Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
—	ELI LILLY & CO	28,962	$209M	10.4%	$7200.99	—	—	Call	532457908
—	SPDR S&P 500 ETF TRUST	10,176	$189M	9.4%	$18537.24	—	—	Put	78462F953
—	IMMUNOMEDICS 15FEB20 4.75PCT	2,680,000	$182M	9.1%	$68.00	$68.00	—	NOTE	452907108
—	BIOGEN INC	6,663	$173M	8.7%	$26031.97	—	—	Call	09062X903
—	ISHARES RUSSELL 2000 ETF	17,673	$162M	8.1%	$9185.88	—	—	Put	464287955
—	ABBVIE INC	13,966	$79.77M	4.0%	$5712.01	—	—	Call	00287Y909
—	GILEAD SCIENCES INC	8,440	$77.53M	3.9%	$9186.02	—	—	Call	375558903
—	JOHNSON & JOHNSON	6,374	$68.97M	3.5%	$10820.05	—	—	Call	478160904
—	HCA HOLDINGS INC	6,798	$53.06M	2.7%	$7804.94	—	—	Call	40412C901
—	AMGEN INC	3,441	$51.59M	2.6%	$14993.03	—	—	Put	031162950
—	ELI LILLY & CO	4,803	$34.59M	1.7%	$7200.92	—	—	Put	532457958
—	MEDICINES CO	9,501	$30.18M	1.5%	$3177.03	—	—	Call	584688905
—	SPDR S&P BIOTECH ETF	5,337	$27.57M	1.4%	$5166.01	—	—	Put	78464A950
—	BIOGEN INC	1,052	$27.39M	1.4%	$26032.32	—	—	Put	09062X953
SPY	SPDR S&P 500 ETF TRUST	108,899	$22.39M	1.1%	$205.56	$205.56	—	UNIT	78462F103
—	JOHNSON & JOHNSON	2,061	$22.3M	1.1%	$10819.99	—	—	Put	478160954
—	EDWARDS LIFESCIENCES CORP	2,477	$21.85M	1.1%	$8821.15	—	—	Call	28176E908
AMGN	AMGEN INC	143,486	$21.51M	1.1%	$149.93 *	$110.79	0.0%	COM	031162100
—	REGENERON PHARMACEUTICALS INC	588	$21.19M	1.1%	$36044.22	—	—	Put	75886F957
—	EDWARDS LIFESCIENCES CORP	2,201	$19.41M	1.0%	$8820.99	—	—	Put	28176E958
—	SAREPTA THERAPEUTICS INC	8,824	$17.22M	0.9%	$1951.95	—	—	Put	803607950
—	CYTORI THERAPEUTICS INC	7,305,690	$14.31M	0.7%	$1.96	$0.25	—	COM	23283K105
REGN	REGENERON PHARMACEUTICALS INC	39,027	$14.07M	0.7%	$360.44 *	$409.79	0.0%	COM	75886F107
SRPT	SAREPTA THERAPEUTICS INC	505,937	$9.876M	0.5%	$19.52 *	$17.47	0.0%	COM	803607100
BIIB	BIOGEN INC	37,077	$9.652M	0.5%	$260.32	$264.15	0.0%	COM	09062X103
—	GLOBAL BLOOD THERAPEUTICS INC	5,627	$8.924M	0.4%	$1585.93	—	—	Call	37890U908
—	ABBVIE INC	1,546	$8.831M	0.4%	$5712.16	—	—	Put	00287Y959
—	ACORDA THERAPEUTICS INC 15JUN21 1.75%	9,600,000	$8.58M	0.4%	$0.89	$0.90	—	NOTE	00484MAA4
—	RETROPHIN INC	6,251	$8.539M	0.4%	$1366.02	—	—	Put	761299956
—	UNITED THERAPEUTICS CORP	750	$8.357M	0.4%	$11142.67	—	—	Call	91307C902
—	REGULUS THERAPEUTIC INC	11,703	$8.11M	0.4%	$692.98	—	—	Call	75915K901
—	EXPRESS SCRIPTS HOLDING CO	1,064	$7.309M	0.4%	$6869.36	—	—	Put	30219G958
—	LINKEDIN CORP	579	$6.621M	0.3%	$11435.23	—	—	Call	53578A908
—	PORTOLA PHARMACEUTICALS INC	3,221	$6.571M	0.3%	$2040.05	—	—	Call	737010908
—	GW PHARMACEUTICALS PLC	908	$6.551M	0.3%	$7214.76	—	—	Put	36197T953
—	ANACOR PHARMACEUTICALS INC	1,214	$6.489M	0.3%	$5345.14	—	—	Call	032420901
—	DEPOMED INC	4,208	$5.862M	0.3%	$1393.06	—	—	Call	249908904
