KYVERNA THERAPEUTICS INC

Institution	Shares	Value ($000)
Propel Bio Management, LLC	666,666	$6,267
AIGH Capital Management LLC	1,500,000	$14,100
Monashee Investment Management LLC	195,000	$1,833
HEIGHTS CAPITAL MANAGEMENT, INC	271,822	$2,555
DEERFIELD MANAGEMENT COMPANY, L.P.	2,000,000	$18,800
ACT CAPITAL MANAGEMENT, LLC	25,100	$236
Burkehill Global Management, LP	200,000	$1,880
RFG Advisory, LLC	445,200	$4,185
683 Capital Management, LLC	114,900	$1,080
ADAR1 Capital Management, LLC	57,428	$540
ADAGE CAPITAL PARTNERS GP, L.L.C.	1,666,666	$15,667
Simplify Asset Management Inc.	192,339	$1,808
Maven Securities LTD	146,400	$1,376
EntryPoint Capital, LLC	10,048	$94
Alyeska Investment Group, L.P.	600,000	$5,640
BALYASNY ASSET MANAGEMENT L.P.	980,869	$9,220
Jump Financial, LLC	80,299	$755
Cambria Investment Management, L.P.	17,935	$169
D. E. Shaw & Co., Inc.	518,512	$4,874
AlphaQuest LLC	16,343	$154

Increased Positions (28)

Woodline Partners LP

Value ($000) $7,944 (+425.0%) Shares 845,143 (+235.1%)

MORGAN STANLEY

Value ($000) $9,423 (+801.6%) Shares 1,002,495 (+475.5%)

VANGUARD GROUP INC

Value ($000) $16,744 (+111.0%) Shares 1,781,257 (+34.7%)

BNP PARIBAS ARBITRAGE, SA

Value ($000) $2,370 (+1061.1%) Shares 252,151 (+641.1%)

CITADEL ADVISORS LLC

Value ($000) $2,589 (+2342.7%) Shares 275,446 (+1459.2%)

STIFEL FINANCIAL CORP

Value ($000) $1,182 (+407.6%) Shares 125,790 (+224.0%)

TWO SIGMA INVESTMENTS, LP

Value ($000) $1,930 (+142.8%) Shares 205,267 (+55.0%)

BARCLAYS PLC

Value ($000) $1,548 (+351.1%) Shares 164,668 (+134.7%)

GOLDMAN SACHS GROUP INC

Value ($000) $1,255 (+385.0%) Shares 133,530 (+209.6%)

Phoenix Wealth Advisors

Value ($000) $116 (+83.5%) Shares 12,300 (+17.1%)

TD Asset Management Inc

Value ($000) $2,094 (+111.8%) Shares 222,796 (+35.2%)

BlackRock, Inc.

Value ($000) $5,119 (+77.0%) Shares 544,539 (+13.0%)

WELLS FARGO & COMPANY/MN

Value ($000) $705 (+542.3%) Shares 74,949 (+310.0%)

MILLENNIUM MANAGEMENT LLC

Value ($000) $5,578 (+68.5%) Shares 593,369 (+7.6%)

UBS Group AG

Value ($000) $1,901 (+101.2%) Shares 202,187 (+28.4%)

SUSQUEHANNA INTERNATIONAL GROUP, LLP

Value ($000) $2,245 (+84.6%) Shares 238,828 (+17.8%)

MANUFACTURERS LIFE INSURANCE COMPANY, THE

Value ($000) $1,258 (+102.0%) Shares 134,530 (+29.6%)

Qube Research & Technologies Ltd

Value ($000) $598 (+171.6%) Shares 63,616 (+73.4%)

Jefferies Financial Group Inc.

Value ($000) $301 (+207.6%) Shares 32,001 (+96.3%)

RENAISSANCE TECHNOLOGIES LLC

Value ($000) $1,672 (+69.3%) Shares 177,899 (+8.1%)

Institution	Prev Shares	Curr Shares	Change
Woodline Partners LP	252,212	845,143	+592,931 (+235.1%)
MORGAN STANLEY	174,203	1,002,495	+828,292 (+475.5%)
VANGUARD GROUP INC	1,322,625	1,781,257	+458,632 (+34.7%)
BNP PARIBAS ARBITRAGE, SA	34,022	252,151	+218,129 (+641.1%)
CITADEL ADVISORS LLC	17,666	275,446	+257,780 (+1459.2%)
STIFEL FINANCIAL CORP	38,821	125,790	+86,969 (+224.0%)
TWO SIGMA INVESTMENTS, LP	132,451	205,267	+72,816 (+55.0%)
BARCLAYS PLC	70,167	164,668	+94,501 (+134.7%)
GOLDMAN SACHS GROUP INC	43,132	133,530	+90,398 (+209.6%)
Phoenix Wealth Advisors	10,500	12,300	+1,800 (+17.1%)
TD Asset Management Inc	164,796	222,796	+58,000 (+35.2%)
BlackRock, Inc.	482,054	544,539	+62,485 (+13.0%)
WELLS FARGO & COMPANY/MN	18,280	74,949	+56,669 (+310.0%)
MILLENNIUM MANAGEMENT LLC	551,635	593,369	+41,734 (+7.6%)
UBS Group AG	157,422	202,187	+44,765 (+28.4%)
SUSQUEHANNA INTERNATIONAL GROUP, LLP	202,690	238,828	+36,138 (+17.8%)
MANUFACTURERS LIFE INSURANCE COMPANY, THE	103,808	134,530	+30,722 (+29.6%)
Qube Research & Technologies Ltd	36,691	63,616	+26,925 (+73.4%)
Jefferies Financial Group Inc.	16,300	32,001	+15,701 (+96.3%)
RENAISSANCE TECHNOLOGIES LLC	164,614	177,899	+13,285 (+8.1%)

Decreased Positions (19)

CAXTON CORP

Value ($000) $176 (+28.0%) Shares 18,773 (-18.3%)

Peapod Lane Capital LLC

Value ($000) $1,728 (-9.6%) Shares 183,820 (-42.3%)

Bain Capital Life Sciences Investors, LLC

Value ($000) $29,234 (+44.6%) Shares 3,110,000 (-7.7%)

Kera Capital Partners, Inc.

