Rock Springs Capital Management LP Diversified Active

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
UNH	UNITEDHEALTH GROUP INC	40,800	$13,468	0.7%	$337.21	0.0%	COM	91324P102
IMNM	IMMUNOME INC	347,666	$7,468	0.4%	$17.55	0.0%	COM	45257U108
RAPT	RAPT THERAPEUTICS INC	213,731	$7,239	0.4%	$31.06	0.0%	COM NEW	75382E208
SGRY	SURGERY PARTNERS INC	310,000	$4,790	0.2%	$18.38	0.0%	COM	86881A100
PTCT	PTC THERAPEUTICS INC	61,879	$4,700	0.2%	$72.67	0.0%	COM	69366J200
TERN	TERNS PHARMACEUTICALS INC	108,481	$4,383	0.2%	$23.11	0.0%	COM	880881107
RCUS	ARCUS BIOSCIENCES INC	180,000	$4,289	0.2%	$20.40	0.0%	COM	03969F109
TBPH	THERAVANCE BIOPHARMA INC	208,771	$3,906	0.2%	$16.59	0.0%	COM	G8807B106
—	INDIVIOR PLC	105,100	$3,771	0.2%	$35.88	—	ORD	G4766E116
ERAS	ERASCA INC	951,710	$3,540	0.2%	$2.81	0.0%	COM	29479A108
TNGX	TANGO THERAPEUTICS INC	386,915	$3,428	0.2%	$8.62	0.0%	COM	87583X109
OLMA	OLEMA PHARMACEUTICALS INC	98,240	$2,456	0.1%	$17.79	0.0%	COM	68062P106
CYTK	CYTOKINETICS INC	35,853	$2,278	0.1%	$62.21	0.0%	COM NEW	23282W605
ROIV	ROIVANT SCIENCES LTD	88,750	$1,926	0.1%	$19.73	0.0%	SHS	G76279101
CORT	CORCEPT THERAPEUTICS INC	50,250	$1,749	0.1%	$78.55	0.0%	COM	218352102
TEVA	TEVA PHARMACEUTICAL INDS LTD	45,500	$1,420	0.1%	$31.21	—	SPONSORED ADS	881624209
LEGN	LEGEND BIOTECH CORP	33,800	$735	0.0%	$21.74	—	SPONSORED ADS	52490G102
JAZZ	JAZZ PHARMACEUTICALS PLC	1,750	$298	0.0%	$153.31	0.0%	SHS USD	G50871105

Increased Positions (30)

TVTX TRAVERE THERAPEUTICS INC 4.3%

Value ($000) $84,456 (+63.2%) Shares 2,210,322 (+2.1%) Est. Cost $14.26 Unrealized +128.0%

EXAS EXACT SCIENCES CORP 3.1%

Value ($000) $61,119 (+88.2%) Shares 601,800 (+1.4%) Est. Cost $54.04 Unrealized +48.6%

MDGL MADRIGAL PHARMACEUTICALS INC 4.2%

Value ($000) $81,305 (+28.7%) Shares 139,618 (+1.4%) Est. Cost $123.32 Unrealized +314.2%

KYMR KYMERA THERAPEUTICS INC 2.0%

Value ($000) $38,662 (+51.7%) Shares 496,871 (+10.3%) Est. Cost $34.27 Unrealized +97.0%

ZLAB ZAI LAB LTD 0.7%

Value ($000) $14,316 (-46.6%) Shares 811,546 (+2.6%) Est. Cost $50.50 Unrealized —

XBI SPDR SERIES TRUST 1.4%

Value ($000) $27,068 (+78.0%) Shares 222,000 (+46.3%) Est. Cost $95.27 Unrealized —

RARE ULTRAGENYX PHARMACEUTICAL IN 1.5%

Value ($000) $29,147 (-22.3%) Shares 1,267,241 (+1.7%) Est. Cost $57.80 Unrealized -43.1%

DYN DYNE THERAPEUTICS INC 0.9%

Value ($000) $17,857 (+71.3%) Shares 912,955 (+10.8%) Est. Cost $18.27 Unrealized +3.7%

LENZ LENZ THERAPEUTICS INC 0.2%

Value ($000) $4,119 (-62.6%) Shares 257,460 (+9.0%) Est. Cost $32.86 Unrealized -11.3%