—	BIOMARIN PHARMACEUTICAL 0.75%	5,000,000	$5.794M	0.3%	$1.16	$1.16	—	NOTE	09061GAE1
—	TENAX THERAPEUTICS INC	2,771,109	$5.681M	0.3%	$2.05	$3.75	—	COM	88032L100
—	BLUEPRINT MEDICINES CORP	3,000	$5.415M	0.3%	$1805.00	—	—	Call	09627Y909
—	ACADIA PHARMACEUTICALS INC	1,840	$5.145M	0.3%	$2796.20	—	—	Call	004225908
ABUS	ARBUTUS BIOPHARMA CORP	1,197,338	$4.945M	0.2%	$4.13 *	$7.22	-50.5%	COM	03879J100
—	RETROPHIN INC	3,617	$4.941M	0.2%	$1366.05	—	—	Call	761299906
—	LEXICON PHARMACEUTICALS INC	4,092	$4.89M	0.2%	$1195.01	—	—	Call	528872902
NWBO	NORTHWEST BIOTHERAPEUTICS INC	3,317,519	$4.844M	0.2%	$1.46 *	$3.48	-43.3%	COM	66737P600
—	ALEXION PHARMACEUTICALS INC	342	$4.761M	0.2%	$13921.05	—	—	Put	015351959
—	TOKAI PHARMACEUTICALS INC	812,200	$4.556M	0.2%	$5.61	$5.61	—	COM	88907J107
—	VERTEX PHARMACEUTICALS INC	550	$4.372M	0.2%	$7949.09	—	—	Call	92532F900
—	REXAHN PHARMACEUTICALS INC	13,212,254	$4.361M	0.2%	$0.33	$0.33	—	COM	761640101
—	EIGER BIOPHARMACEUTICALS INC	259,643	$4.354M	0.2%	$16.77	$16.77	—	COM	28249U105
—	ZOGENIX INC	4,639	$4.286M	0.2%	$923.91	—	—	Call	98978L904
—	DYNAVAX TECHNOLOGIES CORP	220,000	$4.233M	0.2%	$19.24	$21.82	—	COM	268158201
—	EAGLE PHARMACEUTICALS INC	1,000	$4.05M	0.2%	$4050.00	—	—	Call	269796908
—	ACADIA PHARMACEUTICALS INC	1,393	$3.895M	0.2%	$2796.12	—	—	Put	004225958
—	ALEXION PHARMACEUTICALS INC	27,856	$3.878M	0.2%	$139.22	$140.97	—	COM	015351109
—	INTREXON CORP	111,907	$3.793M	0.2%	$33.89	$33.52	—	COM	46122T102
—	INVIVO THERAPEUTICS HOLDINGS CORP	542,500	$3.787M	0.2%	$6.98	$6.98	—	COM	46186M209
—	CELGENE CORP	313	$3.748M	0.2%	$11974.44	—	—	Call	151020904
—	REGENERON PHARMACEUTICALS INC	103	$3.713M	0.2%	$36048.54	—	—	Call	75886F907
—	CLOVIS ONCOLOGY INC	1,862	$3.575M	0.2%	$1919.98	—	—	Call	189464900
—	INTREXON CORP	1,014	$3.436M	0.2%	$3388.56	—	—	Put	46122T952
—	NEWLINK GENETICS CORP	1,854	$3.374M	0.2%	$1819.85	—	—	Call	651511907
—	INTRA CELLULAR THERAPIES INC	1,208	$3.358M	0.2%	$2779.80	—	—	Put	46116X951
—	BARCLAYS BK PLC IPATH S&P 500 MT ETN	300,000	$3.264M	0.2%	$10.88	$11.17	—	ETN	06740C519
RGNX	REGENXBIO INC	300,329	$3.244M	0.2%	$10.80 *	$15.54	-17.6%	COM	75901B107
—	SAGE THERAPEUTICS INC	100,000	$3.206M	0.2%	$32.06	$34.46	—	COM	78667J108
—	INTEC PHARMA LTD JERUSALEM	714,062	$2.949M	0.1%	$4.13	$5.49	—	SHS	M53644106
—	AMICUS THERAPEUTICS INC	3,485	$2.945M	0.1%	$845.05	—	—	Put	03152W959
—	PARATEK PHARMACEUTICALS INC	192,322	$2.918M	0.1%	$15.17	$19.57	—	COM	699374302
—	ADAMAS PHARMACEUTICALS INC	199,890	$2.89M	0.1%	$14.46	$14.46	—	COM	00548A106
—	EXPRESS SCRIPTS HOLDING CO	41,311	$2.838M	0.1%	$68.70	$68.70	—	COM	30219G108
—	INTRA CELLULAR THERAPIES INC	1,020	$2.836M	0.1%	$2780.39	—	—	Call	46116X901
