| BAKER BROS. ADVISORS LP | 11,045,336 | $107,361 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 8,262,296 | $80 |
| RTW INVESTMENTS, LP | 7,140,352 | $69,404 |
| BlackRock, Inc. | 6,069,633 | $58,997 |
| VANGUARD GROUP INC | 3,776,198 | $36,705 |
| STATE STREET CORP | 3,693,107 | $35,897 |
| FMR LLC | 2,981,580 | $28,981 |
| FCPM III SERVICES B.V. | 2,808,368 | $27,297 |
| D. E. Shaw & Co., Inc. | 2,575,042 | $25,029 |
| TORONTO DOMINION BANK | 2,229,527 | $21,671 |
| Erste Asset Management GmbH | 2,120,000 | $20,619 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,807,368 | $17,568 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,750,194 | $17,016 |
| Commodore Capital LP | 1,425,000 | $13,851 |
| Rosalind Advisors, Inc. | 1,410,497 | $13,710 |
| ADAR1 Capital Management, LLC | 1,241,322 | $12,066 |
| DIMENSIONAL FUND ADVISORS LP | 1,119,357 | $10,881 |
| Redmile Group, LLC | 1,099,756 | $10,690 |
| JPMORGAN CHASE & CO | 925,173 | $8,993 |
| MILLENNIUM MANAGEMENT LLC | 834,562 | $8,112 |
| MORGAN STANLEY | 814,888 | $7,921 |
| Boxer Capital Management, LLC | 750,000 | $7,290 |
| Jefferies Financial Group Inc. | 714,226 | $6,942 |
| GOLDMAN SACHS GROUP INC | 658,096 | $6,397 |
| Invesco Ltd. | 613,015 | $5,959 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 606,844 | $5,899 |
| UBS Group AG | 604,313 | $5,874 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 587,890 | $5,714 |
| JANE STREET GROUP, LLC | 584,330 | $5,680 |
| NAN FUNG TRINITY (HK) LTD | 575,527 | $5,594 |
| Woodline Partners LP | 570,988 | $5,550 |
| NORTHERN TRUST CORP | 539,600 | $5,245 |
| BNP PARIBAS ARBITRAGE, SA | 460,704 | $4,478 |
| TWO SIGMA INVESTMENTS, LP | 444,074 | $4,316 |
| RENAISSANCE TECHNOLOGIES LLC | 405,053 | $3,937 |
| Quinn Opportunity Partners LLC | 392,915 | $3,819 |
| Jump Financial, LLC | 296,843 | $2,885 |
| BARCLAYS PLC | 292,185 | $2,840 |
| TD Asset Management Inc | 266,484 | $2,590 |
| Omega Fund Management, LLC | 248,672 | $2,417 |
| DIADEMA PARTNERS LP | 230,997 | $2,245 |
| Caption Management, LLC | 228,570 | $2,222 |
| BANK OF AMERICA CORP /DE/ | 215,330 | $2,093 |
| Bank of New York Mellon Corp | 209,222 | $2,034 |
| WELLINGTON MANAGEMENT GROUP LLP | 208,669 | $2,028 |
| HRT FINANCIAL LP | 183,592 | $2 |
| Trexquant Investment LP | 180,494 | $1,754 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 178,911 | $1,755 |
| Resolute Capital Asset Partners LLC | 175,000 | $1,701 |
| CITADEL ADVISORS LLC | 158,359 | $1,539 |
| Hudson Bay Capital Management LP | 153,650 | $1,493 |
| AMERICAN CENTURY COMPANIES INC | 148,086 | $1,439 |
| Rafferty Asset Management, LLC | 140,909 | $1,370 |
| TUDOR INVESTMENT CORP ET AL | 128,380 | $1,248 |
| SummitTX Capital, L.P. | 108,803 | $1,058 |
| MARSHALL WACE, LLP | 93,585 | $910 |
| WELLS FARGO & COMPANY/MN | 90,724 | $882 |
| RHUMBLINE ADVISERS | 89,311 | $868 |
| Point72 Asset Management, L.P. | 72,210 | $702 |
| SG Americas Securities, LLC | 71,955 | $1 |
| Squarepoint Ops LLC | 67,271 | $654 |
| Susquehanna Portfolio Strategies, LLC | 66,875 | $650 |
| Nan Fung Group Holdings Ltd | 63,719 | $619 |
| ALLIANCEBERNSTEIN L.P. | 62,140 | $604 |
| ACT CAPITAL MANAGEMENT, LLC | 61,500 | $598 |
| Persistent Asset Partners Ltd | 61,488 | $598 |
| Nuveen, LLC | 57,614 | $560 |
| ACADIAN ASSET MANAGEMENT LLC | 56,723 | $1 |
| DEUTSCHE BANK AG\ | 53,944 | $524 |
| Brevan Howard Capital Management LP | 52,961 | $515 |
| PROFUND ADVISORS LLC | 52,145 | $507 |
| NEOS Investment Management LLC | 52,052 | $506 |
| TEMA ETFS LLC | 51,282 | $498 |
| RAYMOND JAMES FINANCIAL INC | 47,364 | $460 |
| Creative Planning | 45,161 | $439 |
| Aquatic Capital Management LLC | 44,632 | $434 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 44,045 | $451 |
| STATE OF WISCONSIN INVESTMENT BOARD | 41,181 | $400 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 40,352 | $393 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 36,038 | $350 |
| Schonfeld Strategic Advisors LLC | 35,220 | $342 |
| OSAIC HOLDINGS, INC. | 35,200 | $342 |
| MetLife Investment Management, LLC | 34,328 | $334 |
| XTX Topco Ltd | 33,163 | $322 |
| Voya Investment Management LLC | 32,093 | $312 |
| TWO SIGMA ADVISERS, LP | 30,700 | $298 |
| GSA CAPITAL PARTNERS LLP | 29,147 | $0 |
| AlphaQuest LLC | 28,080 | $273 |
| Virtus Investment Advisers, LLC | 26,133 | $254 |
| Dynamic Technology Lab Private Ltd | 25,905 | $252 |
| BALYASNY ASSET MANAGEMENT L.P. | 25,319 | $246 |
| INTECH INVESTMENT MANAGEMENT LLC | 24,704 | $240 |
| Ballentine Partners, LLC | 23,665 | $230 |
| NISA INVESTMENT ADVISORS, LLC | 20,952 | $204 |
| CITIGROUP INC | 20,194 | $196 |
| HighTower Advisors, LLC | 20,123 | $196 |
| AXQ CAPITAL, LP | 19,862 | $193 |
| Police & Firemen's Retirement System of New Jersey | 18,445 | $179 |
| 9823 Capital, L.P. | 18,332 | $178 |
| Centiva Capital, LP | 18,000 | $175 |
| 64 other institutions | 360,588 | $3,438 |