GREAT POINT PARTNERS LLC Quant / Systematic

CIK: 0001281446 · Show all filings

Period: Q2 2025 (← Previous) (Next →)

Filing Date: Aug 14, 2025

Total Value ($000): $153,802 (100.0% shares, 0.0% debt)

Holdings (26)

IONS IONIS PHARMACEUTICALS INC 12.8%

Value ($000) $19,755 Shares 500,000 Est. Cost $35.97 Unrealized -9.0%

RZLT REZOLUTE INC 8.8%

Value ($000) $13,529 Shares 3,033,462 Est. Cost $4.03 Unrealized -7.9%

AMLX AMYLYX PHARMACEUTICALS INC 8.3%

Value ($000) $12,820 Shares 2,000,000 Est. Cost $3.68 Unrealized +32.1%

LEGN LEGEND BIOTECH CORP 8.1%

Value ($000) $12,422 Shares 350,000 Est. Cost $34.87 Unrealized —

ABVX ABIVAX SA 6.4%

Value ($000) $9,881 Shares 1,291,617 Est. Cost $12.06 Unrealized —

NGNE NEUROGENE INC 4.7%

Value ($000) $7,264 Shares 485,859 Est. Cost $14.71 Unrealized +6.7%

AKBA AKEBIA THERAPEUTICS INC 4.7%

Value ($000) $7,229 Shares 1,985,915 Est. Cost $2.04 Unrealized +34.6%

EOLS EVOLUS INC 4.3%

Value ($000) $6,632 Shares 720,118 Est. Cost $9.83 Unrealized +4.1%

ACLX ARCELLX INC 4.3%

Value ($000) $6,585 Shares 100,000 Est. Cost $64.73 Unrealized -3.8%

XENE XENON PHARMACEUTICALS INC 4.1%

Value ($000) $6,260 Shares 200,000 Est. Cost $41.35 Unrealized -21.1%

— AKERO THERAPEUTICS INC 3.6%

Value ($000) $5,541 Shares 103,848 Est. Cost $53.36 Unrealized —

JBIO JADE BIOSCIENCES INC 3.2%

Value ($000) $4,976 Shares 498,054 Est. Cost $33.31 Unrealized 0.0%

CYTK CYTOKINETICS INC 3.2%

Value ($000) $4,956 Shares 150,000 Est. Cost $51.61 Unrealized -32.6%

IMVT IMMUNOVANT INC 2.7%

Value ($000) $4,195 Shares 262,176 Est. Cost $20.92 Unrealized -27.7%

UNCY UNICYCIVE THERAPEUTICS INC 2.5%

Value ($000) $3,800 Shares 796,558 Est. Cost $6.18 Unrealized 0.0%

KALV KALVISTA PHARMACEUTICALS INC 2.4%

Value ($000) $3,653 Shares 323,170 Est. Cost $11.31 Unrealized +8.1%

TSHA TAYSHA GENE THERAPIES INC 2.3%

Value ($000) $3,465 Shares 1,500,000 Est. Cost $2.17 Unrealized 0.0%

DBVT DBV TECHNOLOGIES S A 2.2%

Value ($000) $3,432 Shares 374,679 Est. Cost $9.16 Unrealized —

ZURA ZURA BIO LTD 2.2%

Value ($000) $3,329 Shares 3,170,194 Est. Cost $6.43 Unrealized -81.4%

UPB UPSTREAM BIO INC 2.1%

Value ($000) $3,294 Shares 300,000 Est. Cost $22.33 Unrealized -58.6%

CNTX CONTEXT THERAPEUTICS INC 2.0%

Value ($000) $3,069 Shares 4,683,711 Est. Cost $1.72 Unrealized -58.3%

CNTA CENTESSA PHARMACEUTICALS PLC 1.9%

Value ($000) $2,957 Shares 225,000 Est. Cost $13.97 Unrealized —