—	ONCOSEC MEDICAL INC	1,111,348	$2.834M	0.1%	$2.55	$3.47	—	COM	68234L207
—	BIO BLAST PHARMA LTD	1,133,937	$2.824M	0.1%	$2.49	$2.49	—	SHS	M20156101
—	AKORN INC	1,194	$2.809M	0.1%	$2352.60	—	—	Put	009728956
—	AVALANCHE BIOTECHNOLOGIES INC	540,632	$2.795M	0.1%	$5.17	$8.34	—	COM	05337G107
NBIX	NEUROCRINE BIOSCIENCES INC	70,000	$2.769M	0.1%	$39.56	$39.68	0.0%	COM	64125C109
—	NIVALIS THERAPEUTICS INC	662,058	$2.761M	0.1%	$4.17	$11.19	—	COM	65481J109
—	SYNERGY PHARMACEUTICALS INC	9,727	$2.685M	0.1%	$276.04	—	—	Call	871639908
—	MOMENTA PHARMACEUTICALS INC	280,225	$2.589M	0.1%	$9.24	$12.52	—	COM	60877T100
—	DERMIRA INC	122,600	$2.535M	0.1%	$20.68	$20.68	—	COM	24983L104
—	TRANSENTERIX INC	5,916	$2.514M	0.1%	$424.95	—	—	Call	89366M901
—	DYNAVAX TECHNOLOGIES CORP	1,300	$2.501M	0.1%	$1923.85	—	—	Call	268158901
—	ANACOR PHARMACEUTICALS INC	44,439	$2.375M	0.1%	$53.44	$81.09	—	COM	032420101
—	ZOGENIX INC	254,424	$2.351M	0.1%	$9.24	$9.24	—	COM	98978L204
—	LA JOLLA PHARMACEUTICAL CO	112,184	$2.346M	0.1%	$20.91	$24.90	—	COM	503459604
—	SAREPTA THERAPEUTICS INC	1,193	$2.329M	0.1%	$1952.22	—	—	Call	803607900
—	FIBROGEN INC.	109,100	$2.323M	0.1%	$21.29	$21.29	—	COM	31572Q808
—	NEWLINK GENETICS CORP	127,459	$2.32M	0.1%	$18.20	$36.28	—	COM	651511107
—	DBV TECHNOLOGIES S A	70,000	$2.279M	0.1%	$32.56	$34.87	—	COM	23306J101
—	GLOBAL BLOOD THERAPEUTICS INC	137,000	$2.173M	0.1%	$15.86	$42.16	—	COM	37890U108
—	INTRA CELLULAR THERAPIES INC	78,000	$2.168M	0.1%	$27.79	$27.79	—	COM	46116X101
—	RETROPHIN INC	156,774	$2.142M	0.1%	$13.66	$13.66	—	COM	761299106
—	ADVAXIS INC	2,325	$2.099M	0.1%	$902.80	—	—	Call	007624908
—	LION BIOTECHNOLOGIES INC	412,246	$2.094M	0.1%	$5.08	$8.51	—	COM	53619R102
—	RADIUS HEALTH INC	65,000	$2.044M	0.1%	$31.45	$31.45	—	COM	750469207
SRNE	SORRENTO THERAPEUTICS INC	379,800	$2.043M	0.1%	$5.38 *	$11.18	-48.0%	COM	83587F202
—	AMICUS THERAPEUTICS INC	2,405	$2.032M	0.1%	$844.91	—	—	Call	03152W909
OASMY	OASMIA PHARMACEUTICAL AB	477,836	$2.021M	0.1%	$4.23	$3.62	—	ADR	67421W109
—	HALOZYME THERAPEUTICS INC	2,029	$1.921M	0.1%	$946.77	—	—	Call	40637H909
—	AKORN INC	815	$1.918M	0.1%	$2353.37	—	—	Call	009728906
—	REDHILL BIOPHARMA LTD	156,523	$1.917M	0.1%	$12.25	$12.91	—	ADS	757468103
—	MEDICINES CO 01JUN17 1.375%	1,500,000	$1.913M	0.1%	$1.28	$1.19	—	DBCV	584688AC9
—	INVIVO THERAPEUTICS HOLDINGS CORP	2,725	$1.902M	0.1%	$697.98	—	—	Call	46186M909
VRTX	VERTEX PHARMACEUTICALS INC	23,320	$1.854M	0.1%	$79.50 *	$106.76	-15.3%	COM	92532F100
—	SERES THERAPEUTICS INC	69,287	$1.84M	0.1%	$26.56	$27.02	—	COM	81750R102
ACUR	ACURA PHARMACEUTICALS INC	648,884	$1.836M	0.1%	$2.83 *	$3.40	-37.5%	COM	00509L802
—	CEMPRA INC	1,044	$1.829M	0.1%	$1751.92	—	—	Call	15130J909
