Location: Miami Beach, FL
CIK: 0001535610 · Show all filings
Period: Q2 2016 (← Previous) (Next →)
Filing Date: Aug 15, 2016
Total Value: $1.917B (99.2% shares, 0.8% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| — | ELI LILLY & CO | 30,121 | $237M | 12.4% | $7875.00 | — | — | Call | 532457908 |
| — | SPDR S&P 500 | 8,415 | $176M | 9.2% | $20952.94 | — | — | Put | 78462F953 |
| — | ISHARES RUSSELL 2000 ETF | 13,600 | $156M | 8.2% | $11496.99 | — | — | Put | 464287951 |
| — | ABBVIE INC | 18,007 | $111M | 5.8% | $6190.98 | — | — | Call | 00287Y909 |
| — | HCA HOLDINGS INC | 9,291 | $71.55M | 3.7% | $7701.00 | — | — | Call | 40412C901 |
| — | AMGEN INC | 3,942 | $59.98M | 3.1% | $15215.12 | — | — | Put | 031162950 |
| — | SAREPTA THERAPEUTICS INC | 29,250 | $55.78M | 2.9% | $1907.01 | — | — | Put | 803607950 |
| — | MONSANTO CO | 5,334 | $55.16M | 2.9% | $10341.02 | — | — | Call | 61166W901 |
| — | BIOGEN INC | 1,866 | $45.12M | 2.4% | $24182.21 | — | — | Call | 09062X903 |
| — | REGENERON PHARMACEUTICALS INC | 1,160 | $40.51M | 2.1% | $34923.28 | — | — | Put | 75886F957 |
| — | ELI LILLY & CO | 4,891 | $38.52M | 2.0% | $7875.08 | — | — | Put | 532457958 |
| — | PFIZER INC | 10,000 | $35.21M | 1.8% | $3521.00 | — | — | Call | 717081903 |
| — | JOHNSON & JOHNSON | 2,809 | $34.07M | 1.8% | $12129.94 | — | — | Call | 478160904 |
| — | DEXCOM INC | 4,214 | $33.43M | 1.7% | $7933.08 | — | — | Put | 252131957 |
| — | SAREPTA THERAPEUTICS INC | 15,225 | $29.03M | 1.5% | $1907.00 | — | — | Call | 803607900 |
| REGN | REGENERON PHARMACEUTICALS INC | 71,525 | $24.98M | 1.3% | $349.23 * | $397.62 | -3.7% | COM | 75886F107 |
| AMGN | AMGEN INC | 154,082 | $23.44M | 1.2% | $152.15 * | $111.19 | +5.0% | COM | 031162100 |
| — | ABBOTT LABS | 5,000 | $19.66M | 1.0% | $3931.00 | — | — | Put | 002824950 |
| — | MANNKIND CORP | 52,978 | $18.27M | 1.0% | $344.88 | — | — | Put | 56400P951 |
| — | TEVA PHARMACEUTICAL INDUSTRIES LTD | 3,618 | $18.17M | 0.9% | $5022.94 | — | — | Call | 881624909 |
| — | TESARO INC | 2,158 | $18.14M | 0.9% | $8405.00 | — | — | Call | 881569907 |
| — | RETROPHIN INC | 9,445 | $16.82M | 0.9% | $1781.05 | — | — | Call | 761299906 |
| — | DYNAVAX TECHNOLOGIES CORP | 10,712 | $15.62M | 0.8% | $1457.99 | — | — | Call | 268158901 |
| — | ACADIA PHARMACEUTICALS INC | 4,674 | $15.17M | 0.8% | $3246.04 | — | — | Call | 004225908 |
| SRPT | SAREPTA THERAPEUTICS INC | 783,497 | $14.94M | 0.8% | $19.07 * | $17.82 | +3.6% | COM | 803607100 |
| — | ABBVIE INC | 2,347 | $14.53M | 0.8% | $6190.88 | — | — | Put | 00287Y959 |
| — | SHIRE PLC | 698 | $12.85M | 0.7% | $18408.31 | — | — | Put | 82481R956 |
| — | SHIRE PLC | 698 | $12.85M | 0.7% | $18408.31 | — | — | Call | 82481R906 |
| — | SPDR GOLD TRUST | 1,000 | $12.65M | 0.7% | $12652.00 | — | — | Call | 78463V907 |
| — | MEDICINES CO | 3,614 | $12.15M | 0.6% | $3363.03 | — | — | Call | 584688905 |
| — | MYLAN N.V. | 2,804 | $12.12M | 0.6% | $4323.82 | — | — | Call | N59465909 |
| — | SAGE THERAPEUTICS INC | 4,009 | $12.08M | 0.6% | $3012.97 | — | — | Call | 78667J908 |
| — | SAGE THERAPEUTICS INC | 3,496 | $10.53M | 0.5% | $3012.87 | — | — | Put | 78667J958 |
| ABT | ABBOTT LABS | 264,700 | $10.4M | 0.5% | $39.31 * | $33.35 | 0.0% | COM | 002824100 |
| — | SPDR S&P 500 BIOTECH | 1,858 | $10.05M | 0.5% | $5409.04 | — | — | Put | 78464A950 |
