Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
—	ELI LILLY & CO	30,121	$237M	12.4%	—	—	Call	532457908
—	SPDR S&P 500	8,415	$176M	9.2%	—	—	Put	78462F953
—	ISHARES RUSSELL 2000 ETF	13,600	$156M	8.2%	—	—	Put	464287951
—	ABBVIE INC	18,007	$111M	5.8%	—	—	Call	00287Y909
—	HCA HOLDINGS INC	9,291	$71.55M	3.7%	—	—	Call	40412C901
—	AMGEN INC	3,942	$59.98M	3.1%	—	—	Put	031162950
—	SAREPTA THERAPEUTICS INC	29,250	$55.78M	2.9%	—	—	Put	803607950
—	MONSANTO CO	5,334	$55.16M	2.9%	—	—	Call	61166W901
—	BIOGEN INC	1,866	$45.12M	2.4%	—	—	Call	09062X903
—	REGENERON PHARMACEUTICALS INC	1,160	$40.51M	2.1%	—	—	Put	75886F957
—	ELI LILLY & CO	4,891	$38.52M	2.0%	—	—	Put	532457958
—	PFIZER INC	10,000	$35.21M	1.8%	—	—	Call	717081903
—	JOHNSON & JOHNSON	2,809	$34.07M	1.8%	—	—	Call	478160904
—	DEXCOM INC	4,214	$33.43M	1.7%	—	—	Put	252131957
—	SAREPTA THERAPEUTICS INC	15,225	$29.03M	1.5%	—	—	Call	803607900
REGN	REGENERON PHARMACEUTICALS INC	71,525	$24.98M	1.3%	$397.62	-3.7%	COM	75886F107
AMGN	AMGEN INC	154,082	$23.44M	1.2%	$111.19	+5.0%	COM	031162100
—	ABBOTT LABS	5,000	$19.66M	1.0%	—	—	Put	002824950
—	MANNKIND CORP	52,978	$18.27M	1.0%	—	—	Put	56400P951
—	TEVA PHARMACEUTICAL INDUSTRIES LTD	3,618	$18.17M	0.9%	—	—	Call	881624909
—	TESARO INC	2,158	$18.14M	0.9%	—	—	Call	881569907
—	RETROPHIN INC	9,445	$16.82M	0.9%	—	—	Call	761299906
—	DYNAVAX TECHNOLOGIES CORP	10,712	$15.62M	0.8%	—	—	Call	268158901
—	ACADIA PHARMACEUTICALS INC	4,674	$15.17M	0.8%	—	—	Call	004225908
SRPT	SAREPTA THERAPEUTICS INC	783,497	$14.94M	0.8%	$17.82	+3.6%	COM	803607100
—	ABBVIE INC	2,347	$14.53M	0.8%	—	—	Put	00287Y959
—	SHIRE PLC	698	$12.85M	0.7%	—	—	Put	82481R956
—	SHIRE PLC	698	$12.85M	0.7%	—	—	Call	82481R906
—	SPDR GOLD TRUST	1,000	$12.65M	0.7%	—	—	Call	78463V907
—	MEDICINES CO	3,614	$12.15M	0.6%	—	—	Call	584688905
—	MYLAN N.V.	2,804	$12.12M	0.6%	—	—	Call	N59465909
—	SAGE THERAPEUTICS INC	4,009	$12.08M	0.6%	—	—	Call	78667J908
—	SAGE THERAPEUTICS INC	3,496	$10.53M	0.5%	—	—	Put	78667J958
ABT	ABBOTT LABS	264,700	$10.4M	0.5%	$33.35	0.0%	COM	002824100
—	SPDR S&P 500 BIOTECH	1,858	$10.05M	0.5%	—	—	Put	78464A950
—	DEXCOM INC	1,180	$9.361M	0.5%	—	—	Call	252131907
—	DYNAVAX TECHNOLOGIES CORP	5,942	$8.663M	0.5%	—	—	Put	268158951
—	RETROPHIN INC	4,826	$8.595M	0.4%	—	—	Put	761299956