CNTA CENTESSA PHARMACEUTICALS PLC 0.4%

Value ($000) $8,104 (+382.6%) Shares 324,015 (+368.0%) Est. Cost $24.85 Unrealized —

NBIX NEUROCRINE BIOSCIENCES INC 0.9%

Value ($000) $17,800 (+41.3%) Shares 125,500 (+39.8%) Est. Cost $97.62 Unrealized +48.4%

EYPT EYEPOINT INC 0.2%

Value ($000) $4,727 (+948.7%) Shares 258,739 (+717.4%) Est. Cost $13.85 Unrealized +2.3%

INSP INSPIRE MED SYS INC 0.6%

Value ($000) $12,082 (+47.4%) Shares 131,000 (+18.6%) Est. Cost $178.69 Unrealized -46.5%

BBIO BRIDGEBIO PHARMA INC 0.4%

Value ($000) $7,917 (+79.3%) Shares 103,500 (+21.8%) Est. Cost $51.79 Unrealized +26.8%

AZTA AZENTA INC 1.0%

Value ($000) $18,928 (+22.0%) Shares 569,100 (+5.3%) Est. Cost $56.45 Unrealized -42.1%

BSX BOSTON SCIENTIFIC CORP 2.0%

Value ($000) $38,049 (+8.2%) Shares 399,050 (+10.8%) Est. Cost $67.08 Unrealized +46.1%

PHR PHREESIA INC 0.8%

Value ($000) $14,832 (-15.8%) Shares 876,600 (+17.0%) Est. Cost $25.15 Unrealized -18.0%

PCVX VAXCYTE INC 0.1%

Value ($000) $2,169 (+442.4%) Shares 47,000 (+323.4%) Est. Cost $41.90 Unrealized +6.7%

ELVN ENLIVEN THERAPEUTICS INC 0.6%

Value ($000) $12,295 (-12.5%) Shares 798,405 (+16.4%) Est. Cost $17.30 Unrealized +15.1%

DXCM DEXCOM INC 1.2%

Value ($000) $23,050 (+8.1%) Shares 347,300 (+9.6%) Est. Cost $90.94 Unrealized -28.9%

APLS APELLIS PHARMACEUTICALS INC 0.2%

Value ($000) $3,781 (+81.6%) Shares 150,500 (+63.6%) Est. Cost $34.91 Unrealized -32.8%

BCAX BICARA THERAPEUTICS INC 0.4%

Value ($000) $7,222 (+23.4%) Shares 429,095 (+15.8%) Est. Cost $23.20 Unrealized -26.4%

EDAP EDAP TMS S A 0.2%

Value ($000) $4,233 (+45.5%) Shares 1,286,500 (+1.3%) Est. Cost $7.18 Unrealized —

SLNO SOLENO THERAPEUTICS INC 0.6%

Value ($000) $11,439 (+9.5%) Shares 247,053 (+59.9%) Est. Cost $55.78 Unrealized -1.7%

ALKS ALKERMES PLC 0.2%

Value ($000) $3,896 (+21.9%) Shares 139,228 (+30.7%) Est. Cost $28.61 Unrealized +4.7%

OCUL OCULAR THERAPEUTIX INC 0.2%

Value ($000) $4,198 (+19.7%) Shares 345,820 (+15.3%) Est. Cost $11.98 Unrealized +1.4%

MLTX MOONLAKE IMMUNOTHERAPEUTICS 0.0%

Value ($000) $813 (+302.2%) Shares 61,700 (+118.8%) Est. Cost $30.23 Unrealized -61.0%

HTFL HEARTFLOW INC 0.4%

Value ($000) $8,095 (-3.8%) Shares 277,700 (+11.1%) Est. Cost $32.24 Unrealized -0.1%

JANX JANUX THERAPEUTICS INC 0.3%

Value ($000) $4,951 (-3.7%) Shares 358,798 (+70.6%) Est. Cost $40.31 Unrealized -41.7%

