Ticker: APGE CUSIP: 03770N101 Class: Common Stock
Note: Option positions (PUT/CALL) are excluded.
| Institution | Shares | Value ($000) |
|---|---|---|
| First Light Asset Management, LLC | 284,991 | $21,511 |
| STEMPOINT CAPITAL LP | 80,574 | $6,082 |
| Nicholas Investment Partners, LP | 112,924 | $8,524 |
| EVENTIDE ASSET MANAGEMENT, LLC | 436,015 | $32,910 |
| Avoro Capital Advisors LLC | 500,000 | $37,740 |
| ACT CAPITAL MANAGEMENT, LLC | 7,000 | $528 |
| SEVEN GRAND MANAGERS, LLC | 50,000 | $3,774 |
| FORA Capital, LLC | 18,200 | $1,374 |
| Neo Ivy Capital Management | 10,910 | $823 |
| Cinctive Capital Management LP | 33,264 | $2,511 |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 6,324 | $477 |
| FOX RUN MANAGEMENT, L.L.C. | 6,371 | $481 |
| JENNISON ASSOCIATES LLC | 578,627 | $43,675 |
| Pictet Asset Management Holding SA | 312,883 | $23,616 |
| LOOMIS SAYLES & CO L P | 255,439 | $19,281 |
| Quarry LP | 2,500 | $189 |
| FEDERATED HERMES, INC. | 127,931 | $9,656 |
| BANQUE PICTET & CIE SA | 41,800 | $3,155 |
| Vestmark Advisory Solutions, Inc. | 12,674 | $957 |
| Schonfeld Strategic Advisors LLC | 29,145 | $2,200 |
| Institution | Prev Shares | Curr Shares | Change |
|---|---|---|---|
| GREAT POINT PARTNERS LLC | 304,000 | 374,000 | +70,000 (+23.0%) |
| PERCEPTIVE ADVISORS LLC | 1,351,989 | 2,330,651 | +978,662 (+72.4%) |
| First Turn Management, LLC | 402,811 | 474,839 | +72,028 (+17.9%) |
| Novo Holdings A/S | 500,000 | 570,000 | +70,000 (+14.0%) |
| Opaleye Management Inc. | 363,257 | 388,257 | +25,000 (+6.9%) |
| Affinity Asset Advisors, LLC | 1,173,426 | 1,234,926 | +61,500 (+5.2%) |
| Vestal Point Capital, LP | 425,000 | 550,000 | +125,000 (+29.4%) |
| Boxer Capital Management, LLC | 50,000 | 70,000 | +20,000 (+40.0%) |
| AlphaCentric Advisors LLC | 5,649 | 10,751 | +5,102 (+90.3%) |
| Parkman Healthcare Partners LLC | 105,831 | 130,069 | +24,238 (+22.9%) |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 374,407 | 480,453 | +106,046 (+28.3%) |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,158,502 | 2,183,704 | +25,202 (+1.2%) |
| JANUS HENDERSON GROUP PLC | 485,978 | 2,062,604 | +1,576,626 (+324.4%) |
| T. Rowe Price Investment Management, Inc. | 1,441 | 1,555,987 | +1,554,546 (+107879.7%) |
| Woodline Partners LP | 57,321 | 210,466 | +153,145 (+267.2%) |
| Candriam S.C.A. | 126,081 | 191,318 | +65,237 (+51.7%) |
| XTX Topco Ltd | 5,852 | 19,026 | +13,174 (+225.1%) |
| FMR LLC | 6,916,462 | 8,225,038 | +1,308,576 (+18.9%) |
| BlackRock, Inc. | 2,686,026 | 3,783,994 | +1,097,968 (+40.9%) |
| ALPS ADVISORS INC | 22,506 | 44,922 | +22,416 (+99.6%) |
| Institution | Prev Shares | Curr Shares | Change |
|---|---|---|---|
| BRAIDWELL LP | 1,438,745 | 575,067 | -863,678 (-60.0%) |
| Paradigm Biocapital Advisors LP | 1,521,757 | 1,123,243 | -398,514 (-26.2%) |
| Exane Asset Management | 51,543 | 52 | -51,491 (-99.9%) |
| HighVista Strategies LLC | 107,107 | 89,229 | -17,878 (-16.7%) |
| B Group, Inc. | 35,000 | 20,000 | -15,000 (-42.9%) |
| PLATINUM INVESTMENT MANAGEMENT LTD | 93,728 | 69,212 | -24,516 (-26.2%) |
| Sofinnova Investments, Inc. | 565,417 | 534,845 | -30,572 (-5.4%) |
| Persistent Asset Partners Ltd | 14,819 | 2,445 | -12,374 (-83.5%) |
| Granahan Investment Management, LLC | 132,400 | 94,720 | -37,680 (-28.5%) |
| J. Goldman & Co LP | 62,577 | 3,466 | -59,111 (-94.5%) |
| Blackstone Inc. | 190,352 | 51,827 | -138,525 (-72.8%) |
| MERCER GLOBAL ADVISORS INC /ADV | 970,581 | 890,665 | -79,916 (-8.2%) |
| MILLENNIUM MANAGEMENT LLC | 430,463 | 140,727 | -289,736 (-67.3%) |
| ALLIANCEBERNSTEIN L.P. | 1,419,132 | 1,093,657 | -325,475 (-22.9%) |
| Verition Fund Management LLC | 49,523 | 12,700 | -36,823 (-74.4%) |
| CITADEL ADVISORS LLC | 1,169,244 | 766,981 | -402,263 (-34.4%) |
| FRANKLIN RESOURCES INC | 730,761 | 451,002 | -279,759 (-38.3%) |
| BARCLAYS PLC | 365,046 | 133,193 | -231,853 (-63.5%) |
| SummitTX Capital, L.P. | 26,607 | 20,972 | -5,635 (-21.2%) |
| Moody Aldrich Partners LLC | 18,012 | 17,164 | -848 (-4.7%) |
| Institution | Prev Shares | Prev Value ($000) |
|---|---|---|
| Exome Asset Management LLC | 94,400 | $3,751 |
| Commodore Capital LP | 290,000 | $11,522 |
| DIADEMA PARTNERS LP | 64,250 | $2,553 |
| TANG CAPITAL MANAGEMENT LLC | 200,000 | $7,946 |
| Jefferies Financial Group Inc. | 568,084 | $22,570 |
| PRELUDE CAPITAL MANAGEMENT, LLC | 26,241 | $1,043 |
| Aquatic Capital Management LLC | 39,332 | $1,563 |
| Family Manage LLC | 5,589 | $222 |
| ExodusPoint Capital Management, LP | 37,535 | $1,491 |
| BALYASNY ASSET MANAGEMENT L.P. | 72,348 | $2,874 |
| Caption Management, LLC | 4,800 | $191 |
| Caitong International Asset Management Co., Ltd | 97 | $4 |
| Washington Trust Advisors, Inc. | 96 | $4 |
| NATIXIS ADVISORS, L.P. | 12,475 | $0 |
| Rise Advisors, LLC | 16 | $1 |
| Federation des caisses Desjardins du Quebec | 10 | $0 |
| PRINCIPAL SECURITIES, INC. | 5 | $0 |
| MONTAG A & ASSOCIATES INC | 4 | $0 |