LEAP THERAPEUTICS INC

Ticker: CYPH CUSIP: 52187K200 Class: COM NEW

Holders for Q4 2025 Position Changes for Q4 2025

Note: Option positions (PUT/CALL) are excluded.

New Positions (13)

Caitong International Asset Management Co., Ltd
Value ($000) $44 Shares 38,191
Texas Capital Bank Wealth Management Services Inc
Value ($000) $121 Shares 104,200
CITIGROUP INC
Value ($000) $85 Shares 73,022
Qube Research & Technologies Ltd
Value ($000) $72 Shares 62,486
Sequoia Financial Advisors, LLC
Value ($000) $56 Shares 48,000
Toroso Investments, LLC
Value ($000) $41 Shares 35,314
MILLENNIUM MANAGEMENT LLC
Value ($000) $37 Shares 32,267
Keystone Financial Group
Value ($000) $14 Shares 11,712
Tower Research Capital LLC (TRC)
Value ($000) $15 Shares 12,605
IHT Wealth Management, LLC
Value ($000) $13 Shares 11,000
Cetera Investment Advisers
Value ($000) $12 Shares 10,000
OPTIMA CAPITAL LLC
Value ($000) $1 Shares 798
Fortitude Family Office, LLC
Value ($000) $0 Shares 182

Increased Positions (13)

Simplify Asset Management Inc.
Value ($000) $2,172 (+390.4%) Shares 1,872,322 (+91.9%)
BlackRock, Inc.
Value ($000) $2,717 (+4678.6%) Shares 2,342,174 (+1770.2%)
VANGUARD GROUP INC
Value ($000) $2,467 (+368.3%) Shares 2,127,109 (+83.3%)
SUSQUEHANNA INTERNATIONAL GROUP, LLP
Value ($000) $646 (+1551.6%) Shares 557,179 (+546.4%)
GEODE CAPITAL MANAGEMENT, LLC
Value ($000) $615 (+333.8%) Shares 530,192 (+69.8%)
GROUP ONE TRADING, L.P.
Value ($000) $187 (+10728.0%) Shares 161,579 (+4137.6%)
SIMPLEX TRADING, LLC
Value ($000) $79 (+3933300.0%) Shares 67,818 (+1243.2%)
UBS Group AG
Value ($000) $36 (+19750.5%) Shares 31,145 (+7686.3%)
NORTHERN TRUST CORP
Value ($000) $102 (+263.2%) Shares 87,562 (+42.1%)
STATE STREET CORP
Value ($000) $163 (+185.0%) Shares 140,113 (+11.5%)
ROYAL BANK OF CANADA
Value ($000) $11 Shares 9,881 (+7500.8%)
TWO SIGMA INVESTMENTS, LP
Value ($000) $84 (+160.3%) Shares 72,172 (+1.9%)
Farther Finance Advisors, LLC
Value ($000) $2 (+425.8%) Shares 2,058 (+105.8%)

Decreased Positions (6)

Key Client Fiduciary Advisors, LLC
Value ($000) $98 (+56.7%) Shares 84,587 (-38.7%)
HighTower Advisors, LLC
Value ($000) $59 (-88.3%) Shares 50,500 (-95.4%)
BANK OF AMERICA CORP /DE/
Value ($000) $1 (-99.9%) Shares 453 (-100.0%)
LPL Financial LLC
Value ($000) $38 (+132.5%) Shares 32,764 (-9.0%)
OSAIC HOLDINGS, INC.
Value ($000) $2 (+308.0%) Shares 1,850 (-1.7%)
MORGAN STANLEY
Value ($000) $1 (+150.2%) Shares 486 (-1.6%)

Exited Positions (8)

GILEAD SCIENCES, INC.
Value ($000) $2,415 Shares 5,319,148
JANE STREET GROUP, LLC
Value ($000) $75 Shares 165,389
TWO SIGMA ADVISERS, LP
Value ($000) $45 Shares 99,680
ADAR1 Capital Management, LLC
Value ($000) $12 Shares 25,830
XTX Topco Ltd
Value ($000) $14 Shares 30,664
Baird Financial Group, Inc.
Value ($000) $9 Shares 20,000
ACADIAN ASSET MANAGEMENT LLC
Value ($000) $1 Shares 1,237,113
HRT FINANCIAL LP
Value ($000) $0 Shares 118,625