Opaleye Management Inc. Quant / Systematic

CIK: 0001595855 · Show all filings

Period: Q1 2023 (← Previous) (Next →)

Filing Date: May 15, 2023

Total Value ($000): $333,877 (100.0% shares, 0.0% debt)

Holdings (41)

HROW HARROW HEALTH INC 23.9%

Value ($000) $79,879 Shares 3,775,000 Est. Cost $6.06 Unrealized +181.3%

OCUL OCULAR THERAPEUTIX INC 9.6%

Value ($000) $32,178 Shares 6,105,900 Est. Cost $5.00 Unrealized -5.0%

TELA TELA BIO INC 6.6%

Value ($000) $22,055 Shares 2,072,813 Est. Cost $9.44 Unrealized +16.8%

RYTM RHYTHM PHARMACEUTICALS INC 3.9%

Value ($000) $13,112 Shares 735,000 Est. Cost $12.73 Unrealized +97.2%

CRNX CRINETICS PHARMACEUTICALS INC 3.8%

Value ($000) $12,623 Shares 785,794 Est. Cost $20.67 Unrealized -10.5%

— KARYOPHARM THERAPEUTICS INC 3.3%

Value ($000) $10,934 Shares 2,810,800 Est. Cost $3.74 Unrealized —

KROS KEROS THERAPEUTICS INC 3.0%

Value ($000) $10,163 Shares 238,000 Est. Cost $49.36 Unrealized +2.3%

— TRACON PHARMACEUTICALS INC 2.7%

Value ($000) $9,005 Shares 4,764,508 Est. Cost $4.42 Unrealized —

ETON ETON PHARMACEUTICALS INC 2.5%

Value ($000) $8,412 Shares 2,185,000 Est. Cost $6.13 Unrealized -40.5%

TARA PROTARA THERAPEUTICS INC 2.4%

Value ($000) $8,078 Shares 2,692,594 Est. Cost $29.10 Unrealized -88.6%

BHVN BIOHAVEN LTD 2.2%

Value ($000) $7,376 Shares 540,000 Est. Cost $14.12 Unrealized +12.7%

CYTK CYTOKINETICS INC 2.2%

Value ($000) $7,302 Shares 207,500 Est. Cost $18.45 Unrealized +121.2%

KALV KALVISTA PHARMACEUTICALS INC 2.2%

Value ($000) $7,256 Shares 923,200 Est. Cost $5.36 Unrealized +39.3%

PCVX VAXCYTE INC 2.0%

Value ($000) $6,634 Shares 177,000 Est. Cost $38.73 Unrealized +9.5%

LRMR LARIMAR THERAPEUTICS INC 1.9%

Value ($000) $6,347 Shares 1,401,000 Est. Cost $7.31 Unrealized -28.5%

TBPH THERAVANCE BIOPHARMA INC 1.8%

Value ($000) $5,927 Shares 546,304 Est. Cost $10.56 Unrealized +0.1%

ARQT ARCUTIS BIOTHERAPEUTICS INC 1.7%

Value ($000) $5,522 Shares 502,000 Est. Cost $14.47 Unrealized 0.0%

FDMT 4D MOLECULAR THERAPEUTICS INC 1.6%

Value ($000) $5,398 Shares 314,000 Est. Cost $20.97 Unrealized -7.3%

— JOUNCE THERAPEUTICS INC 1.6%

Value ($000) $5,328 Shares 2,880,000 Est. Cost $1.85 Unrealized —

— MARINUS PHARMACEUTICALS INC 1.6%

Value ($000) $5,279 Shares 765,000 Est. Cost $3.98 Unrealized —

XOMA XOMA CORP DEL 1.5%

Value ($000) $5,130 Shares 243,000 Est. Cost $10.28 Unrealized +104.6%

EWTX EDGEWISE THERAPEUTICS INC 1.5%

Value ($000) $5,003 Shares 750,000 Est. Cost $10.54 Unrealized -12.1%