| — | DEXCOM INC | 1,180 | $9.361M | 0.5% | $7933.05 | — | — | Call | 252131907 |
| — | DYNAVAX TECHNOLOGIES CORP | 5,942 | $8.663M | 0.5% | $1457.93 | — | — | Put | 268158951 |
| — | RETROPHIN INC | 4,826 | $8.595M | 0.4% | $1780.98 | — | — | Put | 761299956 |
| — | ACORDA THERAPEUTICS INC 1.75% | 9,600,000 | $8.388M | 0.4% | $0.87 | $0.90 | — | NOTE | 00484MAA4 |
| — | IONIS PHARMACEUTICALS INC | 3,600 | $8.384M | 0.4% | $2328.89 | — | — | Call | 462222900 |
| — | ALKERMES PLC | 1,335 | $7.93M | 0.4% | $5940.07 | — | — | Call | G01767905 |
| — | CORSICANTO LTD 3.5% | 7,756,000 | $7.877M | 0.4% | $1.02 | $1.02 | — | NOTE | 220480AB3 |
| — | LEXICON PHARMACEUTICALS INC | 5,320 | $7.634M | 0.4% | $1434.96 | — | — | Call | 528872902 |
| — | NOVAVAX INC | 10,447 | $7.595M | 0.4% | $727.00 | — | — | Put | 670002954 |
| — | ONCOBIOLOGICS INC | 2,068,968 | $7.035M | 0.4% | $3.40 | $3.40 | — | COM | 68235M105 |
| — | CELGENE CORP | 695 | $6.855M | 0.4% | $9863.31 | — | — | Call | 151020904 |
| — | TENAX THERAPEUTICS INC | 2,606,035 | $6.671M | 0.3% | $2.56 | $3.75 | — | COM | 88032L100 |
| — | LION BIOTECHNOLOGIES INC | 7,526 | $6.096M | 0.3% | $809.99 | — | — | Put | 53619R952 |
| — | BIO PATH HOLDINGS INC | 2,988,295 | $5.947M | 0.3% | $1.99 | $1.99 | — | COM | 09057N102 |
| — | INTRA CELLULAR THERAPIES INC | 1,467 | $5.695M | 0.3% | $3882.07 | — | — | Put | 46116X951 |
| — | IPATH S&P 500 MT | 3,972 | $5.485M | 0.3% | $1380.92 | $11.17 | — | Call | 06740C519 |
| — | ALNYLAM PHARMACEUTICALS INC | 987 | $5.477M | 0.3% | $5549.14 | — | — | Call | 02043Q907 |
| — | SHIRE PLC | 29,550 | $5.44M | 0.3% | $184.09 | $184.09 | — | COM | 82481R106 |
| — | INTRA CELLULAR THERAPIES INC | 1,373 | $5.33M | 0.3% | $3882.01 | — | — | Call | 46116X901 |
| — | VERTEX PHARMACEUTICALS INC | 609 | $5.239M | 0.3% | $8602.63 | — | — | Call | 92532F900 |
| — | EXPRESS SCRIPTS HOLDING CO. | 665 | $5.041M | 0.3% | $7580.45 | — | — | Put | 30219E953 |
| — | TEVA PHARMACEUTICAL INDUSTRIES LTD | 1,000 | $5.023M | 0.3% | $5023.00 | — | — | Put | 881624959 |
| — | AMICUS THERAPEUTICS INC | 7,992 | $4.364M | 0.2% | $546.05 | — | — | Call | 03152W909 |
| — | PARATEK PHARMACEUTICALS INC | 305,964 | $4.256M | 0.2% | $13.91 | $17.47 | — | COM | 699374302 |
| — | KITE PHARMA INC | 851 | $4.255M | 0.2% | $5000.00 | — | — | Call | 49803L909 |
| — | DYNAVAX TECHNOLOGIES CORP | 290,505 | $4.236M | 0.2% | $14.58 | $20.06 | — | COM | 268158201 |
| — | GLOBAL BLOOD THERAPEUTICS INC | 254,029 | $4.214M | 0.2% | $16.59 | $30.38 | — | COM | 37890U108 |
| — | TOKAI PHARMACEUTICALS | 749,205 | $4.128M | 0.2% | $5.51 | $5.61 | — | COM | 88907J107 |
| — | CYTORI THERAPEUTICS INC | 1,966,708 | $4.11M | 0.2% | $2.09 | $2.09 | — | COM | 23283K204 |
| ABUS | ARBUTUS BIOPHARMA CORP | 1,176,031 | $4.093M | 0.2% | $3.48 * | $7.22 | -41.4% | COM | 03879J100 |
| — | CEMPRA INC | 2,340 | $3.859M | 0.2% | $1649.15 | — | — | Put | 15130J959 |
| — | CEL SCI CORP | 8,163,816 | $3.755M | 0.2% | $0.46 | $0.46 | — | COM | 150837508 |
| — | NEUROCRINE BIOSCIENCES INC | 813 | $3.695M | 0.2% | $4544.90 | — | — | Call | 64125C909 |
| — | HORIZON PHARMA PLC | 2,205 | $3.632M | 0.2% | $1647.17 | — | — | Call | G4617B905 |
| — | EIGER BIOPHARMACEUTICALS INC | 175,249 | $3.473M | 0.2% | $19.82 | $16.77 | — | COM | 28249U105 |
| — | NEWLINK GENETICS CORP | 5,771 | $3.463M | 0.2% | $600.07 | — | — | Call | 651511907 |
