5AM Venture Management, LLC Long-Term Concentrated

Location: San Francisco, CA

CIK: 0001799883 · Show all filings

Period: Q4 2025 (← Previous) (Next →)

Filing Date: Feb 17, 2026

Total Value: $318M (100.0% shares, 0.0% debt)

Holdings (21)

TRDA ENTRADA THERAPEUTICS INC 13.1%

Value $41.7M Shares 4,056,379 Est. Cost $17.12 Unrealized —

CAMP CAMP4 THERAPEUTICS CORP 11.3%

Value $35.98M Shares 5,869,091 Est. Cost $5.03 Unrealized -15.4%

TYRA TYRA BIOSCIENCES INC 8.5%

Value $27.06M Shares 1,029,298 Est. Cost $15.46 Unrealized +18.8%

VRDN VIRIDIAN THERAPEUTICS INC 7.2%

Value $22.92M Shares 736,595 Est. Cost $17.93 Unrealized +52.9%

PHVS PHARVARIS N V 7.0%

Value $22.13M Shares 797,600 Est. Cost $19.05 Unrealized +26.4%

ERAS ERASCA INC 6.3%

Value $20.11M Shares 5,405,404 Est. Cost $2.16 Unrealized +30.3%

EYPT EYEPOINT INC 6.0%

Value $19.18M Shares 1,050,000 Est. Cost $9.03 Unrealized +56.9%

MPLT MAPLIGHT THERAPEUTICS INC 5.2%

Value $16.69M Shares 950,011 Est. Cost $16.75 Unrealized 0.0%

CNTA CENTESSA PHARMACEUTICALS PLC 4.6%

Value $14.53M Shares 580,945 Est. Cost $11.45 Unrealized —

CLDX CELLDEX THERAPEUTICS INC NEW 4.2%

Value $13.51M Shares 497,270 Est. Cost $32.09 Unrealized -17.9%

TECX TECTONIC THERAPEUTIC INC 4.0%

Value $12.65M Shares 606,660 Est. Cost $16.21 Unrealized +14.6%

ELVN ENLIVEN THERAPEUTICS INC 3.7%

Value $11.9M Shares 772,477 Est. Cost $20.34 Unrealized -2.1%

ARTV ARTIVA BIOTHERAPEUTICS INC 3.2%

Value $10.1M Shares 2,353,304 Est. Cost $11.59 Unrealized -67.4%

SRZN SURROZEN INC 2.8%

Value $8.758M Shares 387,500 Est. Cost $12.54 Unrealized +29.1%

BHVN BIOHAVEN LTD 2.6%

Value $8.343M Shares 738,972 Est. Cost $26.32 Unrealized -52.9%

TARA PROTARA THERAPEUTICS INC 2.3%

Value $7.301M Shares 1,369,782 Est. Cost $4.20 Unrealized +32.4%

GHRS GH RESEARCH PLC 2.3%

Value $7.273M Shares 572,665 Est. Cost $10.15 Unrealized +34.2%

SKYE SKYE BIOSCIENCE INC 2.3%

Value $7.258M Shares 9,681,763 Est. Cost $11.84 Unrealized -87.7%

ZNTL ZENTALIS PHARMACEUTICALS INC 1.7%

Value $5.33M Shares 3,947,913 Est. Cost $4.25 Unrealized -65.8%

SLN SILENCE THERAPEUTICS PLC 0.9%

Value $2.895M Shares 476,200 Est. Cost $21.60 Unrealized —

— RALLYBIO CORP 0.8%

Value $2.491M Shares 3,630,724 Est. Cost $17.58 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
TRDA	ENTRADA THERAPEUTICS INC	4,056,379	$41.7M	13.1%	$17.12	—	COM	29384C108
CAMP	CAMP4 THERAPEUTICS CORP	5,869,091	$35.98M	11.3%	$5.03	-15.4%	COM	13463J101
TYRA	TYRA BIOSCIENCES INC	1,029,298	$27.06M	8.5%	$15.46	+18.8%	COM	90240B106
VRDN	VIRIDIAN THERAPEUTICS INC	736,595	$22.92M	7.2%	$17.93	+52.9%	COM	92790C104
PHVS	PHARVARIS N V	797,600	$22.13M	7.0%	$19.05	+26.4%	COM	N69605108
ERAS	ERASCA INC	5,405,404	$20.11M	6.3%	$2.16	+30.3%	COM	29479A108
EYPT	EYEPOINT INC	1,050,000	$19.18M	6.0%	$9.03	+56.9%	COM NEW	30233G209
MPLT	MAPLIGHT THERAPEUTICS INC	950,011	$16.69M	5.2%	$16.75	0.0%	COM	56565P103
CNTA	CENTESSA PHARMACEUTICALS PLC	580,945	$14.53M	4.6%	$11.45	—	SPONSORED ADS	152309100
CLDX	CELLDEX THERAPEUTICS INC NEW	497,270	$13.51M	4.2%	$32.09	-17.9%	COM NEW	15117B202
TECX	TECTONIC THERAPEUTIC INC	606,660	$12.65M	4.0%	$16.21	+14.6%	COM	878972108
ELVN	ENLIVEN THERAPEUTICS INC	772,477	$11.9M	3.7%	$20.34	-2.1%	COM	29337E102
ARTV	ARTIVA BIOTHERAPEUTICS INC	2,353,304	$10.1M	3.2%	$11.59	-67.4%	COM	04317A107
SRZN	SURROZEN INC	387,500	$8.758M	2.8%	$12.54	+29.1%	COM NEW	86889P208
BHVN	BIOHAVEN LTD	738,972	$8.343M	2.6%	$26.32	-52.9%	COM	G1110E107
TARA	PROTARA THERAPEUTICS INC	1,369,782	$7.301M	2.3%	$4.20	+32.4%	COM STK	74365U107
GHRS	GH RESEARCH PLC	572,665	$7.273M	2.3%	$10.15	+34.2%	ORDINARY SHARES	G3855L106
SKYE	SKYE BIOSCIENCE INC	9,681,763	$7.258M	2.3%	$11.84	-87.7%	COM NEW	83086J200
ZNTL	ZENTALIS PHARMACEUTICALS INC	3,947,913	$5.33M	1.7%	$4.25	-65.8%	COM	98943L107
SLN	SILENCE THERAPEUTICS PLC	476,200	$2.895M	0.9%	$21.60	—	ADS	82686Q101
—	RALLYBIO CORP	3,630,724	$2.491M	0.8%	$17.58	—	COM	75120L100