—	SANGAMO BIOSCIENCES INC	3,005	$1.818M	0.1%	$604.99	—	—	Call	800677906
—	BIODELIVERY SCIENCES INTERNATIONAL INC	555,969	$1.796M	0.1%	$3.23	$5.78	—	COM	09060J106
—	ADURO BIOTECH INC	1,401	$1.795M	0.1%	$1281.23	—	—	Call	00739L901
—	GW PHARMACEUTICALS PLC	24,603	$1.775M	0.1%	$72.15	$79.22	—	ADS	36197T103
—	CARDICA INC	498,600	$1.775M	0.1%	$3.56	$3.56	—	COM	14141R309
—	ACHILLION PHARMACEUTICALS INC	2,298	$1.774M	0.1%	$771.98	—	—	Call	00448Q901
—	CEMPRA INC	100,000	$1.752M	0.1%	$17.52	$32.75	—	COM	15130J109
—	FOAMIX PHARMACEUTICALS LTD	260,400	$1.698M	0.1%	$6.52	$8.92	—	SHS	M46135105
—	BRISTOL-MYERS SQUIBB CO	264	$1.686M	0.1%	$6386.36	—	—	Call	110122908
—	RELYPSA INC	122,905	$1.665M	0.1%	$13.55	$13.55	—	COM	759531106
PRTA	PROTHENA CORP PLC	40,000	$1.646M	0.1%	$41.15 *	$39.14	0.0%	SHS	G72800108
—	AETERNA ZENTARIS INC	492,485	$1.635M	0.1%	$3.32	$4.48	—	COM	007975402
—	KITE PHARMA INC	605	$1.632M	0.1%	$2697.52	—	—	Call	49803L909
—	ALLIQUA BIOMEDICAL INC	1,967,208	$1.613M	0.1%	$0.82	$1.60	—	COM	019621200
—	LIPOCINE INC	151,086	$1.534M	0.1%	$10.15	$8.58	—	COM	53630X104
GALT	GALECTIN THERAPEUTICS INC.	1,072,765	$1.534M	0.1%	$1.43 *	$2.29	-41.4%	COM	363225202
—	PROGENICS PHARMACEUTICALS INC	345,197	$1.505M	0.1%	$4.36	$4.36	—	COM	743187106
—	HORIZON PHARMA PLC	908	$1.505M	0.1%	$1657.49	—	—	Call	G4617B905
COLL	COLLEGIUM PHARMACEUTICAL INC	82,100	$1.49M	0.1%	$18.15	$18.18	0.0%	COM	19459J104
—	DEPOMED INC	106,057	$1.477M	0.1%	$13.93	$13.93	—	COM	249908104
NBIX	NEUROCRINE BIOSCIENCES INC	365	$1.444M	0.1%	$3956.16 *	$39.68	0.0%	Call	64125C109
—	T2 BIOSYSTEMS INC	145,000	$1.43M	0.1%	$9.86	$13.31	—	COM	89853L104
—	MYLAN N.V.	304	$1.409M	0.1%	$4634.87	—	—	Call	N59465909
—	ENDO INTERNATIONAL PLC	50,000	$1.408M	0.1%	$28.16	$28.16	—	SHS	G30401106
—	AMARIN CORP PLC	870,792	$1.332M	0.1%	$1.53	$1.53	—	ADR	023111206
—	AMARIN CORP PLC	8,684	$1.329M	0.1%	$153.04	—	—	Call	023111906
—	ACCELERON PHARMA INC	50,000	$1.32M	0.1%	$26.40	$26.40	—	COM	00434H108
—	BRAINSTORM CELL THERAPEUTICS INC	493,191	$1.317M	0.1%	$2.67	$4.17	—	COM	10501E201
—	FORWARD PHARMA A/S	76,785	$1.305M	0.1%	$17.00	$25.15	—	ADR	34986J105
ACAD	ACADIA PHARMACEUTICALS INC	46,258	$1.293M	0.1%	$27.95 *	$35.23	-38.0%	COM	004225108
—	IMMUNOCELLULAR THERAPEUTICS INC	4,411,371	$1.279M	0.1%	$0.29	$0.48	—	COM	452536105
—	AKORN INC	53,729	$1.264M	0.1%	$23.53	$23.53	—	COM	009728106
—	NEUROMETRIX EQUITY WARRANTS EXPIRING 29 MAY 2020	3,130,468	$1.252M	0.1%	$0.40	$0.31	—	*W	641255153
—	MIRATI THERAPEUTICS INC	56,400	$1.207M	0.1%	$21.40	$27.41	—	COM	60468T105
—	CEMPRA INC	672	$1.177M	0.1%	$1751.49	—	—	Put	15130J959
—	MEDGENICS EQUITY WARRANTS EXP 13 FEB 2018	1,564,370	$1.173M	0.1%	$0.75	$0.99	—	*W	58436Q112
