Opaleye Management Inc. Quant / Systematic

CIK: 0001595855 · Show all filings

Period: Q4 2022 (← Previous) (Next →)

Filing Date: Feb 10, 2023

Total Value ($000): $287,572 (100.0% shares, 0.0% debt)

Holdings (40)

HROW HARROW HEALTH INC 19.4%

Value ($000) $55,719 Shares 3,775,000 Est. Cost $6.06 Unrealized +97.2%

TELA TELA BIO INC 8.3%

Value ($000) $23,837 Shares 2,072,813 Est. Cost $9.44 Unrealized -5.1%

RYTM RHYTHM PHARMACEUTICALS INC 7.4%

Value ($000) $21,403 Shares 735,000 Est. Cost $12.73 Unrealized +101.8%

OCUL OCULAR THERAPEUTIX INC 5.9%

Value ($000) $17,071 Shares 6,075,000 Est. Cost $5.00 Unrealized -33.8%

CRNX CRINETICS PHARMACEUTICALS INC 4.7%

Value ($000) $13,396 Shares 732,000 Est. Cost $20.83 Unrealized -15.4%

CYTK CYTOKINETICS INC 4.0%

Value ($000) $11,455 Shares 250,000 Est. Cost $18.45 Unrealized +132.9%

KROS KEROS THERAPEUTICS INC 4.0%

Value ($000) $11,429 Shares 238,000 Est. Cost $49.36 Unrealized -5.4%

PCVX VAXCYTE INC 3.0%

Value ($000) $8,487 Shares 177,000 Est. Cost $38.73 Unrealized +1.3%

BHVN BIOHAVEN LTD 2.6%

Value ($000) $7,495 Shares 540,000 Est. Cost $14.12 Unrealized 0.0%

FDMT 4D MOLECULAR THERAPEUTICS INC 2.5%

Value ($000) $7,329 Shares 330,000 Est. Cost $20.97 Unrealized -26.3%

TARA PROTARA THERAPEUTICS INC 2.5%

Value ($000) $7,216 Shares 2,692,594 Est. Cost $29.10 Unrealized -89.2%

— TRACON PHARMACEUTICALS INC 2.4%

Value ($000) $6,839 Shares 4,590,000 Est. Cost $4.51 Unrealized —

LRMR LARIMAR THERAPEUTICS INC 2.2%

Value ($000) $6,443 Shares 1,560,000 Est. Cost $7.31 Unrealized -53.3%

KALV KALVISTA PHARMACEUTICALS INC 2.2%

Value ($000) $6,241 Shares 923,200 Est. Cost $5.36 Unrealized 0.0%

ETON ETON PHARMACEUTICALS INC 2.1%

Value ($000) $6,119 Shares 2,170,000 Est. Cost $6.13 Unrealized -56.1%

EWTX EDGEWISE THERAPEUTICS INC 1.9%

Value ($000) $5,466 Shares 611,400 Est. Cost $10.83 Unrealized -13.4%

PRQR PROQR THERAPEUTICS NV 1.9%

Value ($000) $5,402 Shares 1,460,000 Est. Cost $3.64 Unrealized -64.1%

PHAT PHATHOM PHARMACEUTICALS INC 1.6%

Value ($000) $4,684 Shares 417,500 Est. Cost $10.31 Unrealized 0.0%

XOMA XOMA CORP DEL 1.6%

Value ($000) $4,471 Shares 243,000 Est. Cost $10.28 Unrealized +76.8%

CDXS CODEXIS INC 1.6%

Value ($000) $4,462 Shares 957,500 Est. Cost $3.62 Unrealized +51.2%

URGN UROGEN PHARMA LTD 1.5%

Value ($000) $4,334 Shares 488,656 Est. Cost $7.81 Unrealized +21.3%

— KARYOPHARM THERAPEUTICS INC 1.5%

