Location: Miami Beach, FL
CIK: 0001535610 · Show all filings
Period: Q3 2016 (← Previous) (Next →)
Filing Date: Nov 14, 2016
Total Value: $2.669B (99.8% shares, 0.2% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| — | SPDR S&P 500 ETF TRUST | 14,000 | $303M | 11.3% | $21630.00 | — | — | Put | 78462F953 |
| — | ELI LILLY & CO | 29,347 | $236M | 8.8% | $8026.00 | — | — | Call | 532457908 |
| — | SPDR S&P 500 ETF TRUST | 10,000 | $216M | 8.1% | $21630.00 | — | — | Call | 78462F903 |
| — | ISHARES RUSSELL 2000 | 14,892 | $185M | 6.9% | $12420.96 | — | — | Put | 464287955 |
| — | SAREPTA THERAPEUTICS INC | 26,748 | $164M | 6.2% | $6140.98 | — | — | Put | 803607950 |
| — | GILEAD SCIENCES INC | 11,691 | $92.5M | 3.5% | $7911.98 | — | — | Call | 375558903 |
| — | REGENERON PHARMACEUTICALS INC | 1,792 | $72.04M | 2.7% | $40202.01 | — | — | Put | 75886F957 |
| — | ISHARES RUSSELL 2000 | 5,441 | $67.58M | 2.5% | $12421.06 | — | — | Call | 464287905 |
| — | HCA HOLDINGS INC | 7,680 | $58.08M | 2.2% | $7563.02 | — | — | Call | 40412C901 |
| — | MONSANTO CO | 5,607 | $57.3M | 2.1% | $10220.08 | — | — | Call | 61166W901 |
| — | AMGEN INC | 2,569 | $42.85M | 1.6% | $16680.81 | — | — | Put | 031162900 |
| — | ELI LILLY & CO | 4,898 | $39.31M | 1.5% | $8025.93 | — | — | Put | 532457958 |
| — | CELGENE CORP | 3,451 | $36.07M | 1.4% | $10452.91 | — | — | Call | 151020904 |
| SRPT | SAREPTA THERAPEUTICS INC | 536,282 | $32.93M | 1.2% | $61.41 * | $17.82 | +69.6% | COM | 803607100 |
| REGN | REGENERON PHARMACEUTICALS INC | 75,919 | $30.52M | 1.1% | $402.02 | $397.70 | +0.3% | COM | 75886F107 |
| — | BRISTOL MYERS SQUIBB CO. | 5,409 | $29.16M | 1.1% | $5391.94 | — | — | Call | 110122908 |
| — | ALKERMES PLC | 3,249 | $28.2M | 1.1% | $8679.90 | — | — | Call | G01767905 |
| — | MERCK & CO INC | 4,487 | $28M | 1.0% | $6240.92 | — | — | Call | 58933Y905 |
| — | ABBVIE INC | 4,136 | $26.09M | 1.0% | $6307.06 | — | — | Call | 00287Y909 |
| — | CELGENE CORP | 2,415 | $25.24M | 0.9% | $10453.00 | — | — | Put | 151020954 |
| — | ACADIA PHARMACEUTICALS INC | 7,784 | $24.76M | 0.9% | $3181.01 | — | — | Call | 00404A909 |
| AMGN | AMGEN INC | 133,176 | $22.21M | 0.8% | $166.81 * | $111.19 | +14.9% | COM | 031162100 |
| — | AGIOS PHARMACEUTICALS INC | 4,108 | $21.7M | 0.8% | $5281.89 | — | — | Call | 00847X904 |
| — | SAREPTA THERAPEUTICS INC | 3,526 | $21.65M | 0.8% | $6140.95 | — | — | Call | 803607900 |
| — | ABBOTT LABORATORIES | 5,000 | $21.14M | 0.8% | $4229.00 | — | — | Put | 002824950 |
| — | CLOVIS ONCOLOGY INC | 5,850 | $21.09M | 0.8% | $3604.96 | — | — | Call | 189464900 |
| — | BIOGEN INC | 667 | $20.88M | 0.8% | $31302.85 | — | — | Call | 09062X903 |
| — | EXPRESS SCRIPTS HOLDING CO | 2,897 | $20.43M | 0.8% | $7053.16 | — | — | Call | 30219G908 |
| — | BRISTOL MYERS SQUIBB CO. | 3,469 | $18.7M | 0.7% | $5392.04 | — | — | Put | 110122958 |
| — | VERTEX PHARMACEUTICALS INC | 1,955 | $17.05M | 0.6% | $8721.23 | — | — | Call | 92532F900 |
| — | CEMPRA INC | 6,323 | $15.3M | 0.6% | $2420.05 | — | — | Put | 15130J959 |
| — | RETROPHIN INC | 6,293 | $14.08M | 0.5% | $2238.04 | — | — | Call | 761299906 |
| — | PUMA BIOTECHNOLOGY INC | 2,021 | $13.55M | 0.5% | $6705.10 | — | — | Call | 74587V907 |
| — | SHIRE PLC | 698 | $13.53M | 0.5% | $19385.39 | — | — | Call | 82481R906 |
| — | SHIRE PLC | 698 | $13.53M | 0.5% | $19385.39 | — | — | Put | 82481R956 |
| — | SPDR SERIES TRUST | 1,958 | $12.98M | 0.5% | $6629.21 | — | — | Put | 78464A950 |
| — | UNITED THERAPEUTICS CORP | 1,098 | $12.96M | 0.5% | $11807.83 | — | — | Put | 91307C952 |
