GREAT POINT PARTNERS LLC Quant / Systematic

CIK: 0001281446 · Show all filings

Period: Q3 2025 (← Previous) (Next →)

Filing Date: Nov 14, 2025

Total Value ($000): $242,496 (100.0% shares, 0.0% debt)

Holdings (30)

AMLX AMYLYX PHARMACEUTICALS INC 9.5%

Value ($000) $23,103 Shares 1,700,000 Est. Cost $3.68 Unrealized +155.7%

RZLT REZOLUTE INC COM NEW 9.5%

Value ($000) $23,047 Shares 2,451,809 Est. Cost $4.03 Unrealized +65.3%

NKTR NEKTAR THERAPEUTICS COM NEW 7.0%

Value ($000) $17,070 Shares 300,000 Est. Cost $33.10 Unrealized 0.0%

ZURA ZURA BIO LTD CLASS A ORD SHS 6.8%

Value ($000) $16,523 Shares 3,815,930 Est. Cost $5.64 Unrealized -68.1%

SLNO SOLENO THERAPEUTICS INC 6.3%

Value ($000) $15,210 Shares 225,000 Est. Cost $74.14 Unrealized 0.0%

ASND ASCENDIS PHARMA A/S SPONSORED ADR 6.1%

Value ($000) $14,911 Shares 75,000 Est. Cost $198.81 Unrealized —

ABVX ABIVAX SA SPONSORED ADS 5.3%

Value ($000) $12,735 Shares 150,000 Est. Cost $12.06 Unrealized —

APGE APOGEE THERAPEUTICS INC 5.0%

Value ($000) $12,078 Shares 304,000 Est. Cost $38.18 Unrealized 0.0%

DNTH DIANTHUS THERAPEUTICS INC 4.3%

Value ($000) $10,459 Shares 265,803 Est. Cost $25.56 Unrealized 0.0%

CYTK CYTOKINETICS INC COM NEW 3.4%

Value ($000) $8,244 Shares 150,000 Est. Cost $51.61 Unrealized -20.2%

IMVT IMMUNOVANT INC 3.3%

Value ($000) $8,060 Shares 500,000 Est. Cost $18.67 Unrealized -13.3%

XENE XENON PHARMACEUTICALS INC 3.3%

Value ($000) $8,030 Shares 200,000 Est. Cost $41.35 Unrealized -14.8%

NGNE NEUROGENE INC 3.2%

Value ($000) $7,743 Shares 446,814 Est. Cost $14.71 Unrealized +36.5%

EPRX EUPRAXIA PHARMACEUTICALS INC 2.9%

Value ($000) $7,080 Shares 1,200,000 Est. Cost $5.44 Unrealized 0.0%

UPB UPSTREAM BIO INC 2.3%

Value ($000) $5,643 Shares 300,000 Est. Cost $22.33 Unrealized -30.4%

JBIO JADE BIOSCIENCES INC COM NEW 2.3%

Value ($000) $5,459 Shares 632,599 Est. Cost $27.97 Unrealized -70.8%

IONS IONIS PHARMACEUTICALS INC 2.2%

Value ($000) $5,234 Shares 80,000 Est. Cost $35.97 Unrealized +35.7%

— AKERO THERAPEUTICS INC 2.0%

Value ($000) $4,931 Shares 103,848 Est. Cost $53.36 Unrealized —

TSHA TAYSHA GENE THERAPIES INC COM SHS 2.0%

Value ($000) $4,905 Shares 1,500,000 Est. Cost $2.17 Unrealized +30.3%

CNTX CONTEXT THERAPEUTICS INC 1.9%

Value ($000) $4,538 Shares 4,683,711 Est. Cost $1.72 Unrealized -53.0%

PHVS PHARVARIS N V 1.6%

Value ($000) $3,870 Shares 155,105 Est. Cost $22.18 Unrealized 0.0%

DBVT DBV TECHNOLOGIES S A SPONSORED ADS 1.6%

Value ($000) $3,786 Shares 378,594 Est. Cost $9.17 Unrealized —

LEGN LEGEND BIOTECH CORP SPONSORED ADS 1.5%

Value ($000) $3,700 Shares 113,460 Est. Cost $34.87 Unrealized —

ORKA ORUKA THERAPEUTICS INC 1.5%

Value ($000) $3,525 Shares 183,330 Est. Cost $14.82 Unrealized 0.0%

UNCY UNICYCIVE THERAPEUTICS INC COM NEW 1.4%

Value ($000) $3,473 Shares 796,558 Est. Cost $6.18 Unrealized -29.5%