Value ($000) $4,282 Shares 1,206,841 Est. Cost $3.55 Unrealized —

— ASTRIA THERAPEUTICS INC 1.4%

Value ($000) $3,897 Shares 261,703 Est. Cost $11.91 Unrealized —

LQDA LIQUIDIA CORPORATION 1.2%

Value ($000) $3,567 Shares 560,000 Est. Cost $5.49 Unrealized -2.1%

ZNTL ZENTALIS PHARMACEUTICALS INC 1.2%

Value ($000) $3,373 Shares 167,500 Est. Cost $21.51 Unrealized 0.0%

— MARINUS PHARMACEUTICALS INC 1.1%

Value ($000) $3,288 Shares 826,200 Est. Cost $3.98 Unrealized —

EDAP EDAP TMS S A 1.1%

Value ($000) $3,270 Shares 306,713 Est. Cost $10.10 Unrealized —

WHWK AADI BIOSCIENCE INC 1.1%

Value ($000) $3,234 Shares 252,046 Est. Cost $13.06 Unrealized 0.0%

— MORPHOSYS AG 1.1%

Value ($000) $3,210 Shares 896,600 Est. Cost $3.78 Unrealized —

— MERSANA THERAPEUTICS INC 0.9%

Value ($000) $2,696 Shares 460,000 Est. Cost $4.19 Unrealized —

— THESEUS PHARMACEUTICALS INC 0.9%

Value ($000) $2,664 Shares 535,000 Est. Cost $5.30 Unrealized —

FENC FENNEC PHARMACEUTICALS INC 0.9%

Value ($000) $2,613 Shares 272,200 Est. Cost $8.85 Unrealized 0.0%

IDYA IDEAYA BIOSCIENCES INC 0.9%

Value ($000) $2,522 Shares 138,800 Est. Cost $16.78 Unrealized +0.2%

STXS STEREOTAXIS INC 0.9%

Value ($000) $2,453 Shares 1,185,000 Est. Cost $2.93 Unrealized -33.4%

BCAB BIOATLA INC 0.8%

Value ($000) $2,160 Shares 261,800 Est. Cost $8.30 Unrealized 0.0%

— FORTRESS BIOTECH INC 0.5%

Value ($000) $1,343 Shares 2,050,000 Est. Cost $2.69 Unrealized —

— ALLAKOS INC 0.4%

Value ($000) $1,292 Shares 153,500 Est. Cost $6.12 Unrealized —

TBPH THERAVANCE BIOPHARMA INC 0.3%

Value ($000) $983 Shares 87,600 Est. Cost $10.51 Unrealized 0.0%

TRVI TREVI THERAPEUTICS INC 0.3%

Value ($000) $936 Shares 485,000 Est. Cost $1.97 Unrealized 0.0%

MODD MODULAR MEDICAL INC 0.2%

Value ($000) $490 Shares 245,000 Est. Cost $3.92 Unrealized -23.2%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
HROW	HARROW HEALTH INC	3,775,000	$55,719	19.4%	$6.06	+97.2%	COM	415858109
TELA	TELA BIO INC	2,072,813	$23,837	8.3%	$9.44	-5.1%	COM	872381108
RYTM	RHYTHM PHARMACEUTICALS INC	735,000	$21,403	7.4%	$12.73	+101.8%	COM	76243J105
OCUL	OCULAR THERAPEUTIX INC	6,075,000	$17,071	5.9%	$5.00	-33.8%	COM	67576A100
CRNX	CRINETICS PHARMACEUTICALS INC	732,000	$13,396	4.7%	$20.83	-15.4%	COM	22663K107
CYTK	CYTOKINETICS INC	250,000	$11,455	4.0%	$18.45	+132.9%	COM NEW	23282W605
KROS	KEROS THERAPEUTICS INC	238,000	$11,429	4.0%	$49.36	-5.4%	COM	492327101