| — | HUMANA INC | 700 | $12.38M | 0.5% | $17688.57 | — | — | Put | 444859952 |
| — | EXPRESS SCRIPTS HOLDING CO | 1,691 | $11.93M | 0.4% | $7053.22 | — | — | Put | 30219G958 |
| — | ASTRAZENECA PLC | 3,520 | $11.57M | 0.4% | $3286.08 | — | — | Call | 046353908 |
| — | LEXICON PHARMACEUTICALS INC | 6,263 | $11.32M | 0.4% | $1806.96 | — | — | Call | 528872902 |
| — | HESS CORP | 2,059 | $11.04M | 0.4% | $5361.83 | — | — | Call | 42809H907 |
| — | DEPOMED INC | 4,321 | $10.8M | 0.4% | $2498.96 | — | — | Call | 249908904 |
| — | MYLAN N.V. | 2,804 | $10.69M | 0.4% | $3812.05 | — | — | Call | N59465909 |
| — | DYNAVAX TECHNOLOGIES CORP | 9,984 | $10.47M | 0.4% | $1048.98 | — | — | Call | 268158901 |
| — | ALNYLAM PHARMACEUTICALS INC | 1,448 | $9.815M | 0.4% | $6778.31 | — | — | Call | 02043Q907 |
| — | ONCOBIOLOGICS INC | 2,268,585 | $9.643M | 0.4% | $4.25 | $3.48 | — | COM | 68235M105 |
| — | BLUEBIRD BIO INC | 1,380 | $9.354M | 0.4% | $6778.26 | — | — | Call | 09609G900 |
| BMY | BRISTOL MYERS SQUIBB CO. | 156,887 | $8.459M | 0.3% | $53.92 * | $46.14 | 0.0% | COM | 110122108 |
| — | DYNAVAX TECHNOLOGIES CORP | 7,628 | $8.002M | 0.3% | $1049.03 | — | — | Put | 268158951 |
| — | IONIS PHARMACEUTICALS INC | 2,171 | $7.955M | 0.3% | $3664.21 | — | — | Call | 462222900 |
| — | CLOVIS ONCOLOGY INC | 2,091 | $7.538M | 0.3% | $3604.97 | — | — | Put | 189464950 |
| — | ABBVIE INC | 1,178 | $7.43M | 0.3% | $6307.30 | — | — | Put | 00287Y959 |
| — | HORIZON PHARMA PLC | 4,088 | $7.412M | 0.3% | $1813.11 | — | — | Call | G4617B905 |
| — | ACHILLION PHARMACEUTICALS INC | 9,039 | $7.322M | 0.3% | $810.05 | — | — | Call | 00448Q901 |
| — | CEMPRA INC | 3,019 | $7.306M | 0.3% | $2420.01 | — | — | Call | 15130J909 |
| — | TENET HEALTHCARE CORP | 3,179 | $7.204M | 0.3% | $2266.12 | — | — | Call | 88033G907 |
| — | AMICUS THERAPEUTICS INC | 9,632 | $7.128M | 0.3% | $740.03 | — | — | Call | 03152W909 |
| — | DEXCOM INC | 806 | $7.065M | 0.3% | $8765.51 | — | — | Call | 252131907 |
| — | OPHTHOTECH CORP | 1,517 | $6.998M | 0.3% | $4613.05 | — | — | Call | 683745903 |
| — | EXELIXIS INC | 5,392 | $6.896M | 0.3% | $1278.93 | — | — | Put | 30161Q954 |
| — | KITE PHARMA INC | 1,177 | $6.575M | 0.2% | $5586.24 | — | — | Put | 49803L959 |
| — | AXOVANT SCIENCES LTD | 4,680 | $6.552M | 0.2% | $1400.00 | — | — | Call | G0750W904 |
| — | LION BIOTECHNOLOGIES INC | 7,901 | $6.503M | 0.2% | $823.06 | — | — | Put | 53619R952 |
| — | NEUROCRINE BIOSCIENCES INC | 1,214 | $6.148M | 0.2% | $5064.25 | — | — | Call | 64125C909 |
| — | GILEAD SCIENCES INC | 771 | $6.1M | 0.2% | $7911.80 | — | — | Put | 375558953 |
| — | KITE PHARMA INC | 1,082 | $6.044M | 0.2% | $5585.95 | — | — | Call | 49803L909 |
| — | SHIRE PLC | 31,172 | $6.043M | 0.2% | $193.86 | $184.60 | — | COM | 82481R106 |
| — | HALOZYME THERAPEUTICS INC | 4,901 | $5.92M | 0.2% | $1207.92 | — | — | Call | 40637H909 |
| — | ALNYLAM PHARMACEUTICALS INC | 869 | $5.89M | 0.2% | $6777.91 | — | — | Put | 02043Q957 |
| — | PTC THERAPEUTICS INC | 3,989 | $5.589M | 0.2% | $1401.10 | — | — | Call | 69366J900 |
| — | TENAX THERAPEUTICS INC | 2,412,857 | $5.55M | 0.2% | $2.30 | $3.75 | — | COM | 88032L100 |
| — | DYNAVAX TECHNOLOGIES CORP | 521,875 | $5.474M | 0.2% | $10.49 | $15.82 | — | COM | 268158201 |
| — | SAGE THERAPEUTICS INC | 1,165 | $5.365M | 0.2% | $4605.15 | — | — | Call | 78667J908 |
| — | HUMANA INC | 278 | $4.918M | 0.2% | $17690.65 | — | — | Call | 444859902 |
| — | LA JOLLA PHARMACEUTICAL CO | 2,064 | $4.91M | 0.2% | $2378.88 | — | — | Call | 503459904 |