—	ACORDA THERAPEUTICS INC 1.75%	9,600,000	$8.388M	0.4%	$0.90	—	NOTE	00484MAA4
—	IONIS PHARMACEUTICALS INC	3,600	$8.384M	0.4%	—	—	Call	462222900
—	ALKERMES PLC	1,335	$7.93M	0.4%	—	—	Call	G01767905
—	CORSICANTO LTD 3.5%	7,756,000	$7.877M	0.4%	$1.02	—	NOTE	220480AB3
—	LEXICON PHARMACEUTICALS INC	5,320	$7.634M	0.4%	—	—	Call	528872902
—	NOVAVAX INC	10,447	$7.595M	0.4%	—	—	Put	670002954
—	ONCOBIOLOGICS INC	2,068,968	$7.035M	0.4%	$3.40	—	COM	68235M105
—	CELGENE CORP	695	$6.855M	0.4%	—	—	Call	151020904
—	TENAX THERAPEUTICS INC	2,606,035	$6.671M	0.3%	$3.75	—	COM	88032L100
—	LION BIOTECHNOLOGIES INC	7,526	$6.096M	0.3%	—	—	Put	53619R952
—	BIO PATH HOLDINGS INC	2,988,295	$5.947M	0.3%	$1.99	—	COM	09057N102
—	INTRA CELLULAR THERAPIES INC	1,467	$5.695M	0.3%	—	—	Put	46116X951
—	IPATH S&P 500 MT	3,972	$5.485M	0.3%	$11.17	—	Call	06740C519
—	ALNYLAM PHARMACEUTICALS INC	987	$5.477M	0.3%	—	—	Call	02043Q907
—	SHIRE PLC	29,550	$5.44M	0.3%	$184.09	—	COM	82481R106
—	INTRA CELLULAR THERAPIES INC	1,373	$5.33M	0.3%	—	—	Call	46116X901
—	VERTEX PHARMACEUTICALS INC	609	$5.239M	0.3%	—	—	Call	92532F900
—	EXPRESS SCRIPTS HOLDING CO.	665	$5.041M	0.3%	—	—	Put	30219E953
—	TEVA PHARMACEUTICAL INDUSTRIES LTD	1,000	$5.023M	0.3%	—	—	Put	881624959
—	AMICUS THERAPEUTICS INC	7,992	$4.364M	0.2%	—	—	Call	03152W909
—	PARATEK PHARMACEUTICALS INC	305,964	$4.256M	0.2%	$17.47	—	COM	699374302
—	KITE PHARMA INC	851	$4.255M	0.2%	—	—	Call	49803L909
—	DYNAVAX TECHNOLOGIES CORP	290,505	$4.236M	0.2%	$20.06	—	COM	268158201
—	GLOBAL BLOOD THERAPEUTICS INC	254,029	$4.214M	0.2%	$30.38	—	COM	37890U108
—	TOKAI PHARMACEUTICALS	749,205	$4.128M	0.2%	$5.61	—	COM	88907J107
—	CYTORI THERAPEUTICS INC	1,966,708	$4.11M	0.2%	$2.09	—	COM	23283K204
ABUS	ARBUTUS BIOPHARMA CORP	1,176,031	$4.093M	0.2%	$7.22	-41.4%	COM	03879J100
—	CEMPRA INC	2,340	$3.859M	0.2%	—	—	Put	15130J959
—	CEL SCI CORP	8,163,816	$3.755M	0.2%	$0.46	—	COM	150837508
—	NEUROCRINE BIOSCIENCES INC	813	$3.695M	0.2%	—	—	Call	64125C909
—	HORIZON PHARMA PLC	2,205	$3.632M	0.2%	—	—	Call	G4617B905
—	EIGER BIOPHARMACEUTICALS INC	175,249	$3.473M	0.2%	$16.77	—	COM	28249U105
—	NEWLINK GENETICS CORP	5,771	$3.463M	0.2%	—	—	Call	651511907
—	ALNYLAM PHARMACEUTICALS INC	606	$3.363M	0.2%	—	—	Put	02043Q957
—	INVIVO THERAPEUTICS HOLDINGS CORP	580,343	$3.354M	0.2%	$6.90	—	COM	46186M209
