Avoro Capital Advisors LLC Diversified Active

Location: New York, NY

CIK: 0001633313 · Show all filings

Period: Q4 2021 (← Previous) (Next →)

Filing Date: Feb 14, 2022

Total Value: $5.876B (100.0% shares, 0.0% debt)

Holdings (41)

— HORIZON THERAPEUTICS PLC 17.0%

Value $1.002B Shares 9,295,000 Est. Cost $48.54 Unrealized —

— MIRATI THERAPEUTICS INC 12.7%

Value $744M Shares 5,075,000 Est. Cost $51.83 Unrealized —

UTHR UNITED THERAPEUTICS CORP 11.2%

Value $656M Shares 3,035,000 Est. Cost $133.73 Unrealized +46.8%

APLS APELLIS PHARMACEUTICALS INC 6.9%

Value $405M Shares 8,555,555 Est. Cost $48.16 Unrealized -18.2%

ARGX ARGENX SE 5.8%

Value $338M Shares 965,000 Est. Cost $83.19 Unrealized —

SRPT SAREPTA THERAPEUTICS INC 4.8%

Value $281M Shares 3,125,000 Est. Cost $99.17 Unrealized -13.8%

ASND ASCENDIS PHARMA 4.6%

Value $269M Shares 2,000,000 Est. Cost $132.69 Unrealized —

BMRN BIOMARIN PHARMACEUTICAL INC 4.2%

Value $247M Shares 2,800,000 Est. Cost $83.48 Unrealized -1.2%

FOLD AMICUS THERAPEUTICS INC 3.6%

Value $214M Shares 18,500,000 Est. Cost $11.30 Unrealized -1.3%

ALNY ALNYLAM PHARMACEUTICALS INC 3.1%

Value $182M Shares 1,075,000 Est. Cost $154.71 Unrealized +20.1%

IOVA IOVANCE BIOTHERAPEUTICS INC 2.8%

Value $166M Shares 8,675,000 Est. Cost $16.48 Unrealized +33.6%

XENE XENON PHARMACEUTICALS INC 2.7%

Value $156M Shares 4,985,000 Est. Cost $16.29 Unrealized +83.4%

— IVERIC BIO INC 2.1%

Value $121M Shares 7,250,000 Est. Cost $6.39 Unrealized —

MDGL MADRIGAL PHARMACEUTICALS INC 2.1%

Value $121M Shares 1,425,000 Est. Cost $124.06 Unrealized -33.8%

XBI SPDR SERIES TRUST - S&P BIOTECH 2.0%

Value $118M Shares 1,050,000 Est. Cost $111.96 Unrealized —

— ARENA PHARMACEUTICALS INC 2.0%

Value $115M Shares 1,235,000 Est. Cost $72.64 Unrealized —

GLUE MONTE ROSA THERAPEUTICS INC 1.2%

Value $67.62M Shares 3,311,434 Est. Cost $20.37 Unrealized +2.8%

KURA KURA ONCOLOGY INC 1.0%

Value $56M Shares 4,000,000 Est. Cost $25.17 Unrealized -35.6%

ACAD ACADIA PHARMACEUTICALS INC 0.9%

Value $51.35M Shares 2,200,000 Est. Cost $48.41 Unrealized -58.4%

SNDX SYNDAX PHARMACEUTICALS INC 0.8%

Value $47.61M Shares 2,175,000 Est. Cost $20.70 Unrealized -10.7%

WHWK AADI BIOSCIENCES INC 0.8%

Value $44.18M Shares 1,829,402 Est. Cost $30.48 Unrealized -17.6%

— MERSANA THERAPEUTICS INC 0.7%

Value $42.3M Shares 6,800,000 Est. Cost $23.19 Unrealized —

MNKD MANNKIND CORP 0.7%

Value $38.46M Shares 8,800,000 Est. Cost $3.55 Unrealized +30.3%

— MARINUS PHARMACEUTICALS INC 0.7%