| — | ALNYLAM PHARMACEUTICALS INC | 606 | $3.363M | 0.2% | $5549.50 | — | — | Put | 02043Q957 |
| — | INVIVO THERAPEUTICS HOLDINGS CORP | 580,343 | $3.354M | 0.2% | $5.78 | $6.90 | — | COM | 46186M209 |
| — | INTEC PHARMA LTD | 743,545 | $3.346M | 0.2% | $4.50 | $5.45 | — | SHS | M53644106 |
| — | REGULUS THERAPEUTIC INC | 11,560 | $3.341M | 0.2% | $289.01 | — | — | Call | 75915K901 |
| — | LA JOLLA PHARMACEUTICAL CO | 206,131 | $3.298M | 0.2% | $16.00 | $20.85 | — | COM | 503459604 |
| RGNX | REGENXBIO INC | 411,926 | $3.295M | 0.2% | $8.00 * | $14.34 | -22.6% | COM | 75901B107 |
| — | DURECT CORP | 2,540,278 | $3.099M | 0.2% | $1.22 | $1.22 | — | COM | 266605104 |
| — | ACHILLION PHARMACEUTICALS INC | 3,827 | $2.985M | 0.2% | $779.98 | — | — | Call | 00448Q901 |
| — | LION BIOTECHNOLOGIES INC | 367,242 | $2.975M | 0.2% | $8.10 | $8.51 | — | COM | 53619R102 |
| — | INTREXON CORP | 120,359 | $2.962M | 0.2% | $24.61 | $32.90 | — | COM | 46122T102 |
| — | NIVALIS THERAPEUTICS INC | 641,492 | $2.951M | 0.2% | $4.60 | $11.19 | — | COM | 65481J109 |
| ILMN | ILLUMINA INC | 20,000 | $2.808M | 0.1% | $140.40 | $142.06 | 0.0% | COM | 452327109 |
| — | BARCLAYS BANK IPATH S&P 500 MT | 260,000 | $2.805M | 0.1% | $10.79 | $11.17 | — | ETN | 06740C519 |
| EDAP | EDAP TMS S A | 847,225 | $2.804M | 0.1% | $3.31 | $3.31 | — | ADR | 268311107 |
| — | INTREXON CORP | 1,136 | $2.796M | 0.1% | $2461.27 | — | — | Put | 46122T952 |
| — | INTRA CELLULAR THERAPIES INC | 71,943 | $2.793M | 0.1% | $38.82 | $27.79 | — | COM | 46116X101 |
| — | PIERIS PHARMACEUTICALS ORD SHS | 1,615,992 | $2.602M | 0.1% | $1.61 | $1.64 | — | COM | 720795103 |
| — | SANGAMO BIOSCIENCES INC | 4,400 | $2.548M | 0.1% | $579.09 | — | — | Call | 800677906 |
| — | CEMPRA INC | 1,537 | $2.535M | 0.1% | $1649.32 | — | — | Call | 15130J909 |
| — | OPGEN INC | 1,625,000 | $2.47M | 0.1% | $1.52 | $1.52 | — | COM | 68373L109 |
| — | OPKO HEALTH INC | 2,645 | $2.47M | 0.1% | $933.84 | — | — | Put | 68375N953 |
| — | ADVERUM BIOTECHNOLOGIES INC. | 779,926 | $2.465M | 0.1% | $3.16 | $3.16 | — | COM | 00773U108 |
| — | AXOVANT SCIENCES LTD | 190,000 | $2.44M | 0.1% | $12.84 | $12.60 | — | COM | G0750W104 |
| — | VISTAGEN THERAPEUTICS INC | 623,317 | $2.431M | 0.1% | $3.90 | $3.90 | — | COM | 92840H202 |
| — | BIOGEN INC | 100 | $2.418M | 0.1% | $24180.00 | — | — | Put | 09062X953 |
| BIIB | BIOGEN INC | 10,000 | $2.418M | 0.1% | $241.80 * | $264.15 | -0.2% | COM | 09062X103 |
| — | LA JOLLA PHARMACEUTICAL CO | 1,458 | $2.333M | 0.1% | $1600.14 | — | — | Call | 503459904 |
| — | ZOGENIX INC | 289,200 | $2.328M | 0.1% | $8.05 | $9.10 | — | COM | 98978L204 |
| — | IONIS PHARMACEUTICALS INC | 984 | $2.292M | 0.1% | $2329.27 | — | — | Put | 462222950 |
| — | REXAHN PHARMACEUTICALS INC | 9,071,168 | $2.279M | 0.1% | $0.25 | $0.33 | — | COM | 761640101 |
| — | VERTEX PHARMACEUTICALS INC | 260 | $2.237M | 0.1% | $8603.85 | — | — | Put | 92532F950 |
| — | CLOVIS ONCOLOGY INC | 1,626 | $2.231M | 0.1% | $1372.08 | — | — | Call | 189464900 |
| — | ZOGENIX INC | 12,072 | $2.199M | 0.1% | $182.16 | — | — | Call | 98978L904 |
| — | NOVAVAX INC | 3,001 | $2.182M | 0.1% | $727.09 | — | — | Call | 670002904 |
| — | ABBOTT LABS | 555 | $2.182M | 0.1% | $3931.53 | — | — | Call | 002824900 |
| — | SAGE THERAPEUTICS INC | 68,950 | $2.077M | 0.1% | $30.12 | $34.46 | — | COM | 78667J108 |
