GREAT POINT PARTNERS LLC Quant / Systematic

CIK: 0001281446 · Show all filings

Period: Q4 2024 (← Previous) (Next →)

Filing Date: Feb 14, 2025

Total Value ($000): $212,200 (100.0% shares, 0.0% debt)

Holdings (26)

IONS IONIS PHARMACEUTICALS INC 8.3%

Value ($000) $17,655 Shares 505,007 Est. Cost $39.21 Unrealized -4.7%

CYTK CYTOKINETICS INC 8.0%

Value ($000) $16,934 Shares 360,000 Est. Cost $51.77 Unrealized +0.3%

KALV KALVISTA PHARMACEUTICALS INC 7.1%

Value ($000) $15,136 Shares 1,787,003 Est. Cost $11.31 Unrealized -8.4%

VRDN VIRIDIAN THERAPEUTICS INC 6.8%

Value ($000) $14,378 Shares 750,000 Est. Cost $18.37 Unrealized +18.3%

PLRX PLIANT THERAPEUTICS INC 6.5%

Value ($000) $13,894 Shares 1,055,000 Est. Cost $16.18 Unrealized -15.6%

ABVX ABIVAX SA 5.7%

Value ($000) $12,067 Shares 1,648,523 Est. Cost $12.06 Unrealized —

— DYNAVAX TECHNOLOGIES CORP 5.2%

Value ($000) $10,982 Shares 860,000 Est. Cost $11.86 Unrealized —

NGNE NEUROGENE INC 4.8%

Value ($000) $10,122 Shares 442,761 Est. Cost $14.51 Unrealized +156.4%

EOLS EVOLUS INC 4.7%

Value ($000) $9,887 Shares 895,524 Est. Cost $9.65 Unrealized +45.7%

XENE XENON PHARMACEUTICALS INC 4.5%

Value ($000) $9,615 Shares 245,272 Est. Cost $41.35 Unrealized 0.0%

— UNICYCIVE THERAPEUTICS INC 4.1%

Value ($000) $8,720 Shares 10,980,000 Est. Cost $0.49 Unrealized —

ZURA ZURA BIO LTD 3.7%

Value ($000) $7,925 Shares 3,170,194 Est. Cost $6.43 Unrealized -44.6%

AUTL AUTOLUS THERAPEUTICS PLC 3.3%

Value ($000) $7,072 Shares 3,009,392 Est. Cost $4.32 Unrealized —

JSPR JASPER THERAPEUTICS INC 3.2%

Value ($000) $6,892 Shares 322,380 Est. Cost $17.76 Unrealized +17.2%

— MERUS N V 3.1%

Value ($000) $6,648 Shares 158,092 Est. Cost $52.47 Unrealized —

DNTH DIANTHUS THERAPEUTICS INC 2.8%

Value ($000) $5,995 Shares 275,000 Est. Cost $22.14 Unrealized +16.1%

BBOT HELIX ACQUISITION CORP II 2.5%

Value ($000) $5,250 Shares 500,000 Est. Cost $10.35 Unrealized +1.5%

UPB UPSTREAM BIO INC 2.3%

Value ($000) $4,932 Shares 300,000 Est. Cost $22.33 Unrealized 0.0%

CNTX CONTEXT THERAPEUTICS INC 2.3%

Value ($000) $4,918 Shares 4,683,711 Est. Cost $1.72 Unrealized +0.4%

VYGR VOYAGER THERAPEUTICS INC 2.2%

Value ($000) $4,688 Shares 826,751 Est. Cost $7.91 Unrealized —

ORKA ORUKA THERAPEUTICS INC 2.1%

Value ($000) $4,436 Shares 228,803 Est. Cost $34.79 Unrealized -29.9%

MREO MEREO BIOPHARMA GROUP PLC 1.9%