— MORPHOSYS AG 1.4%

Value ($000) $4,728 Shares 1,194,000 Est. Cost $3.82 Unrealized —

IDYA IDEAYA BIOSCIENCES INC 1.4%

Value ($000) $4,709 Shares 343,000 Est. Cost $16.71 Unrealized -0.3%

URGN UROGEN PHARMA LTD 1.4%

Value ($000) $4,666 Shares 505,000 Est. Cost $7.85 Unrealized +17.2%

— THESEUS PHARMACEUTICALS INC 1.3%

Value ($000) $4,334 Shares 488,100 Est. Cost $5.30 Unrealized —

EDAP EDAP TMS S A 1.3%

Value ($000) $4,233 Shares 382,400 Est. Cost $10.29 Unrealized —

— ASTRIA THERAPEUTICS INC 1.2%

Value ($000) $4,096 Shares 302,000 Est. Cost $12.13 Unrealized —

LQDA LIQUIDIA CORPORATION 1.2%

Value ($000) $3,975 Shares 575,200 Est. Cost $5.52 Unrealized +23.6%

— FORTRESS BIOTECH INC 1.1%

Value ($000) $3,750 Shares 4,573,600 Est. Cost $1.66 Unrealized —

PHAT PHATHOM PHARMACEUTICALS INC 1.1%

Value ($000) $3,541 Shares 496,000 Est. Cost $10.07 Unrealized -12.8%

CDXS CODEXIS INC 0.9%

Value ($000) $3,105 Shares 750,000 Est. Cost $3.62 Unrealized +44.7%

IOVA IOVANCE BIOTHERAPEUTICS INC 0.8%

Value ($000) $2,572 Shares 421,000 Est. Cost $6.90 Unrealized 0.0%

RLAY RELAY THERAPEUTICS INC 0.6%

Value ($000) $2,067 Shares 125,500 Est. Cost $17.93 Unrealized 0.0%

— KEZAR LIFE SCIENCES INC 0.6%

Value ($000) $1,956 Shares 625,000 Est. Cost $3.13 Unrealized —

MLYS MINERALYS THERAPEUTICS INC 0.5%

Value ($000) $1,801 Shares 115,000 Est. Cost $16.83 Unrealized 0.0%

STXS STEREOTAXIS INC 0.5%

Value ($000) $1,769 Shares 867,100 Est. Cost $2.93 Unrealized -23.4%

TRVI TREVI THERAPEUTICS INC 0.5%

Value ($000) $1,546 Shares 835,800 Est. Cost $2.09 Unrealized +8.1%

PRQR PROQR THERAPEUTICS NV 0.4%

Value ($000) $1,391 Shares 653,000 Est. Cost $3.64 Unrealized -16.1%

NYXH NYXOAH S A 0.1%

Value ($000) $430 Shares 57,585 Est. Cost $5.60 Unrealized 0.0%

MODD MODULAR MEDICAL INC 0.1%

Value ($000) $266 Shares 183,500 Est. Cost $3.92 Unrealized -42.0%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
HROW	HARROW HEALTH INC	3,775,000	$79,879	23.9%	$6.06	+181.3%	COM	415858109
OCUL	OCULAR THERAPEUTIX INC	6,105,900	$32,178	9.6%	$5.00	-5.0%	COM	67576A100
TELA	TELA BIO INC	2,072,813	$22,055	6.6%	$9.44	+16.8%	COM	872381108
RYTM	RHYTHM PHARMACEUTICALS INC	735,000	$13,112	3.9%	$12.73	+97.2%	COM	76243J105
CRNX	CRINETICS PHARMACEUTICALS INC	785,794	$12,623	3.8%	$20.67	-10.5%	COM	22663K107
—	KARYOPHARM THERAPEUTICS INC	2,810,800	$10,934	3.3%	$3.74	—	COM	48576U106
KROS	KEROS THERAPEUTICS INC	238,000	$10,163	3.0%	$49.36	+2.3%	COM	492327101