MLYS MINERALYS THERAPEUTICS INC 0.8%

Value ($000) $15,517 (+0.2%) Shares 427,596 (+4.7%) Est. Cost $14.80 Unrealized +170.9%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
TVTX	TRAVERE THERAPEUTICS INC	2,210,322 (+2.1%)	$84,456 (+63.2%)	4.3%	$14.26	+128.0%	COM	89422G107
EXAS	EXACT SCIENCES CORP	601,800 (+1.4%)	$61,119 (+88.2%)	3.1%	$54.04	+48.6%	COM	30063P105
MDGL	MADRIGAL PHARMACEUTICALS INC	139,618 (+1.4%)	$81,305 (+28.7%)	4.2%	$123.32	+314.2%	COM	558868105
KYMR	KYMERA THERAPEUTICS INC	496,871 (+10.3%)	$38,662 (+51.7%)	2.0%	$34.27	+97.0%	COM	501575104
ZLAB	ZAI LAB LTD	811,546 (+2.6%)	$14,316 (-46.6%)	0.7%	$50.50	—	ADR	98887Q104
XBI	SPDR SERIES TRUST	222,000 (+46.3%)	$27,068 (+78.0%)	1.4%	$95.27	—	STATE STREET SPD	78464A870
RARE	ULTRAGENYX PHARMACEUTICAL IN	1,267,241 (+1.7%)	$29,147 (-22.3%)	1.5%	$57.80	-43.1%	COM	90400D108
DYN	DYNE THERAPEUTICS INC	912,955 (+10.8%)	$17,857 (+71.3%)	0.9%	$18.27	+3.7%	COM	26818M108
LENZ	LENZ THERAPEUTICS INC	257,460 (+9.0%)	$4,119 (-62.6%)	0.2%	$32.86	-11.3%	COM	52635N103
CNTA	CENTESSA PHARMACEUTICALS PLC	324,015 (+368.0%)	$8,104 (+382.6%)	0.4%	$24.85	—	SPONSORED ADS	152309100
NBIX	NEUROCRINE BIOSCIENCES INC	125,500 (+39.8%)	$17,800 (+41.3%)	0.9%	$97.62	+48.4%	COM	64125C109
EYPT	EYEPOINT INC	258,739 (+717.4%)	$4,727 (+948.7%)	0.2%	$13.85	+2.3%	COM NEW	30233G209
INSP	INSPIRE MED SYS INC	131,000 (+18.6%)	$12,082 (+47.4%)	0.6%	$178.69	-46.5%	COM	457730109
BBIO	BRIDGEBIO PHARMA INC	103,500 (+21.8%)	$7,917 (+79.3%)	0.4%	$51.79	+26.8%	COM	10806X102
AZTA	AZENTA INC	569,100 (+5.3%)	$18,928 (+22.0%)	1.0%	$56.45	-42.1%	COM	114340102
BSX	BOSTON SCIENTIFIC CORP	399,050 (+10.8%)	$38,049 (+8.2%)	2.0%	$67.08	+46.1%	COM	101137107
PHR	PHREESIA INC	876,600 (+17.0%)	$14,832 (-15.8%)	0.8%	$25.15	-18.0%	COM	71944F106
PCVX	VAXCYTE INC	47,000 (+323.4%)	$2,169 (+442.4%)	0.1%	$41.90	+6.7%	COM	92243G108
ELVN	ENLIVEN THERAPEUTICS INC	798,405 (+16.4%)	$12,295 (-12.5%)	0.6%	$17.30	+15.1%	COM	29337E102
DXCM	DEXCOM INC	347,300 (+9.6%)	$23,050 (+8.1%)	1.2%	$90.94	-28.9%	COM	252131107
APLS	APELLIS PHARMACEUTICALS INC	150,500 (+63.6%)	$3,781 (+81.6%)	0.2%	$34.91	-32.8%	COM	03753U106
BCAX	BICARA THERAPEUTICS INC	429,095 (+15.8%)	$7,222 (+23.4%)	0.4%	$23.20	-26.4%	COM	055477103
EDAP	EDAP TMS S A	1,286,500 (+1.3%)	$4,233 (+45.5%)	0.2%	$7.18	—	SPONSORED ADR	268311107
SLNO	SOLENO THERAPEUTICS INC	247,053 (+59.9%)	$11,439 (+9.5%)	0.6%	$55.78	-1.7%	COM	834203309
ALKS	ALKERMES PLC	139,228 (+30.7%)	$3,896 (+21.9%)	0.2%	$28.61	+4.7%	SHS	G01767105
OCUL	OCULAR THERAPEUTIX INC	345,820 (+15.3%)	$4,198 (+19.7%)	0.2%	$11.98	+1.4%	COM	67576A100
MLTX	MOONLAKE IMMUNOTHERAPEUTICS	61,700 (+118.8%)	$813 (+302.2%)	0.0%	$30.23	-61.0%	CLASS A ORD	61559X104
HTFL	HEARTFLOW INC	277,700 (+11.1%)	$8,095 (-3.8%)	0.4%	$32.24	-0.1%	COM	42238D107
JANX	JANUX THERAPEUTICS INC	358,798 (+70.6%)	$4,951 (-3.7%)	0.3%	$40.31	-41.7%	COM	47103J105
MLYS	MINERALYS THERAPEUTICS INC	427,596 (+4.7%)	$15,517 (+0.2%)	0.8%	$14.80	+170.9%	COM	603170101

