Avoro Capital Advisors LLC Diversified Active

Location: New York, NY

CIK: 0001633313 · Show all filings

Period: Q4 2024 (← Previous) (Next →)

Filing Date: Feb 14, 2025

Total Value: $7.07B (100.0% shares, 0.0% debt)

Holdings (39)

UTHR UNITED THERAPEUTICS CORP 13.8%

Value $974M Shares 2,760,300 Est. Cost $134.94 Unrealized +172.4%

ARGX ARGENX SE 10.8%

Value $762M Shares 1,238,467 Est. Cost $186.36 Unrealized —

ASND ASCENDIS PHARMA 9.9%

Value $703M Shares 5,103,055 Est. Cost $127.20 Unrealized —

MDGL MADRIGAL PHARMACEUTICALS INC 8.9%

Value $626M Shares 2,029,000 Est. Cost $138.83 Unrealized +102.6%

KRYS KRYSTAL BIOTECH INC 5.8%

Value $412M Shares 2,628,822 Est. Cost $86.03 Unrealized +106.2%

APLS APELLIS PHARMACEUTICALS INC. 5.5%

Value $390M Shares 12,222,222 Est. Cost $47.01 Unrealized -36.0%

SRPT SAREPTA THERAPEUTICS INC 4.4%

Value $311M Shares 2,555,555 Est. Cost $106.42 Unrealized +15.2%

— INTRA-CELLULAR THERAPIES INC 3.6%

Value $255M Shares 3,050,000 Est. Cost $70.93 Unrealized —

VERA VERA THERAPEUTICS INC 3.4%

Value $237M Shares 5,610,000 Est. Cost $37.64 Unrealized +17.6%

XENE XENON PHARMACEUTICALS INC 3.1%

Value $222M Shares 5,666,666 Est. Cost $18.87 Unrealized +119.1%

FOLD AMICUS THERAPEUTICS INC. 3.1%

Value $218M Shares 23,175,000 Est. Cost $10.47 Unrealized -0.7%

RNAM AVIDITY BIOSCIENCES INC 3.1%

Value $218M Shares 7,500,000 Est. Cost $22.34 Unrealized +87.1%

ARWR ARROWHEAD PHARMACEUTICALS INC. 3.0%

Value $209M Shares 11,111,111 Est. Cost $29.27 Unrealized -29.6%

KYMR KYMERA THERAPEUTICS INC 2.9%

Value $207M Shares 5,150,000 Est. Cost $35.02 Unrealized +29.0%

MLTX MOONLAKE IMMUNOTHERAPEUTICS 2.1%

Value $150M Shares 2,770,100 Est. Cost $35.93 Unrealized +42.1%

SLNO SOLENO THERAPEUTICS INC 1.6%

Value $113M Shares 2,525,000 Est. Cost $40.48 Unrealized +28.0%

— BLUEPRINT MEDICINES CORP 1.5%

Value $103M Shares 1,185,000 Est. Cost $87.22 Unrealized —

PCVX VAXCYTE INC 1.4%

Value $96.19M Shares 1,175,000 Est. Cost $79.91 Unrealized +24.3%

BMRN BIOMARIN PHARMACEUTICAL INC 1.4%

Value $96.13M Shares 1,462,500 Est. Cost $85.96 Unrealized -22.1%

— MERUS N V 1.3%

Value $89.36M Shares 2,125,000 Est. Cost $38.90 Unrealized —

BCRX BIOCRYST PHARMACEUTICALS INC 1.3%

Value $89.22M Shares 11,865,000 Est. Cost $10.72 Unrealized -29.2%

ALKS ALKERMES PLC 1.0%

Value $70.46M Shares 2,450,000 Est. Cost $28.75 Unrealized 0.0%

