Avoro Capital Advisors LLC Diversified Active

Location: NEW YORK, NY

CIK: 0001633313 · Show all filings

Period: Q1 2025 (← Previous) (Next →)

Filing Date: May 15, 2025

Total Value ($000): $6,406,568 (100.0% shares, 0.0% debt)

Holdings (33)

UTHR UNITED THERAPEUTICS CORP 12.9%

Value ($000) $824,622 Shares 2,675,000 Est. Cost $134.94 Unrealized +154.0%

ASND ASCENDIS PHARMA 12.7%

Value ($000) $813,277 Shares 5,218,000 Est. Cost $127.83 Unrealized —

ARGX ARGENX SE 11.4%

Value ($000) $731,058 Shares 1,235,177 Est. Cost $186.36 Unrealized —

MDGL MADRIGAL PHARMACEUTICALS INC 10.5%

Value ($000) $669,821 Shares 2,022,222 Est. Cost $138.83 Unrealized +136.7%

KRYS KRYSTAL BIOTECH INC 7.7%

Value ($000) $492,399 Shares 2,731,000 Est. Cost $89.11 Unrealized +88.8%

— BLUEPRINT MEDICINES CORP 5.3%

Value ($000) $340,764 Shares 3,850,000 Est. Cost $88.11 Unrealized —

APLS APELLIS PHARMACEUTICALS INC. 4.2%

Value ($000) $267,300 Shares 12,222,222 Est. Cost $47.01 Unrealized -41.2%

RNAM AVIDITY BIOSCIENCES INC 3.5%

Value ($000) $225,090 Shares 7,625,000 Est. Cost $22.48 Unrealized +38.5%

XENE XENON PHARMACEUTICALS INC 3.0%

Value ($000) $192,633 Shares 5,741,666 Est. Cost $19.12 Unrealized +98.6%

SLNO SOLENO THERAPEUTICS INC 2.8%

Value ($000) $180,411 Shares 2,525,000 Est. Cost $40.48 Unrealized +20.3%

KYMR KYMERA THERAPEUTICS INC 2.8%

Value ($000) $176,810 Shares 6,460,000 Est. Cost $35.31 Unrealized +3.2%

SRPT SAREPTA THERAPEUTICS INC 2.7%

Value ($000) $170,708 Shares 2,674,835 Est. Cost $106.36 Unrealized -1.0%

FOLD AMICUS THERAPEUTICS INC. 2.6%

Value ($000) $167,280 Shares 20,500,000 Est. Cost $10.47 Unrealized -11.6%

ARWR ARROWHEAD PHARMACEUTICALS INC. 2.2%

Value ($000) $141,556 Shares 11,111,111 Est. Cost $29.27 Unrealized -37.9%

VERA VERA THERAPEUTICS INC 2.1%

Value ($000) $136,960 Shares 5,701,900 Est. Cost $37.55 Unrealized -14.4%

— MERUS N V 2.0%

Value ($000) $126,270 Shares 3,000,000 Est. Cost $39.83 Unrealized —

MLTX MOONLAKE IMMUNOTHERAPEUTICS 1.7%

Value ($000) $108,228 Shares 2,770,100 Est. Cost $35.93 Unrealized +19.9%

— INTRA-CELLULAR THERAPIES INC 1.3%

Value ($000) $82,450 Shares 625,000 Est. Cost $70.93 Unrealized —

ALKS ALKERMES PLC 1.3%

Value ($000) $80,899 Shares 2,450,000 Est. Cost $28.75 Unrealized +13.4%

BCRX BIOCRYST PHARMACEUTICALS INC 1.0%

Value ($000) $65,250 Shares 8,700,000 Est. Cost $10.72 Unrealized -24.7%

OCUL OCULAR THERAPEUTIX INC 0.9%

Value ($000) $59,080 Shares 8,060,000 Est. Cost $6.99 Unrealized +9.9%

CNTA CENTESSA PHARMACEUTICALS PLC 0.9%

Value ($000) $58,239 Shares 4,050,000 Est. Cost $14.38 Unrealized —

— 89BIO INC 0.7%

Value ($000) $46,165 Shares 6,350,000 Est. Cost $7.63 Unrealized —

MNKD MANNKIND CORP 0.7%

Value ($000) $44,013 Shares 8,750,000 Est. Cost $3.56 Unrealized +57.5%

PCVX VAXCYTE INC 0.6%

Value ($000) $37,760 Shares 1,000,000 Est. Cost $79.91 Unrealized +0.1%

— TOURMALINE BIO INC 0.6%

Value ($000) $36,884 Shares 2,425,000 Est. Cost $23.43 Unrealized —

RARE ULTRAGENYX PHARMACEUTICAL INC 0.5%

Value ($000) $30,054 Shares 830,000 Est. Cost $49.13 Unrealized -15.3%

TSHA TAYSHA GENE THERAPIES INC 0.4%

Value ($000) $27,800 Shares 19,999,999 Est. Cost $2.04 Unrealized -18.0%