| ABT | ABBOTT LABORATORIES | 112,888 | $4.774M | 0.2% | $42.29 * | $33.35 | +8.3% | COM | 002824100 |
| — | AERIE PHARMACEUTICALS INC | 1,180 | $4.453M | 0.2% | $3773.73 | — | — | Call | 00771V908 |
| — | CYTRX CORP. | 7,424,786 | $4.368M | 0.2% | $0.59 | $0.59 | — | COM | 232828509 |
| — | SYNERGY PHARMACEUTICALS INC. | 7,912 | $4.36M | 0.2% | $551.06 | — | — | Call | 871639908 |
| — | AMARIN CORPORATION PLC | 13,648 | $4.354M | 0.2% | $319.02 | — | — | Call | 023111906 |
| — | MEDICINES CO | 1,150 | $4.34M | 0.2% | $3773.91 | — | — | Call | 584688905 |
| — | NEWLINK GENETICS CORP | 2,887 | $4.336M | 0.2% | $1501.91 | — | — | Call | 651511907 |
| — | PUMA BIOTECHNOLOGY INC | 643 | $4.311M | 0.2% | $6704.51 | — | — | Put | 74587V957 |
| — | ACORDA THERAPEUTICS INC 15 JUN 21 1.75% | 5,100,000 | $4.16M | 0.2% | $0.82 | $0.90 | — | NOTE | 00484MAA4 |
| — | TENET HEALTHCARE CORP | 1,744 | $3.952M | 0.1% | $2266.06 | — | — | Put | 88033G957 |
| — | CELGENE CORP | 37,728 | $3.944M | 0.1% | $104.54 | $104.54 | — | COM | 151020104 |
| — | MANNKIND CORP | 62,303 | $3.863M | 0.1% | $62.00 | — | — | Put | 56400P951 |
| RGNX | REGENXBIO ORD SHS | 263,177 | $3.687M | 0.1% | $14.01 * | $14.34 | -23.0% | COM | 75901B107 |
| — | REGULUS THERAPEUTIC INC | 11,000 | $3.63M | 0.1% | $330.00 | — | — | Call | 75915K901 |
| — | GW PHARMACEUTICALS PLC | 273 | $3.624M | 0.1% | $13274.73 | — | — | Call | 36197T903 |
| — | CYTORI THERAPEUTICS INC. | 1,762,846 | $3.579M | 0.1% | $2.03 | $2.09 | — | COM | 23283K204 |
| — | NOVO NORDISK A/S | 859 | $3.573M | 0.1% | $4159.49 | — | — | Put | 670100955 |
| — | OPGEN INC. | 2,161,467 | $3.545M | 0.1% | $1.64 | $1.55 | — | COM | 68373L109 |
| — | TESARO INC | 333 | $3.338M | 0.1% | $10024.02 | — | — | Call | 881569907 |
| UTHR | UNITED THERAPEUTICS CORP | 28,112 | $3.319M | 0.1% | $118.06 | $120.15 | 0.0% | COM | 91307C102 |
| — | ZOGENIX INC | 1,228 | $3.265M | 0.1% | $2658.79 | — | — | Call | 98978L904 |
| — | BIOGEN INC | 100 | $3.13M | 0.1% | $31300.00 | — | — | Put | 09062X953 |
| — | EIGER BIOPHARMACEUTICALS INC. | 230,803 | $3.09M | 0.1% | $13.39 | $15.96 | — | COM | 28249U105 |
| ABUS | ARBUTUS BIOPHARMA CORP | 878,531 | $3.022M | 0.1% | $3.44 * | $7.22 | -45.9% | COM | 03879J100 |
| — | INTEC PHARMA LTD. | 498,006 | $2.898M | 0.1% | $5.82 | $5.45 | — | COM | M53644106 |
| — | LA JOLLA PHARMACEUTICAL CO | 120,964 | $2.878M | 0.1% | $23.79 | $20.85 | — | COM | 503459604 |
| — | PIERIS PHARMACEUTICALS INC | 1,543,307 | $2.824M | 0.1% | $1.83 | $1.64 | — | COM | 720795103 |
| — | TESARO INC | 27,500 | $2.757M | 0.1% | $100.25 | $100.25 | — | COM | 881569107 |
| — | IONIS PHARMACEUTICALS INC | 737 | $2.7M | 0.1% | $3663.50 | — | — | Put | 462222950 |
| — | OPKO HEALTH INC | 2,491 | $2.638M | 0.1% | $1059.01 | — | — | Call | 68375N903 |
| — | SANGAMO BIOSCIENCES INC | 5,611 | $2.598M | 0.1% | $463.02 | — | — | Call | 800677906 |
| THC | TENET HEALTHCARE CORP | 112,831 | $2.557M | 0.1% | $22.66 * | $26.03 | 0.0% | COM | 88033G407 |
| — | GW PHARMACEUTICALS PLC | 192 | $2.548M | 0.1% | $13270.83 | — | — | Put | 36197T953 |
| — | REGENERON PHARMACEUTICALS INC | 63 | $2.533M | 0.1% | $40206.35 | — | — | Call | 75886F907 |
| — | DURECT CORP | 1,800,000 | $2.502M | 0.1% | $1.39 | $1.22 | — | COM | 266605104 |
| — | EXELIXIS INC | 1,930 | $2.468M | 0.1% | $1278.76 | — | — | Call | 30161Q904 |
| — | DERMIRA INC | 722 | $2.442M | 0.1% | $3382.27 | — | — | Call | 24983L904 |
| — | HCA HOLDINGS INC | 316 | $2.39M | 0.1% | $7563.29 | — | — | Put | 40412C951 |
| — | SOPHIRIS BIO INC. | 757,033 | $2.354M | 0.1% | $3.11 | $3.11 | — | COM | 83578Q209 |