| — | AMARIN CORPORATION PLC | 9,411 | $2.033M | 0.1% | $216.02 | — | — | Call | 023111906 |
| — | ALCOBRA LTD | 4,467 | $2.006M | 0.1% | $449.07 | — | — | Call | M2239P909 |
| — | CELSION CORP. | 1,519,365 | $1.93M | 0.1% | $1.27 | $1.28 | — | COM | 15117N404 |
| — | NEURALSTEM INC | 6,503,800 | $1.893M | 0.1% | $0.29 | $0.29 | — | COM | 64127R302 |
| — | MOMENTA PHARMACEUTICALS INC | 1,736 | $1.875M | 0.1% | $1080.07 | — | — | Call | 60877T900 |
| — | FORWARD PHARMA A/S | 102,135 | $1.856M | 0.1% | $18.17 | $23.42 | — | ADR | 34986J105 |
| — | BIODELIVERY SCIENCES INTERNATIONAL INC | 785,799 | $1.854M | 0.1% | $2.36 | $4.78 | — | COM | 09060J106 |
| — | CAPSTONE TURBINE CORP | 1,336,901 | $1.845M | 0.1% | $1.38 | $1.38 | — | COM | 14067D409 |
| — | OPHTHOTECH CORP | 361 | $1.842M | 0.1% | $5102.49 | — | — | Call | 683745903 |
| — | HALOZYME THERAPEUTICS INC | 2,101 | $1.813M | 0.1% | $862.92 | — | — | Call | 40637H909 |
| OPK | OPKO HEALTH INC | 190,554 | $1.78M | 0.1% | $9.34 * | $11.72 | -13.3% | COM | 68375N103 |
| — | ALLIQUA BIOMEDICAL INC | 1,500,000 | $1.68M | 0.1% | $1.12 | $1.60 | — | COM | 019621200 |
| — | REDHILL BIOPHARMA LTD | 147,500 | $1.611M | 0.1% | $10.92 | $12.91 | — | COM | 757468103 |
| — | FOAMIX PHARMACEUTICALS LTD | 253,706 | $1.611M | 0.1% | $6.35 | $8.92 | — | SHS | M46135105 |
| — | ACADIA PHARMACEUTICALS INC | 495 | $1.607M | 0.1% | $3246.46 | — | — | Put | 004225958 |
| — | FIBROGEN INC | 97,274 | $1.596M | 0.1% | $16.41 | $21.29 | — | COM | 31572Q808 |
| — | GW PHARMACEUTICALS PLC | 172 | $1.575M | 0.1% | $9156.98 | — | — | Call | 36197T903 |
| — | MOMENTA PHARMACEUTICALS INC | 145,600 | $1.572M | 0.1% | $10.80 | $12.52 | — | COM | 60877T100 |
| — | VANDA PHARMACEUTICALS INC | 1,390 | $1.555M | 0.1% | $1118.71 | — | — | Call | 921659908 |
| — | DEPOMED INC | 788 | $1.546M | 0.1% | $1961.93 | — | — | Call | 249908904 |
| — | WAFERGEN BIO SYSTEMS INC | 1,867,250 | $1.533M | 0.1% | $0.82 | $0.77 | — | COM | 93041P308 |
| — | FLEXION THERAPEUTICS INC | 100,800 | $1.508M | 0.1% | $14.96 | $12.31 | — | COM | 33938J106 |
| — | REGENERON PHARMACEUTICALS INC | 43 | $1.502M | 0.1% | $34930.23 | — | — | Call | 75886F907 |
| — | ADURO BIOTECH INC | 1,322 | $1.495M | 0.1% | $1130.86 | — | — | Call | 00739L901 |
| — | ADAMAS PHARMACEUTICALS INC | 97,600 | $1.478M | 0.1% | $15.14 | $14.46 | — | COM | 00548A106 |
| SRNE | SORRENTO THERAPEUTICS INC | 253,805 | $1.421M | 0.1% | $5.60 * | $11.18 | -42.8% | COM | 83587F202 |
| — | LEXICON PHARMACEUTICALS INC | 979 | $1.405M | 0.1% | $1435.14 | — | — | Put | 528872952 |
| — | EXELIXIS INC | 1,783 | $1.393M | 0.1% | $781.27 | — | — | Call | 30161Q904 |
| — | OPKO HEALTH INC | 1,491 | $1.393M | 0.1% | $934.27 | — | — | Call | 68375N903 |
| — | PUMA BIOTECHNOLOGY INC | 458 | $1.364M | 0.1% | $2978.17 | — | — | Call | 74587V907 |
| — | BIO BLAST PHARMA LTD | 830,253 | $1.328M | 0.1% | $1.60 | $2.49 | — | SHS | M20156101 |
| — | INSMED INC | 1,346 | $1.327M | 0.1% | $985.88 | — | — | Call | 457669907 |
| — | RICEBRAN TECHNOLOGIES INC | 785,476 | $1.304M | 0.1% | $1.66 | $3.68 | — | COM | 762831204 |
| — | SCYNEXIS INC | 572,928 | $1.243M | 0.1% | $2.17 | $2.17 | — | COM | 811292101 |
| — | EXPRESS SCRIPTS HOLDING CO. | 16,386 | $1.242M | 0.1% | $75.80 | $75.80 | — | COM | 30219E103 |
