 Share Price $39.55 Est. Cost/Share $39.55 Unrealized @ Report Date —

RYTM RHYTHM PHARMACEUTICALS INC 3.8%

Value $124M Shares 5,422,312 Share Price $22.96 * Est. Cost/Share $24.09 Unrealized @ Report Date -7.8%

— EIDOS THERAPEUTICS INC 3.8%

Value $124M Shares 2,162,671 Share Price $57.39 Est. Cost/Share $20.34 Unrealized @ Report Date —

— ZOGENIX INC 3.6%

Value $118M Shares 2,260,751 Share Price $52.13 Est. Cost/Share $37.11 Unrealized @ Report Date —

PHAT PHATHOM PHARMACEUTICALS INC 3.4%

Value $114M Shares 3,646,808 Share Price $31.14 * Est. Cost/Share $25.13 Unrealized @ Report Date 0.0%

TGTX TG THERAPEUTICS INC 3.3%

Value $110M Shares 9,880,323 Share Price $11.10 * Est. Cost/Share $10.91 Unrealized @ Report Date -30.3%

— SATSUMA PHARMACEUTICALS INC 2.8%

Value $92.14M Shares 4,681,858 Share Price $19.68 Est. Cost/Share $15.01 Unrealized @ Report Date —

— ORCHARD THERAPEUTICS PLC 2.7%

Value $87.86M Shares 6,389,901 Share Price $13.75 Est. Cost/Share $15.39 Unrealized @ Report Date —

— 89BIO INC 2.5%

Value $83.11M Shares 3,161,214 Share Price $26.29 Est. Cost/Share $26.29 Unrealized @ Report Date —

— FORTY SEVEN INC 2.3%

Value $76.11M Shares 1,933,250 Share Price $39.37 Est. Cost/Share $39.37 Unrealized @ Report Date —

WVE WAVE LIFE SCIENCES LTD 1.9%

Value $62.32M Shares 7,775,207 Share Price $8.01 * Est. Cost/Share $17.26 Unrealized @ Report Date +42.1%

— RETROPHIN INC 1.8%

Value $60.38M Shares 4,252,453 Share Price $14.20 Est. Cost/Share $11.75 Unrealized @ Report Date —

— AUDENTES THERAPEUTICS INC 1.6%

Value $54M Shares 902,383 Share Price $59.84 Est. Cost/Share $59.84 Unrealized @ Report Date —

— PREVAIL THERAPEUTICS INC 1.6%

Value $53.25M Shares 3,363,605 Share Price $15.83 Est. Cost/Share $13.03 Unrealized @ Report Date —

CRNX CRINETICS PHARMACEUTICALS INC 1.4%

Value $47.05M Shares 1,875,209 Share Price $25.09 * Est. Cost/Share $29.55 Unrealized @ Report Date -35.6%

ARDX ARDELYX INC 1.2%

Value $40.22M Shares 5,358,863 Share Price $7.50 * Est. Cost/Share $6.08 Unrealized @ Report Date 0.0%

AXSM AXSOME THERAPEUTICS INC 1.2%

Value $38.02M Shares 367,816 Share Price $103.36 * Est. Cost/Share $9.29 Unrealized @ Report Date +335.0%

— IGM BIOSCIENCES INC 1.1%

Value $37.5M Shares 982,723 Share Price $38.16 Est. Cost/Share $28.47 Unrealized @ Report Date —

STOK STOKE THERAPEUTICS INC 1.0%

Value $31.72M Shares 1,119,963 Share Price $28.32 * Est. Cost/Share $26.85 Unrealized @ Report Date -6.3%

RLMD RELMADA THERAPEUTICS INC 0.9%

Value $29.7M Shares 761,666 Share Price $39.00 * Est. Cost/Share $28.22 Unrealized @ Report Date 0.0%

— MOMENTA PHARMACEUTICALS INC 0.9%

Value $28.53M Shares 1,445,801 Share Price $19.73 Est. Cost/Share $19.73 Unrealized @ Report Date —

— SOLID BIOSCIENCES INC 0.6%

Value $20.34M Shares 4,571,164 Share Price $4.45 Est. Cost/Share $8.67 Unrealized @ Report Date —

— SCPHARMACEUTICALS INC 0.6%

Value $18.38M Shares 3,247,005 Share Price $5.66 Est. Cost/Share $11.02 Unrealized @ Report Date —

ALEC ALECTOR INC 0.5%

Value $17.23M Shares 1,000,000 Share Price $17.23 Est. Cost/Share $18.92 Unrealized @ Report Date -10.1%

— KALA PHARMACEUTICALS INC 0.5%

Value $16.74M Shares 4,537,478 Share Price $3.69 Est. Cost/Share $13.25 Unrealized @ Report Date —

GRTX GALERA THERAPEUTICS INC 0.4%

Value $13.87M Shares 1,054,178 Share Price $13.16 * Est. Cost/Share $12.19 Unrealized @ Report Date 0.0%

— DYNAVAX TECHNOLOGIES CORP 0.4%

Value $13.53M Shares 2,365,912 Share Price $5.72 Est. Cost/Share $3.57 Unrealized @ Report Date —

— PORTOLA PHARMACEUTICALS INC 0.3%

Value $10.25M Shares 429,399 Share Price $23.88 Est. Cost/Share $26.82 Unrealized @ Report Date —