| — | ABBOTT LABORATORIES | 555 | $2.347M | 0.1% | $4228.83 | — | — | Call | 002824900 |
| — | DERMIRA INC | 678 | $2.293M | 0.1% | $3382.01 | — | — | Put | 24983L954 |
| — | PARATEK PHARMACEUTICALS INC | 175,000 | $2.277M | 0.1% | $13.01 | $17.47 | — | COM | 699374302 |
| — | VERTEX PHARMACEUTICALS INC | 260 | $2.267M | 0.1% | $8719.23 | — | — | Put | 92532F950 |
| — | BARCLAYS BANK PLC | 65,000 | $2.215M | 0.1% | $34.08 | $34.08 | — | IPATH | 06740Q260 |
| — | ENDO INTERNATIONAL PLC | 1,096 | $2.208M | 0.1% | $2014.60 | — | — | Put | G30401956 |
| — | CIDARA THERAPEUTICS INC. | 190,358 | $2.18M | 0.1% | $11.45 | $11.59 | — | COM | 171757107 |
| — | NIVALIS THERAPEUTICS INC | 267,650 | $2.176M | 0.1% | $8.13 | $11.19 | — | COM | 65481J109 |
| — | OPKO HEALTH INC | 2,027 | $2.147M | 0.1% | $1059.20 | — | — | Put | 68375N953 |
| — | VERSARTIS INC. | 174,968 | $2.143M | 0.1% | $12.25 | $12.25 | — | COM | 92529L102 |
| — | EXACT SCIENCES CORP | 1,153 | $2.137M | 0.1% | $1853.43 | — | — | Put | 30063P955 |
| — | INSMED INC | 1,459 | $2.118M | 0.1% | $1451.68 | — | — | Call | 457669907 |
| — | SYNERGY PHARMACEUTICALS INC. | 3,842 | $2.117M | 0.1% | $551.02 | — | — | Put | 871639958 |
| — | FORWARD PHARMA A/S | 99,053 | $2.08M | 0.1% | $21.00 | $23.42 | — | ADR | 34986J105 |
| — | VANDA PHARMACEUTICALS INC | 1,247 | $2.075M | 0.1% | $1663.99 | — | — | Call | 921659908 |
| — | LION BIOTECHNOLOGIES INC | 246,342 | $2.027M | 0.1% | $8.23 | $8.51 | — | COM | 53619R102 |
| — | REXAHN PHARMACEUTICALS INC | 9,464,849 | $1.988M | 0.1% | $0.21 | $0.33 | — | COM | 761640101 |
| — | PROTHENA CORPORATION PLC | 325 | $1.949M | 0.1% | $5996.92 | — | — | Call | G72800990 |
| — | ACTINIUM PHARMACEUTICALS INC | 1,382,629 | $1.867M | 0.1% | $1.35 | $1.35 | — | COM | 00507W107 |
| — | FOAMIX PHARMACEUTICALS LTD | 201,564 | $1.866M | 0.1% | $9.26 | $8.92 | — | SHS | M46135105 |
| — | BIODELIVERY SCIENCES INTERNATIONAL INC | 689,900 | $1.863M | 0.1% | $2.70 | $4.78 | — | COM | 09060J106 |
| — | BIO PATH HOLDINGS INC | 1,314,692 | $1.841M | 0.1% | $1.40 | $1.99 | — | COM | 09057N102 |
| EDIT | EDITAS MEDICINE INC. | 135,000 | $1.82M | 0.1% | $13.48 * | $20.49 | 0.0% | COM | 28106W103 |
| — | INSMED INC | 1,247 | $1.811M | 0.1% | $1452.29 | — | — | Put | 457669957 |
| — | AGENUS INC | 2,500 | $1.795M | 0.1% | $718.00 | — | — | Put | 00847G955 |
| NTLA | INTELLIA THERAPEUTICS INC | 104,841 | $1.784M | 0.1% | $17.02 * | $19.36 | 0.0% | COM | 45826J105 |
| — | ACADIA PHARMACEUTICALS INC | 548 | $1.743M | 0.1% | $3180.66 | — | — | Put | 00404A959 |
| — | ZOGENIX INC | 150,000 | $1.715M | 0.1% | $11.43 | $9.10 | — | COM | 98978L204 |
| — | HEMISPHERX BIOPHARMA INC. | 1,351,850 | $1.69M | 0.1% | $1.25 | $1.25 | — | COM | 42366C301 |
| — | AMICUS THERAPEUTICS INC | 2,282 | $1.689M | 0.1% | $740.14 | — | — | Put | 03152W959 |
| — | NEVRO CORP | 161 | $1.681M | 0.1% | $10440.99 | — | — | Call | 64157F903 |
| — | GLOBAL BLOOD THERAPEUTICS INC | 721 | $1.662M | 0.1% | $2305.13 | — | — | Call | 37890U908 |
| — | ADVERUM BIOTECHNOLOGIES | 402,603 | $1.655M | 0.1% | $4.11 | $3.16 | — | COM | 00773U108 |
| EDAP | EDAP TMS S A | 545,918 | $1.583M | 0.1% | $2.90 | $3.31 | — | ADR | 268311107 |
| — | CYTORI THERAPEUTICS INC. | 895,017 | $1.547M | 0.1% | $1.73 | $0.79 | — | *W | 23283K121 |
| — | CARDIOME PHARMA CORP | 484,505 | $1.521M | 0.1% | $3.14 | $3.14 | — | COM | 14159U301 |
| — | WAFERGEN BIO SYSTEMS INC. | 1,578,616 | $1.52M | 0.1% | $0.96 | $0.77 | — | COM | 93041P308 |
| — | FIBROGEN INC | 72,669 | $1.504M | 0.1% | $20.70 | $21.29 | — | COM | 31572Q808 |