Exited Positions (12)

— MERUS N V 2.9%

Value ($000) $56,212 Shares 597,051 Est. Cost $32.74 Unrealized —

— AKERO THERAPEUTICS INC 1.5%

Value ($000) $29,747 Shares 626,526 Est. Cost $29.53 Unrealized —

MREO MEREO BIOPHARMA GROUP PLC 0.5%

Value ($000) $9,416 Shares 4,570,649 Est. Cost $2.73 Unrealized —

WST WEST PHARMACEUTICAL SVSC INC 0.1%

Value ($000) $2,558 Shares 9,750 Est. Cost $299.09 Unrealized -8.6%

KRRO KORRO BIO INC 0.1%

Value ($000) $1,711 Shares 35,719 Est. Cost $55.25 Unrealized -57.7%

CATX PERSPECTIVE THERAPEUTICS INC 0.1%

Value ($000) $1,524 Shares 444,383 Est. Cost $14.00 Unrealized -79.6%

— APPLIED THERAPEUTICS INC 0.1%

Value ($000) $1,256 Shares 2,075,991 Est. Cost $12.37 Unrealized —

IMVT IMMUNOVANT INC 0.1%

Value ($000) $1,176 Shares 72,965 Est. Cost $28.27 Unrealized -21.1%

CRL CHARLES RIV LABS INTL INC 0.0%

Value ($000) $422 Shares 2,700 Est. Cost $133.35 Unrealized +36.0%

NVAX NOVAVAX INC 0.0%

Value ($000) $390 Shares 45,000 Est. Cost $31.79 Unrealized -76.3%

PRTA PROTHENA CORP PLC 0.0%

Value ($000) $248 Shares 25,398 Est. Cost $17.57 Unrealized -42.1%

CGEN COMPUGEN LTD 0.0%

Value ($000) $20 Shares 13,430 Est. Cost $6.12 Unrealized -72.9%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
—	MERUS N V	597,051	$56,212	2.9%	$32.74	—	—	N5749R100
—	AKERO THERAPEUTICS INC	626,526	$29,747	1.5%	$29.53	—	—	00973Y108
MREO	MEREO BIOPHARMA GROUP PLC	4,570,649	$9,416	0.5%	$2.73	—	—	589492107
WST	WEST PHARMACEUTICAL SVSC INC	9,750	$2,558	0.1%	$299.09	-8.6%	—	955306105
KRRO	KORRO BIO INC	35,719	$1,711	0.1%	$55.25	-57.7%	—	500946108
CATX	PERSPECTIVE THERAPEUTICS INC	444,383	$1,524	0.1%	$14.00	-79.6%	—	46489V302
—	APPLIED THERAPEUTICS INC	2,075,991	$1,256	0.1%	$12.37	—	—	03828A101
IMVT	IMMUNOVANT INC	72,965	$1,176	0.1%	$28.27	-21.1%	—	45258J102
CRL	CHARLES RIV LABS INTL INC	2,700	$422	0.0%	$133.35	+36.0%	—	159864107
NVAX	NOVAVAX INC	45,000	$390	0.0%	$31.79	-76.3%	—	670002401
PRTA	PROTHENA CORP PLC	25,398	$248	0.0%	$17.57	-42.1%	—	G72800108
CGEN	COMPUGEN LTD	13,430	$20	0.0%	$6.12	-72.9%	—	M25722105

Decreased Positions (26)

GPCR STRUCTURE THERAPEUTICS INC 2.7%

Value ($000) $52,040 (+95.4%) Shares 748,236 (-21.3%) Est. Cost $39.12 Unrealized —

