GREAT POINT PARTNERS LLC Quant / Systematic

Location: Greenwich, CT

CIK: 0001281446 · Show all filings

Period: Q4 2023 (← Previous) (Next →)

Filing Date: Feb 14, 2024

Total Value: $587M (100.0% shares, 0.0% debt)

Holdings (34)

— ALPINE IMMUNE SCIENCES INC 12.0%

Value $70.59M Shares 3,703,433 Est. Cost $9.38 Unrealized —

CYTK CYTOKINETICS INC 7.1%

Value $41.74M Shares 500,000 Est. Cost $40.16 Unrealized -9.8%

URGN UROGEN PHARMA LTD 6.7%

Value $39.31M Shares 2,620,545 Est. Cost $16.05 Unrealized -19.1%

PLRX PLIANT THERAPEUTICS INC 5.6%

Value $33.02M Shares 1,823,184 Est. Cost $17.59 Unrealized -13.6%

RARE ULTRAGENYX PHARMACEUTICAL IN 5.3%

Value $30.99M Shares 648,000 Est. Cost $41.00 Unrealized -5.4%

XENE XENON PHARMACEUTICALS INC 4.7%

Value $27.64M Shares 600,000 Est. Cost $24.44 Unrealized +44.5%

— RAPT THERAPEUTICS INC 4.7%

Value $27.33M Shares 1,099,753 Est. Cost $20.58 Unrealized —

ALKS ALKERMES PLC 4.1%

Value $24.27M Shares 875,044 Est. Cost $29.77 Unrealized -12.7%

— AEROVATE THERAPEUTICS INC 4.0%

Value $23.48M Shares 1,037,690 Est. Cost $21.89 Unrealized —

PCVX VAXCYTE INC 3.9%

Value $22.61M Shares 360,000 Est. Cost $26.90 Unrealized +93.0%

EOLS EVOLUS INC 3.6%

Value $21.06M Shares 2,000,000 Est. Cost $8.90 Unrealized +0.5%

ANAB ANAPTYSBIO INC 3.6%

Value $20.93M Shares 976,981 Est. Cost $23.39 Unrealized -26.3%

IMCR IMMUNOCORE HLDGS PLC 3.4%

Value $20.02M Shares 293,000 Est. Cost $50.92 Unrealized —

NGNE NEUROGENE INC 3.3%

Value $19.27M Shares 994,229 Est. Cost $14.32 Unrealized 0.0%

FOLD AMICUS THERAPEUTICS INC 3.1%

Value $18.17M Shares 1,280,500 Est. Cost $11.96 Unrealized -5.1%

— TOURMALINE BIO INC 3.0%

Value $17.62M Shares 672,885 Est. Cost $26.18 Unrealized —

ABVX ABIVAX SA 2.8%

Value $16.59M Shares 1,550,000 Est. Cost $10.70 Unrealized —

ZURA ZURA BIO LTD 2.6%

Value $15.39M Shares 3,295,000 Est. Cost $8.03 Unrealized -37.8%

— OPTINOSE INC 1.9%

Value $11.4M Shares 8,839,939 Est. Cost $1.78 Unrealized —

APGE APOGEE THERAPEUTICS INC 1.9%

Value $11.18M Shares 400,000 Est. Cost $22.03 Unrealized -9.0%

ARVN ARVINAS INC 1.6%

Value $9.635M Shares 234,082 Est. Cost $23.38 Unrealized 0.0%

— KARUNA THERAPEUTICS INC 1.6%

Value $9.574M Shares 30,250 Est. Cost $169.09 Unrealized —

VTGN VISTAGEN THERAPEUTICS INC 1.6%

Value $9.554M Shares 1,858,735 Est. Cost $3.78 Unrealized 0.0%

TERN TERNS PHARMACEUTICALS INC 1.4%

Value $8.502M Shares 1,309,975 Est. Cost $5.81 Unrealized -9.0%

— INTRA-CELLULAR THERAPIES INC 1.4%

Value $7.922M Shares 110,607 Est. Cost $52.09 Unrealized —

SRPT SAREPTA THERAPEUTICS INC 1.3%

Value $7.714M Shares 80,000 Est. Cost $124.83 Unrealized -23.2%

INSM INSMED INC 1.2%

Value $7.001M Shares 225,912 Est. Cost $22.87 Unrealized +13.4%

PBYI PUMA BIOTECHNOLOGY INC 0.8%

Value $4.734M Shares 1,093,273 Est. Cost $3.31 Unrealized 0.0%

OCUL OCULAR THERAPEUTIX INC 0.5%

Value $3.122M Shares 700,000 Est. Cost $2.96 Unrealized 0.0%

