| ORBIMED ADVISORS LLC | 6,306,127 | $23,017 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 6,306,127 | $23,017 |
| Redmile Group, LLC | 5,539,724 | $20,220 |
| NEXTBio Capital Management LP | 3,149,907 | $11,497 |
| Prosight Management, LP | 2,381,502 | $8,692 |
| VANGUARD GROUP INC | 2,377,746 | $8,679 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,926,140 | $7 |
| CLARK ESTATES INC/NY | 1,475,648 | $5,386 |
| 683 Capital Management, LLC | 1,390,000 | $5,074 |
| PINNACLE ASSOCIATES LTD | 1,350,638 | $4,930 |
| BANK OF AMERICA CORP /DE/ | 1,106,617 | $4,039 |
| Point72 Asset Management, L.P. | 1,068,231 | $3,899 |
| GEODE CAPITAL MANAGEMENT, LLC | 618,277 | $2,258 |
| abrdn plc | 531,177 | $1,939 |
| T. Rowe Price Investment Management, Inc. | 506,377 | $2 |
| MARSHALL WACE, LLP | 489,912 | $1,788 |
| MILLENNIUM MANAGEMENT LLC | 477,408 | $1,743 |
| TWO SIGMA INVESTMENTS, LP | 437,729 | $1,598 |
| BlackRock, Inc. | 418,529 | $1,528 |
| FMR LLC | 392,600 | $1,433 |
| RENAISSANCE TECHNOLOGIES LLC | 340,700 | $1,244 |
| TD Asset Management Inc | 251,050 | $916 |
| STATE STREET CORP | 215,418 | $786 |
| SPHERA FUNDS MANAGEMENT LTD. | 195,212 | $713 |
| TWO SIGMA ADVISERS, LP | 170,600 | $623 |
| Pathstone Holdings, LLC | 157,083 | $573 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 148,427 | $542 |
| NORTHERN TRUST CORP | 145,445 | $531 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 135,056 | $486 |
| GOLDMAN SACHS GROUP INC | 128,165 | $468 |
| Bank of New York Mellon Corp | 110,394 | $403 |
| LBJ Family Wealth Advisors, Ltd. | 82,177 | $0 |
| ACADIAN ASSET MANAGEMENT LLC | 79,367 | $0 |
| CITADEL ADVISORS LLC | 68,846 | $251 |
| Connor, Clark & Lunn Investment Management Ltd. | 65,734 | $240 |
| Squarepoint Ops LLC | 64,785 | $236 |
| JANE STREET GROUP, LLC | 54,046 | $197 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 42,300 | $154 |
| EP Wealth Advisors, LLC | 41,167 | $150 |
| PIPER SANDLER & CO. | 39,467 | $144 |
| Qube Research & Technologies Ltd | 38,757 | $141 |
| Invesco Ltd. | 28,231 | $103 |
| CHOREO, LLC | 27,251 | $77 |
| OMERS ADMINISTRATION Corp | 26,500 | $97 |
| RITHOLTZ WEALTH MANAGEMENT | 26,000 | $95 |
| XTX Topco Ltd | 24,873 | $91 |
| CITIGROUP INC | 24,832 | $91 |
| DIMENSIONAL FUND ADVISORS LP | 23,192 | $85 |
| Mallini Complete Financial Planning LLC | 22,632 | $83 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 20,881 | $76 |
| MORGAN STANLEY | 18,108 | $66 |
| PRUDENTIAL FINANCIAL INC | 17,700 | $65 |
| AMERICAN CENTURY COMPANIES INC | 17,282 | $63 |
| Keel Point, LLC | 14,270 | $52 |
| Engineers Gate Manager LP | 13,670 | $50 |
| UBS Group AG | 13,204 | $48 |
| Creative Planning | 12,335 | $45 |
| AMERIPRISE FINANCIAL INC | 11,500 | $42 |
| STONERIDGE INVESTMENT PARTNERS LLC | 10,453 | $0 |
| BNP PARIBAS ARBITRAGE, SA | 540 | $2 |
| JPMORGAN CHASE & CO | 343 | $1 |
| SBI Securities Co., Ltd. | 92 | $0 |
| Optiver Holding B.V. | 66 | $0 |
| ROYAL BANK OF CANADA | 64 | $0 |
| CWM, LLC | 43 | $0 |