OCUL OCULAR THERAPEUTIX INC 1.0%

Value $68.83M Shares 8,060,000 Est. Cost $6.99 Unrealized +39.5%

MNKD MANNKIND CORP 0.8%

Value $56.26M Shares 8,750,000 Est. Cost $3.56 Unrealized +88.6%

— TOURMALINE BIO INC 0.6%

Value $45.07M Shares 2,222,222 Est. Cost $24.18 Unrealized —

QURE UNIQURE NV 0.5%

Value $38.41M Shares 2,175,000 Est. Cost $8.63 Unrealized 0.0%

RARE ULTRAGENYX PHARMACEUTICAL INC 0.5%

Value $34.92M Shares 830,000 Est. Cost $49.13 Unrealized +1.0%

TSHA TAYSHA GENE THERAPIES INC 0.5%

Value $34.6M Shares 19,999,999 Est. Cost $2.04 Unrealized +1.7%

— 89BIO INC 0.5%

Value $32.06M Shares 4,100,000 Est. Cost $7.82 Unrealized —

GLUE MONTE ROSA THERAPEUTICS INC 0.4%

Value $30.15M Shares 4,345,000 Est. Cost $14.44 Unrealized -48.0%

SNDX SYNDAX PHARMACEUTICALS INC 0.4%

Value $30.08M Shares 2,275,000 Est. Cost $18.81 Unrealized -9.0%

IOVA IOVANCE BIOTHERAPEUTICS INC 0.4%

Value $25.9M Shares 3,500,000 Est. Cost $14.36 Unrealized -35.5%

SEPN SEPTERNA INC 0.4%

Value $25.42M Shares 1,110,000 Est. Cost $23.65 Unrealized 0.0%

AUTL AUTOLUS THERAPEUTICS PLC 0.3%

Value $23.29M Shares 9,910,642 Est. Cost $6.38 Unrealized —

CGON CG ONCOLOGY INC 0.3%

Value $20.08M Shares 700,000 Est. Cost $40.84 Unrealized -16.2%

KURA KURA ONCOLOGY INC 0.3%

Value $19.6M Shares 2,250,000 Est. Cost $22.49 Unrealized -36.0%

RCKT ROCKET PHARMACEUTICALS INC 0.2%

Value $15.08M Shares 1,200,000 Est. Cost $15.05 Unrealized 0.0%

OLMA OLEMA PHARMACEUTICALS INC 0.1%

Value $9.631M Shares 1,651,982 Est. Cost $9.99 Unrealized 0.0%

WHWK AADI BIOSCIENCES INC 0.1%

Value $8.99M Shares 2,849,402 Est. Cost $24.27 Unrealized -90.7%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
UTHR	UNITED THERAPEUTICS CORP	2,760,300	$974M	13.8%	$134.94	+172.4%	Common	91307C102
ARGX	ARGENX SE	1,238,467	$762M	10.8%	$186.36	—	Sponsored ADR	04016X101
ASND	ASCENDIS PHARMA	5,103,055	$703M	9.9%	$127.20	—	Sponsored ADR	04351P101
MDGL	MADRIGAL PHARMACEUTICALS INC	2,029,000	$626M	8.9%	$138.83	+102.6%	Common	558868105
KRYS	KRYSTAL BIOTECH INC	2,628,822	$412M	5.8%	$86.03	+106.2%	Common	501147102
APLS	APELLIS PHARMACEUTICALS INC.	12,222,222	$390M	5.5%	$47.01	-36.0%	Common	03753U106
SRPT	SAREPTA THERAPEUTICS INC	2,555,555	$311M	4.4%	$106.42	+15.2%	Common	803607100
—	INTRA-CELLULAR THERAPIES INC	3,050,000	$255M	3.6%	$70.93	—	Common	46116X101
VERA	VERA THERAPEUTICS INC	5,610,000	$237M	3.4%	$37.64	+17.6%	Common	92337R101