—	OCERA THERAPEUTICS INC	399,035	$1.173M	0.1%	$2.94	$5.77	—	COM	67552A108
OPK	OPKO HEALTH INC	112,011	$1.164M	0.1%	$10.39 *	$12.81	-28.7%	COM	68375N103
—	DYNAVAX TECHNOLOGIES CORP	605	$1.164M	0.1%	$1923.97	—	—	Put	268158951
—	RICEBRAN TECHNOLOGIES INC	1,017,458	$1.14M	0.1%	$1.12	$3.68	—	COM	762831204
—	OPKO HEALTH INC	1,095	$1.138M	0.1%	$1039.27	—	—	Put	68375N953
LAB	FLUIDIGM INC	139,506	$1.126M	0.1%	$8.07 *	$19.90	-63.8%	COM	34385P108
—	SYNERGY PHARMACEUTICALS INC	392,273	$1.083M	0.1%	$2.76	$2.76	—	COM	871639308
CSBR	CHAMPIONS ONCOLOGY INC	295,328	$1.075M	0.1%	$3.64	$5.47	-32.9%	COM	15870P307
—	XTL BIOPHARMACEUTICALS LTD	1,040,194	$1.073M	0.1%	$1.03	$2.30	—	ADR	98386D208
—	MAST THERAPEUTICS INC	3,877,356	$1.062M	0.1%	$0.27	$0.27	—	COM	576314108
—	INSMED INC	771	$977K	0.0%	$1267.19	—	—	Put	457669957
—	REGULUS THERAPEUTIC INC	140,000	$970K	0.0%	$6.93	$14.53	—	COM	75915K101
—	MANNKIND CORP	6,000	$966K	0.0%	$161.00	—	—	Call	56400P901
—	ZAFGEN INC	1,446	$966K	0.0%	$668.05	—	—	Call	98885E903
—	SAGE THERAPEUTICS INC	293	$939K	0.0%	$3204.78	—	—	Call	78667J908
—	ONCOTHYREON INC	739,004	$939K	0.0%	$1.27	$1.27	—	COM	682324108
—	DISCOVERY LABORATORIES INC	566,352	$934K	0.0%	$1.65	$1.65	—	COM	254668502
—	TONIX PHARMACEUTICALS HOLDING CORP	385,248	$928K	0.0%	$2.41	$3.20	—	COM	890260201
—	INTERCEPT PHARMACEUTICALS INC	72	$925K	0.0%	$12847.22	—	—	Put	45845P958
—	QUEST RESOURCE HOLDING ORD SHS	2,131,914	$895K	0.0%	$0.42	$1.62	—	COM	74836W104
—	INOTEK PHARMACEUTICALS CORP	116,454	$862K	0.0%	$7.40	$8.91	—	COM	45780V102
—	ABEONA THERAPEUTICS INC	334,108	$855K	0.0%	$2.56	$4.32	—	COM	00289Y107
—	IGNYTA INC	125,000	$846K	0.0%	$6.77	$7.36	—	COM	451731103
—	BIOPHARMX CORP	775,000	$845K	0.0%	$1.09	$1.09	—	COM	09072X101
—	ARALEZ PHARMACEUTICALS INC	236,364	$839K	0.0%	$3.55	$3.55	—	COM	03852X100
—	THERAPEUTICSMD INC	130,400	$835K	0.0%	$6.40	$6.40	—	COM	88338N107
—	TOBIRA THERAPEUTICS INC	100,000	$818K	0.0%	$8.18	$9.04	—	COM	88883P101
—	ACHILLION PHARMACEUTICALS INC	105,648	$816K	0.0%	$7.72	$7.72	—	COM	00448Q201
SGMO	SANGAMO BIOSCIENCES INC	134,500	$814K	0.0%	$6.05	$13.56	-55.7%	COM	800677106
—	ARIAD PHARMACEUTICALS INC	1,265	$808K	0.0%	$638.74	—	—	Call	04033A900
—	CYNAPSUS THERAPEUTICS INC	66,522	$792K	0.0%	$11.91	$15.63	—	COM	23257Y859
—	PSIVIDA CORP	293,585	$787K	0.0%	$2.68	$2.68	—	COM	74440J101
—	ACHILLION PHARMACEUTICALS INC	1,005	$776K	0.0%	$772.14	—	—	Put	00448Q951
—	WAFERGEN BIO SYSTEMS INC	1,195,470	$765K	0.0%	$0.64	$0.73	—	COM	93041P308
—	ALCOBRA LTD	200,868	$761K	0.0%	$3.79	$5.87	—	SHS	M2239P109
—	IONIS PHARMACEUTICALS INC	186	$753K	0.0%	$4048.39	—	—	Put	462222950
—	CYTOKINETICS INC	1,066	$752K	0.0%	$705.44	—	—	Call	23282W905