— CIDARA THERAPEUTICS INC 2.3%

Value ($000) $45,256 (+89.5%) Shares 204,878 (-17.9%) Est. Cost $70.46 Unrealized —

ARGX ARGENX SE 4.5%

Value ($000) $86,828 (-17.5%) Shares 103,250 (-27.7%) Est. Cost $160.49 Unrealized —

AGIO AGIOS PHARMACEUTICALS INC 1.1%

Value ($000) $21,753 (-43.5%) Shares 799,163 (-16.6%) Est. Cost $33.80 Unrealized +3.8%

COGT COGENT BIOSCIENCES INC 1.5%

Value ($000) $30,158 (+108.3%) Shares 849,030 (-15.8%) Est. Cost $6.84 Unrealized +310.7%

EVH EVOLENT HEALTH INC 0.5%

Value ($000) $10,700 (-57.1%) Shares 2,675,000 (-9.3%) Est. Cost $20.50 Unrealized -72.9%

VERA VERA THERAPEUTICS INC 1.5%

Value ($000) $28,793 (+60.5%) Shares 568,579 (-7.9%) Est. Cost $35.12 Unrealized +1.1%

OMDA OMADA HEALTH INC 0.6%

Value ($000) $11,677 (-42.6%) Shares 740,000 (-19.6%) Est. Cost $17.31 Unrealized +17.2%

ALNY ALNYLAM PHARMACEUTICALS INC 1.5%

Value ($000) $28,333 (-16.3%) Shares 71,250 (-4.0%) Est. Cost $107.54 Unrealized +311.5%

CAI CARIS LIFE SCIENCES INC 1.0%

Value ($000) $18,549 (-22.7%) Shares 687,500 (-13.4%) Est. Cost $26.95 Unrealized +4.5%

CMPX COMPASS THERAPEUTICS INC 1.1%

Value ($000) $21,089 (+34.7%) Shares 3,927,202 (-12.2%) Est. Cost $3.23 Unrealized +43.1%

ZBIO ZENAS BIOPHARMA INC 0.9%

Value ($000) $18,230 (+41.4%) Shares 502,077 (-13.5%) Est. Cost $17.98 Unrealized +82.9%

ACRS ACLARIS THERAPEUTICS INC 0.7%

Value ($000) $13,406 (+53.1%) Shares 4,453,741 (-3.4%) Est. Cost $6.19 Unrealized -59.2%

TARS TARSUS PHARMACEUTICALS INC 1.1%

Value ($000) $21,317 (+24.4%) Shares 260,344 (-9.7%) Est. Cost $48.01 Unrealized +55.5%

ACLX ARCELLX INC 0.6%

Value ($000) $11,075 (-24.6%) Shares 169,859 (-5.1%) Est. Cost $62.26 Unrealized +28.1%

SRRK SCHOLAR ROCK HLDG CORP 1.7%

Value ($000) $32,310 (+9.3%) Shares 733,477 (-7.6%) Est. Cost $32.85 Unrealized +14.2%

AGL AGILON HEALTH INC 0.2%

Value ($000) $4,477 (-37.6%) Shares 6,500,000 (-6.7%) Est. Cost $29.66 Unrealized -97.4%

NAMS NEWAMSTERDAM PHARMA COMPANY 1.0%

Value ($000) $19,546 (+15.3%) Shares 557,194 (-6.5%) Est. Cost $19.88 Unrealized +83.0%

ACHC ACADIA HEALTHCARE COMPANY IN 0.1%

Value ($000) $1,703 (-59.5%) Shares 120,000 (-29.4%) Est. Cost $53.71 Unrealized -64.8%

RYTM RHYTHM PHARMACEUTICALS INC 3.8%

Value ($000) $74,394 (+2.7%) Shares 695,010 (-3.1%) Est. Cost $17.22 Unrealized +516.0%

REGN REGENERON PHARMACEUTICALS 0.4%

Value ($000) $7,796 (+22.7%) Shares 10,100 (-10.6%) Est. Cost $587.92 Unrealized +15.4%

XENE XENON PHARMACEUTICALS INC 1.8%

Value ($000) $35,309 (+3.2%) Shares 787,788 (-7.5%) Est. Cost $24.19 Unrealized +73.6%