| — | PTC THERAPEUTICS INC | 1,740 | $1.221M | 0.1% | $701.72 | — | — | Call | 69366J900 |
| — | AMICUS THERAPEUTICS INC | 2,234 | $1.22M | 0.1% | $546.11 | — | — | Put | 03152W959 |
| — | IGNYTA INC | 225,000 | $1.22M | 0.1% | $5.42 | $6.50 | — | COM | 451731103 |
| — | TEARLAB CORP. | 1,882,347 | $1.205M | 0.1% | $0.64 | $0.64 | — | COM | 878193101 |
| — | DERMIRA INC | 412 | $1.205M | 0.1% | $2924.76 | — | — | Call | 24983L904 |
| COLL | COLLEGIUM PHARMACEUTICAL INC | 101,410 | $1.202M | 0.1% | $11.85 * | $17.86 | -7.5% | COM | 19459J104 |
| — | AERIE PHARMACEUTICALS INC | 674 | $1.186M | 0.1% | $1759.64 | — | — | Call | 00771V908 |
| CSBR | CHAMPIONS ONCOLOGY INC | 546,728 | $1.175M | 0.1% | $2.15 * | $4.47 | -26.1% | COM | 15870P307 |
| — | PRONAI THERAPEUTICS INC | 590,011 | $1.174M | 0.1% | $1.99 | $1.99 | — | COM | 74346L101 |
| — | TONIX PHARMACEUTICALS HOLDINGS CORP | 585,914 | $1.166M | 0.1% | $1.99 | $2.79 | — | COM | 890260201 |
| — | XTL BIOPHARMACEUTICALS LTD | 1,001,170 | $1.161M | 0.1% | $1.16 | $2.30 | — | ADR | 98386D208 |
| — | BRAINSTORM CELL THERAPEUTICS INC | 476,719 | $1.149M | 0.1% | $2.41 | $4.17 | — | COM | 10501E201 |
| — | CEMPRA INC | 64,065 | $1.056M | 0.1% | $16.48 | $32.75 | — | COM | 15130J109 |
| — | NOVAVAX INC | 142,726 | $1.038M | 0.1% | $7.27 | $7.27 | — | COM | 670002104 |
| — | IMMUNOCELLULAR THERAPEUTICS INC | 4,452,128 | $1.025M | 0.1% | $0.23 | $0.48 | — | COM | 452536105 |
| — | EYEGATE PHARMACEUTICALS INC | 386,940 | $1.002M | 0.1% | $2.59 | $2.59 | — | COM | 30233M107 |
| — | ONCOSEC MEDICAL INC | 608,052 | $997K | 0.1% | $1.64 | $3.47 | — | COM | 68234L207 |
| — | IMMUNOMEDICS INC | 425,000 | $986K | 0.1% | $2.32 | $68.00 | — | COM | 452907108 |
| — | THERAPEUTICSMD INC | 1,153 | $980K | 0.1% | $849.96 | — | — | Call | 88338N907 |
| GALT | GALECTIN THERAPEUTICS INC | 662,467 | $974K | 0.1% | $1.47 | $2.29 | -36.0% | COM | 363225202 |
| — | RIGEL PHARMACEUTICALS INC | 435,957 | $972K | 0.1% | $2.23 | $2.23 | — | COM | 766559603 |
| ACUR | ACURA PHARMACEUTICALS INC | 518,444 | $959K | 0.1% | $1.85 * | $3.40 | -24.1% | COM | 00509L802 |
| — | AMPLIPHI BIOSCIENCES CORP | 613,782 | $951K | 0.0% | $1.55 | $1.55 | — | COM | 03211P202 |
| — | KITOV PHARMACEUTICALS HOLDINGS | 1,210,785 | $944K | 0.0% | $0.78 | $0.75 | — | *W | 49803V115 |
| — | ENDO INTERNATIONAL PLC | 60,061 | $936K | 0.0% | $15.58 | $26.05 | — | SHS | G30401106 |
| — | GENVEC INC | 1,625,435 | $931K | 0.0% | $0.57 | $0.57 | — | COM | 37246C307 |
| — | JUNO THERAPEUTICS INC | 240 | $923K | 0.0% | $3845.83 | — | — | Call | 48205A909 |
| — | DEXTERA SURGICAL INC. | 482,000 | $868K | 0.0% | $1.80 | $1.80 | — | COM | 252366109 |
| — | AETERNA ZENTARIS INC | 265,803 | $867K | 0.0% | $3.26 | $4.48 | — | COM | 007975402 |
| — | WINDTREE THERAPEUTICS INC | 448,509 | $866K | 0.0% | $1.93 | $1.93 | — | COM | 97382D105 |
| — | DERMIRA INC | 289 | $845K | 0.0% | $2923.88 | — | — | Put | 24983L954 |
| — | CLOVIS ONCOLOGY INC | 59,836 | $821K | 0.0% | $13.72 | $18.46 | — | COM | 189464100 |
| — | CASCADIAN THERAPEUTICS INC | 864,402 | $815K | 0.0% | $0.94 | $0.94 | — | COM | 14740B101 |
| — | VTV THERAPEUTICS INC | 139,747 | $811K | 0.0% | $5.80 | $6.52 | — | CL A | 918385105 |
| — | OCERA THERAPEUTICS INC | 424,035 | $806K | 0.0% | $1.90 | $5.54 | — | COM | 67552A108 |