—	OTONOMY INC	50,000	$746K	0.0%	$14.92	$14.92	—	COM	68906L105
—	BENITEC BIOPHARMA LTD OPTIONS	422,101	$739K	0.0%	$1.75	$5.82	—	ADR	082053307
PRQR	PROQR THERAPEUTICS N V	149,934	$732K	0.0%	$4.88 *	$7.45	-31.8%	SHS	N71542109
—	VTV THERAPEUTICS INC	139,747	$721K	0.0%	$5.16	$6.52	—	CL A	918385105
—	BELLICUM PHARMACEUTICALS INC	77,020	$720K	0.0%	$9.35	$9.35	—	COM	079481107
—	ANTHERA PHARMACEUTICALS INC	198,918	$720K	0.0%	$3.62	$3.62	—	COM	03674U201
—	EXELIXIS INC	1,783	$713K	0.0%	$399.89	—	—	Call	30161Q904
—	ANTARES PHARMA INC	775,212	$675K	0.0%	$0.87	$1.66	—	COM	036642106
NTRA	NATERA INC	69,272	$659K	0.0%	$9.51 *	$16.90	-49.9%	COM	632307104
—	HORIZON PHARMA PLC	390	$646K	0.0%	$1656.41	—	—	Put	G4617B955
—	PTC THERAPEUTICS INC	1,000	$644K	0.0%	$644.00	—	—	Call	69366J900
—	RELYPSA INC	473	$641K	0.0%	$1355.18	—	—	Call	759531906
—	CAPNIA ORD SHS	530,524	$637K	0.0%	$1.20	$1.20	—	COM	14066L105
—	OMEROS CORP	415	$637K	0.0%	$1534.94	—	—	Call	682143902
—	CYCLACEL PHARMACEUTICALS INC	1,632,259	$628K	0.0%	$0.38	$0.82	—	COM	23254L306
—	HEAT BIOLOGICS INC	902,007	$626K	0.0%	$0.69	$0.83	—	COM	42237K102
—	COMBIMATRIX EQUITY WARRANTS	911,041	$610K	0.0%	$0.67	$0.67	—	*W	20009T147
—	AKARI THERAPEUTICS PLC	40,705	$606K	0.0%	$14.89	$14.89	—	ADR	00972G108
—	PROGENICS PHARMACEUTICALS INC	1,384	$603K	0.0%	$435.69	—	—	Call	743187906
HALO	HALOZYME THERAPEUTICS INC	60,000	$568K	0.0%	$9.47	$9.41	0.0%	COM	40637H109
—	RELYPSA INC	415	$562K	0.0%	$1354.22	—	—	Put	759531956
—	STRATA SKIN SCIENCES INC	573,077	$542K	0.0%	$0.95	$0.95	—	COM	86272A107
—	BLUEPRINT MEDICINES CORP	29,624	$535K	0.0%	$18.06	$18.06	—	COM	09627Y109
—	NOVAVAX INC	1,025	$529K	0.0%	$516.10	—	—	Call	670002904
—	REVANCE THERAPEUTICS INC	302	$527K	0.0%	$1745.03	—	—	Call	761330909
—	SUPERCONDUCTOR TECHNOLOGIES	2,734,500	$523K	0.0%	$0.19	$0.55	—	COM	867931404
—	IPATH S&P 500 MT	479	$521K	0.0%	$1087.68	$11.17	—	Call	06740C519
ALKS	ALKERMES PLC	15,000	$513K	0.0%	$34.20 *	$70.02	-43.6%	SHS	G01767105
—	CAPRICOR THERAPEUTICS INC	202,083	$513K	0.0%	$2.54	$4.85	—	COM	14070B101
—	CIDARA THERAPEUTICS INC	40,277	$512K	0.0%	$12.71	$12.71	—	COM	171757107
FOLD	AMICUS THERAPEUTICS INC	59,324	$501K	0.0%	$8.45 *	$7.92	-10.5%	COM	03152W109
—	ALCOBRA LTD	1,312	$497K	0.0%	$378.81	—	—	Call	M2239P909
—	ADVAXIS INC	537	$485K	0.0%	$903.17	—	—	Put	007624958
—	GILEAD SCIENCES INC	50	$459K	0.0%	$9180.00	—	—	Put	375558953
INSM	INSMED INC	35,867	$454K	0.0%	$12.66 *	$13.15	0.0%	COM	457669307
—	NOVAVAX INC	880	$454K	0.0%	$515.91	—	—	Put	670002954
—	SENSEONICS HOLDINGS INC	153,900	$440K	0.0%	$2.86	$2.86	—	COM	81727U105
—	CESCA THERAPEUTICS ORD SHS	111,094	$432K	0.0%	$3.89	$3.89	—	COM	157131202