Value ($000) $4,025 Shares 1,150,000 Est. Cost $3.50 Unrealized —

RZLT REZOLUTE INC 1.4%

Value ($000) $3,047 Shares 621,894 Est. Cost $5.04 Unrealized 0.0%

— PROMIS NEUROSCIENCES INC 1.2%

Value ($000) $2,507 Shares 2,645,128 Est. Cost $1.25 Unrealized —

— OPTINOSE INC 1.2%

Value ($000) $2,473 Shares 370,269 Est. Cost $6.68 Unrealized —

URGN UROGEN PHARMA LTD 0.9%

Value ($000) $2,001 Shares 187,843 Est. Cost $15.87 Unrealized -24.6%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
IONS	IONIS PHARMACEUTICALS INC	505,007	$17,655	8.3%	$39.21	-4.7%	COM	462222100
CYTK	CYTOKINETICS INC	360,000	$16,934	8.0%	$51.77	+0.3%	COM NEW	23282W605
KALV	KALVISTA PHARMACEUTICALS INC	1,787,003	$15,136	7.1%	$11.31	-8.4%	COM	483497103
VRDN	VIRIDIAN THERAPEUTICS INC	750,000	$14,378	6.8%	$18.37	+18.3%	COM	92790C104
PLRX	PLIANT THERAPEUTICS INC	1,055,000	$13,894	6.5%	$16.18	-15.6%	COM	729139105
ABVX	ABIVAX SA	1,648,523	$12,067	5.7%	$12.06	—	SPONSORED ADS	00370M103
—	DYNAVAX TECHNOLOGIES CORP	860,000	$10,982	5.2%	$11.86	—	COM NEW	268158201
NGNE	NEUROGENE INC	442,761	$10,122	4.8%	$14.51	+156.4%	COM	64135M105
EOLS	EVOLUS INC	895,524	$9,887	4.7%	$9.65	+45.7%	COM	30052C107
XENE	XENON PHARMACEUTICALS INC	245,272	$9,615	4.5%	$41.35	0.0%	COM	98420N105
—	UNICYCIVE THERAPEUTICS INC	10,980,000	$8,720	4.1%	$0.49	—	COM	90466Y103
ZURA	ZURA BIO LTD	3,170,194	$7,925	3.7%	$6.43	-44.6%	CLASS A ORD SHS	G9TY5A101
AUTL	AUTOLUS THERAPEUTICS PLC	3,009,392	$7,072	3.3%	$4.32	—	SPON ADS	05280R100
JSPR	JASPER THERAPEUTICS INC	322,380	$6,892	3.2%	$17.76	+17.2%	COM NEW	471871202
—	MERUS N V	158,092	$6,648	3.1%	$52.47	—	COM	N5749R100
DNTH	DIANTHUS THERAPEUTICS INC	275,000	$5,995	2.8%	$22.14	+16.1%	COM	252828108
BBOT	HELIX ACQUISITION CORP II	500,000	$5,250	2.5%	$10.35	+1.5%	CL A ORD SHS	G4444H101
UPB	UPSTREAM BIO INC	300,000	$4,932	2.3%	$22.33	0.0%	COM	91678A107
CNTX	CONTEXT THERAPEUTICS INC	4,683,711	$4,918	2.3%	$1.72	+0.4%	COM	21077P108
VYGR	VOYAGER THERAPEUTICS INC	826,751	$4,688	2.2%	$7.91	—	COM	92915B106
ORKA	ORUKA THERAPEUTICS INC	228,803	$4,436	2.1%	$34.79	-29.9%	COM	687604108
MREO	MEREO BIOPHARMA GROUP PLC	1,150,000	$4,025	1.9%	$3.50	—	SPON ADS	589492107
RZLT	REZOLUTE INC	621,894	$3,047	1.4%	$5.04	0.0%	COM NEW	76200L309
—	PROMIS NEUROSCIENCES INC	2,645,128	$2,507	1.2%	$1.25	—	COM NEW	74346M406
—	OPTINOSE INC	370,269	$2,473	1.2%	$6.68	—	COM NEW	68404V209
URGN	UROGEN PHARMA LTD	187,843	$2,001	0.9%	$15.87	-24.6%	COM	M96088105