| RA CAPITAL MANAGEMENT, L.P. | 20,064,545 | $130,620 |
| VIKING GLOBAL INVESTORS LP | 3,482,434 | $22,671 |
| Commodore Capital LP | 3,400,000 | $22,134 |
| Vivo Capital, LLC | 2,325,000 | $15,136 |
| Point72 Asset Management, L.P. | 2,274,416 | $14,806 |
| VANGUARD GROUP INC | 2,212,834 | $14,406 |
| Laurion Capital Management LP | 2,052,133 | $13,359 |
| BVF INC/IL | 1,915,000 | $12,467 |
| Nantahala Capital Management, LLC | 1,547,229 | $10,072 |
| JANUS HENDERSON GROUP PLC | 1,500,000 | $9,795 |
| Pictet Asset Management Holding SA | 1,352,424 | $8,804 |
| Woodline Partners LP | 1,311,021 | $8,535 |
| AWM Investment Company, Inc. | 1,300,000 | $8,463 |
| BlackRock, Inc. | 1,234,414 | $8,036 |
| MORGAN STANLEY | 1,084,400 | $7,059 |
| BALYASNY ASSET MANAGEMENT L.P. | 866,269 | $5,639 |
| PERCEPTIVE ADVISORS LLC | 829,870 | $5,402 |
| Octagon Capital Advisors LP | 700,000 | $4,557 |
| Siren, L.L.C. | 700,000 | $4,557 |
| GEODE CAPITAL MANAGEMENT, LLC | 542,109 | $3,531 |
| Ikarian Capital, LLC | 447,165 | $2,911 |
| BOOTHBAY FUND MANAGEMENT, LLC | 417,996 | $2,721 |
| Boxer Capital Management, LLC | 373,892 | $2,434 |
| BANK OF AMERICA CORP /DE/ | 351,141 | $2,286 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 315,000 | $2,051 |
| MARSHALL WACE, LLP | 290,589 | $1,892 |
| CITADEL ADVISORS LLC | 267,789 | $1,743 |
| TWO SIGMA INVESTMENTS, LP | 267,425 | $1,741 |
| Walleye Capital LLC | 255,974 | $1,666 |
| GOLDMAN SACHS GROUP INC | 241,618 | $1,573 |
| STATE STREET CORP | 217,490 | $1,416 |
| Artia Global Partners LP | 205,324 | $1,337 |
| MILLENNIUM MANAGEMENT LLC | 197,943 | $1,289 |
| JANE STREET GROUP, LLC | 192,733 | $1,255 |
| 683 Capital Management, LLC | 186,916 | $1,217 |
| Polymer Capital Management (HK) LTD | 160,000 | $1,042 |
| RENAISSANCE TECHNOLOGIES LLC | 147,900 | $963 |
| MONIMUS CAPITAL MANAGEMENT, LP | 138,398 | $901 |
| DIMENSIONAL FUND ADVISORS LP | 135,216 | $880 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 125,498 | $817 |
| SPHERA FUNDS MANAGEMENT LTD. | 121,467 | $791 |
| ExodusPoint Capital Management, LP | 120,728 | $786 |
| NORTHERN TRUST CORP | 118,257 | $770 |
| READYSTATE ASSET MANAGEMENT LP | 113,502 | $739 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 100,000 | $651 |
| XTX Topco Ltd | 98,036 | $638 |
| RBF Capital, LLC | 95,042 | $619 |
| BNP PARIBAS ARBITRAGE, SA | 89,575 | $583 |
| Connor, Clark & Lunn Investment Management Ltd. | 73,306 | $477 |
| Hudson Bay Capital Management LP | 69,391 | $452 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 63,000 | $410 |
| BARCLAYS PLC | 55,717 | $363 |
| Jump Financial, LLC | 55,438 | $361 |
| Resolute Capital Asset Partners LLC | 50,000 | $326 |
| GSA CAPITAL PARTNERS LLP | 43,440 | $0 |
| SIMPLEX TRADING, LLC | 43,194 | $281 |
| ADAR1 Capital Management, LLC | 36,842 | $240 |
| Rangeley Capital, LLC | 36,200 | $236 |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 36,125 | $235 |
| Rathbones Group PLC | 32,003 | $208 |
| CITIGROUP INC | 31,337 | $204 |
| Qube Research & Technologies Ltd | 31,234 | $203 |
| Squarepoint Ops LLC | 31,213 | $203 |
| OMERS ADMINISTRATION Corp | 27,600 | $180 |
| Trexquant Investment LP | 24,306 | $158 |
| ACADIAN ASSET MANAGEMENT LLC | 20,838 | $0 |
| TWO SIGMA ADVISERS, LP | 20,806 | $135 |
| AMERICAN CENTURY COMPANIES INC | 15,750 | $103 |
| Lighthouse Investment Partners, LLC | 14,580 | $95 |
| Jefferies Financial Group Inc. | 13,729 | $89 |
| China Universal Asset Management Co., Ltd. | 11,202 | $73 |
| BANK OF MONTREAL /CAN/ | 10,001 | $65 |
| Tower Research Capital LLC (TRC) | 9,489 | $62 |
| UBS Group AG | 8,068 | $53 |
| JPMORGAN CHASE & CO | 5,241 | $34 |
| Mirae Asset Global Investments Co., Ltd. | 3,341 | $22 |
| FMR LLC | 1,664 | $11 |
| GF FUND MANAGEMENT CO. LTD. | 1,350 | $9 |
| ROYAL BANK OF CANADA | 383 | $2 |
| NISA INVESTMENT ADVISORS, LLC | 195 | $1 |
| Parallel Advisors, LLC | 135 | $1 |
| Cornerstone Financial Management LLC | 121 | $1 |
| OPTIMA CAPITAL LLC | 108 | $1 |
| Allworth Financial LP | 28 | $0 |
| Larson Financial Group LLC | 13 | $0 |
| OSAIC HOLDINGS, INC. | 8 | $0 |
| CWM, LLC | 5 | $0 |