| — | VISTAGEN THERAPEUTICS INC | 349,096 | $1.452M | 0.1% | $4.16 | $3.90 | — | COM | 92840H202 |
| — | ONCOSEC MEDICAL INC | 834,004 | $1.426M | 0.1% | $1.71 | $2.99 | — | COM | 68234L207 |
| — | IGNYTA INC | 225,900 | $1.421M | 0.1% | $6.29 | $6.50 | — | COM | 451731103 |
| — | MEDIGUS LTD | 1,042,813 | $1.373M | 0.1% | $1.32 | $1.32 | — | COM | 58471G102 |
| — | INOTEK PHARMACEUTICALS CORP | 144,002 | $1.365M | 0.1% | $9.48 | $9.06 | — | COM | 45780V102 |
| — | ACHILLION PHARMACEUTICALS INC | 1,681 | $1.362M | 0.1% | $810.23 | — | — | Put | 00448Q951 |
| — | BIOBLAST PHARMA LTD | 784,057 | $1.356M | 0.1% | $1.73 | $2.49 | — | SHS | M20156101 |
| — | ONCOBIOLOGICS INC | 926,651 | $1.332M | 0.0% | $1.44 | $0.97 | — | *W | 68235M121 |
| — | AXOVANT SCIENCES LTD | 93,109 | $1.304M | 0.0% | $14.01 | $12.60 | — | COM | G0750W104 |
| — | THERAPEUTICSMD INC | 1,910 | $1.301M | 0.0% | $681.15 | — | — | Call | 88338N907 |
| — | PRONAI THERAPEUTICS INC. | 687,734 | $1.252M | 0.0% | $1.82 | $1.97 | — | COM | 74346L101 |
| — | SAGE THERAPEUTICS INC | 265 | $1.22M | 0.0% | $4603.77 | — | — | Put | 78667J958 |
| — | ENDO INTERNATIONAL PLC | 59,237 | $1.194M | 0.0% | $20.16 | $26.05 | — | SHS | G30401106 |
| — | ALCOBRA LTD | 4,826 | $1.192M | 0.0% | $247.00 | — | — | Call | M2239P909 |
| — | CAPRICOR THERAPEUTICS INC. | 357,436 | $1.183M | 0.0% | $3.31 | $4.09 | — | COM | 14070B101 |
| — | ACORDA THERAPEUTICS INC | 563 | $1.176M | 0.0% | $2088.81 | — | — | Put | 00484M956 |
| — | CHECK CAP LTD | 585,569 | $1.159M | 0.0% | $1.98 | $1.98 | — | SHS | M2361E112 |
| — | BIOCRYST PHARMACEUTICALS INC | 2,584 | $1.14M | 0.0% | $441.18 | — | — | Call | 09058V903 |
| — | ONCONOVA THERAPEUTICS INC | 725,434 | $1.124M | 0.0% | $1.55 | $1.55 | — | *W | 68232V116 |
| — | MANNKIND CORP | 1,785,368 | $1.107M | 0.0% | $0.62 | $0.62 | — | COM | 56400P201 |
| — | CELSION CORP. | 894,406 | $1.091M | 0.0% | $1.22 | $1.28 | — | COM | 15117N404 |
| — | LEXICON PHARMACEUTICALS INC | 600 | $1.084M | 0.0% | $1806.67 | — | — | Put | 528872952 |
| — | IMMUNOCELLULAR THERAPEUTICS | 15,161,641 | $1.077M | 0.0% | $0.07 | $0.07 | — | *W | 452536113 |
| — | RICEBRAN TECHNOLOGIES | 794,436 | $1.073M | 0.0% | $1.35 | $3.65 | — | COM | 762831204 |
| — | STEMLINE THERAPEUTICS INC | 98,050 | $1.062M | 0.0% | $10.83 | $10.83 | — | COM | 85858C107 |
| — | BRAINSTORM CELL THERAPEUTICS | 444,500 | $1.062M | 0.0% | $2.39 | $4.17 | — | COM | 10501E201 |
| — | OCERA THERAPEUTICS INC | 400,035 | $1.06M | 0.0% | $2.65 | $5.54 | — | COM | 67552A108 |
| — | PACIRA PHARMACEUTICALS INC | 309 | $1.057M | 0.0% | $3420.71 | — | — | Call | 695127900 |
| — | CALITHERA BIOSCIENCES INC. | 324,500 | $1.055M | 0.0% | $3.25 | $3.25 | — | COM | 13089P101 |
| — | RADIUS HEALTH INC | 195 | $1.055M | 0.0% | $5410.26 | — | — | Call | 750469907 |
| — | ONCONOVA THERAPEUTICS INC | 392,023 | $1.039M | 0.0% | $2.65 | $2.65 | — | COM | 68232V306 |
| — | ALLIQUA BIOMEDICAL INC | 1,321,726 | $1.031M | 0.0% | $0.78 | $1.60 | — | COM | 019621200 |
| — | CEL SCI CORP | 3,372,642 | $1.029M | 0.0% | $0.31 | $0.46 | — | COM | 150837508 |
| — | DRAGONWAVE INC. | 378,338 | $1.018M | 0.0% | $2.69 | $2.69 | — | COM | 26144M400 |
| — | VTV THERAPEUTICS INC | 134,747 | $969K | 0.0% | $7.19 | $6.52 | — | CL A | 918385105 |
| — | IMMUNOMEDICS INC. | 297,310 | $966K | 0.0% | $3.25 | $68.00 | — | COM | 452907108 |
| — | ONCOBIOLOGICS INC | 902,050 | $905K | 0.0% | $1.00 | $0.76 | — | *W | 68235M113 |
| CSBR | CHAMPIONS ONCOLOGY INC | 538,593 | $905K | 0.0% | $1.68 * | $4.47 | -58.1% | COM | 15870P307 |
