Location: Baltimore, MD
CIK: 0001595725 · Show all filings
Period: Q3 2025 (← Previous) (Next →)
Filing Date: Nov 14, 2025
Total Value: $1.712B (99.6% shares, 0.4% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| ARGX | ARGENX SE | 142,750 | $105M | 6.2% | $160.49 | — | SPONSORED ADR | 04016X101 |
| LLY | ELI LILLY & CO | 105,400 | $80.42M | 4.7% | $683.47 | +8.6% | COM | 532457108 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 717,102 | $72.42M | 4.2% | $17.22 | +439.1% | COM | 76243J105 |
| MDGL | MADRIGAL PHARMACEUTICALS INC | 137,746 | $63.18M | 3.7% | $118.06 | +216.0% | COM | 558868105 |
| RVMD | REVOLUTION MEDICINES INC | 1,335,270 | $62.36M | 3.6% | $31.87 | +22.8% | COM | 76155X100 |
| — | MERUS N V | 597,051 | $56.21M | 3.3% | $32.74 | — | COM | N5749R100 |
| MIRM | MIRUM PHARMACEUTICALS INC | 761,126 | $55.8M | 3.3% | $14.67 | +333.5% | COM | 604749101 |
| INSM | INSMED INC | 385,000 | $55.44M | 3.2% | $39.44 | +210.6% | COM PAR $.01 | 457669307 |
| TVTX | TRAVERE THERAPEUTICS INC | 2,164,773 | $51.74M | 3.0% | $13.87 | +35.5% | COM | 89422G107 |
| ASND | ASCENDIS PHARMA A/S | 214,500 | $42.64M | 2.5% | $92.14 | — | SPONSORED ADR | 04351P101 |
| IRTC | IRHYTHM TECHNOLOGIES INC | 235,000 | $40.42M | 2.4% | $74.37 | +113.7% | COM | 450056106 |
| AGIO | AGIOS PHARMACEUTICALS INC | 958,542 | $38.48M | 2.2% | $33.80 | +11.3% | COM | 00847X104 |
| RARE | ULTRAGENYX PHARMACEUTICAL IN | 1,246,341 | $37.49M | 2.2% | $58.22 | -48.5% | COM | 90400D108 |
| ISRG | INTUITIVE SURGICAL INC | 82,000 | $36.67M | 2.1% | $264.69 | +81.3% | COM NEW | 46120E602 |
| BSX | BOSTON SCIENTIFIC CORP | 360,250 | $35.17M | 2.1% | $63.75 | +62.5% | COM | 101137107 |
| XENE | XENON PHARMACEUTICALS INC | 851,744 | $34.2M | 2.0% | $24.19 | +45.6% | COM | 98420N105 |
| ALNY | ALNYLAM PHARMACEUTICALS INC | 74,250 | $33.86M | 2.0% | $107.54 | +278.7% | COM | 02043Q107 |
| EXAS | EXACT SCIENCES CORP | 593,500 | $32.47M | 1.9% | $53.67 | -6.9% | COM | 30063P105 |
| PEN | PENUMBRA INC | 120,500 | $30.53M | 1.8% | $179.03 | +40.9% | COM | 70975L107 |
| — | AKERO THERAPEUTICS INC | 626,526 | $29.75M | 1.7% | $29.53 | — | COM | 00973Y108 |
| SRRK | SCHOLAR ROCK HLDG CORP | 794,133 | $29.57M | 1.7% | $32.85 | +6.5% | COM | 80706P103 |
| ZLAB | ZAI LAB LTD | 791,193 | $26.81M | 1.6% | $51.35 | — | ADR | 98887Q104 |
| GPCR | STRUCTURE THERAPEUTICS INC | 951,154 | $26.63M | 1.6% | $39.12 | — | SPONSORED ADS | 86366E106 |
| KYMR | KYMERA THERAPEUTICS INC | 450,374 | $25.49M | 1.5% | $30.84 | +46.2% | COM | 501575104 |
| THC | TENET HEALTHCARE CORP | 125,000 | $25.38M | 1.5% | $148.69 | +19.3% | COM NEW | 88033G407 |
| EVH | EVOLENT HEALTH INC | 2,950,000 | $24.96M | 1.5% | $20.50 | -52.7% | CL A | 30050B101 |
| CAI | CARIS LIFE SCIENCES INC | 793,651 | $24.01M | 1.4% | $26.95 | +18.3% | COM | 142152107 |
| — | CIDARA THERAPEUTICS INC | 249,402 | $23.88M | 1.4% | $70.46 | — | COM NEW | 171757206 |
| DXCM | DEXCOM INC | 316,900 | $21.32M | 1.2% | $93.46 | -15.3% | COM | 252131107 |