SRRK SCHOLAR ROCK HLDG CORP 1.4%

Value ($000) $2,182 Shares 61,607 Est. Cost $31.39 Unrealized 0.0%

— PROMIS NEUROSCIENCES INC 0.8%

Value ($000) $1,280 Shares 2,645,128 Est. Cost $1.25 Unrealized —

PLRX PLIANT THERAPEUTICS INC 0.6%

Value ($000) $986 Shares 850,000 Est. Cost $16.18 Unrealized -91.3%

BBOT HELIX ACQUISITION CORP II 0.2%

Value ($000) $312 Shares 29,381 Est. Cost $10.35 Unrealized +4.5%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
IONS	IONIS PHARMACEUTICALS INC	500,000	$19,755	12.8%	$35.97	-9.0%	COM	462222100
RZLT	REZOLUTE INC	3,033,462	$13,529	8.8%	$4.03	-7.9%	COM NEW	76200L309
AMLX	AMYLYX PHARMACEUTICALS INC	2,000,000	$12,820	8.3%	$3.68	+32.1%	COM	03237H101
LEGN	LEGEND BIOTECH CORP	350,000	$12,422	8.1%	$34.87	—	SPONSORED ADS	52490G102
ABVX	ABIVAX SA	1,291,617	$9,881	6.4%	$12.06	—	SPONSORED ADS	00370M103
NGNE	NEUROGENE INC	485,859	$7,264	4.7%	$14.71	+6.7%	COM	64135M105
AKBA	AKEBIA THERAPEUTICS INC	1,985,915	$7,229	4.7%	$2.04	+34.6%	COM	00972D105
EOLS	EVOLUS INC	720,118	$6,632	4.3%	$9.83	+4.1%	COM	30052C107
ACLX	ARCELLX INC	100,000	$6,585	4.3%	$64.73	-3.8%	COMMON STOCK	03940C100
XENE	XENON PHARMACEUTICALS INC	200,000	$6,260	4.1%	$41.35	-21.1%	COM	98420N105
—	AKERO THERAPEUTICS INC	103,848	$5,541	3.6%	$53.36	—	COM	00973Y108
JBIO	JADE BIOSCIENCES INC	498,054	$4,976	3.2%	$33.31	0.0%	COM NEW	008064206
CYTK	CYTOKINETICS INC	150,000	$4,956	3.2%	$51.61	-32.6%	COM NEW	23282W605
IMVT	IMMUNOVANT INC	262,176	$4,195	2.7%	$20.92	-27.7%	COM	45258J102
UNCY	UNICYCIVE THERAPEUTICS INC	796,558	$3,800	2.5%	$6.18	0.0%	COM NEW	90466Y202
KALV	KALVISTA PHARMACEUTICALS INC	323,170	$3,653	2.4%	$11.31	+8.1%	COM	483497103
TSHA	TAYSHA GENE THERAPIES INC	1,500,000	$3,465	2.3%	$2.17	0.0%	COM SHS	877619106
DBVT	DBV TECHNOLOGIES S A	374,679	$3,432	2.2%	$9.16	—	SPONSORED ADS	23306J309
ZURA	ZURA BIO LTD	3,170,194	$3,329	2.2%	$6.43	-81.4%	CLASS A ORD SHS	G9TY5A101
UPB	UPSTREAM BIO INC	300,000	$3,294	2.1%	$22.33	-58.6%	COM	91678A107
CNTX	CONTEXT THERAPEUTICS INC	4,683,711	$3,069	2.0%	$1.72	-58.3%	COM	21077P108
CNTA	CENTESSA PHARMACEUTICALS PLC	225,000	$2,957	1.9%	$13.97	—	SPONSORED ADS	152309100
SRRK	SCHOLAR ROCK HLDG CORP	61,607	$2,182	1.4%	$31.39	0.0%	COM	80706P103
—	PROMIS NEUROSCIENCES INC	2,645,128	$1,280	0.8%	$1.25	—	COM NEW	74346M406
PLRX	PLIANT THERAPEUTICS INC	850,000	$986	0.6%	$16.18	-91.3%	COM	729139105
BBOT	HELIX ACQUISITION CORP II	29,381	$312	0.2%	$10.35	+4.5%	CL A ORD SHS	G4444H101