BICYCLE THERAPEUTICS PLC

Institution	Shares	Value ($000)
Forefront Analytics, LLC	13,371	$95
FOX RUN MANAGEMENT, L.L.C.	19,771	$140
SCHRODER INVESTMENT MANAGEMENT GROUP	584,770	$3,976
Marex Group plc	78,406	$555
Walleye Capital LLC	111,659	$791
Pinnacle Wealth Management Advisory Group, LLC	10,000	$71
Brooklyn Investment Group	10,216	$69
Aquatic Capital Management LLC	18,817	$133
MARSHALL WACE, LLP	38,795	$275
BNP Paribas Investment Partners S.A.	568,225	$4
GOLDMAN SACHS GROUP INC	24,732	$175
D. E. Shaw & Co., Inc.	21,548	$153
SIMPLEX TRADING, LLC	19,986	$142
RAYMOND JAMES FINANCIAL INC	12,336	$87
Vontobel Holding Ltd.	10,000	$71
Invesco Ltd.	10,092	$71
Farther Finance Advisors, LLC	218	$2
SRS Capital Advisors, Inc.	29	$0

Increased Positions (32)

Birchview Capital, LP

Value ($000) $3,276 (+174.8%) Shares 462,700 (+200.5%)

Long Focus Capital Management, LLC

Value ($000) $11,562 (+5.3%) Shares 1,633,091 (+15.1%)

MONIMUS CAPITAL MANAGEMENT, LP

Value ($000) $664 (+0.7%) Shares 93,840 (+10.1%)

ARMISTICE CAPITAL, LLC

Value ($000) $22,911 (-0.6%) Shares 3,236,000 (+8.7%)

Virtus Investment Advisers, LLC

Value ($000) $253 (+149.5%) Shares 35,709 (+172.7%)

Rangeley Capital, LLC

Value ($000) $935 (-7.1%) Shares 132,000 (+1.5%)

MOORE CAPITAL MANAGEMENT, LP

Value ($000) $1,947 (+101.2%) Shares 275,000 (+120.0%)

XTX Topco Ltd

Value ($000) $338 (+274.4%) Shares 47,674 (+309.3%)

WESTFIELD CAPITAL MANAGEMENT CO LP

Value ($000) $21,353 (-6.6%) Shares 3,016,026 (+2.2%)

CITADEL ADVISORS LLC

Value ($000) $1,921 (+31.3%) Shares 271,383 (+43.6%)

SUSQUEHANNA INTERNATIONAL GROUP, LLP

Value ($000) $768 (+272.4%) Shares 108,423 (+307.2%)

RENAISSANCE TECHNOLOGIES LLC

Value ($000) $4,012 (-0.1%) Shares 566,600 (+9.2%)

Candriam S.C.A.

Value ($000) $8,442 (-7.0%) Shares 1,192,279 (+1.7%)

Quadrature Capital Ltd

Value ($000) $331 (+53.4%) Shares 46,728 (+67.5%)

WOODSTOCK CORP

Value ($000) $206 (+11.4%) Shares 29,146 (+21.8%)

BlackRock, Inc.

Value ($000) $2,357 (+7.8%) Shares 332,889 (+17.9%)

ALPS ADVISORS INC

Value ($000) $290 (+55.5%) Shares 40,995 (+69.9%)

Engineers Gate Manager LP

Value ($000) $170 (+63.9%) Shares 24,047 (+79.2%)

State of Tennessee, Department of Treasury

Value ($000) $393 (+13.1%) Shares 61,153 (+36.4%)

Jump Financial, LLC

Value ($000) $219 (+32.4%) Shares 31,000 (+44.7%)

Institution	Prev Shares	Curr Shares	Change
Birchview Capital, LP	154,000	462,700	+308,700 (+200.5%)
Long Focus Capital Management, LLC	1,418,695	1,633,091	+214,396 (+15.1%)
MONIMUS CAPITAL MANAGEMENT, LP	85,224	93,840	+8,616 (+10.1%)
ARMISTICE CAPITAL, LLC	2,978,000	3,236,000	+258,000 (+8.7%)
Virtus Investment Advisers, LLC	13,094	35,709	+22,615 (+172.7%)
Rangeley Capital, LLC	130,000	132,000	+2,000 (+1.5%)
MOORE CAPITAL MANAGEMENT, LP	125,000	275,000	+150,000 (+120.0%)
XTX Topco Ltd	11,648	47,674	+36,026 (+309.3%)
WESTFIELD CAPITAL MANAGEMENT CO LP	2,952,543	3,016,026	+63,483 (+2.2%)
CITADEL ADVISORS LLC	189,027	271,383	+82,356 (+43.6%)
SUSQUEHANNA INTERNATIONAL GROUP, LLP	26,629	108,423	+81,794 (+307.2%)
RENAISSANCE TECHNOLOGIES LLC	518,700	566,600	+47,900 (+9.2%)
Candriam S.C.A.	1,172,387	1,192,279	+19,892 (+1.7%)
Quadrature Capital Ltd	27,894	46,728	+18,834 (+67.5%)
WOODSTOCK CORP	23,927	29,146	+5,219 (+21.8%)
BlackRock, Inc.	282,418	332,889	+50,471 (+17.9%)
ALPS ADVISORS INC	24,123	40,995	+16,872 (+69.9%)
Engineers Gate Manager LP	13,421	24,047	+10,626 (+79.2%)
State of Tennessee, Department of Treasury	44,842	61,153	+16,311 (+36.4%)
Jump Financial, LLC	21,421	31,000	+9,579 (+44.7%)

Decreased Positions (27)

Point72 Asset Management, L.P.