SYRE SPYRE THERAPEUTICS INC 0.5%

Value $2.69M Shares 125,000 Est. Cost $13.78 Unrealized 0.0%

ACLX ARCELLX INC 0.5%

Value $2.679M Shares 48,264 Est. Cost $33.94 Unrealized +32.9%

— MERUS N V 0.1%

Value $550K Shares 20,000 Est. Cost $27.50 Unrealized —

AXSM AXSOME THERAPEUTICS INC 0.1%

Value $395K Shares 4,963 Est. Cost $66.86 Unrealized 0.0%

— MURAL ONCOLOGY PUB LTD CO 0.0%

Value $68,133 Shares 11,509 Est. Cost $5.92 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
—	ALPINE IMMUNE SCIENCES INC	3,703,433	$70.59M	12.0%	$9.38	—	COM	02083G100
CYTK	CYTOKINETICS INC	500,000	$41.74M	7.1%	$40.16	-9.8%	COM NEW	23282W605
URGN	UROGEN PHARMA LTD	2,620,545	$39.31M	6.7%	$16.05	-19.1%	COM	M96088105
PLRX	PLIANT THERAPEUTICS INC	1,823,184	$33.02M	5.6%	$17.59	-13.6%	COM	729139105
RARE	ULTRAGENYX PHARMACEUTICAL IN	648,000	$30.99M	5.3%	$41.00	-5.4%	COM	90400D108
XENE	XENON PHARMACEUTICALS INC	600,000	$27.64M	4.7%	$24.44	+44.5%	COM	98420N105
—	RAPT THERAPEUTICS INC	1,099,753	$27.33M	4.7%	$20.58	—	COM	75382E109
ALKS	ALKERMES PLC	875,044	$24.27M	4.1%	$29.77	-12.7%	SHS	G01767105
—	AEROVATE THERAPEUTICS INC	1,037,690	$23.48M	4.0%	$21.89	—	COM	008064107
PCVX	VAXCYTE INC	360,000	$22.61M	3.9%	$26.90	+93.0%	COM	92243G108
EOLS	EVOLUS INC	2,000,000	$21.06M	3.6%	$8.90	+0.5%	COM	30052C107
ANAB	ANAPTYSBIO INC	976,981	$20.93M	3.6%	$23.39	-26.3%	COM	032724106
IMCR	IMMUNOCORE HLDGS PLC	293,000	$20.02M	3.4%	$50.92	—	ADS	45258D105
NGNE	NEUROGENE INC	994,229	$19.27M	3.3%	$14.32	0.0%	COM	64135M105
FOLD	AMICUS THERAPEUTICS INC	1,280,500	$18.17M	3.1%	$11.96	-5.1%	COM	03152W109
—	TOURMALINE BIO INC	672,885	$17.62M	3.0%	$26.18	—	COM	89157D105
ABVX	ABIVAX SA	1,550,000	$16.59M	2.8%	$10.70	—	SPONSORED ADS	00370M103
ZURA	ZURA BIO LTD	3,295,000	$15.39M	2.6%	$8.03	-37.8%	CLASS A ORD SHS	G9TY5A101
—	OPTINOSE INC	8,839,939	$11.4M	1.9%	$1.78	—	COM	68404V100
APGE	APOGEE THERAPEUTICS INC	400,000	$11.18M	1.9%	$22.03	-9.0%	COM	03770N101
ARVN	ARVINAS INC	234,082	$9.635M	1.6%	$23.38	0.0%	COM	04335A105
—	KARUNA THERAPEUTICS INC	30,250	$9.574M	1.6%	$169.09	—	COM	48576A100
VTGN	VISTAGEN THERAPEUTICS INC	1,858,735	$9.554M	1.6%	$3.78	0.0%	COM	92840H400
TERN	TERNS PHARMACEUTICALS INC	1,309,975	$8.502M	1.4%	$5.81	-9.0%	COM	880881107
—	INTRA-CELLULAR THERAPIES INC	110,607	$7.922M	1.4%	$52.09	—	COM	46116X101
SRPT	SAREPTA THERAPEUTICS INC	80,000	$7.714M	1.3%	$124.83	-23.2%	COM	803607100
INSM	INSMED INC	225,912	$7.001M	1.2%	$22.87	+13.4%	COM PAR $.01	457669307
PBYI	PUMA BIOTECHNOLOGY INC	1,093,273	$4.734M	0.8%	$3.31	0.0%	COM	74587V107
OCUL	OCULAR THERAPEUTIX INC	700,000	$3.122M	0.5%	$2.96	0.0%	COM	67576A100
SYRE	SPYRE THERAPEUTICS INC	125,000	$2.69M	0.5%	$13.78	0.0%	COM NEW	00773J202
ACLX	ARCELLX INC	48,264	$2.679M	0.5%	$33.94	+32.9%	COMMON STOCK	03940C100
—	MERUS N V	20,000	$550K	0.1%	$27.50	—	COM	N5749R100
AXSM	AXSOME THERAPEUTICS INC	4,963	$395K	0.1%	$66.86	0.0%	COM	05464T104
—	MURAL ONCOLOGY PUB LTD CO	11,509	$68,133	0.0%	$5.92	—	ORD SHS	G63365103