EcoR1 Capital, LLC Quant / Systematic

Location: San Francisco, CA

CIK: 0001587114 · Show all filings

Period: Q1 2017 (← Previous) (Next →)

Filing Date: May 19, 2017

Total Value: $396M (94.6% shares, 5.4% debt)

Holdings (33)

— ASSEMBLY BIOSCIENCES INC 19.0%

Value $75.02M Shares 2,943,164 Est. Cost $8.38 Unrealized —

IRWD IRONWOOD PHARMACEUTICALS INC 12.5%

Value $49.57M Shares 2,905,515 Est. Cost $9.45 Unrealized +44.6%

GLPG GALAPAGOS NV 12.0%

Value $47.49M Shares 551,041 Est. Cost $57.70 Unrealized —

— GILEAD SCIENCES INC 8.6%

Value $33.96M Shares 500,000 Est. Cost — Unrealized —

ASND ASCENDIS PHARMA A S 7.3%

Value $28.72M Shares 1,025,700 Est. Cost $20.59 Unrealized —

KURA KURA ONCOLOGY INC COM 5.8%

Value $22.98M Shares 2,611,906 Est. Cost $10.12 Unrealized -27.5%

— THERAVANCE BIOPHARMA INC 5.4%

Value $21.44M Shares 17,000,000 Est. Cost $1.14 Unrealized —

ACRS ACLARIS THERAPEUTICS INC 5.1%

Value $20.07M Shares 673,100 Est. Cost $26.78 Unrealized +7.7%

CTMX CYTOMX THERAPEUTICS INC 3.5%

Value $13.73M Shares 794,969 Est. Cost $13.16 Unrealized 0.0%

— CASCADIAN THERAPEUTICS INC 3.1%

Value $12.42M Shares 3,000,000 Est. Cost $4.14 Unrealized —

FATE FATE THERAPEUTICS INC 2.9%

Value $11.54M Shares 2,537,026 Est. Cost $3.66 Unrealized 0.0%

— ATARA BIOTHERAPEUTICS INC 2.3%

Value $8.935M Shares 434,812 Est. Cost $17.40 Unrealized —

— ATYR PHARMA INC 2.0%

Value $8.024M Shares 2,292,659 Est. Cost $2.92 Unrealized —

— OVASCIENCE INC 1.7%

Value $6.568M Shares 3,512,332 Est. Cost $1.87 Unrealized —

— JOUNCE THERAPEUTICS INC 1.4%

Value $5.683M Shares 258,457 Est. Cost $21.99 Unrealized —

XNCR XENCOR INC 1.4%

Value $5.617M Shares 234,813 Est. Cost $24.05 Unrealized +0.2%

— KINDRED BIOSCIENCES INC 1.0%

Value $3.841M Shares 544,880 Est. Cost $7.10 Unrealized —

— NABRIVA THERAPEUTICS AG 0.8%

Value $3.177M Shares 264,773 Est. Cost $9.50 Unrealized —

— REGULUS THERAPEUTICS INC 0.6%

Value $2.492M Shares 1,510,000 Est. Cost $1.65 Unrealized —

— ADVERUM BIOTECHNOLOGIES INC 0.6%

Value $2.361M Shares 874,447 Est. Cost $4.11 Unrealized —

— VERSARTIS INC 0.5%

Value $2.135M Shares 100,000 Est. Cost $21.35 Unrealized —

— VIVEVE MED INC 0.4%

Value $1.583M Shares 250,000 Est. Cost $6.33 Unrealized —

AGIO AGIOS PHARMACEUTICALS INC 0.3%

Value $1.361M Shares 23,300 Est. Cost $43.55 Unrealized +10.1%

— DICERNA PHARMACEUTICALS INC 0.3%

Value $1.299M Shares 382,000 Est. Cost $3.40 Unrealized —

— FIBROGEN INC 0.3%

Value $1.036M Shares 42,009 Est. Cost $24.72 Unrealized —

— SYROS PHARMACEUTICALS INC 0.3%

Value $1.013M Shares 63,596 Est. Cost $13.87 Unrealized —

BMY BRISTOL MYERS SQUIBB CO 0.2%

Value $928K Shares 17,060 Est. Cost $39.73 Unrealized +0.5%

— CHEMOCENTRYX INC 0.2%

Value $859K Shares 118,000 Est. Cost $7.28 Unrealized —

SNDX SYNDAX PHARMACEUTICALS INC COM 0.1%

