| Point72 Asset Management, L.P. | 5,961,631 | $5,931 |
| DAFNA Capital Management LLC | 2,793,586 | $2,779 |
| VANGUARD GROUP INC | 2,103,869 | $2,093 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,838,700 | $1,829 |
| TWO SIGMA INVESTMENTS, LP | 1,495,916 | $1,488 |
| Spruce Street Capital LP | 1,421,532 | $1,414 |
| RENAISSANCE TECHNOLOGIES LLC | 1,349,200 | $1,342 |
| TWO SIGMA ADVISERS, LP | 1,267,700 | $1,261 |
| Casdin Capital, LLC | 1,228,190 | $1,222 |
| ACADIAN ASSET MANAGEMENT LLC | 1,217,103 | $1 |
| Syncona Portfolio Ltd | 1,213,056 | $1,207 |
| MILLENNIUM MANAGEMENT LLC | 610,387 | $607 |
| BlackRock, Inc. | 601,866 | $599 |
| SUPERSTRING CAPITAL MANAGEMENT LP | 462,963 | $461 |
| GEODE CAPITAL MANAGEMENT, LLC | 456,115 | $454 |
| GSA CAPITAL PARTNERS LLP | 333,199 | $0 |
| CITADEL ADVISORS LLC | 319,457 | $318 |
| UBS Group AG | 214,501 | $213 |
| STATE STREET CORP | 127,443 | $127 |
| NORTHERN TRUST CORP | 105,052 | $105 |
| RAYMOND JAMES FINANCIAL INC | 91,323 | $91 |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 77,797 | $70 |
| ALGERT GLOBAL LLC | 76,800 | $0 |
| FMR LLC | 71,540 | $71 |
| PRUDENTIAL FINANCIAL INC | 59,800 | $59 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 50,104 | $50 |
| JANE STREET GROUP, LLC | 45,194 | $45 |
| HARBOURVEST PARTNERS LLC | 29,018 | $29 |
| Parametrica Management Ltd | 27,840 | $28 |
| XTX Topco Ltd | 15,333 | $15 |
| Quadrant Private Wealth Management, LLC | 15,286 | $15 |
| Scientech Research LLC | 12,355 | $12 |
| Advisors Asset Management, Inc. | 8,313 | $8 |
| JPMORGAN CHASE & CO | 3,077 | $3 |
| SIMPLEX TRADING, LLC | 2,397 | $2 |
| SBI Securities Co., Ltd. | 1,530 | $2 |
| BNP PARIBAS ARBITRAGE, SA | 1,447 | $1 |
| NISA INVESTMENT ADVISORS, LLC | 883 | $1 |
| BANK OF AMERICA CORP /DE/ | 525 | $1 |
| MARK SHEPTOFF FINANCIAL PLANNING, LLC | 500 | $0 |
| SRS Capital Advisors, Inc. | 99 | $0 |
| ROYAL BANK OF CANADA | 69 | $0 |
| WELLS FARGO & COMPANY/MN | 40 | $0 |
| Optiver Holding B.V. | 32 | $0 |
| CITIGROUP INC | 1 | $0 |
| Smartleaf Asset Management LLC | 1 | $0 |
| BARCLAYS PLC | 1 | $0 |