—	INTEC PHARMA LTD	743,545	$3.346M	0.2%	$5.45	—	SHS	M53644106
—	REGULUS THERAPEUTIC INC	11,560	$3.341M	0.2%	—	—	Call	75915K901
—	LA JOLLA PHARMACEUTICAL CO	206,131	$3.298M	0.2%	$20.85	—	COM	503459604
RGNX	REGENXBIO INC	411,926	$3.295M	0.2%	$14.34	-22.6%	COM	75901B107
—	DURECT CORP	2,540,278	$3.099M	0.2%	$1.22	—	COM	266605104
—	ACHILLION PHARMACEUTICALS INC	3,827	$2.985M	0.2%	—	—	Call	00448Q901
—	LION BIOTECHNOLOGIES INC	367,242	$2.975M	0.2%	$8.51	—	COM	53619R102
—	INTREXON CORP	120,359	$2.962M	0.2%	$32.90	—	COM	46122T102
—	NIVALIS THERAPEUTICS INC	641,492	$2.951M	0.2%	$11.19	—	COM	65481J109
ILMN	ILLUMINA INC	20,000	$2.808M	0.1%	$142.06	0.0%	COM	452327109
—	BARCLAYS BANK IPATH S&P 500 MT	260,000	$2.805M	0.1%	$11.17	—	ETN	06740C519
EDAP	EDAP TMS S A	847,225	$2.804M	0.1%	$3.31	—	ADR	268311107
—	INTREXON CORP	1,136	$2.796M	0.1%	—	—	Put	46122T952
—	INTRA CELLULAR THERAPIES INC	71,943	$2.793M	0.1%	$27.79	—	COM	46116X101
—	PIERIS PHARMACEUTICALS ORD SHS	1,615,992	$2.602M	0.1%	$1.64	—	COM	720795103
—	SANGAMO BIOSCIENCES INC	4,400	$2.548M	0.1%	—	—	Call	800677906
—	CEMPRA INC	1,537	$2.535M	0.1%	—	—	Call	15130J909
—	OPGEN INC	1,625,000	$2.47M	0.1%	$1.52	—	COM	68373L109
—	OPKO HEALTH INC	2,645	$2.47M	0.1%	—	—	Put	68375N953
—	ADVERUM BIOTECHNOLOGIES INC.	779,926	$2.465M	0.1%	$3.16	—	COM	00773U108
—	AXOVANT SCIENCES LTD	190,000	$2.44M	0.1%	$12.60	—	COM	G0750W104
—	VISTAGEN THERAPEUTICS INC	623,317	$2.431M	0.1%	$3.90	—	COM	92840H202
—	BIOGEN INC	100	$2.418M	0.1%	—	—	Put	09062X953
BIIB	BIOGEN INC	10,000	$2.418M	0.1%	$264.15	-0.2%	COM	09062X103
—	LA JOLLA PHARMACEUTICAL CO	1,458	$2.333M	0.1%	—	—	Call	503459904
—	ZOGENIX INC	289,200	$2.328M	0.1%	$9.10	—	COM	98978L204
—	IONIS PHARMACEUTICALS INC	984	$2.292M	0.1%	—	—	Put	462222950
—	REXAHN PHARMACEUTICALS INC	9,071,168	$2.279M	0.1%	$0.33	—	COM	761640101
—	VERTEX PHARMACEUTICALS INC	260	$2.237M	0.1%	—	—	Put	92532F950
—	CLOVIS ONCOLOGY INC	1,626	$2.231M	0.1%	—	—	Call	189464900
—	ZOGENIX INC	12,072	$2.199M	0.1%	—	—	Call	98978L904
—	ABBOTT LABS	555	$2.182M	0.1%	—	—	Call	002824900
—	NOVAVAX INC	3,001	$2.182M	0.1%	—	—	Call	670002904
—	SAGE THERAPEUTICS INC	68,950	$2.077M	0.1%	$34.46	—	COM	78667J108
—	AMARIN CORPORATION PLC	9,411	$2.033M	0.1%	—	—	Call	023111906
—	ALCOBRA LTD	4,467	$2.006M	0.1%	—	—	Call	M2239P909
