FENNEC PHARMACEUTICALS INC

Institution	Shares	Value ($000)
Potomac Capital Management, Inc.	95,100	$732
AWM Investment Company, Inc.	711,869	$5,481
APIS CAPITAL ADVISORS, LLC	204,000	$1,571
Stonepine Capital Management, LLC	50,000	$385
1492 Capital Management LLC	28,092	$216
Hillsdale Investment Management Inc.	44,000	$339
Trexquant Investment LP	51,380	$396
MARSHALL WACE, LLP	127,693	$983
Qube Research & Technologies Ltd	44,692	$344
Point72 Asset Management, L.P.	21,298	$164
DEUTSCHE BANK AG\	17,365	$134
TWO SIGMA ADVISERS, LP	13,000	$100
LAZARD ASSET MANAGEMENT LLC	13,121	$101
Squarepoint Ops LLC	13,109	$101
Pinnacle Wealth Planning Services, Inc.	507	$4
UBS ASSET MANAGEMENT AMERICAS INC	303	$2
Quaker Wealth Management, LLC	160	$1
OPTIMA CAPITAL LLC	63	$0
State of Alaska, Department of Revenue	1,570	$0
True Wealth Design, LLC	1	$0

Increased Positions (25)

Solas Capital Management, LLC

Value ($000) $19,718 (-3.7%) Shares 2,560,726 (+17.0%)

AIGH Capital Management LLC

Value ($000) $12,178 (+90.9%) Shares 1,581,501 (+132.1%)

Rosalind Advisors, Inc.

Value ($000) $20,124 (+3.5%) Shares 2,613,508 (+25.8%)

BRIDGEWAY CAPITAL MANAGEMENT, LLC

Value ($000) $639 (+122.4%) Shares 83,005 (+170.4%)

VANGUARD GROUP INC

Value ($000) $8,221 (-8.1%) Shares 1,067,651 (+11.7%)

CITADEL ADVISORS LLC

Value ($000) $1,538 (+52.9%) Shares 199,749 (+85.8%)

STATE OF WISCONSIN INVESTMENT BOARD

Value ($000) $393 (+30.7%) Shares 51,000 (+58.9%)

BlackRock, Inc.

Value ($000) $9,504 (-16.2%) Shares 1,234,277 (+1.9%)

XTX Topco Ltd

Value ($000) $206 (+3.7%) Shares 26,786 (+26.1%)

GOLDMAN SACHS GROUP INC

Value ($000) $336 (+35.4%) Shares 43,589 (+64.5%)

JONES FINANCIAL COMPANIES LLLP

Value ($000) $192 (+126.1%) Shares 24,952 (+165.4%)

MILLENNIUM MANAGEMENT LLC

Value ($000) $188 (+66.2%) Shares 24,402 (+102.1%)

STATE STREET CORP

Value ($000) $2,716 (-14.9%) Shares 352,775 (+3.4%)

RENAISSANCE TECHNOLOGIES LLC

Value ($000) $154 (+55.2%) Shares 20,000 (+88.7%)

MORGAN STANLEY

Value ($000) $1,867 (-14.2%) Shares 242,476 (+4.3%)

WELLS FARGO & COMPANY/MN

Value ($000) $201 (+26.5%) Shares 26,159 (+53.7%)

BANK OF AMERICA CORP /DE/

Value ($000) $174 (+37.9%) Shares 22,533 (+67.6%)

ARROWSTREET CAPITAL, LIMITED PARTNERSHIP

Value ($000) $250 (-1.3%) Shares 32,460 (+20.0%)

BARCLAYS PLC

Value ($000) $282 (+80.0%) Shares 36,597 (+16.9%)

MetLife Investment Management, LLC

Value ($000) $100 (+11.6%) Shares 13,019 (+35.7%)

Institution	Prev Shares	Curr Shares	Change
Solas Capital Management, LLC	2,187,902	2,560,726	+372,824 (+17.0%)
AIGH Capital Management LLC	681,501	1,581,501	+900,000 (+132.1%)
Rosalind Advisors, Inc.	2,076,840	2,613,508	+536,668 (+25.8%)
BRIDGEWAY CAPITAL MANAGEMENT, LLC	30,700	83,005	+52,305 (+170.4%)
VANGUARD GROUP INC	955,764	1,067,651	+111,887 (+11.7%)
CITADEL ADVISORS LLC	107,496	199,749	+92,253 (+85.8%)
STATE OF WISCONSIN INVESTMENT BOARD	32,100	51,000	+18,900 (+58.9%)
BlackRock, Inc.	1,211,806	1,234,277	+22,471 (+1.9%)
XTX Topco Ltd	21,247	26,786	+5,539 (+26.1%)
GOLDMAN SACHS GROUP INC	26,490	43,589	+17,099 (+64.5%)
JONES FINANCIAL COMPANIES LLLP	9,400	24,952	+15,552 (+165.4%)
MILLENNIUM MANAGEMENT LLC	12,077	24,402	+12,325 (+102.1%)
STATE STREET CORP	341,201	352,775	+11,574 (+3.4%)
RENAISSANCE TECHNOLOGIES LLC	10,600	20,000	+9,400 (+88.7%)
MORGAN STANLEY	232,402	242,476	+10,074 (+4.3%)
WELLS FARGO & COMPANY/MN	17,015	26,159	+9,144 (+53.7%)
BANK OF AMERICA CORP /DE/	13,443	22,533	+9,090 (+67.6%)
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	27,055	32,460	+5,405 (+20.0%)
BARCLAYS PLC	31,319	36,597	+5,278 (+16.9%)
MetLife Investment Management, LLC	9,593	13,019	+3,426 (+35.7%)

