GREAT POINT PARTNERS LLC Quant / Systematic

CIK: 0001281446 · Show all filings

Period: Q1 2025 (← Previous) (Next →)

Filing Date: May 15, 2025

Total Value ($000): $188,796 (100.0% shares, 0.0% debt)

Holdings (32)

CYTK CYTOKINETICS INC 7.9%

Value ($000) $14,870 Shares 370,000 Est. Cost $51.61 Unrealized -11.0%

KALV KALVISTA PHARMACEUTICALS INC 6.2%

Value ($000) $11,706 Shares 1,014,367 Est. Cost $11.31 Unrealized -9.8%

EOLS EVOLUS INC 6.0%

Value ($000) $11,365 Shares 944,743 Est. Cost $9.83 Unrealized +33.0%

ABVX ABIVAX SA 5.4%

Value ($000) $10,238 Shares 1,638,111 Est. Cost $12.06 Unrealized —

VRDN VIRIDIAN THERAPEUTICS INC 5.4%

Value ($000) $10,110 Shares 750,000 Est. Cost $18.37 Unrealized -7.3%

— MERUS N V 5.3%

Value ($000) $9,982 Shares 237,156 Est. Cost $49.01 Unrealized —

AKBA AKEBIA THERAPEUTICS INC 5.1%

Value ($000) $9,550 Shares 4,973,840 Est. Cost $2.04 Unrealized 0.0%

XENE XENON PHARMACEUTICALS INC 4.4%

Value ($000) $8,229 Shares 245,272 Est. Cost $41.35 Unrealized -8.2%

ASND ASCENDIS PHARMA A/S 4.1%

Value ($000) $7,793 Shares 50,000 Est. Cost $155.86 Unrealized —

— DYNAVAX TECHNOLOGIES CORP 4.1%

Value ($000) $7,729 Shares 595,879 Est. Cost $11.86 Unrealized —

IONS IONIS PHARMACEUTICALS INC 4.0%

Value ($000) $7,543 Shares 250,000 Est. Cost $39.21 Unrealized -16.5%

AMLX AMYLYX PHARMACEUTICALS INC 3.4%

Value ($000) $6,414 Shares 1,811,996 Est. Cost $3.56 Unrealized 0.0%

IMVT IMMUNOVANT INC 3.4%

Value ($000) $6,409 Shares 375,000 Est. Cost $20.92 Unrealized 0.0%

— UNICYCIVE THERAPEUTICS INC 3.3%

Value ($000) $6,312 Shares 10,980,000 Est. Cost $0.49 Unrealized —

NGNE NEUROGENE INC 2.9%

Value ($000) $5,515 Shares 470,964 Est. Cost $14.68 Unrealized +18.3%

DNTH DIANTHUS THERAPEUTICS INC 2.6%

Value ($000) $4,989 Shares 275,000 Est. Cost $22.14 Unrealized -0.5%

SMMT SUMMIT THERAPEUTICS INC 2.6%

Value ($000) $4,823 Shares 250,000 Est. Cost — Unrealized —

LEGN LEGEND BIOTECH CORP 2.5%

Value ($000) $4,690 Shares 138,240 Est. Cost $33.93 Unrealized —

PCVX VAXCYTE INC 2.3%

Value ($000) $4,362 Shares 115,517 Est. Cost $79.95 Unrealized 0.0%

AUTL AUTOLUS THERAPEUTICS PLC 2.2%

Value ($000) $4,230 Shares 2,728,910 Est. Cost $4.32 Unrealized —

BBOT HELIX ACQUISITION CORP II 2.2%

Value ($000) $4,224 Shares 373,833 Est. Cost $10.35 Unrealized +3.8%

ZURA ZURA BIO LTD 2.2%

Value ($000) $4,090 Shares 3,170,194 Est. Cost $6.43 Unrealized -75.5%

BEAM BEAM THERAPEUTICS INC 1.8%

Value ($000) $3,429 Shares 175,562 Est. Cost $26.20 Unrealized 0.0%

ACLX ARCELLX INC 1.6%

Value ($000) $2,952 Shares 45,000 Est. Cost $67.74 Unrealized 0.0%

MREO MEREO BIOPHARMA GROUP PLC 1.5%

Value ($000) $2,869 Shares 1,275,000 Est. Cost $3.38 Unrealized —

CNTX CONTEXT THERAPEUTICS INC 1.5%

Value ($000) $2,866 Shares 4,683,711 Est. Cost $1.72 Unrealized -49.5%

RZLT REZOLUTE INC 1.3%

Value ($000) $2,416 Shares 833,042 Est. Cost $4.87 Unrealized -10.5%