—	CELSION CORP.	1,519,365	$1.93M	0.1%	$1.28	—	COM	15117N404
—	NEURALSTEM INC	6,503,800	$1.893M	0.1%	$0.29	—	COM	64127R302
—	MOMENTA PHARMACEUTICALS INC	1,736	$1.875M	0.1%	—	—	Call	60877T900
—	FORWARD PHARMA A/S	102,135	$1.856M	0.1%	$23.42	—	ADR	34986J105
—	BIODELIVERY SCIENCES INTERNATIONAL INC	785,799	$1.854M	0.1%	$4.78	—	COM	09060J106
—	CAPSTONE TURBINE CORP	1,336,901	$1.845M	0.1%	$1.38	—	COM	14067D409
—	OPHTHOTECH CORP	361	$1.842M	0.1%	—	—	Call	683745903
—	HALOZYME THERAPEUTICS INC	2,101	$1.813M	0.1%	—	—	Call	40637H909
OPK	OPKO HEALTH INC	190,554	$1.78M	0.1%	$11.72	-13.3%	COM	68375N103
—	ALLIQUA BIOMEDICAL INC	1,500,000	$1.68M	0.1%	$1.60	—	COM	019621200
—	REDHILL BIOPHARMA LTD	147,500	$1.611M	0.1%	$12.91	—	COM	757468103
—	FOAMIX PHARMACEUTICALS LTD	253,706	$1.611M	0.1%	$8.92	—	SHS	M46135105
—	ACADIA PHARMACEUTICALS INC	495	$1.607M	0.1%	—	—	Put	004225958
—	FIBROGEN INC	97,274	$1.596M	0.1%	$21.29	—	COM	31572Q808
—	GW PHARMACEUTICALS PLC	172	$1.575M	0.1%	—	—	Call	36197T903
—	MOMENTA PHARMACEUTICALS INC	145,600	$1.572M	0.1%	$12.52	—	COM	60877T100
—	VANDA PHARMACEUTICALS INC	1,390	$1.555M	0.1%	—	—	Call	921659908
—	DEPOMED INC	788	$1.546M	0.1%	—	—	Call	249908904
—	WAFERGEN BIO SYSTEMS INC	1,867,250	$1.533M	0.1%	$0.77	—	COM	93041P308
—	FLEXION THERAPEUTICS INC	100,800	$1.508M	0.1%	$12.31	—	COM	33938J106
—	REGENERON PHARMACEUTICALS INC	43	$1.502M	0.1%	—	—	Call	75886F907
—	ADURO BIOTECH INC	1,322	$1.495M	0.1%	—	—	Call	00739L901
—	ADAMAS PHARMACEUTICALS INC	97,600	$1.478M	0.1%	$14.46	—	COM	00548A106
SRNE	SORRENTO THERAPEUTICS INC	253,805	$1.421M	0.1%	$11.18	-42.8%	COM	83587F202
—	LEXICON PHARMACEUTICALS INC	979	$1.405M	0.1%	—	—	Put	528872952
—	EXELIXIS INC	1,783	$1.393M	0.1%	—	—	Call	30161Q904
—	OPKO HEALTH INC	1,491	$1.393M	0.1%	—	—	Call	68375N903
—	PUMA BIOTECHNOLOGY INC	458	$1.364M	0.1%	—	—	Call	74587V907
—	BIO BLAST PHARMA LTD	830,253	$1.328M	0.1%	$2.49	—	SHS	M20156101
—	INSMED INC	1,346	$1.327M	0.1%	—	—	Call	457669907
—	RICEBRAN TECHNOLOGIES INC	785,476	$1.304M	0.1%	$3.68	—	COM	762831204
—	SCYNEXIS INC	572,928	$1.243M	0.1%	$2.17	—	COM	811292101
—	EXPRESS SCRIPTS HOLDING CO.	16,386	$1.242M	0.1%	$75.80	—	COM	30219E103
—	PTC THERAPEUTICS INC	1,740	$1.221M	0.1%	—	—	Call	69366J900
—	AMICUS THERAPEUTICS INC	2,234	$1.22M	0.1%	—	—	Put	03152W959