| OMDA | OMADA HEALTH INC | 919,950 | $20.34M | 1.2% | $17.31 | +18.3% | COM | 68170A108 |
| CLDX | CELLDEX THERAPEUTICS INC NEW | 721,538 | $18.67M | 1.1% | $32.64 | -29.0% | COM NEW | 15117B202 |
| VERA | VERA THERAPEUTICS INC | 617,396 | $17.94M | 1.0% | $35.12 | -34.1% | CL A | 92337R101 |
| PHR | PHREESIA INC | 749,116 | $17.62M | 1.0% | $25.92 | +4.9% | COM | 71944F106 |
| TARS | TARSUS PHARMACEUTICALS INC | 288,344 | $17.14M | 1.0% | $48.01 | +2.5% | COM | 87650L103 |
| NAMS | NEWAMSTERDAM PHARMA COMPANY | 595,929 | $16.95M | 1.0% | $19.88 | +20.6% | ORDINARY SHARES | N62509109 |
| CMPX | COMPASS THERAPEUTICS INC | 4,474,702 | $15.66M | 0.9% | $3.23 | -2.1% | COM | 20454B104 |
| PHVS | PHARVARIS N V | 623,402 | $15.55M | 0.9% | $26.42 | -16.1% | COM | N69605108 |
| AZTA | AZENTA INC | 540,400 | $15.52M | 0.9% | $57.72 | -46.3% | COM | 114340102 |
| MLYS | MINERALYS THERAPEUTICS INC | 408,313 | $15.48M | 0.9% | $13.61 | +59.0% | COM | 603170101 |
| FOLD | AMICUS THERAPEUTICS INC | 1,947,374 | $15.35M | 0.9% | $10.81 | -34.1% | COM | 03152W109 |
| XBI | SPDR SERIES TRUST | 151,750 | $15.21M | 0.9% | $82.93 | — | S&P BIOTECH | 78464A870 |
| ACLX | ARCELLX INC | 178,982 | $14.69M | 0.9% | $62.26 | +15.6% | COMMON STOCK | 03940C100 |
| SMMT | SUMMIT THERAPEUTICS INC | 710,000 | $14.67M | 0.9% | $14.06 | +72.5% | COM | 86627T108 |
| COGT | COGENT BIOSCIENCES INC | 1,008,308 | $14.48M | 0.8% | $6.84 | +73.1% | COM | 19240Q201 |
| ELVN | ENLIVEN THERAPEUTICS INC | 686,107 | $14.04M | 0.8% | $16.88 | +19.4% | COM | 29337E102 |
| ZBIO | ZENAS BIOPHARMA INC | 580,677 | $12.89M | 0.8% | $17.98 | -9.5% | COM | 98937L105 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 89,750 | $12.6M | 0.7% | $78.79 | +72.0% | COM | 64125C109 |
| ARDX | ARDELYX INC | 2,286,273 | $12.6M | 0.7% | $5.10 | +6.5% | COM | 039697107 |
| DHR | DANAHER CORPORATION | 61,500 | $12.19M | 0.7% | $216.22 | -8.3% | COM | 235851102 |
| LENZ | LENZ THERAPEUTICS INC | 236,227 | $11M | 0.6% | $33.19 | +10.8% | COM | 52635N103 |
| SLNO | SOLENO THERAPEUTICS INC | 154,528 | $10.45M | 0.6% | $56.35 | +31.6% | COM | 834203309 |
| DYN | DYNE THERAPEUTICS INC | 824,061 | $10.42M | 0.6% | $18.20 | -37.3% | COM | 26818M108 |
| MREO | MEREO BIOPHARMA GROUP PLC | 4,570,649 | $9.416M | 0.6% | $2.73 | — | SPON ADS | 589492107 |
| ACRS | ACLARIS THERAPEUTICS INC | 4,609,309 | $8.758M | 0.5% | $6.19 | -71.9% | COM | 00461U105 |
| GOSS | GOSSAMER BIO INC | 3,266,960 | $8.592M | 0.5% | $2.62 | -15.8% | COM | 38341P102 |
| HTFL | HEARTFLOW INC | 250,000 | $8.415M | 0.5% | $32.24 | 0.0% | COM | 42238D107 |
| INSP | INSPIRE MED SYS INC | 110,500 | $8.199M | 0.5% | $194.09 | -47.8% | COM | 457730109 |
| AGL | AGILON HEALTH INC | 6,966,300 | $7.175M | 0.4% | $29.66 | -94.9% | COM | 00857U107 |
| EW | EDWARDS LIFESCIENCES CORP | 88,000 | $6.844M | 0.4% | $63.05 | +23.9% | COM | 28176E108 |
| AMLX | AMYLYX PHARMACEUTICALS INC | 499,764 | $6.792M | 0.4% | $3.97 | +137.2% | COM | 03237H101 |
| — | GOSSAMER BIO INC | 9,573,000 | $6.719M | 0.4% | $1.01 | — | NOTE 5.000% 6/0 | 38341PAA0 |