Decreased Positions (22)

Lion Point Capital, LP

Value ($000) $866 (-24.8%) Shares 112,434 (-8.6%)

Southpoint Capital Advisors LP

Value ($000) $21,135 (-44.6%) Shares 2,744,741 (-32.7%)

JANE STREET GROUP, LLC

Value ($000) $185 (-72.8%) Shares 24,044 (-66.9%)

NORTHERN TRUST CORP

Value ($000) $863 (-29.4%) Shares 112,092 (-14.1%)

UBS Group AG

Value ($000) $38 (-70.0%) Shares 4,995 (-63.6%)

RHUMBLINE ADVISERS

Value ($000) $224 (-28.7%) Shares 29,038 (-13.4%)

GEODE CAPITAL MANAGEMENT, LLC

Value ($000) $2,288 (-18.7%) Shares 297,100 (-1.2%)

Bank of New York Mellon Corp

Value ($000) $379 (-22.5%) Shares 49,219 (-5.9%)

INTECH INVESTMENT MANAGEMENT LLC

Value ($000) $80 (-24.5%) Shares 10,452 (-8.2%)

Russell Investments Group, Ltd.

Value ($000) $23 (-34.5%) Shares 2,924 (-20.4%)

Quadrature Capital Ltd

Value ($000) $114 (-20.8%) Shares 14,761 (-3.7%)

PNC Financial Services Group, Inc.

Value ($000) $5 (-45.9%) Shares 637 (-34.2%)

FMR LLC

Value ($000) $19 (-26.8%) Shares 2,423 (-11.0%)

CITIGROUP INC

Value ($000) $4 (-45.9%) Shares 530 (-34.6%)

CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM

Value ($000) $11 (-30.2%) Shares 1,441 (-15.2%)

Tower Research Capital LLC (TRC)

Value ($000) $11 (-29.9%) Shares 1,384 (-14.8%)

Sterling Capital Management LLC

Value ($000) $8 (-29.3%) Shares 1,030 (-14.0%)

NATIONAL BANK OF CANADA /FI/

Value ($000) $1 (-59.4%) Shares 97 (-47.8%)

OSAIC HOLDINGS, INC.

Value ($000) $1 (-32.4%) Shares 75 (-20.2%)

Hughes Financial Services, LLC

Value ($000) $1 (-9.9%) Shares 97 (-10.2%)

Institution	Prev Shares	Curr Shares	Change
Lion Point Capital, LP	123,000	112,434	-10,566 (-8.6%)
Southpoint Capital Advisors LP	4,077,214	2,744,741	-1,332,473 (-32.7%)
JANE STREET GROUP, LLC	72,631	24,044	-48,587 (-66.9%)
NORTHERN TRUST CORP	130,553	112,092	-18,461 (-14.1%)
UBS Group AG	13,710	4,995	-8,715 (-63.6%)
RHUMBLINE ADVISERS	33,522	29,038	-4,484 (-13.4%)
GEODE CAPITAL MANAGEMENT, LLC	300,772	297,100	-3,672 (-1.2%)
Bank of New York Mellon Corp	52,278	49,219	-3,059 (-5.9%)
INTECH INVESTMENT MANAGEMENT LLC	11,384	10,452	-932 (-8.2%)
Russell Investments Group, Ltd.	3,674	2,924	-750 (-20.4%)
Quadrature Capital Ltd	15,321	14,761	-560 (-3.7%)
PNC Financial Services Group, Inc.	968	637	-331 (-34.2%)
FMR LLC	2,724	2,423	-301 (-11.0%)
CITIGROUP INC	811	530	-281 (-34.6%)
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	1,699	1,441	-258 (-15.2%)
Tower Research Capital LLC (TRC)	1,624	1,384	-240 (-14.8%)
Sterling Capital Management LLC	1,198	1,030	-168 (-14.0%)
NATIONAL BANK OF CANADA /FI/	186	97	-89 (-47.8%)
OSAIC HOLDINGS, INC.	94	75	-19 (-20.2%)
Hughes Financial Services, LLC	108	97	-11 (-10.2%)

Exited Positions (8)

HARBERT FUND ADVISORS, INC.

Value ($000) $1,664 Shares 177,815

TANG CAPITAL MANAGEMENT LLC

Value ($000) $3,132 Shares 334,593

FRANKLIN RESOURCES INC

Value ($000) $159 Shares 16,978

SUSQUEHANNA INTERNATIONAL GROUP, LLP

Value ($000) $159 Shares 17,023

SRS Capital Advisors, Inc.

Value ($000) $2 Shares 188

FIFTH THIRD BANCORP

Value ($000) $1 Shares 158

SIMPLEX TRADING, LLC

Value ($000) $0 Shares 21,270

SBI Securities Co., Ltd.

Value ($000) $0 Shares 1

Institution	Prev Shares	Prev Value ($000)
HARBERT FUND ADVISORS, INC.	177,815	$1,664
TANG CAPITAL MANAGEMENT LLC	334,593	$3,132
FRANKLIN RESOURCES INC	16,978	$159
SUSQUEHANNA INTERNATIONAL GROUP, LLP	17,023	$159
SRS Capital Advisors, Inc.	188	$2
FIFTH THIRD BANCORP	158	$1
SIMPLEX TRADING, LLC	21,270	$0
SBI Securities Co., Ltd.	1	$0