—	IGNYTA INC	225,000	$1.22M	0.1%	$6.50	—	COM	451731103
—	TEARLAB CORP.	1,882,347	$1.205M	0.1%	$0.64	—	COM	878193101
—	DERMIRA INC	412	$1.205M	0.1%	—	—	Call	24983L904
COLL	COLLEGIUM PHARMACEUTICAL INC	101,410	$1.202M	0.1%	$17.86	-7.5%	COM	19459J104
—	AERIE PHARMACEUTICALS INC	674	$1.186M	0.1%	—	—	Call	00771V908
CSBR	CHAMPIONS ONCOLOGY INC	546,728	$1.175M	0.1%	$4.47	-26.1%	COM	15870P307
—	PRONAI THERAPEUTICS INC	590,011	$1.174M	0.1%	$1.99	—	COM	74346L101
—	TONIX PHARMACEUTICALS HOLDINGS CORP	585,914	$1.166M	0.1%	$2.79	—	COM	890260201
—	XTL BIOPHARMACEUTICALS LTD	1,001,170	$1.161M	0.1%	$2.30	—	ADR	98386D208
—	BRAINSTORM CELL THERAPEUTICS INC	476,719	$1.149M	0.1%	$4.17	—	COM	10501E201
—	CEMPRA INC	64,065	$1.056M	0.1%	$32.75	—	COM	15130J109
—	NOVAVAX INC	142,726	$1.038M	0.1%	$7.27	—	COM	670002104
—	IMMUNOCELLULAR THERAPEUTICS INC	4,452,128	$1.025M	0.1%	$0.48	—	COM	452536105
—	EYEGATE PHARMACEUTICALS INC	386,940	$1.002M	0.1%	$2.59	—	COM	30233M107
—	ONCOSEC MEDICAL INC	608,052	$997K	0.1%	$3.47	—	COM	68234L207
—	IMMUNOMEDICS INC	425,000	$986K	0.1%	$68.00	—	COM	452907108
—	THERAPEUTICSMD INC	1,153	$980K	0.1%	—	—	Call	88338N907
GALT	GALECTIN THERAPEUTICS INC	662,467	$974K	0.1%	$2.29	-36.0%	COM	363225202
—	RIGEL PHARMACEUTICALS INC	435,957	$972K	0.1%	$2.23	—	COM	766559603
ACUR	ACURA PHARMACEUTICALS INC	518,444	$959K	0.1%	$3.40	-24.1%	COM	00509L802
—	AMPLIPHI BIOSCIENCES CORP	613,782	$951K	0.0%	$1.55	—	COM	03211P202
—	KITOV PHARMACEUTICALS HOLDINGS	1,210,785	$944K	0.0%	$0.75	—	*W	49803V115
—	ENDO INTERNATIONAL PLC	60,061	$936K	0.0%	$26.05	—	SHS	G30401106
—	GENVEC INC	1,625,435	$931K	0.0%	$0.57	—	COM	37246C307
—	JUNO THERAPEUTICS INC	240	$923K	0.0%	—	—	Call	48205A909
—	DEXTERA SURGICAL INC.	482,000	$868K	0.0%	$1.80	—	COM	252366109
—	AETERNA ZENTARIS INC	265,803	$867K	0.0%	$4.48	—	COM	007975402
—	WINDTREE THERAPEUTICS INC	448,509	$866K	0.0%	$1.93	—	COM	97382D105
—	DERMIRA INC	289	$845K	0.0%	—	—	Put	24983L954
—	CLOVIS ONCOLOGY INC	59,836	$821K	0.0%	$18.46	—	COM	189464100
—	CASCADIAN THERAPEUTICS INC	864,402	$815K	0.0%	$0.94	—	COM	14740B101
—	VTV THERAPEUTICS INC	139,747	$811K	0.0%	$6.52	—	CL A	918385105
—	OCERA THERAPEUTICS INC	424,035	$806K	0.0%	$5.54	—	COM	67552A108
—	CELATOR PHARMACEUTICALS INC	26,500	$800K	0.0%	$3.37	—	COM	15089R102