—	FLEXION THERAPEUTICS INC.	46,355	$426K	0.0%	$9.19	$9.19	—	COM	33938J106
—	NEWLINK GENETICS CORP	231	$420K	0.0%	$1818.18	—	—	Put	651511957
—	EDAP TMS SA	1,018	$409K	0.0%	$401.77	—	—	Put	268311957
EGRX	EAGLE PHARMACEUTICALS INC	10,000	$405K	0.0%	$40.50 *	$63.45	0.0%	COM	269796108
—	EAGLE PHARMACEUTICALS INC	100	$405K	0.0%	$4050.00	—	—	Put	269796958
—	SPECTRANETICS CORP	279	$405K	0.0%	$1451.61	—	—	Call	84760C907
—	PLURISTEM THERAPEUTICS INC	251,020	$404K	0.0%	$1.61	$2.27	—	COM	72940R102
—	INSPIREMD INC	790,538	$399K	0.0%	$0.50	$0.50	—	COM	45779A507
—	REGULUS THERAPEUTIC INC	574	$398K	0.0%	$693.38	—	—	Put	75915K951
—	TROVAGENE INC	85,000	$395K	0.0%	$4.65	$5.69	—	COM	897238309
—	VALEANT PHARMACEUTICALS INTERNATIONAL INC	149	$392K	0.0%	$2630.87	—	—	Call	91911K902
—	AXOVANT SCIENCES LTD	34,040	$391K	0.0%	$11.49	$11.49	—	COM	G0750W104
—	ELEVEN BIOTHERAPEUTICS INC	1,213,984	$387K	0.0%	$0.32	$0.66	—	COM	286221106
—	THRESHOLD PHARMACEUTICALS INC	837,904	$385K	0.0%	$0.46	$0.48	—	COM	885807206
—	INSMED INC	296	$375K	0.0%	$1266.89	—	—	Call	457669907
—	LIPOCINE INC	350	$355K	0.0%	$1014.29	—	—	Call	53630X904
—	SKYLINE MEDICAL INC	2,001,348	$345K	0.0%	$0.17	$0.17	—	COM	83084T309
—	HISTOGENICS INC.	150,630	$345K	0.0%	$2.29	$4.61	—	COM	43358V109
—	PIERIS PHARMACEUTICALS INC	175,000	$333K	0.0%	$1.90	$1.87	—	COM	720795103
—	THERAPEUTICSMD INC	511	$327K	0.0%	$639.92	—	—	Call	88338N907
—	ZOSANO PHARMA INC	128,600	$296K	0.0%	$2.30	$9.59	—	COM	98979H103
—	BIODELIVERY SCIENCES INTERNATIONAL INC	912	$295K	0.0%	$323.46	—	—	Call	09060J906
IONS	IONIS PHARMACEUTICALS INC	7,002	$284K	0.0%	$40.56	$40.62	0.0%	COM	462222100
—	PARATEK PHARMACEUTICALS INC	186	$282K	0.0%	$1516.13	—	—	Call	699374902
—	CELATOR PHARMACEUTICALS INC	25,000	$276K	0.0%	$11.04	$1.76	—	COM	15089R102
PVCT	PROVECTUS BIOPHARMACEUTICALS	726,200	$275K	0.0%	$0.38	$0.82	-49.5%	COM	74373P108
—	CHIMERIX INC	53,620	$274K	0.0%	$5.11	$5.11	—	COM	16934W106
—	VERTEX PHARMACEUTICALS INC	33	$262K	0.0%	$7939.39	—	—	Put	92532F950
—	ARBUTUS BIOPHARMA CORP	630	$260K	0.0%	$412.70	—	—	Call	03879J900
—	THERAPEUTICSMD INC	404	$259K	0.0%	$641.09	—	—	Put	88338N957
—	CLOVIS ONCOLOGY INC	13,326	$256K	0.0%	$19.21	$34.99	—	COM	189464100
—	JUNO THERAPEUTICS INC	67	$255K	0.0%	$3805.97	—	—	Call	48205A909
—	NANOSPHERE ORD SHS	308,147	$243K	0.0%	$0.79	$2.05	—	COM	63009F204
—	CELLECTAR BIOSCIENCES INC	71,313	$242K	0.0%	$3.39	$3.39	—	COM	15117F302
—	HERON THERAPEUTICS INC	126	$239K	0.0%	$1896.83	—	—	Call	427746902
—	CANCER GENETICS INC	81,300	$231K	0.0%	$2.84	$3.20	—	COM	13739U104
—	DERMIRA INC	100	$207K	0.0%	$2070.00	—	—	Put	24983L954
—	LPATH INC	1,106,870	$206K	0.0%	$0.19	$1.00	—	COM	548910306