| — | RETROPHIN INC | 401 | $897K | 0.0% | $2236.91 | — | — | Put | 761299956 |
| — | NEURALSTEM INC. | 2,787,745 | $892K | 0.0% | $0.32 | $0.29 | — | COM | 64127R302 |
| — | INSPIREMD INC | 29,594,500 | $888K | 0.0% | $0.03 | $0.03 | — | *W | 45779A119 |
| — | REDHILL BIOPHARMA LTD | 63,800 | $888K | 0.0% | $13.92 | $12.91 | — | ADS | 757468103 |
| — | DEXTERA SURGICAL INC | 450,507 | $851K | 0.0% | $1.89 | $1.80 | — | COM | 252366109 |
| — | HORIZON PHARMA PLC | 463 | $839K | 0.0% | $1812.10 | — | — | Put | G4617B955 |
| — | EYEGATE PHARMACEUTICALS INC | 508,598 | $834K | 0.0% | $1.64 | $2.36 | — | COM | 30233M107 |
| — | INTRA CELLULAR THERAPIES INC | 533 | $812K | 0.0% | $1523.45 | — | — | Call | 46116X901 |
| — | WINDTREE THERAPEUTICS INC. | 310,000 | $797K | 0.0% | $2.57 | $1.93 | — | COM | 97382D105 |
| — | MEDGENICS INC | 141,977 | $791K | 0.0% | $5.57 | $5.55 | — | COM | 58436Q203 |
| — | AMPLIPHI BIOSCIENCES CORP | 521,378 | $782K | 0.0% | $1.50 | $1.55 | — | COM | 03211P202 |
| — | RADIUS HEALTH INC | 141 | $763K | 0.0% | $5411.35 | — | — | Put | 750469957 |
| — | IMMUNOCELLULAR THERAPEUTICS | 6,405,230 | $756K | 0.0% | $0.12 | $0.37 | — | COM | 452536105 |
| — | XTL BIOPHARMACEUTICALS LTD | 751,289 | $714K | 0.0% | $0.95 | $2.30 | — | ADR | 98386D208 |
| — | GENVEC INC | 1,510,377 | $696K | 0.0% | $0.46 | $0.57 | — | COM | 37246C307 |
| — | PORTOLA PHARMACEUTICALS INC | 300 | $681K | 0.0% | $2270.00 | — | — | Call | 737010908 |
| — | ARBUTUS BIOPHARMA CORP | 1,949 | $670K | 0.0% | $343.77 | — | — | Call | 03879J900 |
| — | FOAMIX PHARMACEUTICALS LTD | 724 | $670K | 0.0% | $925.41 | — | — | Call | M46135905 |
| — | SUPERCONDUCTOR TECHNOLOGIES INC. | 250,474 | $669K | 0.0% | $2.67 | $2.67 | — | COM | 867931503 |
| — | ANTHERA PHARMACEUTICALS INC | 2,121 | $668K | 0.0% | $314.95 | — | — | Call | 03674U901 |
| — | MIRATI THERAPEUTICS INC. | 99,735 | $659K | 0.0% | $6.61 | $6.61 | — | COM | 60468T105 |
| — | PSIVIDA CORP | 195,100 | $587K | 0.0% | $3.01 | $2.68 | — | COM | 74440J101 |
| — | TENAX THERAPEUTICS INC | 2,534 | $583K | 0.0% | $230.07 | — | — | Call | 88032L900 |
| ACUR | ACURA PHARMACEUTICALS INC | 352,835 | $565K | 0.0% | $1.60 * | $3.40 | -47.9% | COM | 00509L802 |
| — | BLUEPRINT MEDICINES CORP | 190 | $564K | 0.0% | $2968.42 | — | — | Put | 09627Y959 |
| — | PACIRA PHARMACEUTICALS INC | 159 | $544K | 0.0% | $3421.38 | — | — | Put | 695127950 |
| — | ASSEMBLY BIOSCIENCES INC | 75,200 | $542K | 0.0% | $7.21 | $5.56 | — | COM | 045396108 |
| PARNEUR | PARNELL PHARMACEUTICALS HOLDINGS LTD | 369,700 | $532K | 0.0% | $1.44 | $1.63 | — | SHS | Q73622104 |
| — | NEWLINK GENETICS CORP | 34,561 | $519K | 0.0% | $15.02 | $32.40 | — | COM | 651511107 |
| — | SUNSHINE HEART INC. | 908,021 | $518K | 0.0% | $0.57 | $0.57 | — | COM | 86782U106 |
| — | RENNOVA HEALTH INC | 2,724,721 | $516K | 0.0% | $0.19 | $0.19 | — | COM | 759757107 |
| — | MEDICINES CO | 13,508 | $510K | 0.0% | $37.76 | $35.59 | — | COM | 584688105 |
| — | STRATA SKIN SCIENCES INC | 1,000,790 | $510K | 0.0% | $0.51 | $0.80 | — | COM | 86272A107 |
| — | TESARO INC | 50 | $501K | 0.0% | $10020.00 | — | — | Put | 881569957 |
| — | TOKAI PHARMACEUTICALS INC. | 321,600 | $492K | 0.0% | $1.53 | $5.61 | — | COM | 88907J107 |
| — | BIODELIVERY SCIENCES INTERNATIONAL INC | 1,770 | $478K | 0.0% | $270.06 | — | — | Call | 09060J906 |
| — | COMMUNITY HEALTH SYSTEMS INC | 413 | $477K | 0.0% | $1154.96 | — | — | Put | 203668958 |
| — | INOTEK PHARMACEUTICALS CORP | 500 | $474K | 0.0% | $948.00 | — | — | Put | 45780V952 |