—	CYTORI THERAPEUTICS INC	1,004,065	$793K	0.0%	$0.79	—	*W	23283K121
—	INOTEK PHARMACEUTICALS CORP	106,454	$792K	0.0%	$8.91	—	COM	45780V102
—	DERMIRA INC	26,693	$781K	0.0%	$20.68	—	COM	24983L104
—	ACHILLION PHARMACEUTICALS INC	1,000	$780K	0.0%	—	—	Put	00448Q951
—	HCA HOLDINGS INC	100	$770K	0.0%	—	—	Put	40412C951
—	MEDGENICS INC	138,777	$770K	0.0%	$5.55	—	COM	58436Q203
—	HORIZON PHARMA PLC	463	$763K	0.0%	—	—	Put	G4617B955
—	INSMED INC	771	$760K	0.0%	—	—	Put	457669957
—	CELGENE CORP	77	$759K	0.0%	—	—	Put	151020954
—	ARALEZ PHARMACEUTICALS INC	228,364	$754K	0.0%	$3.55	—	COM	03852X100
—	ASTERIAS BIOTHERAPEUTICS INC	308,909	$741K	0.0%	$2.40	—	COM	04624N107
—	PROGENICS PHARMACEUTICALS INC	174,900	$738K	0.0%	$4.36	—	COM	743187106
—	PSIVIDA CORP	257,800	$730K	0.0%	$2.68	—	COM	74440J101
—	KITOV PHARMACEUTICALS HOLDINGS	232,524	$725K	0.0%	$3.12	—	ADR	49803V107
—	CAPRICOR THERAPEUTICS INC	182,083	$719K	0.0%	$4.85	—	COM	14070B101
—	OVASCIENCE INC	135,101	$704K	0.0%	$5.21	—	COM	69014Q101
—	GLOBAL BLOOD THERAPEUTICS INC	421	$698K	0.0%	—	—	Call	37890U908
FOLD	AMICUS THERAPEUTICS INC	125,912	$687K	0.0%	$7.43	-5.9%	COM	03152W109
—	ABEONA THERAPEUTICS ORD SHS	270,000	$637K	0.0%	$4.32	—	COM	00289Y107
PARNEUR	PARNELL PHARMACEUTICALS HOLDINGS LTD	389,400	$635K	0.0%	$1.63	—	SHS	Q73622104
—	STRATA SKIN SCIENCES INC	1,020,524	$623K	0.0%	$0.80	—	COM	86272A107
—	BIOPHARMX CORP	957,000	$622K	0.0%	$1.01	—	COM	09072X101
—	NEUROMETRIX INC	3,060,197	$612K	0.0%	$0.31	—	*W	641255153
—	SERES THERAPEUTICS INC	20,590	$598K	0.0%	$27.02	—	COM	81750R102
ADMA	ADMA BIOLOGICS INC	100,000	$595K	0.0%	$7.00	0.0%	COM	000899104
—	MIRATI THERAPEUTICS INC	107,235	$586K	0.0%	$5.46	—	COM	60468T955
—	CAPNIA INC.	501,240	$581K	0.0%	$1.20	—	COM	14066L105
—	RADIUS HEALTH INC	157	$577K	0.0%	—	—	Call	750469907
—	COMBIMATRIX CORP.	855,171	$573K	0.0%	$0.67	—	*W	20009T147
—	ZAFGEN INC	930	$557K	0.0%	—	—	Call	98885E903
PRQR	PROQR THERAPEUTICS N.V.	110,000	$532K	0.0%	$7.45	-31.0%	SHS	N71542109
—	ANTHERA PHARMACEUTICALS INC	1,677	$518K	0.0%	—	—	Call	03674U901
—	HEARTWARE INTERNATIONAL INC	89	$514K	0.0%	—	—	Put	422368950
NWBO	NORTHWEST BIOTHERAPEUTICS INC	881,585	$512K	0.0%	$3.48	-69.3%	COM	66737P600
—	ASSEMBLY BIOSCIENCES INC	90,362	$502K	0.0%	$5.56	—	COM	045396108
—	REVANCE THERAPEUTICS INC	339	$461K	0.0%	—	—	Call	761330909