Value ($000) $544 (-83.7%) Shares 76,779 (-82.2%)

MILLENNIUM MANAGEMENT LLC

Value ($000) $2,313 (-71.7%) Shares 326,626 (-69.0%)

Eversept Partners, LP

Value ($000) $1,267 (-15.8%) Shares 178,915 (-8.0%)

Jefferies Financial Group Inc.

Value ($000) $2,105 (-32.4%) Shares 297,247 (-26.0%)

BANK OF AMERICA CORP /DE/

Value ($000) $683 (-85.1%) Shares 96,401 (-83.7%)

MORGAN STANLEY

Value ($000) $3,294 (-48.3%) Shares 465,222 (-43.5%)

Legal & General Group Plc

Value ($000) $64 (-95.8%) Shares 9,054 (-95.4%)

TWO SIGMA INVESTMENTS, LP

Value ($000) $935 (-34.6%) Shares 132,032 (-28.5%)

JANE STREET GROUP, LLC

Value ($000) $447 (-43.6%) Shares 63,190 (-38.3%)

TD Asset Management Inc

Value ($000) $1,048 (-24.0%) Shares 147,992 (-16.9%)

GEODE CAPITAL MANAGEMENT, LLC

Value ($000) $178 (-42.4%) Shares 25,129 (-37.1%)

MANUFACTURERS LIFE INSURANCE COMPANY, THE

Value ($000) $869 (-20.0%) Shares 127,863 (-9.0%)

TWO SIGMA ADVISERS, LP

Value ($000) $1,034 (-14.7%) Shares 146,100 (-6.8%)

PINNACLE ASSOCIATES LTD

Value ($000) $1,349 (-11.4%) Shares 190,480 (-3.1%)

STATE STREET CORP

Value ($000) $497 (-13.7%) Shares 70,178 (-5.7%)

ROYAL BANK OF CANADA

Value ($000) $76 (-23.2%) Shares 10,682 (-16.1%)

CITIGROUP INC

Value ($000) $9 (-54.6%) Shares 1,291 (-50.4%)

Cerity Partners LLC

Value ($000) $95 (-14.9%) Shares 13,350 (-7.0%)

GAMMA Investing LLC

Value ($000) $10 (-40.1%) Shares 1,386 (-34.5%)

China Universal Asset Management Co., Ltd.

Value ($000) $53 (-14.9%) Shares 7,540 (-7.0%)

Institution	Prev Shares	Curr Shares	Change
Point72 Asset Management, L.P.	430,900	76,779	-354,121 (-82.2%)
MILLENNIUM MANAGEMENT LLC	1,054,746	326,626	-728,120 (-69.0%)
Eversept Partners, LP	194,440	178,915	-15,525 (-8.0%)
Jefferies Financial Group Inc.	401,926	297,247	-104,679 (-26.0%)
BANK OF AMERICA CORP /DE/	591,535	96,401	-495,134 (-83.7%)
MORGAN STANLEY	822,705	465,222	-357,483 (-43.5%)
Legal & General Group Plc	197,917	9,054	-188,863 (-95.4%)
TWO SIGMA INVESTMENTS, LP	184,537	132,032	-52,505 (-28.5%)
JANE STREET GROUP, LLC	102,459	63,190	-39,269 (-38.3%)
TD Asset Management Inc	178,092	147,992	-30,100 (-16.9%)
GEODE CAPITAL MANAGEMENT, LLC	39,925	25,129	-14,796 (-37.1%)
MANUFACTURERS LIFE INSURANCE COMPANY, THE	140,492	127,863	-12,629 (-9.0%)
TWO SIGMA ADVISERS, LP	156,700	146,100	-10,600 (-6.8%)
PINNACLE ASSOCIATES LTD	196,618	190,480	-6,138 (-3.1%)
STATE STREET CORP	74,405	70,178	-4,227 (-5.7%)
ROYAL BANK OF CANADA	12,733	10,682	-2,051 (-16.1%)
CITIGROUP INC	2,601	1,291	-1,310 (-50.4%)
Cerity Partners LLC	14,350	13,350	-1,000 (-7.0%)
GAMMA Investing LLC	2,116	1,386	-730 (-34.5%)
China Universal Asset Management Co., Ltd.	8,104	7,540	-564 (-7.0%)

Exited Positions (11)

Dynamic Technology Lab Private Ltd

Value ($000) $216 Shares 27,959

Graham Capital Management, L.P.

Value ($000) $96 Shares 12,375

AMERIPRISE FINANCIAL INC

Value ($000) $116 Shares 14,972

Squarepoint Ops LLC

Value ($000) $103 Shares 13,259

Handelsbanken Fonder AB

Value ($000) $1 Shares 150,000

Manchester Capital Management LLC

Value ($000) $5 Shares 590

Walleye Trading LLC

Value ($000) $5 Shares 630

TOTH FINANCIAL ADVISORY CORP

Value ($000) $1 Shares 150

PRINCIPAL SECURITIES, INC.

Value ($000) $0 Shares 18

OSAIC HOLDINGS, INC.

Value ($000) $0 Shares 18

Ronald Blue Trust, Inc.

Value ($000) $0 Shares 11

Institution	Prev Shares	Prev Value ($000)
Dynamic Technology Lab Private Ltd	27,959	$216
Graham Capital Management, L.P.	12,375	$96
AMERIPRISE FINANCIAL INC	14,972	$116
Squarepoint Ops LLC	13,259	$103
Handelsbanken Fonder AB	150,000	$1
Manchester Capital Management LLC	590	$5
Walleye Trading LLC	630	$5
TOTH FINANCIAL ADVISORY CORP	150	$1
PRINCIPAL SECURITIES, INC.	18	$0
OSAIC HOLDINGS, INC.	18	$0
Ronald Blue Trust, Inc.	11	$0