| EcoR1 Capital, LLC | 2,228,000 | $4,300 |
| Affinity Asset Advisors, LLC | 2,057,200 | $3,970 |
| Logos Global Management LP | 2,000,000 | $3,860 |
| Frazier Life Sciences Management, L.P. | 1,953,467 | $3,770 |
| BALYASNY ASSET MANAGEMENT L.P. | 1,096,179 | $2,116 |
| Ikarian Capital, LLC | 957,062 | $1,847 |
| VANGUARD GROUP INC | 883,149 | $1,704 |
| Sio Capital Management, LLC | 740,000 | $1,428 |
| AMERIPRISE FINANCIAL INC | 584,368 | $1,128 |
| TWO SIGMA INVESTMENTS, LP | 456,333 | $881 |
| ADAR1 Capital Management, LLC | 405,531 | $783 |
| RENAISSANCE TECHNOLOGIES LLC | 353,339 | $682 |
| Monashee Investment Management LLC | 274,862 | $530 |
| BOOTHBAY FUND MANAGEMENT, LLC | 254,412 | $491 |
| Hudson Bay Capital Management LP | 242,076 | $467 |
| NOESIS CAPITAL MANGEMENT CORP | 224,200 | $433 |
| GEODE CAPITAL MANAGEMENT, LLC | 222,610 | $430 |
| Walleye Capital LLC | 198,375 | $383 |
| Jefferies Financial Group Inc. | 160,000 | $309 |
| UBS Group AG | 126,556 | $244 |
| MARSHALL WACE, LLP | 121,286 | $234 |
| BANK OF AMERICA CORP /DE/ | 115,793 | $223 |
| TWO SIGMA ADVISERS, LP | 108,400 | $209 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 106,000 | $205 |
| JANE STREET GROUP, LLC | 105,700 | $204 |
| STATE STREET CORP | 72,899 | $141 |
| MCIA Inc | 63,000 | $142 |
| BlackRock, Inc. | 42,727 | $82 |
| NORTHERN TRUST CORP | 40,314 | $78 |
| Persistent Asset Partners Ltd | 39,585 | $76 |
| XTX Topco Ltd | 37,014 | $71 |
| MORGAN STANLEY | 27,595 | $53 |
| PFG Investments, LLC | 21,500 | $41 |
| Vanguard Personalized Indexing Management, LLC | 12,491 | $24 |
| CITIGROUP INC | 5,046 | $10 |
| Tower Research Capital LLC (TRC) | 1,380 | $3 |
| Fortitude Family Office, LLC | 431 | $1 |
| OSAIC HOLDINGS, INC. | 384 | $1 |
| SRS Capital Advisors, Inc. | 91 | $0 |
| SHP Wealth Management | 60 | $0 |
| SBI Securities Co., Ltd. | 22 | $0 |
| SOA Wealth Advisors, LLC. | 13 | $0 |
| BNP PARIBAS ARBITRAGE, SA | 5 | $0 |
| Activest Wealth Management | 4 | $0 |
| JPMORGAN CHASE & CO | 2 | $0 |
| Financial Gravity Asset Management, Inc. | 2 | $0 |
| BARCLAYS PLC | 2 | $0 |
| WELLS FARGO & COMPANY/MN | 1 | $0 |
| Steward Partners Investment Advisory, LLC | 1 | $0 |
| Motiv8 Investments LLC | 1 | $0 |