| — | CELATOR PHARMACEUTICALS INC | 26,500 | $800K | 0.0% | $30.19 | $3.37 | — | COM | 15089R102 |
| — | CYTORI THERAPEUTICS INC | 1,004,065 | $793K | 0.0% | $0.79 | $0.79 | — | *W | 23283K121 |
| — | INOTEK PHARMACEUTICALS CORP | 106,454 | $792K | 0.0% | $7.44 | $8.91 | — | COM | 45780V102 |
| — | DERMIRA INC | 26,693 | $781K | 0.0% | $29.26 | $20.68 | — | COM | 24983L104 |
| — | ACHILLION PHARMACEUTICALS INC | 1,000 | $780K | 0.0% | $780.00 | — | — | Put | 00448Q951 |
| — | HCA HOLDINGS INC | 100 | $770K | 0.0% | $7700.00 | — | — | Put | 40412C951 |
| — | MEDGENICS INC | 138,777 | $770K | 0.0% | $5.55 | $5.55 | — | COM | 58436Q203 |
| — | HORIZON PHARMA PLC | 463 | $763K | 0.0% | $1647.95 | — | — | Put | G4617B955 |
| — | INSMED INC | 771 | $760K | 0.0% | $985.73 | — | — | Put | 457669957 |
| — | CELGENE CORP | 77 | $759K | 0.0% | $9857.14 | — | — | Put | 151020954 |
| — | ARALEZ PHARMACEUTICALS INC | 228,364 | $754K | 0.0% | $3.30 | $3.55 | — | COM | 03852X100 |
| — | ASTERIAS BIOTHERAPEUTICS INC | 308,909 | $741K | 0.0% | $2.40 | $2.40 | — | COM | 04624N107 |
| — | PROGENICS PHARMACEUTICALS INC | 174,900 | $738K | 0.0% | $4.22 | $4.36 | — | COM | 743187106 |
| — | PSIVIDA CORP | 257,800 | $730K | 0.0% | $2.83 | $2.68 | — | COM | 74440J101 |
| — | KITOV PHARMACEUTICALS HOLDINGS | 232,524 | $725K | 0.0% | $3.12 | $3.12 | — | ADR | 49803V107 |
| — | CAPRICOR THERAPEUTICS INC | 182,083 | $719K | 0.0% | $3.95 | $4.85 | — | COM | 14070B101 |
| — | OVASCIENCE INC | 135,101 | $704K | 0.0% | $5.21 | $5.21 | — | COM | 69014Q101 |
| — | GLOBAL BLOOD THERAPEUTICS INC | 421 | $698K | 0.0% | $1657.96 | — | — | Call | 37890U908 |
| FOLD | AMICUS THERAPEUTICS INC | 125,912 | $687K | 0.0% | $5.46 * | $7.43 | -5.9% | COM | 03152W109 |
| — | ABEONA THERAPEUTICS ORD SHS | 270,000 | $637K | 0.0% | $2.36 | $4.32 | — | COM | 00289Y107 |
| PARNEUR | PARNELL PHARMACEUTICALS HOLDINGS LTD | 389,400 | $635K | 0.0% | $1.63 | $1.63 | — | SHS | Q73622104 |
| — | STRATA SKIN SCIENCES INC | 1,020,524 | $623K | 0.0% | $0.61 | $0.80 | — | COM | 86272A107 |
| — | BIOPHARMX CORP | 957,000 | $622K | 0.0% | $0.65 | $1.01 | — | COM | 09072X101 |
| — | NEUROMETRIX INC | 3,060,197 | $612K | 0.0% | $0.20 | $0.31 | — | *W | 641255153 |
| — | SERES THERAPEUTICS INC | 20,590 | $598K | 0.0% | $29.04 | $27.02 | — | COM | 81750R102 |
| ADMA | ADMA BIOLOGICS INC | 100,000 | $595K | 0.0% | $5.95 * | $7.00 | 0.0% | COM | 000899104 |
| — | MIRATI THERAPEUTICS INC | 107,235 | $586K | 0.0% | $5.46 | $5.46 | — | COM | 60468T955 |
| — | CAPNIA INC. | 501,240 | $581K | 0.0% | $1.16 | $1.20 | — | COM | 14066L105 |
| — | RADIUS HEALTH INC | 157 | $577K | 0.0% | $3675.16 | — | — | Call | 750469907 |
| — | COMBIMATRIX CORP. | 855,171 | $573K | 0.0% | $0.67 | $0.67 | — | *W | 20009T147 |
| — | ZAFGEN INC | 930 | $557K | 0.0% | $598.92 | — | — | Call | 98885E903 |
| PRQR | PROQR THERAPEUTICS N.V. | 110,000 | $532K | 0.0% | $4.84 * | $7.45 | -31.0% | SHS | N71542109 |
| — | ANTHERA PHARMACEUTICALS INC | 1,677 | $518K | 0.0% | $308.88 | — | — | Call | 03674U901 |
| — | HEARTWARE INTERNATIONAL INC | 89 | $514K | 0.0% | $5775.28 | — | — | Put | 422368950 |
| NWBO | NORTHWEST BIOTHERAPEUTICS INC | 881,585 | $512K | 0.0% | $0.58 * | $3.48 | -69.3% | COM | 66737P600 |
| — | ASSEMBLY BIOSCIENCES INC | 90,362 | $502K | 0.0% | $5.56 | $5.56 | — | COM | 045396108 |