Value $38.43M Shares 3,235,000 Est. Cost $12.20 Unrealized —

— PRAXIS PRECISION MEDICINES INC 0.6%

Value $35.07M Shares 1,780,000 Est. Cost $41.53 Unrealized —

DSGN DESIGN THERAPEUTICS INC 0.6%

Value $35.03M Shares 1,636,100 Est. Cost $29.71 Unrealized -42.2%

KYMR KYMERA THERAPEUTICS INC 0.6%

Value $34.92M Shares 550,000 Est. Cost $58.02 Unrealized +0.4%

— CYMABAY THERAPEUTICS INC 0.6%

Value $34.81M Shares 10,300,000 Est. Cost $6.26 Unrealized —

PMVP PMV PHARMACEUTICALS INC 0.6%

Value $33.84M Shares 1,465,000 Est. Cost $35.29 Unrealized -31.5%

KRYS KRYSTAL BIOTECH INC 0.6%

Value $33.23M Shares 475,000 Est. Cost $58.21 Unrealized 0.0%

RNAM AVIDITY BIOSCIENCES INC 0.5%

Value $29.24M Shares 1,230,000 Est. Cost $25.02 Unrealized -4.5%

— AMARIN CORP PLC 0.3%

Value $20.22M Shares 6,000,000 Est. Cost $8.22 Unrealized —

NUVL NUVALENT INC 0.3%

Value $18.43M Shares 1,102,671 Est. Cost $29.01 Unrealized -23.2%

TNGX TANGO THERAPEUTICS INC 0.3%

Value $16.96M Shares 1,550,000 Est. Cost $11.99 Unrealized +0.3%

— DICE THERAPEUTICS INC 0.2%

Value $14.24M Shares 562,500 Est. Cost $32.75 Unrealized —

— AVADEL PHARMACEUTICALS PLC 0.2%

Value $13.49M Shares 1,670,000 Est. Cost $7.90 Unrealized —

— ADVERUM BIOTECHNOLOGIES INC 0.2%

Value $12.23M Shares 6,950,000 Est. Cost $11.14 Unrealized —

IOBT IO BIOTECH INC 0.2%

Value $10.24M Shares 2,055,883 Est. Cost $9.66 Unrealized 0.0%

GNCAQ GENOCEA BIOSCIENCES INC 0.1%

Value $5.898M Shares 5,084,184 Est. Cost $2.62 Unrealized -43.2%

FENC FENNEC PHARMACEUTICALS INC 0.1%

Value $5.28M Shares 1,200,000 Est. Cost $9.85 Unrealized -24.5%

SRPT SAREPTA THERAPEUTICS INC 0.0%

Value $2.91M Shares 300,000 Est. Cost $99.17 Unrealized -13.8%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
—	HORIZON THERAPEUTICS PLC	9,295,000	$1.002B	17.0%	$48.54	—	Common	G46188101
—	MIRATI THERAPEUTICS INC	5,075,000	$744M	12.7%	$51.83	—	Common	60468T105
UTHR	UNITED THERAPEUTICS CORP	3,035,000	$656M	11.2%	$133.73	+46.8%	Common	91307C102
APLS	APELLIS PHARMACEUTICALS INC	8,555,555	$405M	6.9%	$48.16	-18.2%	Common	03753U106
ARGX	ARGENX SE	965,000	$338M	5.8%	$83.19	—	Sponsored ADR	04016X101
SRPT	SAREPTA THERAPEUTICS INC	3,125,000	$281M	4.8%	$99.17	-13.8%	Common	803607100
ASND	ASCENDIS PHARMA	2,000,000	$269M	4.6%	$132.69	—	Sponsored ADR	04351P101
BMRN	BIOMARIN PHARMACEUTICAL INC	2,800,000	$247M	4.2%	$83.48	-1.2%	Common	09061G101
FOLD	AMICUS THERAPEUTICS INC	18,500,000	$214M	3.6%	$11.30	-1.3%	Common	03152W109