| — | ADAMAS PHARMACEUTICALS INC | 28,200 | $463K | 0.0% | $16.42 | $14.46 | — | COM | 00548A106 |
| — | NOVAVAX INC | 2,195 | $457K | 0.0% | $208.20 | — | — | Call | 670002904 |
| — | CHIMERIX INC. | 79,900 | $443K | 0.0% | $5.54 | $5.54 | — | COM | 16934W106 |
| — | COMBIMATRIX CORP. | 857,746 | $429K | 0.0% | $0.50 | $0.67 | — | *W | 20009T147 |
| — | AVEXIS ORD SHS | 10,000 | $412K | 0.0% | $41.20 | $41.20 | — | COM | 05366U100 |
| — | LION BIOTECHNOLOGIES INC | 496 | $408K | 0.0% | $822.58 | — | — | Call | 53619R902 |
| — | NEUROMETRIX INC | 3,060,947 | $400K | 0.0% | $0.13 | $0.31 | — | *W | 641255153 |
| — | THERAPEUTICSMD INC | 586 | $399K | 0.0% | $680.89 | — | — | Put | 88338N957 |
| — | FLEXION THERAPEUTICS INC | 202 | $395K | 0.0% | $1955.45 | — | — | Put | 33938J956 |
| PRQR | PROQR THERAPEUTICS N V | 58,910 | $393K | 0.0% | $6.67 * | $7.45 | -26.1% | COM | N71542109 |
| — | CASCADIAN THERAPEUTICS INC. | 238,899 | $392K | 0.0% | $1.64 | $0.94 | — | COM | 14740B101 |
| — | BENITEC BIOPHARMA LTD | 274,573 | $385K | 0.0% | $1.40 | $1.40 | — | ADR | 82053307 |
| — | MEDICINES CO | 100 | $377K | 0.0% | $3770.00 | — | — | Put | 584688955 |
| — | ACORDA THERAPEUTICS INC | 179 | $374K | 0.0% | $2089.39 | — | — | Call | 00484M906 |
| — | BIOPHARMX CORP | 654,462 | $363K | 0.0% | $0.55 | $1.01 | — | COM | 09072X101 |
| CYH | COMMUNITY HEALTH SYSTEMS INC | 31,122 | $359K | 0.0% | $11.54 | $11.53 | 0.0% | COM | 203668108 |
| — | OVASCIENCE INC | 50,000 | $358K | 0.0% | $7.16 | $5.21 | — | COM | 69014Q101 |
| — | AMARIN CORPORATION PLC | 1,121 | $358K | 0.0% | $319.36 | — | — | Put | 023111956 |
| — | FIBROGEN INC | 164 | $339K | 0.0% | $2067.07 | — | — | Call | 31572Q908 |
| — | INCYTE CORP | 36 | $339K | 0.0% | $9416.67 | — | — | Call | 45337C902 |
| — | NEUROMETRIX INC | 219,336 | $338K | 0.0% | $1.54 | $1.76 | — | COM | 641255500 |
| — | MOMENTA PHARMACEUTICALS INC | 275 | $321K | 0.0% | $1167.27 | — | — | Call | 60877T900 |
| — | RIGEL PHARMACEUTICALS INC | 86,900 | $319K | 0.0% | $3.67 | $2.23 | — | COM | 766559603 |
| — | ANAVEX LIFE SCIENCES CORP | 858 | $311K | 0.0% | $362.47 | — | — | Put | 032797950 |
| — | JUNO THERAPEUTICS INC | 103 | $309K | 0.0% | $3000.00 | — | — | Call | 48205A909 |
| — | MEDGENICS INC | 533 | $297K | 0.0% | $557.22 | — | — | Call | 58436Q903 |
| — | ANTHERA PHARMACEUTICALS INC | 94,201 | $297K | 0.0% | $3.15 | $3.62 | — | COM | 03674U201 |
| — | DICERNA PHARMACEUTICALS INC | 50,000 | $294K | 0.0% | $5.88 | $5.88 | — | COM | 253031108 |
| QRHC | QUEST RESOURCE HOLDING CORP | 138,980 | $281K | 0.0% | $2.02 * | $2.35 | 0.0% | COM | 74836W203 |
| — | SYNERGY PHARMACEUTICALS INC. | 348,743 | $268K | 0.0% | $0.77 | $0.77 | — | *W | 871639118 |
| — | CELLECT BIOTECHNOLOGY LTD | 57,348 | $264K | 0.0% | $4.60 | $4.60 | — | ADS | 15116C102 |
| OCUL | OCULAR THERAPEUTIX INC | 38,100 | $262K | 0.0% | $6.88 * | $6.10 | 0.0% | COM | 67576A100 |
| — | RENNOVA HEALTH INC | 3,682,014 | $258K | 0.0% | $0.07 | $0.07 | — | *W | 759757123 |
| — | AETERNA ZENTARIS INC | 740 | $254K | 0.0% | $343.24 | — | — | Put | 007975952 |
| — | DURECT CORP | 1,759 | $245K | 0.0% | $139.28 | — | — | Call | 266605904 |
| — | STEMLINE THERAPEUTICS INC | 222 | $240K | 0.0% | $1081.08 | — | — | Call | 85858C907 |
| — | FLEXION THERAPEUTICS INC | 12,176 | $238K | 0.0% | $19.55 | $12.31 | — | COM | 33938J106 |
| — | CAPNIA INC. | 245,737 | $236K | 0.0% | $0.96 | $1.20 | — | COM | 14066L105 |
| — | THERAPEUTICSMD INC | 34,030 | $232K | 0.0% | $6.82 | $6.82 | — | COM | 88338N107 |