Value ($000) $1,062 (-58.0%) Shares 132,603 (-68.6%)

XTX Topco Ltd

Value ($000) $219 (-25.7%) Shares 23,282 (-52.6%)

JACOBS LEVY EQUITY MANAGEMENT, INC

Value ($000) $1,020 (+15.1%) Shares 108,534 (-26.5%)

TWO SIGMA ADVISERS, LP

Value ($000) $464 (-4.8%) Shares 49,400 (-39.2%)

BANK OF AMERICA CORP /DE/

Value ($000) $270 (-30.8%) Shares 28,709 (-55.8%)

JANE STREET GROUP, LLC

Value ($000) $1,712 (+43.5%) Shares 182,093 (-8.4%)

GEODE CAPITAL MANAGEMENT, LLC

Value ($000) $2,506 (+50.0%) Shares 266,402 (-4.3%)

Ethic Inc.

Value ($000) $119 (+28.7%) Shares 12,609 (-17.9%)

JPMORGAN CHASE & CO

Value ($000) $40 (+0.3%) Shares 4,274 (-36.0%)

Tower Research Capital LLC (TRC)

Value ($000) $48 (+27.6%) Shares 5,073 (-18.6%)

FMR LLC

Value ($000) $66 (+38.0%) Shares 6,976 (-11.9%)

China Universal Asset Management Co., Ltd.

Value ($000) $67 (+47.5%) Shares 7,137 (-5.8%)

SBI Securities Co., Ltd.

Value ($000) $0 (-74.8%) Shares 22 (-83.9%)

GF FUND MANAGEMENT CO. LTD.

Value ($000) $8 (+50.0%) Shares 860 (-4.2%)

EverSource Wealth Advisors, LLC

Value ($000) $2 (+27.7%) Shares 163 (-18.5%)

CWM, LLC

Value ($000) $0 (-33.3%) Shares 263 (-47.3%)

Institution	Prev Shares	Curr Shares	Change
CAXTON CORP	22,981	18,773	-4,208 (-18.3%)
Peapod Lane Capital LLC	318,760	183,820	-134,940 (-42.3%)
Bain Capital Life Sciences Investors, LLC	3,368,370	3,110,000	-258,370 (-7.7%)
Kera Capital Partners, Inc.	421,924	132,603	-289,321 (-68.6%)
XTX Topco Ltd	49,107	23,282	-25,825 (-52.6%)
JACOBS LEVY EQUITY MANAGEMENT, INC	147,712	108,534	-39,178 (-26.5%)
TWO SIGMA ADVISERS, LP	81,300	49,400	-31,900 (-39.2%)
BANK OF AMERICA CORP /DE/	64,964	28,709	-36,255 (-55.8%)
JANE STREET GROUP, LLC	198,851	182,093	-16,758 (-8.4%)
GEODE CAPITAL MANAGEMENT, LLC	278,329	266,402	-11,927 (-4.3%)
Ethic Inc.	15,353	12,609	-2,744 (-17.9%)
JPMORGAN CHASE & CO	6,675	4,274	-2,401 (-36.0%)
Tower Research Capital LLC (TRC)	6,231	5,073	-1,158 (-18.6%)
FMR LLC	7,918	6,976	-942 (-11.9%)
China Universal Asset Management Co., Ltd.	7,580	7,137	-443 (-5.8%)
SBI Securities Co., Ltd.	137	22	-115 (-83.9%)
GF FUND MANAGEMENT CO. LTD.	898	860	-38 (-4.2%)
EverSource Wealth Advisors, LLC	200	163	-37 (-18.5%)
CWM, LLC	499	263	-236 (-47.3%)

Exited Positions (10)

Catalio Capital Management, LP

Value ($000) $3,521 Shares 586,909

PRELUDE CAPITAL MANAGEMENT, LLC

Value ($000) $117 Shares 19,438

FRANKLIN RESOURCES INC

Value ($000) $4,066 Shares 677,587

Trexquant Investment LP

Value ($000) $91 Shares 15,109

AQR CAPITAL MANAGEMENT LLC

Value ($000) $81 Shares 13,542

AMERIPRISE FINANCIAL INC

Value ($000) $77 Shares 12,882

PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO

Value ($000) $28 Shares 4,600

nVerses Capital, LLC

Value ($000) $3 Shares 600

Advisory Services Network, LLC

Value ($000) $1 Shares 86

IFP Advisors, Inc

Value ($000) $0 Shares 16

Institution	Prev Shares	Prev Value ($000)
Catalio Capital Management, LP	586,909	$3,521
PRELUDE CAPITAL MANAGEMENT, LLC	19,438	$117
FRANKLIN RESOURCES INC	677,587	$4,066
Trexquant Investment LP	15,109	$91
AQR CAPITAL MANAGEMENT LLC	13,542	$81
AMERIPRISE FINANCIAL INC	12,882	$77
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO	4,600	$28
nVerses Capital, LLC	600	$3
Advisory Services Network, LLC	86	$1
IFP Advisors, Inc	16	$0