—	TRACON PHARMACEUTICALS INC	4,764,508	$9,005	2.7%	$4.42	—	COM NEW	89237H209
ETON	ETON PHARMACEUTICALS INC	2,185,000	$8,412	2.5%	$6.13	-40.5%	COM	29772L108
TARA	PROTARA THERAPEUTICS INC	2,692,594	$8,078	2.4%	$29.10	-88.6%	COM STK	74365U107
BHVN	BIOHAVEN LTD	540,000	$7,376	2.2%	$14.12	+12.7%	COM	G1110E107
CYTK	CYTOKINETICS INC	207,500	$7,302	2.2%	$18.45	+121.2%	COM NEW	23282W605
KALV	KALVISTA PHARMACEUTICALS INC	923,200	$7,256	2.2%	$5.36	+39.3%	COM	483497103
PCVX	VAXCYTE INC	177,000	$6,634	2.0%	$38.73	+9.5%	COM	92243G108
LRMR	LARIMAR THERAPEUTICS INC	1,401,000	$6,347	1.9%	$7.31	-28.5%	COM	517125100
TBPH	THERAVANCE BIOPHARMA INC	546,304	$5,927	1.8%	$10.56	+0.1%	COM	G8807B106
ARQT	ARCUTIS BIOTHERAPEUTICS INC	502,000	$5,522	1.7%	$14.47	0.0%	COM	03969K108
FDMT	4D MOLECULAR THERAPEUTICS INC	314,000	$5,398	1.6%	$20.97	-7.3%	COM	35104E100
—	JOUNCE THERAPEUTICS INC	2,880,000	$5,328	1.6%	$1.85	—	COM	481116101
—	MARINUS PHARMACEUTICALS INC	765,000	$5,279	1.6%	$3.98	—	COM NEW	56854Q200
XOMA	XOMA CORP DEL	243,000	$5,130	1.5%	$10.28	+104.6%	COM NEW	98419J206
EWTX	EDGEWISE THERAPEUTICS INC	750,000	$5,003	1.5%	$10.54	-12.1%	COM	28036F105
—	MORPHOSYS AG	1,194,000	$4,728	1.4%	$3.82	—	SPONSORED ADS	617760202
IDYA	IDEAYA BIOSCIENCES INC	343,000	$4,709	1.4%	$16.71	-0.3%	COM	45166A102
URGN	UROGEN PHARMA LTD	505,000	$4,666	1.4%	$7.85	+17.2%	COM	M96088105
—	THESEUS PHARMACEUTICALS INC	488,100	$4,334	1.3%	$5.30	—	COM	88369M101
EDAP	EDAP TMS S A	382,400	$4,233	1.3%	$10.29	—	SPONSORED ADR	268311107
—	ASTRIA THERAPEUTICS INC	302,000	$4,096	1.2%	$12.13	—	COM	04635X102
LQDA	LIQUIDIA CORPORATION	575,200	$3,975	1.2%	$5.52	+23.6%	COM NEW	53635D202
—	FORTRESS BIOTECH INC	4,573,600	$3,750	1.1%	$1.66	—	COM	34960Q109
PHAT	PHATHOM PHARMACEUTICALS INC	496,000	$3,541	1.1%	$10.07	-12.8%	COM	71722W107
CDXS	CODEXIS INC	750,000	$3,105	0.9%	$3.62	+44.7%	COM	192005106
IOVA	IOVANCE BIOTHERAPEUTICS INC	421,000	$2,572	0.8%	$6.90	0.0%	COM	462260100
RLAY	RELAY THERAPEUTICS INC	125,500	$2,067	0.6%	$17.93	0.0%	COM	75943R102
—	KEZAR LIFE SCIENCES INC	625,000	$1,956	0.6%	$3.13	—	COM	49372L100
MLYS	MINERALYS THERAPEUTICS INC	115,000	$1,801	0.5%	$16.83	0.0%	COM	603170101
STXS	STEREOTAXIS INC	867,100	$1,769	0.5%	$2.93	-23.4%	COM NEW	85916J409
TRVI	TREVI THERAPEUTICS INC	835,800	$1,546	0.5%	$2.09	+8.1%	COM	89532M101
PRQR	PROQR THERAPEUTICS NV	653,000	$1,391	0.4%	$3.64	-16.1%	SHS EURO	N71542109
NYXH	NYXOAH S A	57,585	$430	0.1%	$5.60	0.0%	SHS	B6S7WD106
MODD	MODULAR MEDICAL INC	183,500	$266	0.1%	$3.92	-42.0%	COM NEW	60785L207