PCVX	VAXCYTE INC	177,000	$8,487	3.0%	$38.73	+1.3%	COM	92243G108
BHVN	BIOHAVEN LTD	540,000	$7,495	2.6%	$14.12	0.0%	COM	G1110E107
FDMT	4D MOLECULAR THERAPEUTICS INC	330,000	$7,329	2.5%	$20.97	-26.3%	COM	35104E100
TARA	PROTARA THERAPEUTICS INC	2,692,594	$7,216	2.5%	$29.10	-89.2%	COM STK	74365U107
—	TRACON PHARMACEUTICALS INC	4,590,000	$6,839	2.4%	$4.51	—	COM NEW	89237H209
LRMR	LARIMAR THERAPEUTICS INC	1,560,000	$6,443	2.2%	$7.31	-53.3%	COM	517125100
KALV	KALVISTA PHARMACEUTICALS INC	923,200	$6,241	2.2%	$5.36	0.0%	COM	483497103
ETON	ETON PHARMACEUTICALS INC	2,170,000	$6,119	2.1%	$6.13	-56.1%	COM	29772L108
EWTX	EDGEWISE THERAPEUTICS INC	611,400	$5,466	1.9%	$10.83	-13.4%	COM	28036F105
PRQR	PROQR THERAPEUTICS NV	1,460,000	$5,402	1.9%	$3.64	-64.1%	SHS EURO	N71542109
PHAT	PHATHOM PHARMACEUTICALS INC	417,500	$4,684	1.6%	$10.31	0.0%	COM	71722W107
XOMA	XOMA CORP DEL	243,000	$4,471	1.6%	$10.28	+76.8%	COM NEW	98419J206
CDXS	CODEXIS INC	957,500	$4,462	1.6%	$3.62	+51.2%	COM	192005106
URGN	UROGEN PHARMA LTD	488,656	$4,334	1.5%	$7.81	+21.3%	COM	M96088105
—	KARYOPHARM THERAPEUTICS INC	1,206,841	$4,282	1.5%	$3.55	—	COM	48576U106
—	ASTRIA THERAPEUTICS INC	261,703	$3,897	1.4%	$11.91	—	COM	04635X102
LQDA	LIQUIDIA CORPORATION	560,000	$3,567	1.2%	$5.49	-2.1%	COM NEW	53635D202
ZNTL	ZENTALIS PHARMACEUTICALS INC	167,500	$3,373	1.2%	$21.51	0.0%	COM	98943L107
—	MARINUS PHARMACEUTICALS INC	826,200	$3,288	1.1%	$3.98	—	COM NEW	56854Q200
EDAP	EDAP TMS S A	306,713	$3,270	1.1%	$10.10	—	SPONSORED ADR	268311107
WHWK	AADI BIOSCIENCE INC	252,046	$3,234	1.1%	$13.06	0.0%	COM	00032Q104
—	MORPHOSYS AG	896,600	$3,210	1.1%	$3.78	—	SPONSORED ADS	617760202
—	MERSANA THERAPEUTICS INC	460,000	$2,696	0.9%	$4.19	—	COM	59045L106
—	THESEUS PHARMACEUTICALS INC	535,000	$2,664	0.9%	$5.30	—	COM	88369M101
FENC	FENNEC PHARMACEUTICALS INC	272,200	$2,613	0.9%	$8.85	0.0%	COM	31447P100
IDYA	IDEAYA BIOSCIENCES INC	138,800	$2,522	0.9%	$16.78	+0.2%	COM	45166A102
STXS	STEREOTAXIS INC	1,185,000	$2,453	0.9%	$2.93	-33.4%	COM NEW	85916J409
BCAB	BIOATLA INC	261,800	$2,160	0.8%	$8.30	0.0%	COM	09077B104
—	FORTRESS BIOTECH INC	2,050,000	$1,343	0.5%	$2.69	—	COM	34960Q109
—	ALLAKOS INC	153,500	$1,292	0.4%	$6.12	—	COM	01671P100
TBPH	THERAVANCE BIOPHARMA INC	87,600	$983	0.3%	$10.51	0.0%	COM	G8807B106
TRVI	TREVI THERAPEUTICS INC	485,000	$936	0.3%	$1.97	0.0%	COM	89532M101
MODD	MODULAR MEDICAL INC	245,000	$490	0.2%	$3.92	-23.2%	COM NEW	60785L207