— ESSA PHARMA INC 0.2%

Value $5.5M Shares 1,000,000 Share Price $5.50 Est. Cost/Share $3.37 Unrealized @ Report Date —

— X4 PHARMACEUTICALS INC 0.1%

Value $2.892M Shares 270,292 Share Price $10.70 Est. Cost/Share $15.00 Unrealized @ Report Date —

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
—	SYNTHORX INC	9,724,598	$680M	20.6%	$69.89	$17.38	—	COM	87167A103
ASND	ASCENDIS PHARMA A S	4,185,342	$582M	17.7%	$139.12	$19.49	—	SPONSORED ADR	04351P101
—	RA PHARMACEUTICALS INC	4,858,260	$228M	6.9%	$46.93	$8.41	—	COM	74933V108
ARVN	ARVINAS INC	3,672,872	$151M	4.6%	$41.09 *	$23.47	+24.7%	COM	04335A105
—	CHEMOCENTRYX INC	3,199,389	$127M	3.8%	$39.55	$39.55	—	COM	16383L106
RYTM	RHYTHM PHARMACEUTICALS INC	5,422,312	$124M	3.8%	$22.96 *	$24.09	-7.8%	COM	76243J105
—	EIDOS THERAPEUTICS INC	2,162,671	$124M	3.8%	$57.39	$20.34	—	COM	28249H104
—	ZOGENIX INC	2,260,751	$118M	3.6%	$52.13	$37.11	—	COM NEW	98978L204
PHAT	PHATHOM PHARMACEUTICALS INC	3,646,808	$114M	3.4%	$31.14 *	$25.13	0.0%	COM	71722W107
TGTX	TG THERAPEUTICS INC	9,880,323	$110M	3.3%	$11.10 *	$10.91	-30.3%	COM	88322Q108
—	SATSUMA PHARMACEUTICALS INC	4,681,858	$92.14M	2.8%	$19.68	$15.01	—	COM	80405P107
—	ORCHARD THERAPEUTICS PLC	6,389,901	$87.86M	2.7%	$13.75	$15.39	—	ADS	68570P101
—	89BIO INC	3,161,214	$83.11M	2.5%	$26.29	$26.29	—	COM	282559103
—	FORTY SEVEN INC	1,933,250	$76.11M	2.3%	$39.37	$39.37	—	COM	34983P104
WVE	WAVE LIFE SCIENCES LTD	7,775,207	$62.32M	1.9%	$8.01 *	$17.26	+42.1%	SHS	Y95308105
—	RETROPHIN INC	4,252,453	$60.38M	1.8%	$14.20	$11.75	—	COM	761299106
—	AUDENTES THERAPEUTICS INC	902,383	$54M	1.6%	$59.84	$59.84	—	COM	05070R104
—	PREVAIL THERAPEUTICS INC	3,363,605	$53.25M	1.6%	$15.83	$13.03	—	COM	74140Y101
CRNX	CRINETICS PHARMACEUTICALS INC	1,875,209	$47.05M	1.4%	$25.09 *	$29.55	-35.6%	COM	22663K107
ARDX	ARDELYX INC	5,358,863	$40.22M	1.2%	$7.50 *	$6.08	0.0%	COM	039697107
AXSM	AXSOME THERAPEUTICS INC	367,816	$38.02M	1.2%	$103.36 *	$9.29	+335.0%	COM	05464T104
—	IGM BIOSCIENCES INC	982,723	$37.5M	1.1%	$38.16	$28.47	—	COM	449585108
STOK	STOKE THERAPEUTICS INC	1,119,963	$31.72M	1.0%	$28.32 *	$26.85	-6.3%	COM	86150R107
RLMD	RELMADA THERAPEUTICS INC	761,666	$29.7M	0.9%	$39.00 *	$28.22	0.0%	COM	75955J402
—	MOMENTA PHARMACEUTICALS INC	1,445,801	$28.53M	0.9%	$19.73	$19.73	—	COM	60877T100
—	SOLID BIOSCIENCES INC	4,571,164	$20.34M	0.6%	$4.45	$8.67	—	COM	83422E105
—	SCPHARMACEUTICALS INC	3,247,005	$18.38M	0.6%	$5.66	$11.02	—	COM	810648105
ALEC	ALECTOR INC	1,000,000	$17.23M	0.5%	$17.23	$18.92	-10.1%	COM	014442107
—	KALA PHARMACEUTICALS INC	4,537,478	$16.74M	0.5%	$3.69	$13.25	—	COM	483119103
GRTX	GALERA THERAPEUTICS INC	1,054,178	$13.87M	0.4%	$13.16 *	$12.19	0.0%	COM	36338D108
—	DYNAVAX TECHNOLOGIES CORP	2,365,912	$13.53M	0.4%	$5.72	$3.57	—	COM NEW	268158201
—	PORTOLA PHARMACEUTICALS INC	429,399	$10.25M	0.3%	$23.88	$26.82	—	COM	737010108
—	ESSA PHARMA INC	1,000,000	$5.5M	0.2%	$5.50	$3.37	—	COM NEW	29668H708
—	X4 PHARMACEUTICALS INC	270,292	$2.892M	0.1%	$10.70	$15.00	—	COM	98420X103