—	ANTARES PHARMA INC	424,100	$445K	0.0%	$1.66	—	COM	036642106
—	RADIUS HEALTH INC	120	$441K	0.0%	—	—	Put	750469957
—	BENITEC BIOPHARMA LTD	345,576	$438K	0.0%	$5.82	—	ADR	082053307
INSM	INSMED INC	43,964	$433K	0.0%	$12.87	-9.4%	COM	457669307
—	IPATH S&P 500 VIX	300	$414K	0.0%	—	—	Call	06742E901
—	CANCER GENETICS INC	199,580	$397K	0.0%	$2.48	—	COM	13739U104
—	MINERVA NEUROSCIENCES INC	38,000	$388K	0.0%	$10.21	—	COM	603380106
—	BIODELIVERY SCIENCES INTERNATIONAL INC	1,626	$384K	0.0%	—	—	Call	09060J906
—	QUEST RESOURCE HOLDING CORP	1,315,708	$382K	0.0%	$1.62	—	COM	74836W104
—	RIGEL PHARMACEUTICALS INC	1,684	$375K	0.0%	—	—	Call	766559903
—	PARATEK PHARMACEUTICALS INC	245	$341K	0.0%	—	—	Call	699374902
—	MEDICINES CO	100	$336K	0.0%	—	—	Put	584688955
—	SUPERCONDUCTOR TECHNOLOGIES INC	1,701,245	$322K	0.0%	$0.55	—	COM	867931404
—	NEWLINK GENETICS CORP	28,261	$318K	0.0%	$36.28	—	COM	651511107
—	ANTHERA PHARMACEUTICALS INC	100,000	$309K	0.0%	$3.62	—	COM	03674U201
—	CYNAPSUS THERAPEUTICS INC	18,194	$305K	0.0%	$15.63	—	COM	23257Y859
—	SKYLINE MEDICAL INC	1,957,037	$298K	0.0%	$0.17	—	COM	83084T309
ACRS	ACLARIS THERAPEUTICS INC	15,812	$292K	0.0%	$19.81	0.0%	COM	00461U105
—	NEUROMETRIX INC	172,236	$286K	0.0%	$1.82	—	COM	641255500
—	MEDIVATION INC	45	$271K	0.0%	—	—	Put	58501N951
—	MEDIVATION INC	4,500	$271K	0.0%	$60.22	—	COM	58501N101
—	HISTOGENICS INC	150,630	$258K	0.0%	$4.61	—	COM	43358V109
—	ACORDA THERAPEUTICS INC	100	$255K	0.0%	—	—	Put	00484M956
—	AMARIN CORPORATION PLC	1,118	$241K	0.0%	—	—	Put	023111956
—	AKARI THERAPEUTICS PLC	17,428	$235K	0.0%	$14.89	—	ADR	00972G108
—	MEDICINES CO	7,000	$235K	0.0%	$33.57	—	COM	584688105
—	ARBUTUS BIOPHARMA CORP	669	$233K	0.0%	—	—	Call	03879J900
—	TENET HEALTHCARE CORP	81	$224K	0.0%	—	—	Call	88033G907
—	CELLECTAR BIOSCIENCES INC	230,013	$219K	0.0%	$0.89	—	*W	15117F120
—	STAFFING 360 SOLUTIONS INC	136,583	$216K	0.0%	$1.58	—	COM	852387208
—	RELYPSA INC	115	$213K	0.0%	—	—	Call	759531906
—	CIDARA THERAPEUTICS INC	20,277	$209K	0.0%	$12.71	—	COM	171757107
—	ONCOBIOLOGICS INC	426,184	$209K	0.0%	$0.49	—	*W	68235M113
—	ATHERSYS INC SHS	91,746	$199K	0.0%	$2.17	—	COM	04744L106
—	ONCOBIOLOGICS INC	436,923	$196K	0.0%	$0.45	—	*W	68235M121
—	LIPOCINE INC	63,875	$194K	0.0%	$8.58	—	COM	53630X104