| — | REVANCE THERAPEUTICS INC | 339 | $461K | 0.0% | $1359.88 | — | — | Call | 761330909 |
| — | ANTARES PHARMA INC | 424,100 | $445K | 0.0% | $1.05 | $1.66 | — | COM | 036642106 |
| — | RADIUS HEALTH INC | 120 | $441K | 0.0% | $3675.00 | — | — | Put | 750469957 |
| — | BENITEC BIOPHARMA LTD | 345,576 | $438K | 0.0% | $1.27 | $5.82 | — | ADR | 082053307 |
| INSM | INSMED INC | 43,964 | $433K | 0.0% | $9.85 * | $12.87 | -9.4% | COM | 457669307 |
| — | IPATH S&P 500 VIX | 300 | $414K | 0.0% | $1380.00 | — | — | Call | 06742E901 |
| — | CANCER GENETICS INC | 199,580 | $397K | 0.0% | $1.99 | $2.48 | — | COM | 13739U104 |
| — | MINERVA NEUROSCIENCES INC | 38,000 | $388K | 0.0% | $10.21 | $10.21 | — | COM | 603380106 |
| — | BIODELIVERY SCIENCES INTERNATIONAL INC | 1,626 | $384K | 0.0% | $236.16 | — | — | Call | 09060J906 |
| — | QUEST RESOURCE HOLDING CORP | 1,315,708 | $382K | 0.0% | $0.29 | $1.62 | — | COM | 74836W104 |
| — | RIGEL PHARMACEUTICALS INC | 1,684 | $375K | 0.0% | $222.68 | — | — | Call | 766559903 |
| — | PARATEK PHARMACEUTICALS INC | 245 | $341K | 0.0% | $1391.84 | — | — | Call | 699374902 |
| — | MEDICINES CO | 100 | $336K | 0.0% | $3360.00 | — | — | Put | 584688955 |
| — | SUPERCONDUCTOR TECHNOLOGIES INC | 1,701,245 | $322K | 0.0% | $0.19 | $0.55 | — | COM | 867931404 |
| — | NEWLINK GENETICS CORP | 28,261 | $318K | 0.0% | $11.25 | $36.28 | — | COM | 651511107 |
| — | ANTHERA PHARMACEUTICALS INC | 100,000 | $309K | 0.0% | $3.09 | $3.62 | — | COM | 03674U201 |
| — | CYNAPSUS THERAPEUTICS INC | 18,194 | $305K | 0.0% | $16.76 | $15.63 | — | COM | 23257Y859 |
| — | SKYLINE MEDICAL INC | 1,957,037 | $298K | 0.0% | $0.15 | $0.17 | — | COM | 83084T309 |
| ACRS | ACLARIS THERAPEUTICS INC | 15,812 | $292K | 0.0% | $18.47 * | $19.81 | 0.0% | COM | 00461U105 |
| — | NEUROMETRIX INC | 172,236 | $286K | 0.0% | $1.66 | $1.82 | — | COM | 641255500 |
| — | MEDIVATION INC | 45 | $271K | 0.0% | $6022.22 | — | — | Put | 58501N951 |
| — | MEDIVATION INC | 4,500 | $271K | 0.0% | $60.22 | $60.22 | — | COM | 58501N101 |
| — | HISTOGENICS INC | 150,630 | $258K | 0.0% | $1.71 | $4.61 | — | COM | 43358V109 |
| — | ACORDA THERAPEUTICS INC | 100 | $255K | 0.0% | $2550.00 | — | — | Put | 00484M956 |
| — | AMARIN CORPORATION PLC | 1,118 | $241K | 0.0% | $215.56 | — | — | Put | 023111956 |
| — | AKARI THERAPEUTICS PLC | 17,428 | $235K | 0.0% | $13.48 | $14.89 | — | ADR | 00972G108 |
| — | MEDICINES CO | 7,000 | $235K | 0.0% | $33.57 | $33.57 | — | COM | 584688105 |
| — | ARBUTUS BIOPHARMA CORP | 669 | $233K | 0.0% | $348.28 | — | — | Call | 03879J900 |
| — | TENET HEALTHCARE CORP | 81 | $224K | 0.0% | $2765.43 | — | — | Call | 88033G907 |
| — | CELLECTAR BIOSCIENCES INC | 230,013 | $219K | 0.0% | $0.95 | $0.89 | — | *W | 15117F120 |
| — | STAFFING 360 SOLUTIONS INC | 136,583 | $216K | 0.0% | $1.58 | $1.58 | — | COM | 852387208 |
| — | RELYPSA INC | 115 | $213K | 0.0% | $1852.17 | — | — | Call | 759531906 |
| — | CIDARA THERAPEUTICS INC | 20,277 | $209K | 0.0% | $10.31 | $12.71 | — | COM | 171757107 |
| — | ONCOBIOLOGICS INC | 426,184 | $209K | 0.0% | $0.49 | $0.49 | — | *W | 68235M113 |
| — | ATHERSYS INC SHS | 91,746 | $199K | 0.0% | $2.17 | $2.17 | — | COM | 04744L106 |
| — | ONCOBIOLOGICS INC | 436,923 | $196K | 0.0% | $0.45 | $0.45 | — | *W | 68235M121 |
| — | LIPOCINE INC | 63,875 | $194K | 0.0% | $3.04 | $8.58 | — | COM | 53630X104 |