| REGN | REGENERON PHARMACEUTICALS | 11,300 | $6.354M | 0.4% | $587.92 | -4.0% | COM | 75886F107 |
| BCAX | BICARA THERAPEUTICS INC | 370,666 | $5.853M | 0.3% | $24.17 | -53.7% | COM | 055477103 |
| JANX | JANUX THERAPEUTICS INC | 210,366 | $5.141M | 0.3% | $52.16 | -53.3% | COM | 47103J105 |
| MBX | MBX BIOSCIENCES INC | 282,624 | $4.946M | 0.3% | $13.37 | 0.0% | COM | 55287L101 |
| TMO | THERMO FISHER SCIENTIFIC INC | 10,000 | $4.85M | 0.3% | $417.06 | +11.4% | COM | 883556102 |
| BBIO | BRIDGEBIO PHARMA INC | 85,000 | $4.415M | 0.3% | $48.77 | 0.0% | COM | 10806X102 |
| ATEC | ALPHATEC HLDGS INC | 302,500 | $4.398M | 0.3% | $9.28 | +49.9% | COM NEW | 02081G201 |
| ACHC | ACADIA HEALTHCARE COMPANY IN | 170,000 | $4.209M | 0.2% | $53.71 | -58.5% | COM | 00404A109 |
| OCUL | OCULAR THERAPEUTIX INC | 300,000 | $3.507M | 0.2% | $11.96 | 0.0% | COM | 67576A100 |
| TLPH | TALPHERA INC | 3,589,186 | $3.206M | 0.2% | $0.78 | -25.3% | COM NEW | 00444T209 |
| ALKS | ALKERMES PLC | 106,537 | $3.196M | 0.2% | $28.20 | 0.0% | SHS | G01767105 |
| SION | SIONNA THERAPEUTICS INC | 99,429 | $2.924M | 0.2% | $16.34 | +33.1% | COM | 829401108 |
| EDAP | EDAP TMS S A | 1,270,000 | $2.908M | 0.2% | $7.23 | — | SPONSORED ADR | 268311107 |
| JSPR | JASPER THERAPEUTICS INC | 1,100,726 | $2.62M | 0.2% | $9.61 | -68.4% | COM NEW | 471871202 |
| WST | WEST PHARMACEUTICAL SVSC INC | 9,750 | $2.558M | 0.1% | $299.09 | -18.8% | COM | 955306105 |
| APLS | APELLIS PHARMACEUTICALS INC | 92,000 | $2.082M | 0.1% | $42.20 | -44.7% | COM | 03753U106 |
| NGNE | NEUROGENE INC | 104,339 | $1.808M | 0.1% | $35.51 | -43.4% | COM | 64135M105 |
| KRRO | KORRO BIO INC | 35,719 | $1.711M | 0.1% | $55.25 | -59.8% | COM | 500946108 |
| CNTA | CENTESSA PHARMACEUTICALS PLC | 69,240 | $1.679M | 0.1% | $24.25 | — | SPONSORED ADS | 152309100 |
| CATX | PERSPECTIVE THERAPEUTICS INC | 444,383 | $1.524M | 0.1% | $14.00 | -74.0% | COM NEW | 46489V302 |
| — | APPLIED THERAPEUTICS INC | 2,075,991 | $1.256M | 0.1% | $12.37 | — | COM | 03828A101 |
| — | MERSANA THERAPEUTICS INC | 152,586 | $1.184M | 0.1% | $7.76 | — | COM | 59045L205 |
| IMVT | IMMUNOVANT INC | 72,965 | $1.176M | 0.1% | $28.27 | -42.7% | COM | 45258J102 |
| NAMS | NEWAMSTERDAM PHARMA COMPANY | 31,600 | $899K | 0.1% | $19.88 | +20.6% | Call | N62509109 |
| EYPT | EYEPOINT PHARMACEUTICALS INC | 31,655 | $451K | 0.0% | $11.51 | 0.0% | COM NEW | 30233G209 |
| CRL | CHARLES RIV LABS INTL INC | 2,700 | $422K | 0.0% | $133.35 | +19.1% | COM | 159864107 |
| PCVX | VAXCYTE INC | 11,100 | $400K | 0.0% | $32.78 | +1.1% | COM | 92243G108 |
| NVAX | NOVAVAX INC | 45,000 | $390K | 0.0% | $31.79 | -75.5% | COM NEW | 670002401 |
| PRTA | PROTHENA CORP PLC | 25,398 | $248K | 0.0% | $17.57 | -56.3% | SHS | G72800108 |
| MLTX | MOONLAKE IMMUNOTHERAPEUTICS | 28,200 | $202K | 0.0% | $52.12 | 0.0% | CLASS A ORD | 61559X104 |
| — | NUVATION BIO INC | 134,028 | $27,087 | 0.0% | $2.67 | — | *W EXP 02/10/202 | 67080N119 |
| CGEN | COMPUGEN LTD | 13,430 | $19,742 | 0.0% | $6.12 | -75.7% | ORD | M25722105 |