—	TRANSENTERIX INC	482	$205K	0.0%	$425.31	—	—	Put	89366M951
—	CLOVIS ONCOLOGY INC	100	$192K	0.0%	$1920.00	—	—	Put	189464950
—	MANNKIND CORP	1,096	$176K	0.0%	$160.58	—	—	Put	56400P951
ARDX	ARDELYX INC	22,278	$173K	0.0%	$7.77 *	$9.84	0.0%	COM	039697107
ALDX	ALDEYRA THERAPEUTICS INC	41,096	$172K	0.0%	$4.19 *	$8.62	-44.3%	COM	01438T106
—	AMARIN CORP PLC	1,118	$171K	0.0%	$152.95	—	—	Put	023111956
—	RENNOVA HEALTH EQUITY WARRANTS	3,225,806	$161K	0.0%	$0.05	$0.44	—	*W	759757115
—	ARQULE INC	100,000	$160K	0.0%	$1.60	$1.60	—	COM	04269E107
—	CERES INC.	720,378	$158K	0.0%	$0.22	$0.30	—	COM	156773400
—	SYNERGY PHARMACEUTICALS EQUITY WARRANTS	285,414	$157K	0.0%	$0.55	$1.23	—	*W	871639118
—	NEUROMETRIX INC	84,263	$154K	0.0%	$1.83	$1.98	—	COM	641255500
—	NXSTAGE MEDICAL INC	100	$150K	0.0%	$1500.00	—	—	Put	67072V953
—	ARALEZ PHARMACEUTICALS INC	375	$133K	0.0%	$354.67	—	—	Call	03852X900
—	TRILLIUM THERAPEUTICS INC	14,137	$131K	0.0%	$9.27	$9.27	—	COM	89620X506
—	KITOV PHARMACEUTICALS HOLDINGS EQUITY WARRANTS	114,720	$126K	0.0%	$1.10	$0.49	—	*W	49803V115
—	NORTHWEST BIOTHERAPEUTICS INC	813	$119K	0.0%	$146.37	—	—	Put	66737P950
—	BIODEL INC	357,500	$118K	0.0%	$0.33	$0.89	—	COM	09064M204
—	BENITEC BIOPHARMA EQUITY WARRANTS EXP 14 AUG 2020	99,555	$100K	0.0%	$1.00	$0.36	—	*W	082053117
—	CYMABAY THERAPEUTICS INC	67,534	$91,000	0.0%	$1.35	$2.64	—	COM	23257D103
—	AKEBIA THERAPEUTICS INC	100	$90,000	0.0%	$900.00	—	—	Call	00972D905
—	PROGENICS PHARMACEUTICALS INC	130	$57,000	0.0%	$438.46	—	—	Put	743187956
—	ANTHERA PHARMACEUTICALS INC	151	$55,000	0.0%	$364.24	—	—	Call	03674U901
—	AVALANCHE BIOTECHNOLOGIES INC	106	$55,000	0.0%	$518.87	—	—	Call	05337G907
—	EYEGATE PHARMACEUTICALS EQUITY WARRANTS	65,393	$49,000	0.0%	$0.75	$1.02	—	*W	30233M115
—	BRAINSTORM CELL THERAPEUTICS INC	175	$47,000	0.0%	$268.57	—	—	Call	10501E901
—	CELLECTAR BIOSCIENCES EQUITY WARRANTS	65,362	$47,000	0.0%	$0.72	$0.72	—	*W	15117F120
—	CYTRX CORP INC	170	$46,000	0.0%	$270.59	—	—	Call	232828909
—	ALLIQUA BIOMEDICAL INC	483	$40,000	0.0%	$82.82	—	—	Call	019621900
—	TONIX PHARMACEUTICALS HOLDING CORP	148	$36,000	0.0%	$243.24	—	—	Call	890260901
—	TENAX THERAPEUTICS INC	173	$35,000	0.0%	$202.31	—	—	Call	88032L900
—	ANTARES PHARMA INC	399	$35,000	0.0%	$87.72	—	—	Call	036642906
—	GALENA BIOPHARMA INC	235	$34,000	0.0%	$144.68	—	—	Put	363256958
—	CELSION CORPORATION	18,789	$27,000	0.0%	$1.44	$2.43	—	COM	15117N404
—	INTELLIPHARMACEUTICS INTERNATIONAL INC	122	$25,000	0.0%	$204.92	—	—	Put	458173951
—	RENNOVA HEALTH INC	30,761	$23,000	0.0%	$0.75	$1.35	—	COM	759757107
—	PERSEON EQUITY WARRANTS	1,887,892	$4,000	0.0%	$0.00	$0.19	—	*W	715270112
—	OPEXA THERAPEUTICS EQUITY WARRANTS	34,097	$2,000	0.0%	$0.06	$0.06	—	*W	68372T129