ASND ASCENDIS PHARMA A/S 2.2%

Value ($000) $43,394 (+1.8%) Shares 203,500 (-5.1%) Est. Cost $92.14 Unrealized —

EW EDWARDS LIFESCIENCES CORP 0.4%

Value ($000) $7,033 (+2.8%) Shares 82,500 (-6.3%) Est. Cost $63.05 Unrealized +30.2%

CLDX CELLDEX THERAPEUTICS INC NEW 1.0%

Value ($000) $18,809 (+0.8%) Shares 692,538 (-4.0%) Est. Cost $32.64 Unrealized -19.3%

INSM INSMED INC 2.8%

Value ($000) $55,562 (+0.2%) Shares 319,250 (-17.1%) Est. Cost $39.44 Unrealized +362.7%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
GPCR	STRUCTURE THERAPEUTICS INC	748,236 (-21.3%)	$52,040 (+95.4%)	2.7%	$39.12	—	SPONSORED ADS	86366E106
—	CIDARA THERAPEUTICS INC	204,878 (-17.9%)	$45,256 (+89.5%)	2.3%	$70.46	—	COM NEW	171757206
ARGX	ARGENX SE	103,250 (-27.7%)	$86,828 (-17.5%)	4.5%	$160.49	—	SPONSORED ADR	04016X101
AGIO	AGIOS PHARMACEUTICALS INC	799,163 (-16.6%)	$21,753 (-43.5%)	1.1%	$33.80	+3.8%	COM	00847X104
COGT	COGENT BIOSCIENCES INC	849,030 (-15.8%)	$30,158 (+108.3%)	1.5%	$6.84	+310.7%	COM	19240Q201
EVH	EVOLENT HEALTH INC	2,675,000 (-9.3%)	$10,700 (-57.1%)	0.5%	$20.50	-72.9%	CL A	30050B101
VERA	VERA THERAPEUTICS INC	568,579 (-7.9%)	$28,793 (+60.5%)	1.5%	$35.12	+1.1%	CL A	92337R101
OMDA	OMADA HEALTH INC	740,000 (-19.6%)	$11,677 (-42.6%)	0.6%	$17.31	+17.2%	COM	68170A108
ALNY	ALNYLAM PHARMACEUTICALS INC	71,250 (-4.0%)	$28,333 (-16.3%)	1.5%	$107.54	+311.5%	COM	02043Q107
CAI	CARIS LIFE SCIENCES INC	687,500 (-13.4%)	$18,549 (-22.7%)	1.0%	$26.95	+4.5%	COM	142152107
CMPX	COMPASS THERAPEUTICS INC	3,927,202 (-12.2%)	$21,089 (+34.7%)	1.1%	$3.23	+43.1%	COM	20454B104
ZBIO	ZENAS BIOPHARMA INC	502,077 (-13.5%)	$18,230 (+41.4%)	0.9%	$17.98	+82.9%	COM	98937L105
ACRS	ACLARIS THERAPEUTICS INC	4,453,741 (-3.4%)	$13,406 (+53.1%)	0.7%	$6.19	-59.2%	COM	00461U105
TARS	TARSUS PHARMACEUTICALS INC	260,344 (-9.7%)	$21,317 (+24.4%)	1.1%	$48.01	+55.5%	COM	87650L103
ACLX	ARCELLX INC	169,859 (-5.1%)	$11,075 (-24.6%)	0.6%	$62.26	+28.1%	COMMON STOCK	03940C100
SRRK	SCHOLAR ROCK HLDG CORP	733,477 (-7.6%)	$32,310 (+9.3%)	1.7%	$32.85	+14.2%	COM	80706P103
AGL	AGILON HEALTH INC	6,500,000 (-6.7%)	$4,477 (-37.6%)	0.2%	$29.66	-97.4%	COM	00857U107
NAMS	NEWAMSTERDAM PHARMA COMPANY	557,194 (-6.5%)	$19,546 (+15.3%)	1.0%	$19.88	+83.0%	ORDINARY SHARES	N62509109
ACHC	ACADIA HEALTHCARE COMPANY IN	120,000 (-29.4%)	$1,703 (-59.5%)	0.1%	$53.71	-64.8%	COM	00404A109
RYTM	RHYTHM PHARMACEUTICALS INC	695,010 (-3.1%)	$74,394 (+2.7%)	3.8%	$17.22	+516.0%	COM	76243J105
REGN	REGENERON PHARMACEUTICALS	10,100 (-10.6%)	$7,796 (+22.7%)	0.4%	$587.92	+15.4%	COM	75886F107
XENE	XENON PHARMACEUTICALS INC	787,788 (-7.5%)	$35,309 (+3.2%)	1.8%	$24.19	+73.6%	COM	98420N105
ASND	ASCENDIS PHARMA A/S	203,500 (-5.1%)	$43,394 (+1.8%)	2.2%	$92.14	—	SPONSORED ADR	04351P101
EW	EDWARDS LIFESCIENCES CORP	82,500 (-6.3%)	$7,033 (+2.8%)	0.4%	$63.05	+30.2%	COM	28176E108
CLDX	CELLDEX THERAPEUTICS INC NEW	692,538 (-4.0%)	$18,809 (+0.8%)	1.0%	$32.64	-19.3%	COM NEW	15117B202
INSM	INSMED INC	319,250 (-17.1%)	$55,562 (+0.2%)	2.8%	$39.44	+362.7%	COM PAR $.01	457669307