SANA SANA BIOTECHNOLOGY INC 1.0%

Value ($000) $2,485 Shares 700,000 Est. Cost $3.62 Unrealized 0.0%

ABSI ABSCI CORPORATION 1.0%

Value ($000) $2,421 Shares 796,438 Est. Cost $2.76 Unrealized 0.0%

HRMY HRMY 10/17/2025 40 Call 1.0%

Value ($000) $2,343 Shares 85,000 Est. Cost — Unrealized —

PLRX PLIANT THERAPEUTICS INC 0.5%

Value ($000) $1,258 Shares 850,000 Est. Cost $16.18 Unrealized -90.6%

CAPR CAPR 12/19/2025 7.5 Put 0.3%

Value ($000) $632 Shares 87,700 Est. Cost — Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
AMLX	AMYLYX PHARMACEUTICALS INC	1,700,000	$23,103	9.5%	$3.68	+155.7%	COM	03237H101
RZLT	REZOLUTE INC COM NEW	2,451,809	$23,047	9.5%	$4.03	+65.3%	COM	76200L309
NKTR	NEKTAR THERAPEUTICS COM NEW	300,000	$17,070	7.0%	$33.10	0.0%	COM	640268306
ZURA	ZURA BIO LTD CLASS A ORD SHS	3,815,930	$16,523	6.8%	$5.64	-68.1%	COM	G9TY5A101
SLNO	SOLENO THERAPEUTICS INC	225,000	$15,210	6.3%	$74.14	0.0%	COM	834203309
ASND	ASCENDIS PHARMA A/S SPONSORED ADR	75,000	$14,911	6.1%	$198.81	—	COM	04351P101
ABVX	ABIVAX SA SPONSORED ADS	150,000	$12,735	5.3%	$12.06	—	COM	00370M103
APGE	APOGEE THERAPEUTICS INC	304,000	$12,078	5.0%	$38.18	0.0%	COM	03770N101
DNTH	DIANTHUS THERAPEUTICS INC	265,803	$10,459	4.3%	$25.56	0.0%	COM	252828108
CYTK	CYTOKINETICS INC COM NEW	150,000	$8,244	3.4%	$51.61	-20.2%	COM	23282W605
IMVT	IMMUNOVANT INC	500,000	$8,060	3.3%	$18.67	-13.3%	COM	45258J102
XENE	XENON PHARMACEUTICALS INC	200,000	$8,030	3.3%	$41.35	-14.8%	COM	98420N105
NGNE	NEUROGENE INC	446,814	$7,743	3.2%	$14.71	+36.5%	COM	64135M105
EPRX	EUPRAXIA PHARMACEUTICALS INC	1,200,000	$7,080	2.9%	$5.44	0.0%	COM	29842P105
UPB	UPSTREAM BIO INC	300,000	$5,643	2.3%	$22.33	-30.4%	COM	91678A107
JBIO	JADE BIOSCIENCES INC COM NEW	632,599	$5,459	2.3%	$27.97	-70.8%	COM	008064206
IONS	IONIS PHARMACEUTICALS INC	80,000	$5,234	2.2%	$35.97	+35.7%	COM	462222100
—	AKERO THERAPEUTICS INC	103,848	$4,931	2.0%	$53.36	—	COM	00973Y108
TSHA	TAYSHA GENE THERAPIES INC COM SHS	1,500,000	$4,905	2.0%	$2.17	+30.3%	COM	877619106
CNTX	CONTEXT THERAPEUTICS INC	4,683,711	$4,538	1.9%	$1.72	-53.0%	COM	21077P108
PHVS	PHARVARIS N V	155,105	$3,870	1.6%	$22.18	0.0%	COM	N69605108
DBVT	DBV TECHNOLOGIES S A SPONSORED ADS	378,594	$3,786	1.6%	$9.17	—	COM	23306J309
LEGN	LEGEND BIOTECH CORP SPONSORED ADS	113,460	$3,700	1.5%	$34.87	—	COM	52490G102
ORKA	ORUKA THERAPEUTICS INC	183,330	$3,525	1.5%	$14.82	0.0%	COM	687604108
UNCY	UNICYCIVE THERAPEUTICS INC COM NEW	796,558	$3,473	1.4%	$6.18	-29.5%	COM	90466Y202
SANA	SANA BIOTECHNOLOGY INC	700,000	$2,485	1.0%	$3.62	0.0%	COM	799566104
ABSI	ABSCI CORPORATION	796,438	$2,421	1.0%	$2.76	0.0%	COM	00091E109
HRMY	HRMY 10/17/2025 40 Call	85,000	$2,343	1.0%	—	—	Call	413197104
PLRX	PLIANT THERAPEUTICS INC	850,000	$1,258	0.5%	$16.18	-90.6%	COM	729139105
CAPR	CAPR 12/19/2025 7.5 Put	87,700	$632	0.3%	—	—	Put	14070B309