| PERCEPTIVE ADVISORS LLC | 11,833,539 | $66,741 |
| Bain Capital Life Sciences Investors, LLC | 7,911,669 | $44,622 |
| Siren, L.L.C. | 7,690,405 | $43,374 |
| Vestal Point Capital, LP | 5,815,000 | $32,797 |
| RA CAPITAL MANAGEMENT, L.P. | 5,811,423 | $32,776 |
| BlackRock, Inc. | 4,869,682 | $27,465 |
| VANGUARD GROUP INC | 3,454,959 | $19,486 |
| CITADEL ADVISORS LLC | 2,663,863 | $15,024 |
| ARMISTICE CAPITAL, LLC | 2,612,000 | $14,732 |
| Point72 Asset Management, L.P. | 2,416,108 | $13,627 |
| FMR LLC | 2,029,898 | $11,449 |
| Redmile Group, LLC | 1,860,542 | $10,493 |
| Alyeska Investment Group, L.P. | 1,682,805 | $9,491 |
| Nantahala Capital Management, LLC | 1,603,336 | $9,043 |
| FRANKLIN RESOURCES INC | 1,599,233 | $9,020 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,400,000 | $7,896 |
| Monashee Investment Management LLC | 1,349,771 | $7,613 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,267,392 | $7,150 |
| STATE STREET CORP | 1,087,413 | $6,133 |
| GOLDMAN SACHS GROUP INC | 1,006,306 | $5,676 |
| Finepoint Capital LP | 961,251 | $5,421 |
| UBS Group AG | 911,409 | $5,140 |
| Birchview Capital, LP | 705,955 | $3,982 |
| DIMENSIONAL FUND ADVISORS LP | 679,084 | $3,830 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 499,293 | $2,816 |
| Parkman Healthcare Partners LLC | 418,371 | $2,360 |
| Ally Bridge Group (NY) LLC | 413,625 | $2,333 |
| NORTHERN TRUST CORP | 412,777 | $2,328 |
| Nuveen, LLC | 394,976 | $2,228 |
| MORGAN STANLEY | 394,266 | $2,224 |
| BALYASNY ASSET MANAGEMENT L.P. | 360,937 | $2,036 |
| BANK OF AMERICA CORP /DE/ | 344,294 | $1,942 |
| Woodline Partners LP | 316,823 | $1,787 |
| Boxer Capital Management, LLC | 300,000 | $1,692 |
| PANAGORA ASSET MANAGEMENT INC | 226,755 | $1,279 |
| JANE STREET GROUP, LLC | 213,409 | $1,204 |
| Susquehanna Portfolio Strategies, LLC | 199,436 | $1,125 |
| APIS CAPITAL ADVISORS, LLC | 196,000 | $1,105 |
| WELLINGTON MANAGEMENT GROUP LLP | 185,682 | $1,047 |
| Schonfeld Strategic Advisors LLC | 182,869 | $1,031 |
| Knott David M Jr | 162,440 | $916 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 161,537 | $911 |
| Ikarian Capital, LLC | 160,409 | $905 |
| TWO SIGMA INVESTMENTS, LP | 153,407 | $865 |
| Invesco Ltd. | 152,126 | $858 |
| Bank of New York Mellon Corp | 144,699 | $816 |
| BARCLAYS PLC | 138,136 | $779 |
| AQR CAPITAL MANAGEMENT LLC | 131,957 | $744 |
| D. E. Shaw & Co., Inc. | 128,260 | $723 |
| MILLENNIUM MANAGEMENT LLC | 116,632 | $658 |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 116,525 | $657 |
| Fisher Asset Management, LLC | 103,481 | $584 |
| AMERICAN CENTURY COMPANIES INC | 97,322 | $549 |
| Quantum Private Wealth, LLC | 94,231 | $531 |
| RHUMBLINE ADVISERS | 82,572 | $466 |
| ALLIANCEBERNSTEIN L.P. | 81,830 | $462 |
| WELLS FARGO & COMPANY/MN | 76,107 | $429 |
| BNP PARIBAS ARBITRAGE, SA | 74,630 | $421 |
| SIMPLEX TRADING, LLC | 60,534 | $341 |
| RENAISSANCE TECHNOLOGIES LLC | 52,800 | $298 |
| BOOTHBAY FUND MANAGEMENT, LLC | 52,799 | $298 |
| Squarepoint Ops LLC | 50,054 | $282 |
| DEUTSCHE BANK AG\ | 39,962 | $225 |
| Y-Intercept (Hong Kong) Ltd | 36,147 | $204 |
| XTX Topco Ltd | 35,633 | $201 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 35,087 | $0 |
| INTECH INVESTMENT MANAGEMENT LLC | 34,485 | $194 |
| JPMORGAN CHASE & CO | 31,757 | $179 |
| CIBC Private Wealth Group, LLC | 30,600 | $173 |
| STATE OF WISCONSIN INVESTMENT BOARD | 30,007 | $169 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 27,344 | $154 |
| FOX RUN MANAGEMENT, L.L.C. | 25,005 | $141 |
| Creative Planning | 24,889 | $140 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 23,460 | $132 |
| HSBC HOLDINGS PLC | 22,151 | $127 |
| SG Americas Securities, LLC | 20,876 | $0 |
| AXQ CAPITAL, LP | 20,647 | $116 |
| Jain Global LLC | 20,270 | $114 |
| Lido Advisors, LLC | 20,175 | $124 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 18,253 | $103 |
| Police & Firemen's Retirement System of New Jersey | 17,389 | $98 |
| HRT FINANCIAL LP | 14,919 | $0 |
| ProShare Advisors LLC | 14,218 | $80 |
| SEI INVESTMENTS CO | 13,078 | $74 |
| China Universal Asset Management Co., Ltd. | 12,695 | $72 |
| Voya Investment Management LLC | 11,160 | $63 |
| COMMONWEALTH EQUITY SERVICES, LLC | 10,852 | $61 |
| Tower Research Capital LLC (TRC) | 10,671 | $60 |
| MARTINGALE ASSET MANAGEMENT L P | 10,574 | $60 |
| Russell Investments Group, Ltd. | 7,204 | $41 |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,100 | $40 |
| GROUP ONE TRADING, L.P. | 6,553 | $37 |
| Legal & General Group Plc | 5,270 | $30 |
| Steward Partners Investment Advisory, LLC | 4,955 | $28 |
| ACADIAN ASSET MANAGEMENT LLC | 4,952 | $0 |
| Ameritas Investment Partners, Inc. | 4,926 | $28 |
| NISA INVESTMENT ADVISORS, LLC | 4,836 | $27 |
| CWM, LLC | 4,494 | $0 |
| ROYAL BANK OF CANADA | 4,296 | $24 |
| Mirae Asset Global Investments Co., Ltd. | 3,786 | $21 |
| 24 other institutions | 27,755 | $139 |