Unchanged Positions (25)

RVMD REVOLUTION MEDICINES INC 5.5%

Value ($000) $106,354 Shares 1,335,270 Est. Cost $31.87 Unrealized +105.7%

LLY ELI LILLY & CO 5.8%

Value ($000) $113,271 Shares 105,400 Est. Cost $683.47 Unrealized +39.8%

FOLD AMICUS THERAPEUTICS INC 1.4%

Value ($000) $27,482 Shares 1,929,931 Est. Cost $10.81 Unrealized -9.1%

ISRG INTUITIVE SURGICAL INC 2.4%

Value ($000) $46,442 Shares 82,000 Est. Cost $264.69 Unrealized +101.1%

PEN PENUMBRA INC 1.9%

Value ($000) $37,465 Shares 120,500 Est. Cost $179.03 Unrealized +54.3%

MIRM MIRUM PHARMACEUTICALS INC 3.1%

Value ($000) $60,214 Shares 762,294 Est. Cost $14.67 Unrealized +389.4%

MBX MBX BIOSCIENCES INC 0.5%

Value ($000) $8,914 Shares 282,624 Est. Cost $13.37 Unrealized +81.5%

— MERSANA THERAPEUTICS INC 0.2%

Value ($000) $4,414 Shares 152,586 Est. Cost $7.76 Unrealized —

SMMT SUMMIT THERAPEUTICS INC 0.6%

Value ($000) $12,418 Shares 710,000 Est. Cost $14.06 Unrealized +33.8%

ATEC ALPHATEC HLDGS INC 0.3%

Value ($000) $6,365 Shares 302,500 Est. Cost $9.28 Unrealized +99.4%

DHR DANAHER CORPORATION 0.7%

Value ($000) $14,079 Shares 61,500 Est. Cost $216.22 Unrealized +1.5%

PHVS PHARVARIS N V 0.9%

Value ($000) $17,299 Shares 623,402 Est. Cost $26.42 Unrealized -8.8%

GOSS GOSSAMER BIO INC 0.5%

Value ($000) $10,128 Shares 3,266,960 Est. Cost $2.62 Unrealized +9.0%

IRTC IRHYTHM TECHNOLOGIES INC 2.1%

Value ($000) $41,698 Shares 235,000 Est. Cost $74.37 Unrealized +138.3%

SION SIONNA THERAPEUTICS INC 0.2%

Value ($000) $4,091 Shares 99,429 Est. Cost $16.34 Unrealized +132.1%

TMO THERMO FISHER SCIENTIFIC INC 0.3%

Value ($000) $5,795 Shares 10,000 Est. Cost $417.06 Unrealized +35.5%

TLPH TALPHERA INC 0.2%

Value ($000) $4,092 Shares 3,589,186 Est. Cost $0.78 Unrealized +55.2%

ARDX ARDELYX INC 0.7%

Value ($000) $13,406 Shares 2,299,473 Est. Cost $5.10 Unrealized +9.3%

AMLX AMYLYX PHARMACEUTICALS INC 0.3%

Value ($000) $6,037 Shares 499,764 Est. Cost $3.97 Unrealized +242.4%

JSPR JASPER THERAPEUTICS INC 0.1%

Value ($000) $2,014 Shares 1,100,726 Est. Cost $9.61 Unrealized -79.1%

THC TENET HEALTHCARE CORP 1.3%

Value ($000) $24,840 Shares 125,000 Est. Cost $148.69 Unrealized +35.9%

NGNE NEUROGENE INC 0.1%