CNTA CENTESSA PHARMACEUTICALS PLC 1.1%

Value ($000) $2,153 Shares 149,702 Est. Cost $14.38 Unrealized —

VYGR VOYAGER THERAPEUTICS INC 1.1%

Value ($000) $2,117 Shares 626,275 Est. Cost $7.91 Unrealized —

— PROMIS NEUROSCIENCES INC 1.0%

Value ($000) $1,840 Shares 2,645,128 Est. Cost $1.25 Unrealized —

UPB UPSTREAM BIO INC 1.0%

Value ($000) $1,836 Shares 300,000 Est. Cost $22.33 Unrealized -57.2%

PLRX PLIANT THERAPEUTICS INC 0.6%

Value ($000) $1,148 Shares 850,000 Est. Cost $16.18 Unrealized -62.5%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
CYTK	CYTOKINETICS INC	370,000	$14,870	7.9%	$51.61	-11.0%	COM NEW	23282W605
KALV	KALVISTA PHARMACEUTICALS INC	1,014,367	$11,706	6.2%	$11.31	-9.8%	COM	483497103
EOLS	EVOLUS INC	944,743	$11,365	6.0%	$9.83	+33.0%	COM	30052C107
ABVX	ABIVAX SA	1,638,111	$10,238	5.4%	$12.06	—	SPONSORED ADS	00370M103
VRDN	VIRIDIAN THERAPEUTICS INC	750,000	$10,110	5.4%	$18.37	-7.3%	COM	92790C104
—	MERUS N V	237,156	$9,982	5.3%	$49.01	—	COM	N5749R100
AKBA	AKEBIA THERAPEUTICS INC	4,973,840	$9,550	5.1%	$2.04	0.0%	COM	00972D105
XENE	XENON PHARMACEUTICALS INC	245,272	$8,229	4.4%	$41.35	-8.2%	COM	98420N105
ASND	ASCENDIS PHARMA A/S	50,000	$7,793	4.1%	$155.86	—	SPONSORED ADR	04351P101
—	DYNAVAX TECHNOLOGIES CORP	595,879	$7,729	4.1%	$11.86	—	COM NEW	268158201
IONS	IONIS PHARMACEUTICALS INC	250,000	$7,543	4.0%	$39.21	-16.5%	COM	462222100
AMLX	AMYLYX PHARMACEUTICALS INC	1,811,996	$6,414	3.4%	$3.56	0.0%	COM	03237H101
IMVT	IMMUNOVANT INC	375,000	$6,409	3.4%	$20.92	0.0%	COM	45258J102
—	UNICYCIVE THERAPEUTICS INC	10,980,000	$6,312	3.3%	$0.49	—	COM	90466Y103
NGNE	NEUROGENE INC	470,964	$5,515	2.9%	$14.68	+18.3%	COM	64135M105
DNTH	DIANTHUS THERAPEUTICS INC	275,000	$4,989	2.6%	$22.14	-0.5%	COM	252828108
SMMT	SUMMIT THERAPEUTICS INC	250,000	$4,823	2.6%	—	—	Put	86627T108
LEGN	LEGEND BIOTECH CORP	138,240	$4,690	2.5%	$33.93	—	SPONSORED ADS	52490G102
PCVX	VAXCYTE INC	115,517	$4,362	2.3%	$79.95	0.0%	COM	92243G108
AUTL	AUTOLUS THERAPEUTICS PLC	2,728,910	$4,230	2.2%	$4.32	—	SPON ADS	05280R100
BBOT	HELIX ACQUISITION CORP II	373,833	$4,224	2.2%	$10.35	+3.8%	CL A ORD SHS	G4444H101
ZURA	ZURA BIO LTD	3,170,194	$4,090	2.2%	$6.43	-75.5%	CLASS A ORD SHS	G9TY5A101
BEAM	BEAM THERAPEUTICS INC	175,562	$3,429	1.8%	$26.20	0.0%	COM	07373V105
ACLX	ARCELLX INC	45,000	$2,952	1.6%	$67.74	0.0%	COMMON STOCK	03940C100
MREO	MEREO BIOPHARMA GROUP PLC	1,275,000	$2,869	1.5%	$3.38	—	SPON ADS	589492107
CNTX	CONTEXT THERAPEUTICS INC	4,683,711	$2,866	1.5%	$1.72	-49.5%	COM	21077P108
RZLT	REZOLUTE INC	833,042	$2,416	1.3%	$4.87	-10.5%	COM NEW	76200L309
CNTA	CENTESSA PHARMACEUTICALS PLC	149,702	$2,153	1.1%	$14.38	—	SPONSORED ADS	152309100
VYGR	VOYAGER THERAPEUTICS INC	626,275	$2,117	1.1%	$7.91	—	COM	92915B106
—	PROMIS NEUROSCIENCES INC	2,645,128	$1,840	1.0%	$1.25	—	COM NEW	74346M406
UPB	UPSTREAM BIO INC	300,000	$1,836	1.0%	$22.33	-57.2%	COM	91678A107
PLRX	PLIANT THERAPEUTICS INC	850,000	$1,148	0.6%	$16.18	-62.5%	COM	729139105