| — | AETERNA ZENTARIS INC | 66,982 | $230K | 0.0% | $3.43 | $4.48 | — | COM | 007975402 |
| — | INTRA CELLULAR THERAPIES INC | 148 | $226K | 0.0% | $1527.03 | — | — | Put | 46116X951 |
| — | INTRA CELLULAR THERAPIES INC | 14,800 | $226K | 0.0% | $15.27 | $27.79 | — | COM | 46116X101 |
| — | CANCER GENETICS INC | 109,048 | $191K | 0.0% | $1.75 | $2.48 | — | COM | 13739U104 |
| — | ATHERSYS INC | 89,139 | $190K | 0.0% | $2.13 | $2.17 | — | COM | 04744L106 |
| — | CELLECTAR BIOSCIENCES INC | 228,788 | $188K | 0.0% | $0.82 | $0.89 | — | *W | 15117F120 |
| — | NOVAVAX INC | 844 | $176K | 0.0% | $208.53 | — | — | Put | 670002954 |
| SRNE | SORRENTO THERAPEUTICS INC | 20,986 | $162K | 0.0% | $7.72 * | $11.18 | -39.8% | COM | 83587F202 |
| — | NATERA INC | 145 | $161K | 0.0% | $1110.34 | — | — | Call | 632307904 |
| SGMO | SANGAMO BIOSCIENCES INC | 32,804 | $152K | 0.0% | $4.63 * | $5.09 | 0.0% | COM | 800677106 |
| — | HISTOGENICS CORP. | 47,823 | $151K | 0.0% | $3.16 | $4.61 | — | COM | 43358V109 |
| — | NEWLINK GENETICS CORP | 100 | $150K | 0.0% | $1500.00 | — | — | Put | 651511957 |
| — | AKARI THERAPEUTICS PLC | 17,428 | $148K | 0.0% | $8.49 | $14.89 | — | ADR | 00972G108 |
| — | EVOKE PHARMA INC. | 63,768 | $144K | 0.0% | $2.26 | $2.26 | — | COM | 30049G104 |
| — | TONIX PHARMACEUTICALS HOLDING CORP. | 203,097 | $142K | 0.0% | $0.70 | $2.79 | — | COM | 890260201 |
| — | ALCOBRA LTD | 559 | $138K | 0.0% | $246.87 | — | — | Put | M2239P959 |
| — | INVIVO THERAPEUTICS HOLDINGS CORP | 199 | $135K | 0.0% | $678.39 | — | — | Call | 46186M909 |
| — | SORRENTO THERAPEUTICS INC | 164 | $127K | 0.0% | $774.39 | — | — | Call | 83587F902 |
| — | RIGEL PHARMACEUTICALS INC | 316 | $116K | 0.0% | $367.09 | — | — | Call | 766559903 |
| PVCT | PROVECTUS BIOPHARMACEUTICALS INC | 1,077,555 | $107K | 0.0% | $0.10 * | $0.27 | -19.2% | COM | 74373P108 |
| — | ATHERSYS INC | 476 | $101K | 0.0% | $212.18 | — | — | Put | 04744L956 |
| — | INOTEK PHARMACEUTICALS CORP | 106 | $100K | 0.0% | $943.40 | — | — | Call | 45780V902 |
| GALT | GALECTIN THERAPEUTICS INC | 87,999 | $99,000 | 0.0% | $1.13 * | $2.29 | -22.4% | COM | 363225202 |
| — | GALECTIN THERAPEUTICS INC | 825 | $93,000 | 0.0% | $112.73 | — | — | Put | 363225952 |
| — | ASTERIAS BIOTHERAPEUTICS INC | 200 | $85,000 | 0.0% | $425.00 | — | — | Call | 04624N907 |
| — | ZOSANO PHARMA CORP. | 103,600 | $82,000 | 0.0% | $0.79 | $9.59 | — | COM | 98979H103 |
| — | GALENA BIOPHARMA INC | 1,624 | $57,000 | 0.0% | $35.10 | — | — | Put | 363256958 |
| — | GREAT PANTHER SILVER LTD | 40,450 | $55,000 | 0.0% | $1.36 | $1.36 | — | COM | 39115V101 |
| — | INSPIREMD INC | 679,224 | $54,000 | 0.0% | $0.08 | $0.08 | — | COM | 45779A507 |
| — | VIKING THERAPEUTICS INC | 117,008 | $53,000 | 0.0% | $0.45 | $0.29 | — | *W | 92686J114 |
| — | EDAP TMS S A | 182 | $53,000 | 0.0% | $291.21 | — | — | Put | 268311957 |
| — | ADAMIS PHARMACEUTICALS CORP | 148 | $51,000 | 0.0% | $344.59 | — | — | Put | 00547W958 |
| — | GALENA BIOPHARMA INC | 141,000 | $49,000 | 0.0% | $0.35 | $0.44 | — | COM | 363256108 |
| — | ALCOBRA LTD | 17,058 | $42,000 | 0.0% | $2.46 | $5.87 | — | SHS | M2239P109 |
| — | TENAX THERAPEUTICS INC | 169 | $39,000 | 0.0% | $230.77 | — | — | Put | 88032L950 |
| — | INFINITY PHARMACEUTICALS INC | 167 | $26,000 | 0.0% | $155.69 | — | — | Call | 45665G903 |
| — | BENITEC BIOPHARMA LTD | 98,146 | $17,000 | 0.0% | $0.17 | $0.36 | — | *W | 082053117 |
| — | EYEGATE PHARMACEUTICALS INC | 46,968 | $16,000 | 0.0% | $0.34 | $1.02 | — | *W | 30233M115 |
| — | ZAFGEN INC | 2,149 | $15,000 | 0.0% | $6.98 | — | — | Call | 98885E903 |