—	ALCOBRA LTD	409	$184K	0.0%	—	—	Put	M2239P959
—	NATERA INC	144	$174K	0.0%	—	—	Call	632307904
—	MOMENTA PHARMACEUTICALS INC	159	$172K	0.0%	—	—	Put	60877T950
—	ZOSANO PHARMA INC	128,600	$170K	0.0%	$9.59	—	COM	98979H103
—	RELYPSA INC	88	$163K	0.0%	—	—	Put	759531956
—	PROGENICS PHARMACEUTICALS INC	361	$152K	0.0%	—	—	Call	743187906
—	REGULUS THERAPEUTIC INC	49,231	$142K	0.0%	$14.53	—	COM	75915K101
—	SERES THERAPEUTICS INC	49	$142K	0.0%	—	—	Call	81750R902
—	CLOVIS ONCOLOGY INC	103	$141K	0.0%	—	—	Put	189464950
—	ARALEZ PHARMACEUTICALS INC	413	$136K	0.0%	—	—	Call	03852X900
—	ADVAXIS INC	140	$113K	0.0%	—	—	Put	007624958
—	ADVAXIS INC	14,000	$113K	0.0%	$8.07	—	COM	007624208
—	GALENA BIOPHARMA INC	2,289	$107K	0.0%	—	—	Put	363256958
—	NEWLINK GENETICS CORP	162	$97,000	0.0%	—	—	Put	651511957
—	DURECT CORP	770	$94,000	0.0%	—	—	Call	266605904
—	TENAX THERAPEUTICS INC	335	$86,000	0.0%	—	—	Call	88032L900
—	ALCOBRA LTD	18,317	$82,000	0.0%	$5.87	—	SHS	M2239P109
AKBA	AKEBIA THERAPEUTICS INC	100	$75,000	0.0%	—	—	Call	00972D105
—	INVIVO THERAPEUTICS HOLDINGS CORP	100	$58,000	0.0%	—	—	Call	46186M909
—	PROGENICS PHARMACEUTICALS INC	130	$55,000	0.0%	—	—	Put	743187956
—	ALLIQUA BIOMEDICAL INC	483	$54,000	0.0%	—	—	Call	019621900
—	GALENA BIOPHARMA INC	113,530	$53,000	0.0%	$0.47	—	COM	363256108
—	EDAP TMS S A	157	$52,000	0.0%	—	—	Put	268311957
—	VIKING THERAPEUTICS INC	176,113	$51,000	0.0%	$0.29	—	*W	92686J114
—	ATHERSYS INC SHS	225	$49,000	0.0%	—	—	Put	04744L956
—	NORTHWEST BIOTHERAPEUTICS INC	813	$47,000	0.0%	—	—	Put	66737P950
—	TENAX THERAPEUTICS INC	169	$43,000	0.0%	—	—	Put	88032L950
—	COMBIMATRIX CORP.	14,391	$41,000	0.0%	$2.85	—	COM	20009T501
PVCT	PROVECTUS BIOPHARMACEUTICALS	93,283	$35,000	0.0%	$0.82	-53.3%	COM	74373P108
—	RENNOVA HEALTH INC	3,225,806	$32,000	0.0%	$0.44	—	*W	759757115
INFIQ	INFINITY PHARMACEUTICALS INC	22,500	$30,000	0.0%	$4.68	0.0%	COM	45665G303
—	INFINITY PHARMACEUTICALS INC	225	$30,000	0.0%	—	—	Put	45665G953
—	BENITEC BIOPHARMA LTD	98,146	$24,000	0.0%	$0.36	—	*W	082053117
—	INFINITY PHARMACEUTICALS INC	167	$22,000	0.0%	—	—	Call	45665G903
—	INTELLIPHARMACEUTICS INTERNATIONAL INC	122	$19,000	0.0%	—	—	Put	458173951
—	MAST THERAPEUTICS INC	369	$17,000	0.0%	—	—	Put	576314958
—	EYEGATE PHARMACEUTICALS INC	53,893	$2,000	0.0%	$1.02	—	*W	30233M115