| BlackRock, Inc. | 8,837,574 | $82,366 |
| Atlas Venture Life Science Advisors, LLC | 6,412,560 | $59,765 |
| VANGUARD GROUP INC | 6,282,376 | $58,552 |
| FMR LLC | 5,717,008 | $53,283 |
| Vestal Point Capital, LP | 5,200,000 | $48,464 |
| STATE STREET CORP | 4,289,566 | $39,979 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,723,131 | $34,700 |
| Pictet Asset Management Holding SA | 2,990,801 | $27,874 |
| AIGH Capital Management LLC | 1,992,021 | $18,566 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,877,838 | $17,505 |
| Hudson Bay Capital Management LP | 1,700,000 | $15,844 |
| MORGAN STANLEY | 1,550,274 | $14,449 |
| GOLDMAN SACHS GROUP INC | 1,506,234 | $14,038 |
| BALYASNY ASSET MANAGEMENT L.P. | 1,489,924 | $13,886 |
| Qube Research & Technologies Ltd | 1,486,562 | $13,855 |
| CITADEL ADVISORS LLC | 1,359,613 | $12,672 |
| MILLENNIUM MANAGEMENT LLC | 1,349,919 | $12,581 |
| RENAISSANCE TECHNOLOGIES LLC | 1,305,084 | $12,163 |
| Jefferies Financial Group Inc. | 1,121,502 | $10,452 |
| BANK OF AMERICA CORP /DE/ | 1,083,818 | $10,101 |
| DIMENSIONAL FUND ADVISORS LP | 1,037,312 | $9,667 |
| DAFNA Capital Management LLC | 999,163 | $9,312 |
| JANE STREET GROUP, LLC | 845,154 | $7,877 |
| MAK CAPITAL ONE LLC | 826,205 | $7,700 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 737,660 | $6,875 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 729,281 | $6,797 |
| Jump Financial, LLC | 667,120 | $6,218 |
| Parkman Healthcare Partners LLC | 645,544 | $6,016 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 633,694 | $5,906 |
| NORTHERN TRUST CORP | 617,035 | $5,751 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 569,624 | $5,229 |
| Pale Fire Capital SE | 544,063 | $5,071 |
| KENNEDY CAPITAL MANAGEMENT LLC | 542,848 | $5,059 |
| ALGERT GLOBAL LLC | 535,290 | $5 |
| Nuveen, LLC | 522,455 | $4,869 |
| BNP PARIBAS ARBITRAGE, SA | 453,311 | $4,225 |
| HRT FINANCIAL LP | 450,938 | $4 |
| AQR CAPITAL MANAGEMENT LLC | 431,758 | $4,024 |
| SG Americas Securities, LLC | 350,092 | $3 |
| Hennion & Walsh Asset Management, Inc. | 313,455 | $2,921 |
| Schonfeld Strategic Advisors LLC | 300,102 | $2,797 |
| Logos Global Management LP | 300,000 | $2,796 |
| BARCLAYS PLC | 292,325 | $2,724 |
| Y-Intercept (Hong Kong) Ltd | 282,025 | $2,628 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 255,022 | $2,377 |
| GROUP ONE TRADING, L.P. | 253,143 | $2,359 |
| Bank of New York Mellon Corp | 211,546 | $1,972 |
| Stonepine Capital Management, LLC | 200,000 | $1,864 |
| Man Group plc | 197,096 | $1,837 |
| Fisher Asset Management, LLC | 191,823 | $1,788 |
| UBS Group AG | 170,728 | $1,591 |
| NORGES BANK | 169,000 | $1,575 |
| Rafferty Asset Management, LLC | 157,010 | $1,463 |
| Point72 Asset Management, L.P. | 156,206 | $1,456 |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 150,925 | $1,407 |
| GC Wealth Management RIA, LLC | 150,030 | $1,398 |
| SPHERA FUNDS MANAGEMENT LTD. | 145,371 | $1,355 |
| Russell Investments Group, Ltd. | 143,079 | $1,334 |
| GSA CAPITAL PARTNERS LLP | 142,809 | $1 |
| Swiss National Bank | 141,500 | $1,319 |
| XTX Topco Ltd | 128,440 | $1,197 |
| UBS ASSET MANAGEMENT AMERICAS INC | 124,422 | $1,160 |
| Invesco Ltd. | 123,994 | $1,156 |
| NOMURA HOLDINGS INC | 115,000 | $1,072 |
| WELLS FARGO & COMPANY/MN | 114,716 | $1,069 |
| RHUMBLINE ADVISERS | 111,679 | $1,041 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 110,000 | $1,025 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 102,456 | $1 |
| Squarepoint Ops LLC | 100,612 | $938 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 100,314 | $706 |
| ORACLE INVESTMENT MANAGEMENT INC | 100,000 | $932 |
| AMERIPRISE FINANCIAL INC | 87,073 | $812 |
| ALPS ADVISORS INC | 84,304 | $786 |
| PERKINS CAPITAL MANAGEMENT INC | 84,000 | $783 |
| Virtus Investment Advisers, LLC | 81,747 | $762 |
| AMERICAN CENTURY COMPANIES INC | 78,925 | $736 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 72,219 | $673 |
| ALLIANCEBERNSTEIN L.P. | 67,790 | $632 |
| Legal & General Group Plc | 63,668 | $593 |
| TUDOR INVESTMENT CORP ET AL | 62,316 | $581 |
| PROFUND ADVISORS LLC | 58,129 | $542 |
| Susquehanna Portfolio Strategies, LLC | 57,379 | $535 |
| DEUTSCHE BANK AG\ | 57,010 | $531 |
| FRANKLIN RESOURCES INC | 52,726 | $491 |
| Erste Asset Management GmbH | 51,200 | $480 |
| Graham Capital Management, L.P. | 50,355 | $469 |
| HSBC HOLDINGS PLC | 49,333 | $455 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 45,613 | $424 |
| MetLife Investment Management, LLC | 43,664 | $407 |
| JPMORGAN CHASE & CO | 43,530 | $406 |
| Brevan Howard Capital Management LP | 43,284 | $403 |
| Lion Point Capital, LP | 42,000 | $391 |
| OSAIC HOLDINGS, INC. | 39,490 | $368 |
| ExodusPoint Capital Management, LP | 39,321 | $366 |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 38,520 | $359 |
| CANADA PENSION PLAN INVESTMENT BOARD | 38,500 | $359 |
| SEI INVESTMENTS CO | 37,514 | $350 |
| INTECH INVESTMENT MANAGEMENT LLC | 36,058 | $336 |
| DARK FOREST CAPITAL MANAGEMENT LP | 35,562 | $331 |
| AlphaQuest LLC | 35,326 | $329 |
| 82 other institutions | 861,172 | $7,881 |