5AM Venture Management, LLC Long-Term Concentrated

Location: San Francisco, CA

CIK: 0001799883 · Show all filings

Period: Q1 2026 (← Previous)

Filing Date: May 15, 2026

Total Value: $360M (100.0% shares, 0.0% debt)

Holdings (20)

New Positions (2)

ALXO ALX ONCOLOGY HLDGS INC 1.7%

Value $6.13M Shares 3,057,325 Est. Cost $1.77 Unrealized 0.0%

RLYB RALLYBIO CORP 0.7%

Value $2.617M Shares 291,788 Est. Cost $5.22 Unrealized 0.0%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
ALXO	ALX ONCOLOGY HLDGS INC	3,057,325	$6.13M	1.7%	$1.77	0.0%	COM	00166B105
RLYB	RALLYBIO CORP	291,788	$2.617M	0.7%	$5.22	0.0%	COM	75120L209

Exited Positions (3)

VRDN VIRIDIAN THERAPEUTICS INC 6.4%

Value $22.92M Shares 736,595 Est. Cost $17.93 Unrealized +72.0%

ELVN ENLIVEN THERAPEUTICS INC 3.3%

Value $11.9M Shares 772,477 Est. Cost $20.34 Unrealized +25.9%

— RALLYBIO CORP 0.7%

Value $2.491M Shares 3,630,724 Est. Cost $17.58 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
VRDN	VIRIDIAN THERAPEUTICS INC	736,595	$22.92M	6.4%	$17.93	+72.0%	—	92790C104
ELVN	ENLIVEN THERAPEUTICS INC	772,477	$11.9M	3.3%	$20.34	+25.9%	—	29337E102
—	RALLYBIO CORP	3,630,724	$2.491M	0.7%	$17.58	—	—	75120L100

Decreased Positions (1)

ERAS ERASCA INC 15.7%

Value $56.4M (+180.5%) Shares 3,485,971 (-35.5%) Est. Cost $2.16 Unrealized +364.5%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
ERAS	ERASCA INC	3,485,971 (-35.5%)	$56.4M (+180.5%)	15.7%	$2.16	+364.5%	COM	29479A108

Unchanged Positions (17)

TYRA TYRA BIOSCIENCES INC 10.9%

Value $39.42M Shares 1,029,298 Est. Cost $15.46 Unrealized +95.6%

CAMP CAMP4 THERAPEUTICS CORP 7.2%

Value $25.88M Shares 5,869,091 Est. Cost $5.03 Unrealized -7.2%

TRDA ENTRADA THERAPEUTICS INC 14.2%

Value $51.19M Shares 4,056,379 Est. Cost $17.12 Unrealized —

CNTA CENTESSA PHARMACEUTICALS PLC 6.4%

Value $23.08M Shares 580,945 Est. Cost $11.45 Unrealized —

TECX TECTONIC THERAPEUTIC INC 5.2%

Value $18.75M Shares 606,660 Est. Cost $16.21 Unrealized +30.1%

EYPT EYEPOINT INC 3.8%

Value $13.53M Shares 1,050,000 Est. Cost $9.03 Unrealized +68.5%

ARTV ARTIVA BIOTHERAPEUTICS INC 4.2%

Value $15.16M Shares 2,353,304 Est. Cost $11.59 Unrealized -61.9%

ZNTL ZENTALIS PHARMACEUTICALS INC 2.6%

Value $9.238M Shares 3,947,913 Est. Cost $4.25 Unrealized -38.5%

MPLT MAPLIGHT THERAPEUTICS INC 5.4%

Value $19.31M Shares 950,011 Est. Cost $16.75 Unrealized +5.2%

SRZN SURROZEN INC 3.1%

Value $11.29M Shares 387,500 Est. Cost $12.54 Unrealized +77.3%

CLDX CELLDEX THERAPEUTICS INC NEW 4.4%

Value $15.77M Shares 497,270 Est. Cost $32.09 Unrealized -20.8%

BHVN BIOHAVEN LTD 1.7%

Value $6.252M Shares 738,972 Est. Cost $26.32 Unrealized -55.3%

SKYE SKYE BIOSCIENCE INC 1.7%

Value $5.95M Shares 9,681,763 Est. Cost $11.84 Unrealized -92.4%

GHRS GH RESEARCH PLC 2.2%

Value $8.052M Shares 572,665 Est. Cost $10.15 Unrealized +54.8%

PHVS PHARVARIS N V 6.3%

Value $22.53M Shares 797,600 Est. Cost $19.05 Unrealized +40.4%

SLN SILENCE THERAPEUTICS PLC 0.7%

Value $2.51M Shares 476,200 Est. Cost $21.60 Unrealized —

TARA PROTARA THERAPEUTICS INC 2.0%

Value $7.137M Shares 1,369,782 Est. Cost $4.20 Unrealized +47.2%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
TYRA	TYRA BIOSCIENCES INC	1,029,298	$39.42M	10.9%	$15.46	+95.6%	COM	90240B106
CAMP	CAMP4 THERAPEUTICS CORP	5,869,091	$25.88M	7.2%	$5.03	-7.2%	COM	13463J101
TRDA	ENTRADA THERAPEUTICS INC	4,056,379	$51.19M	14.2%	$17.12	—	COM	29384C108
CNTA	CENTESSA PHARMACEUTICALS PLC	580,945	$23.08M	6.4%	$11.45	—	SPONSORED ADS	152309100
TECX	TECTONIC THERAPEUTIC INC	606,660	$18.75M	5.2%	$16.21	+30.1%	COM	878972108
EYPT	EYEPOINT INC	1,050,000	$13.53M	3.8%	$9.03	+68.5%	COM NEW	30233G209
ARTV	ARTIVA BIOTHERAPEUTICS INC	2,353,304	$15.16M	4.2%	$11.59	-61.9%	COM	04317A107
ZNTL	ZENTALIS PHARMACEUTICALS INC	3,947,913	$9.238M	2.6%	$4.25	-38.5%	COM	98943L107
MPLT	MAPLIGHT THERAPEUTICS INC	950,011	$19.31M	5.4%	$16.75	+5.2%	COM	56565P103
SRZN	SURROZEN INC	387,500	$11.29M	3.1%	$12.54	+77.3%	COM NEW	86889P208
CLDX	CELLDEX THERAPEUTICS INC NEW	497,270	$15.77M	4.4%	$32.09	-20.8%	COM NEW	15117B202
BHVN	BIOHAVEN LTD	738,972	$6.252M	1.7%	$26.32	-55.3%	COM	G1110E107
SKYE	SKYE BIOSCIENCE INC	9,681,763	$5.95M	1.7%	$11.84	-92.4%	COM NEW	83086J200
GHRS	GH RESEARCH PLC	572,665	$8.052M	2.2%	$10.15	+54.8%	ORDINARY SHARES	G3855L106
PHVS	PHARVARIS N V	797,600	$22.53M	6.3%	$19.05	+40.4%	COM	N69605108
SLN	SILENCE THERAPEUTICS PLC	476,200	$2.51M	0.7%	$21.60	—	ADS	82686Q101
TARA	PROTARA THERAPEUTICS INC	1,369,782	$7.137M	2.0%	$4.20	+47.2%	COM STK	74365U107