ALNY	ALNYLAM PHARMACEUTICALS INC	1,075,000	$182M	3.1%	$154.71	+20.1%	Common	02043Q107
IOVA	IOVANCE BIOTHERAPEUTICS INC	8,675,000	$166M	2.8%	$16.48	+33.6%	Common	462260100
XENE	XENON PHARMACEUTICALS INC	4,985,000	$156M	2.7%	$16.29	+83.4%	Common	98420N105
—	IVERIC BIO INC	7,250,000	$121M	2.1%	$6.39	—	Common	46583P102
MDGL	MADRIGAL PHARMACEUTICALS INC	1,425,000	$121M	2.1%	$124.06	-33.8%	Common	558868105
XBI	SPDR SERIES TRUST - S&P BIOTECH	1,050,000	$118M	2.0%	$111.96	—	ETF	78464A870
—	ARENA PHARMACEUTICALS INC	1,235,000	$115M	2.0%	$72.64	—	Common	040047607
GLUE	MONTE ROSA THERAPEUTICS INC	3,311,434	$67.62M	1.2%	$20.37	+2.8%	Common	61225M102
KURA	KURA ONCOLOGY INC	4,000,000	$56M	1.0%	$25.17	-35.6%	Common	50127T109
ACAD	ACADIA PHARMACEUTICALS INC	2,200,000	$51.35M	0.9%	$48.41	-58.4%	Common	004225108
SNDX	SYNDAX PHARMACEUTICALS INC	2,175,000	$47.61M	0.8%	$20.70	-10.7%	Common	87164F105
WHWK	AADI BIOSCIENCES INC	1,829,402	$44.18M	0.8%	$30.48	-17.6%	Common	00032Q104
—	MERSANA THERAPEUTICS INC	6,800,000	$42.3M	0.7%	$23.19	—	Common	59045L106
MNKD	MANNKIND CORP	8,800,000	$38.46M	0.7%	$3.55	+30.3%	Common	56400P706
—	MARINUS PHARMACEUTICALS INC	3,235,000	$38.43M	0.7%	$12.20	—	Common	56854Q200
—	PRAXIS PRECISION MEDICINES INC	1,780,000	$35.07M	0.6%	$41.53	—	Common	74006W108
DSGN	DESIGN THERAPEUTICS INC	1,636,100	$35.03M	0.6%	$29.71	-42.2%	Common	25056L103
KYMR	KYMERA THERAPEUTICS INC	550,000	$34.92M	0.6%	$58.02	+0.4%	Common	501575104
—	CYMABAY THERAPEUTICS INC	10,300,000	$34.81M	0.6%	$6.26	—	Common	23257D103
PMVP	PMV PHARMACEUTICALS INC	1,465,000	$33.84M	0.6%	$35.29	-31.5%	Common	69353Y103
KRYS	KRYSTAL BIOTECH INC	475,000	$33.23M	0.6%	$58.21	0.0%	Common	501147102
RNAM	AVIDITY BIOSCIENCES INC	1,230,000	$29.24M	0.5%	$25.02	-4.5%	Common	05370A108
—	AMARIN CORP PLC	6,000,000	$20.22M	0.3%	$8.22	—	Sponsored ADR	023111206
NUVL	NUVALENT INC	1,102,671	$18.43M	0.3%	$29.01	-23.2%	Common	670703107
TNGX	TANGO THERAPEUTICS INC	1,550,000	$16.96M	0.3%	$11.99	+0.3%	Common	87583X109
—	DICE THERAPEUTICS INC	562,500	$14.24M	0.2%	$32.75	—	Common	23345J104
—	AVADEL PHARMACEUTICALS PLC	1,670,000	$13.49M	0.2%	$7.90	—	Sponsored ADR	05337M104
—	ADVERUM BIOTECHNOLOGIES INC	6,950,000	$12.23M	0.2%	$11.14	—	Common	00773U108
IOBT	IO BIOTECH INC	2,055,883	$10.24M	0.2%	$9.66	0.0%	Common	449778109
GNCAQ	GENOCEA BIOSCIENCES INC	5,084,184	$5.898M	0.1%	$2.62	-43.2%	Common	372427401
FENC	FENNEC PHARMACEUTICALS INC	1,200,000	$5.28M	0.1%	$9.85	-24.5%	Common	31447P100
SRPT	SAREPTA THERAPEUTICS INC	300,000	$2.91M	0.0%	$99.17	-13.8%	Call	803607100