| — | ALCOBRA LTD | 409 | $184K | 0.0% | $449.88 | — | — | Put | M2239P959 |
| — | NATERA INC | 144 | $174K | 0.0% | $1208.33 | — | — | Call | 632307904 |
| — | MOMENTA PHARMACEUTICALS INC | 159 | $172K | 0.0% | $1081.76 | — | — | Put | 60877T950 |
| — | ZOSANO PHARMA INC | 128,600 | $170K | 0.0% | $1.32 | $9.59 | — | COM | 98979H103 |
| — | RELYPSA INC | 88 | $163K | 0.0% | $1852.27 | — | — | Put | 759531956 |
| — | PROGENICS PHARMACEUTICALS INC | 361 | $152K | 0.0% | $421.05 | — | — | Call | 743187906 |
| — | REGULUS THERAPEUTIC INC | 49,231 | $142K | 0.0% | $2.88 | $14.53 | — | COM | 75915K101 |
| — | SERES THERAPEUTICS INC | 49 | $142K | 0.0% | $2897.96 | — | — | Call | 81750R902 |
| — | CLOVIS ONCOLOGY INC | 103 | $141K | 0.0% | $1368.93 | — | — | Put | 189464950 |
| — | ARALEZ PHARMACEUTICALS INC | 413 | $136K | 0.0% | $329.30 | — | — | Call | 03852X900 |
| — | ADVAXIS INC | 14,000 | $113K | 0.0% | $8.07 | $8.07 | — | COM | 007624208 |
| — | ADVAXIS INC | 140 | $113K | 0.0% | $807.14 | — | — | Put | 007624958 |
| — | GALENA BIOPHARMA INC | 2,289 | $107K | 0.0% | $46.75 | — | — | Put | 363256958 |
| — | NEWLINK GENETICS CORP | 162 | $97,000 | 0.0% | $598.77 | — | — | Put | 651511957 |
| — | DURECT CORP | 770 | $94,000 | 0.0% | $122.08 | — | — | Call | 266605904 |
| — | TENAX THERAPEUTICS INC | 335 | $86,000 | 0.0% | $256.72 | — | — | Call | 88032L900 |
| — | ALCOBRA LTD | 18,317 | $82,000 | 0.0% | $4.48 | $5.87 | — | SHS | M2239P109 |
| AKBA | AKEBIA THERAPEUTICS INC | 100 | $75,000 | 0.0% | $750.00 | — | — | Call | 00972D105 |
| — | INVIVO THERAPEUTICS HOLDINGS CORP | 100 | $58,000 | 0.0% | $580.00 | — | — | Call | 46186M909 |
| — | PROGENICS PHARMACEUTICALS INC | 130 | $55,000 | 0.0% | $423.08 | — | — | Put | 743187956 |
| — | ALLIQUA BIOMEDICAL INC | 483 | $54,000 | 0.0% | $111.80 | — | — | Call | 019621900 |
| — | GALENA BIOPHARMA INC | 113,530 | $53,000 | 0.0% | $0.47 | $0.47 | — | COM | 363256108 |
| — | EDAP TMS S A | 157 | $52,000 | 0.0% | $331.21 | — | — | Put | 268311957 |
| — | VIKING THERAPEUTICS INC | 176,113 | $51,000 | 0.0% | $0.29 | $0.29 | — | *W | 92686J114 |
| — | ATHERSYS INC SHS | 225 | $49,000 | 0.0% | $217.78 | — | — | Put | 04744L956 |
| — | NORTHWEST BIOTHERAPEUTICS INC | 813 | $47,000 | 0.0% | $57.81 | — | — | Put | 66737P950 |
| — | TENAX THERAPEUTICS INC | 169 | $43,000 | 0.0% | $254.44 | — | — | Put | 88032L950 |
| — | COMBIMATRIX CORP. | 14,391 | $41,000 | 0.0% | $2.85 | $2.85 | — | COM | 20009T501 |
| PVCT | PROVECTUS BIOPHARMACEUTICALS | 93,283 | $35,000 | 0.0% | $0.38 | $0.82 | -53.3% | COM | 74373P108 |
| — | RENNOVA HEALTH INC | 3,225,806 | $32,000 | 0.0% | $0.01 | $0.44 | — | *W | 759757115 |
| — | INFINITY PHARMACEUTICALS INC | 225 | $30,000 | 0.0% | $133.33 | — | — | Put | 45665G953 |
| INFIQ | INFINITY PHARMACEUTICALS INC | 22,500 | $30,000 | 0.0% | $1.33 * | $4.68 | 0.0% | COM | 45665G303 |
| — | BENITEC BIOPHARMA LTD | 98,146 | $24,000 | 0.0% | $0.24 | $0.36 | — | *W | 082053117 |
| — | INFINITY PHARMACEUTICALS INC | 167 | $22,000 | 0.0% | $131.74 | — | — | Call | 45665G903 |
| — | INTELLIPHARMACEUTICS INTERNATIONAL INC | 122 | $19,000 | 0.0% | $155.74 | — | — | Put | 458173951 |
| — | MAST THERAPEUTICS INC | 369 | $17,000 | 0.0% | $46.07 | — | — | Put | 576314958 |
| — | EYEGATE PHARMACEUTICALS INC | 53,893 | $2,000 | 0.0% | $0.04 | $1.02 | — | *W | 30233M115 |