XENE	XENON PHARMACEUTICALS INC	5,666,666	$222M	3.1%	$18.87	+119.1%	Common	98420N105
FOLD	AMICUS THERAPEUTICS INC.	23,175,000	$218M	3.1%	$10.47	-0.7%	Common	03152W109
RNAM	AVIDITY BIOSCIENCES INC	7,500,000	$218M	3.1%	$22.34	+87.1%	Common	05370A108
ARWR	ARROWHEAD PHARMACEUTICALS INC.	11,111,111	$209M	3.0%	$29.27	-29.6%	Common	04280A100
KYMR	KYMERA THERAPEUTICS INC	5,150,000	$207M	2.9%	$35.02	+29.0%	Common	501575104
MLTX	MOONLAKE IMMUNOTHERAPEUTICS	2,770,100	$150M	2.1%	$35.93	+42.1%	CLASS A ORD	61559X104
SLNO	SOLENO THERAPEUTICS INC	2,525,000	$113M	1.6%	$40.48	+28.0%	Common	834203309
—	BLUEPRINT MEDICINES CORP	1,185,000	$103M	1.5%	$87.22	—	Common	09627Y109
PCVX	VAXCYTE INC	1,175,000	$96.19M	1.4%	$79.91	+24.3%	Common	92243G108
BMRN	BIOMARIN PHARMACEUTICAL INC	1,462,500	$96.13M	1.4%	$85.96	-22.1%	Common	09061G101
—	MERUS N V	2,125,000	$89.36M	1.3%	$38.90	—	Common	N5749R100
BCRX	BIOCRYST PHARMACEUTICALS INC	11,865,000	$89.22M	1.3%	$10.72	-29.2%	Common	09058V103
ALKS	ALKERMES PLC	2,450,000	$70.46M	1.0%	$28.75	0.0%	Common	G01767105
OCUL	OCULAR THERAPEUTIX INC	8,060,000	$68.83M	1.0%	$6.99	+39.5%	Common	67576A100
MNKD	MANNKIND CORP	8,750,000	$56.26M	0.8%	$3.56	+88.6%	Common	56400P706
—	TOURMALINE BIO INC	2,222,222	$45.07M	0.6%	$24.18	—	Common	89157D105
QURE	UNIQURE NV	2,175,000	$38.41M	0.5%	$8.63	0.0%	Common	N90064101
RARE	ULTRAGENYX PHARMACEUTICAL INC	830,000	$34.92M	0.5%	$49.13	+1.0%	Common	90400D108
TSHA	TAYSHA GENE THERAPIES INC	19,999,999	$34.6M	0.5%	$2.04	+1.7%	Common	877619106
—	89BIO INC	4,100,000	$32.06M	0.5%	$7.82	—	Common	282559103
GLUE	MONTE ROSA THERAPEUTICS INC	4,345,000	$30.15M	0.4%	$14.44	-48.0%	Common	61225M102
SNDX	SYNDAX PHARMACEUTICALS INC	2,275,000	$30.08M	0.4%	$18.81	-9.0%	Common	87164F105
IOVA	IOVANCE BIOTHERAPEUTICS INC	3,500,000	$25.9M	0.4%	$14.36	-35.5%	Common	462260100
SEPN	SEPTERNA INC	1,110,000	$25.42M	0.4%	$23.65	0.0%	Common	81734D104
AUTL	AUTOLUS THERAPEUTICS PLC	9,910,642	$23.29M	0.3%	$6.38	—	Sponsored ADR	05280R100
CGON	CG ONCOLOGY INC	700,000	$20.08M	0.3%	$40.84	-16.2%	Common	156944100
KURA	KURA ONCOLOGY INC	2,250,000	$19.6M	0.3%	$22.49	-36.0%	Common	50127T109
RCKT	ROCKET PHARMACEUTICALS INC	1,200,000	$15.08M	0.2%	$15.05	0.0%	Common	77313F106
OLMA	OLEMA PHARMACEUTICALS INC	1,651,982	$9.631M	0.1%	$9.99	0.0%	Common	68062P106
WHWK	AADI BIOSCIENCES INC	2,849,402	$8.99M	0.1%	$24.27	-90.7%	Common	00032Q104