Value ($000) $2,149 Shares 104,339 Est. Cost $35.51 Unrealized -29.9%

NAMS NEWAMSTERDAM PHARMA COMPANY 0.1%

Value ($000) $1,109 Shares 31,600 Est. Cost $19.88 Unrealized +83.0%

— GOSSAMER BIO INC 0.3%

Value ($000) $6,559 Shares 9,573,000 Est. Cost $1.01 Unrealized —

— NUVATION BIO INC 0.0%

Value ($000) $44 Shares 134,028 Est. Cost $2.67 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
RVMD	REVOLUTION MEDICINES INC	1,335,270	$106,354	5.5%	$31.87	+105.7%	COM	76155X100
LLY	ELI LILLY & CO	105,400	$113,271	5.8%	$683.47	+39.8%	COM	532457108
FOLD	AMICUS THERAPEUTICS INC	1,929,931	$27,482	1.4%	$10.81	-9.1%	COM	03152W109
ISRG	INTUITIVE SURGICAL INC	82,000	$46,442	2.4%	$264.69	+101.1%	COM NEW	46120E602
PEN	PENUMBRA INC	120,500	$37,465	1.9%	$179.03	+54.3%	COM	70975L107
MIRM	MIRUM PHARMACEUTICALS INC	762,294	$60,214	3.1%	$14.67	+389.4%	COM	604749101
MBX	MBX BIOSCIENCES INC	282,624	$8,914	0.5%	$13.37	+81.5%	COM	55287L101
—	MERSANA THERAPEUTICS INC	152,586	$4,414	0.2%	$7.76	—	COM	59045L205
SMMT	SUMMIT THERAPEUTICS INC	710,000	$12,418	0.6%	$14.06	+33.8%	COM	86627T108
ATEC	ALPHATEC HLDGS INC	302,500	$6,365	0.3%	$9.28	+99.4%	COM NEW	02081G201
DHR	DANAHER CORPORATION	61,500	$14,079	0.7%	$216.22	+1.5%	COM	235851102
PHVS	PHARVARIS N V	623,402	$17,299	0.9%	$26.42	-8.8%	COM	N69605108
GOSS	GOSSAMER BIO INC	3,266,960	$10,128	0.5%	$2.62	+9.0%	COM	38341P102
IRTC	IRHYTHM TECHNOLOGIES INC	235,000	$41,698	2.1%	$74.37	+138.3%	COM	450056106
SION	SIONNA THERAPEUTICS INC	99,429	$4,091	0.2%	$16.34	+132.1%	COM	829401108
TMO	THERMO FISHER SCIENTIFIC INC	10,000	$5,795	0.3%	$417.06	+35.5%	COM	883556102
TLPH	TALPHERA INC	3,589,186	$4,092	0.2%	$0.78	+55.2%	COM NEW	00444T209
ARDX	ARDELYX INC	2,299,473	$13,406	0.7%	$5.10	+9.3%	COM	039697107
AMLX	AMYLYX PHARMACEUTICALS INC	499,764	$6,037	0.3%	$3.97	+242.4%	COM	03237H101
JSPR	JASPER THERAPEUTICS INC	1,100,726	$2,014	0.1%	$9.61	-79.1%	COM NEW	471871202
THC	TENET HEALTHCARE CORP	125,000	$24,840	1.3%	$148.69	+35.9%	COM NEW	88033G407
NGNE	NEUROGENE INC	104,339	$2,149	0.1%	$35.51	-29.9%	COM	64135M105
NAMS	NEWAMSTERDAM PHARMA COMPANY	31,600	$1,109	0.1%	$19.88	+83.0%	CALL	N62509109
—	GOSSAMER BIO INC	9,573,000	$6,559	0.3%	$1.01	—	NOTE 5.000% 6/0	38341PAA0
—	NUVATION BIO INC	134,028	$44	0.0%	$2.67	—	*W EXP 02/10/202	67080N119