Value $484K Shares 35,301 Est. Cost $12.54 Unrealized -17.2%

— CASCADIAN THERAPEUTICS INC 0.1%

Value $430K Shares 103,800 Est. Cost — Unrealized —

— OREXIGEN THERAPEUTICS INC 0.1%

Value $405K Shares 117,726 Est. Cost $3.44 Unrealized —

WVE WAVE LIFE SCIENCES LTD 0.1%

Value $275K Shares 10,000 Est. Cost $27.93 Unrealized 0.0%

— FORWARD PHARMA A/S 0.0%

Value $108K Shares 5,025 Est. Cost $21.49 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
—	ASSEMBLY BIOSCIENCES INC	2,943,164	$75.02M	19.0%	$8.38	—	COM	045396108
IRWD	IRONWOOD PHARMACEUTICALS INC	2,905,515	$49.57M	12.5%	$9.45	+44.6%	COM	46333X108
GLPG	GALAPAGOS NV	551,041	$47.49M	12.0%	$57.70	—	SPONSORED ADR	36315X101
—	GILEAD SCIENCES INC	500,000	$33.96M	8.6%	—	—	Call	375558903
ASND	ASCENDIS PHARMA A S	1,025,700	$28.72M	7.3%	$20.59	—	SPONSORED ADR	04351P101
KURA	KURA ONCOLOGY INC COM	2,611,906	$22.98M	5.8%	$10.12	-27.5%	COM	50127T109
—	THERAVANCE BIOPHARMA INC	17,000,000	$21.44M	5.4%	$1.14	—	NOTE	88339KAA0
ACRS	ACLARIS THERAPEUTICS INC	673,100	$20.07M	5.1%	$26.78	+7.7%	COM	00461U105
CTMX	CYTOMX THERAPEUTICS INC	794,969	$13.73M	3.5%	$13.16	0.0%	COM	23284F105
—	CASCADIAN THERAPEUTICS INC	3,000,000	$12.42M	3.1%	$4.14	—	COM	14740B606
FATE	FATE THERAPEUTICS INC	2,537,026	$11.54M	2.9%	$3.66	0.0%	COM	31189P102
—	ATARA BIOTHERAPEUTICS INC	434,812	$8.935M	2.3%	$17.40	—	COM	046513107
—	ATYR PHARMA INC	2,292,659	$8.024M	2.0%	$2.92	—	COM	002120103
—	OVASCIENCE INC	3,512,332	$6.568M	1.7%	$1.87	—	COM	69014Q101
—	JOUNCE THERAPEUTICS INC	258,457	$5.683M	1.4%	$21.99	—	COM	481116101
XNCR	XENCOR INC	234,813	$5.617M	1.4%	$24.05	+0.2%	COM	98401F105
—	KINDRED BIOSCIENCES INC	544,880	$3.841M	1.0%	$7.10	—	COM	494577109
—	NABRIVA THERAPEUTICS AG	264,773	$3.177M	0.8%	$9.50	—	SPONSORED ADR	62957M104
—	REGULUS THERAPEUTICS INC	1,510,000	$2.492M	0.6%	$1.65	—	COM	75915K101
—	ADVERUM BIOTECHNOLOGIES INC	874,447	$2.361M	0.6%	$4.11	—	COM	00773U108
—	VERSARTIS INC	100,000	$2.135M	0.5%	$21.35	—	COM	92529L102
—	VIVEVE MED INC	250,000	$1.583M	0.4%	$6.33	—	COM	92852W204
AGIO	AGIOS PHARMACEUTICALS INC	23,300	$1.361M	0.3%	$43.55	+10.1%	COM	00847X104
—	DICERNA PHARMACEUTICALS INC	382,000	$1.299M	0.3%	$3.40	—	COM	253031108
—	FIBROGEN INC	42,009	$1.036M	0.3%	$24.72	—	COM	31572Q808
—	SYROS PHARMACEUTICALS INC	63,596	$1.013M	0.3%	$13.87	—	COM	87184Q107
BMY	BRISTOL MYERS SQUIBB CO	17,060	$928K	0.2%	$39.73	+0.5%	COM	110122108
—	CHEMOCENTRYX INC	118,000	$859K	0.2%	$7.28	—	COM	16383L106
SNDX	SYNDAX PHARMACEUTICALS INC COM	35,301	$484K	0.1%	$12.54	-17.2%	COM	87164F105
—	CASCADIAN THERAPEUTICS INC	103,800	$430K	0.1%	—	—	Call	14740B906
—	OREXIGEN THERAPEUTICS INC	117,726	$405K	0.1%	$3.44	—	COM	686164302
WVE	WAVE LIFE SCIENCES LTD	10,000	$275K	0.1%	$27.93	0.0%	SHS	Y95308105
—	FORWARD PHARMA A/S	5,025	$108K	0.0%	$21.49	—	SPONSORED ADR	34986J105