QURE UNIQURE NV 0.4%

Value ($000) $23,055 Shares 2,175,000 Est. Cost $8.63 Unrealized +62.4%

GLUE MONTE ROSA THERAPEUTICS INC 0.3%

Value ($000) $21,555 Shares 4,645,548 Est. Cost $13.91 Unrealized -55.9%

AUTL AUTOLUS THERAPEUTICS PLC 0.2%

Value ($000) $15,361 Shares 9,910,642 Est. Cost $6.38 Unrealized —

SEPN SEPTERNA INC 0.1%

Value ($000) $7,744 Shares 1,337,500 Est. Cost $21.57 Unrealized -47.1%

WHWK WHITEHAWK THERAPEUTICS INC 0.1%

Value ($000) $5,072 Shares 2,849,402 Est. Cost $24.27 Unrealized -89.2%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
UTHR	UNITED THERAPEUTICS CORP	2,675,000	$824,622	12.9%	$134.94	+154.0%	Common	91307C102
ASND	ASCENDIS PHARMA	5,218,000	$813,277	12.7%	$127.83	—	Sponsored ADR	04351P101
ARGX	ARGENX SE	1,235,177	$731,058	11.4%	$186.36	—	Sponsored ADR	04016X101
MDGL	MADRIGAL PHARMACEUTICALS INC	2,022,222	$669,821	10.5%	$138.83	+136.7%	Common	558868105
KRYS	KRYSTAL BIOTECH INC	2,731,000	$492,399	7.7%	$89.11	+88.8%	Common	501147102
—	BLUEPRINT MEDICINES CORP	3,850,000	$340,764	5.3%	$88.11	—	Common	09627Y109
APLS	APELLIS PHARMACEUTICALS INC.	12,222,222	$267,300	4.2%	$47.01	-41.2%	Common	03753U106
RNAM	AVIDITY BIOSCIENCES INC	7,625,000	$225,090	3.5%	$22.48	+38.5%	Common	05370A108
XENE	XENON PHARMACEUTICALS INC	5,741,666	$192,633	3.0%	$19.12	+98.6%	Common	98420N105
SLNO	SOLENO THERAPEUTICS INC	2,525,000	$180,411	2.8%	$40.48	+20.3%	Common	834203309
KYMR	KYMERA THERAPEUTICS INC	6,460,000	$176,810	2.8%	$35.31	+3.2%	Common	501575104
SRPT	SAREPTA THERAPEUTICS INC	2,674,835	$170,708	2.7%	$106.36	-1.0%	Common	803607100
FOLD	AMICUS THERAPEUTICS INC.	20,500,000	$167,280	2.6%	$10.47	-11.6%	Common	03152W109
ARWR	ARROWHEAD PHARMACEUTICALS INC.	11,111,111	$141,556	2.2%	$29.27	-37.9%	Common	04280A100
VERA	VERA THERAPEUTICS INC	5,701,900	$136,960	2.1%	$37.55	-14.4%	Common	92337R101
—	MERUS N V	3,000,000	$126,270	2.0%	$39.83	—	Common	N5749R100
MLTX	MOONLAKE IMMUNOTHERAPEUTICS	2,770,100	$108,228	1.7%	$35.93	+19.9%	CLASS A ORD	61559X104
—	INTRA-CELLULAR THERAPIES INC	625,000	$82,450	1.3%	$70.93	—	Common	46116X101
ALKS	ALKERMES PLC	2,450,000	$80,899	1.3%	$28.75	+13.4%	Common	G01767105
BCRX	BIOCRYST PHARMACEUTICALS INC	8,700,000	$65,250	1.0%	$10.72	-24.7%	Common	09058V103
OCUL	OCULAR THERAPEUTIX INC	8,060,000	$59,080	0.9%	$6.99	+9.9%	Common	67576A100
CNTA	CENTESSA PHARMACEUTICALS PLC	4,050,000	$58,239	0.9%	$14.38	—	SPONSORED ADR	152309100
—	89BIO INC	6,350,000	$46,165	0.7%	$7.63	—	Common	282559103
MNKD	MANNKIND CORP	8,750,000	$44,013	0.7%	$3.56	+57.5%	Common	56400P706
PCVX	VAXCYTE INC	1,000,000	$37,760	0.6%	$79.91	+0.1%	Common	92243G108
—	TOURMALINE BIO INC	2,425,000	$36,884	0.6%	$23.43	—	Common	89157D105
RARE	ULTRAGENYX PHARMACEUTICAL INC	830,000	$30,054	0.5%	$49.13	-15.3%	Common	90400D108
TSHA	TAYSHA GENE THERAPIES INC	19,999,999	$27,800	0.4%	$2.04	-18.0%	Common	877619106
QURE	UNIQURE NV	2,175,000	$23,055	0.4%	$8.63	+62.4%	Common	N90064101
GLUE	MONTE ROSA THERAPEUTICS INC	4,645,548	$21,555	0.3%	$13.91	-55.9%	Common	61225M102
AUTL	AUTOLUS THERAPEUTICS PLC	9,910,642	$15,361	0.2%	$6.38	—	Sponsored ADR	05280R100
SEPN	SEPTERNA INC	1,337,500	$7,744	0.1%	$21.57	-47.1%	Common	81734D104
WHWK	WHITEHAWK THERAPEUTICS INC	2,849,402	$5,072	0.1%	$24.27	-89.2%	Common	00032Q104