| Frazier Life Sciences Management, L.P. | 4,567,274 | $189,222 |
| TRV GP IV, LLC | 4,473,958 | $185,356 |
| Deep Track Capital, LP | 4,246,440 | $175,930 |
| ARCH Venture Management, LLC | 4,120,053 | $170,694 |
| JANUS HENDERSON GROUP PLC | 3,142,587 | $130,197 |
| BlackRock, Inc. | 2,287,155 | $94,757 |
| a16z Capital Management, L.L.C. | 1,702,225 | $70,523 |
| VANGUARD GROUP INC | 1,697,015 | $70,307 |
| VR Adviser, LLC | 1,548,569 | $64,157 |
| Alphabet Inc. | 1,388,583 | $57,529 |
| General Catalyst Group Management, LLC | 1,035,910 | $42,918 |
| Woodline Partners LP | 1,035,229 | $42,890 |
| TRV GP V, LLC | 950,800 | $39,392 |
| Logos Global Management LP | 950,000 | $39,359 |
| Bellevue Group AG | 887,708 | $36,778 |
| MARSHALL WACE, LLP | 847,472 | $35,111 |
| ArrowMark Colorado Holdings LLC | 767,383 | $31,793 |
| Casdin Capital, LLC | 758,857 | $31,439 |
| FMR LLC | 728,605 | $30,186 |
| Ikarian Capital, LLC | 644,680 | $26,709 |
| Caligan Partners LP | 550,191 | $22,794 |
| STATE STREET CORP | 533,005 | $22,082 |
| GEODE CAPITAL MANAGEMENT, LLC | 527,281 | $21,850 |
| Foresite Capital Management IV, LLC | 522,657 | $21,654 |
| Squadron Capital Management LLC | 490,000 | $20,301 |
| BESSEMER GROUP INC | 481,790 | $20 |
| Matrix Capital Management Company, LP | 480,000 | $19,886 |
| HHLR ADVISORS, LTD. | 457,535 | $18,956 |
| CITADEL ADVISORS LLC | 448,217 | $18,570 |
| BOOTHBAY FUND MANAGEMENT, LLC | 409,372 | $16,960 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 378,015 | $15,661 |
| EVENTIDE ASSET MANAGEMENT, LLC | 324,041 | $13,425 |
| WASHINGTON UNIVERSITY | 280,802 | $11,634 |
| MORGAN STANLEY | 258,086 | $10,693 |
| Mass General Brigham, Inc | 239,994 | $9,943 |
| Parkman Healthcare Partners LLC | 209,266 | $8,670 |
| BALYASNY ASSET MANAGEMENT L.P. | 199,212 | $8,253 |
| Alyeska Investment Group, L.P. | 196,124 | $8,125 |
| Ensign Peak Advisors, Inc | 185,794 | $7,697 |
| ADAR1 Capital Management, LLC | 179,532 | $7,438 |
| NORTHERN TRUST CORP | 176,259 | $7,302 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 175,969 | $7,290 |
| TCG Crossover Management, LLC | 173,816 | $7,201 |
| HighVista Strategies LLC | 170,353 | $7,058 |
| MILLENNIUM MANAGEMENT LLC | 154,470 | $6,400 |
| Invesco Ltd. | 134,033 | $5,553 |
| STEMPOINT CAPITAL LP | 125,877 | $5,215 |
| Freestone Grove Partners LP | 118,876 | $4,925 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 115,711 | $5 |
| GOLDMAN SACHS GROUP INC | 114,455 | $4,742 |
| Integral Health Asset Management, LLC | 100,000 | $4,143 |
| AMERIPRISE FINANCIAL INC | 96,688 | $4,006 |
| Foresite Capital Management V, LLC | 86,291 | $3,575 |
| MPM BioImpact LLC | 81,145 | $3,362 |
| SPHERA FUNDS MANAGEMENT LTD. | 71,843 | $2,976 |
| SummitTX Capital, L.P. | 69,560 | $2,882 |
| RAYMOND JAMES FINANCIAL INC | 67,718 | $2,806 |
| WELLINGTON MANAGEMENT GROUP LLP | 61,205 | $2,536 |
| Bank of New York Mellon Corp | 60,436 | $2,504 |
| OSAIC HOLDINGS, INC. | 59,762 | $2,476 |
| Nuveen, LLC | 57,258 | $2,372 |
| FRANKLIN RESOURCES INC | 55,229 | $2,288 |
| Trexquant Investment LP | 52,459 | $2,173 |
| SEVEN GRAND MANAGERS, LLC | 50,000 | $2,072 |
| Schonfeld Strategic Advisors LLC | 48,200 | $1,997 |
| BARCLAYS PLC | 39,508 | $1,637 |
| D. E. Shaw & Co., Inc. | 33,694 | $1,396 |
| ALLIANCEBERNSTEIN L.P. | 33,220 | $1,376 |
| XTX Topco Ltd | 33,021 | $1,368 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 31,295 | $1,297 |
| Cinctive Capital Management LP | 29,134 | $1,207 |
| UBS Group AG | 28,698 | $1,189 |
| AQR CAPITAL MANAGEMENT LLC | 27,439 | $1,137 |
| RENAISSANCE TECHNOLOGIES LLC | 27,100 | $1,123 |
| TUDOR INVESTMENT CORP ET AL | 24,059 | $997 |
| WELLS FARGO & COMPANY/MN | 24,008 | $995 |
| RHUMBLINE ADVISERS | 23,731 | $983 |
| GILDER GAGNON HOWE & CO LLC | 23,282 | $965 |
| Russell Investments Group, Ltd. | 22,545 | $934 |
| Verition Fund Management LLC | 22,512 | $933 |
| AMERICAN CENTURY COMPANIES INC | 21,509 | $891 |
| JPMORGAN CHASE & CO | 20,007 | $829 |
| ACUTA CAPITAL PARTNERS, LLC | 20,000 | $829 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 19,100 | $635 |
| BANK OF AMERICA CORP /DE/ | 18,381 | $762 |
| DEUTSCHE BANK AG\ | 15,522 | $643 |
| TWO SIGMA ADVISERS, LP | 14,800 | $613 |
| PSP Research LLC | 12,672 | $525 |
| MetLife Investment Management, LLC | 11,801 | $489 |
| China Universal Asset Management Co., Ltd. | 11,441 | $474 |
| CITIGROUP INC | 11,252 | $466 |
| STRS OHIO | 11,200 | $464 |
| Falcon Wealth Planning | 10,030 | $416 |
| SG Americas Securities, LLC | 8,493 | $0 |
| TWO SIGMA INVESTMENTS, LP | 7,245 | $300 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 6,897 | $286 |
| Virtus Investment Advisers, LLC | 6,846 | $284 |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,700 | $278 |
| Persistent Asset Partners Ltd | 6,605 | $274 |
| INTECH INVESTMENT MANAGEMENT LLC | 6,443 | $267 |
| 42 other institutions | 87,641 | $3,504 |