| Sanofi | 12,197,737 | $96,972 |
| PERCEPTIVE ADVISORS LLC | 10,326,103 | $82,093 |
| JOHNSON & JOHNSON | 6,641,064 | $52,796 |
| Rubric Capital Management LP | 6,175,331 | $49,094 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,000,000 | $31,800 |
| Prosight Management, LP | 3,209,788 | $25,518 |
| MILLENNIUM MANAGEMENT LLC | 3,176,390 | $25,252 |
| BlackRock, Inc. | 3,069,844 | $24,405 |
| 683 Capital Management, LLC | 2,559,082 | $20,345 |
| MORGAN STANLEY | 1,829,252 | $14,543 |
| Knoll Capital Management, LLC | 1,250,000 | $9,938 |
| Erste Asset Management GmbH | 789,702 | $6,275 |
| STATE STREET CORP | 729,445 | $5,799 |
| 22NW, LP | 586,519 | $4,663 |
| GEODE CAPITAL MANAGEMENT, LLC | 573,783 | $4,562 |
| Long Focus Capital Management, LLC | 524,745 | $4,172 |
| VANGUARD GROUP INC | 494,753 | $3,933 |
| GOLDMAN SACHS GROUP INC | 456,744 | $3,631 |
| Opaleye Management Inc. | 390,844 | $3,107 |
| D. E. Shaw & Co., Inc. | 381,763 | $3,035 |
| J. Goldman & Co LP | 319,687 | $2,542 |
| Hennion & Walsh Asset Management, Inc. | 308,509 | $2,453 |
| Woodline Partners LP | 300,323 | $2,388 |
| Jefferies Financial Group Inc. | 298,242 | $2,371 |
| STEMPOINT CAPITAL LP | 287,689 | $2,287 |
| NORTHERN TRUST CORP | 258,210 | $2,053 |
| UBS Group AG | 222,015 | $1,765 |
| BANK OF AMERICA CORP /DE/ | 208,454 | $1,657 |
| Privium Fund Management B.V. | 200,000 | $1,590 |
| ROYCE & ASSOCIATES LP | 176,057 | $1,400 |
| CITADEL ADVISORS LLC | 143,445 | $1,140 |
| Nuveen, LLC | 131,142 | $1,043 |
| WELLINGTON MANAGEMENT GROUP LLP | 130,610 | $1,038 |
| BNP PARIBAS ARBITRAGE, SA | 127,999 | $1,018 |
| BLAIR WILLIAM & CO/IL | 125,400 | $997 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 111,422 | $886 |
| AQR CAPITAL MANAGEMENT LLC | 108,014 | $859 |
| Bank of New York Mellon Corp | 101,090 | $804 |
| JANE STREET GROUP, LLC | 98,242 | $781 |
| BARCLAYS PLC | 95,730 | $761 |
| Russell Investments Group, Ltd. | 95,719 | $761 |
| PLATINUM INVESTMENT MANAGEMENT LTD | 93,922 | $747 |
| Invesco Ltd. | 90,881 | $723 |
| ExodusPoint Capital Management, LP | 86,926 | $691 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 76,902 | $611 |
| KENNEDY CAPITAL MANAGEMENT LLC | 70,738 | $562 |
| DAVENPORT & Co LLC | 69,200 | $550 |
| Trexquant Investment LP | 67,537 | $537 |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 66,400 | $528 |
| Fort Sheridan Advisors LLC | 65,569 | $521 |
| Y-Intercept (Hong Kong) Ltd | 65,558 | $521 |
| Quantinno Capital Management LP | 60,756 | $483 |
| RAYMOND JAMES FINANCIAL INC | 57,232 | $455 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 56,235 | $447 |
| RHUMBLINE ADVISERS | 56,207 | $447 |
| ALLIANCEBERNSTEIN L.P. | 54,590 | $434 |
| BROWN ADVISORY INC | 50,000 | $398 |
| WELLS FARGO & COMPANY/MN | 49,788 | $396 |
| STATE OF WISCONSIN INVESTMENT BOARD | 42,645 | $339 |
| DEUTSCHE BANK AG\ | 40,711 | $324 |
| XTX Topco Ltd | 38,030 | $302 |
| Jump Financial, LLC | 37,000 | $294 |
| VARCOV Co. | 32,945 | $262 |
| LETKO, BROSSEAU & ASSOCIATES INC | 32,000 | $254 |
| Virtus Investment Advisers, LLC | 29,824 | $237 |
| AlphaCentric Advisors LLC | 28,496 | $227 |
| Engineers Gate Manager LP | 26,839 | $213 |
| CreativeOne Wealth, LLC | 26,424 | $210 |
| SkyView Investment Advisors, LLC | 24,000 | $0 |
| JPMORGAN CHASE & CO | 23,946 | $190 |
| HSBC HOLDINGS PLC | 23,792 | $189 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 22,776 | $0 |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 22,578 | $176 |
| FOX RUN MANAGEMENT, L.L.C. | 22,493 | $179 |
| SG Americas Securities, LLC | 22,357 | $0 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 21,006 | $167 |
| Beacon Pointe Advisors, LLC | 20,763 | $165 |
| MetLife Investment Management, LLC | 20,033 | $159 |
| Voleon Capital Management LP | 16,587 | $132 |
| INTECH INVESTMENT MANAGEMENT LLC | 16,016 | $127 |
| CITIGROUP INC | 15,552 | $124 |
| Creative Planning | 15,446 | $123 |
| CIBC Private Wealth Group, LLC | 15,000 | $119 |
| Perigon Wealth Management, LLC | 15,000 | $119 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 14,898 | $118 |
| FMR LLC | 13,825 | $110 |
| China Universal Asset Management Co., Ltd. | 13,116 | $104 |
| Abel Hall, LLC | 12,295 | $98 |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 12,237 | $97 |
| Hobbs Group Advisors, LLC | 11,953 | $95 |
| ProShare Advisors LLC | 11,780 | $94 |
| Police & Firemen's Retirement System of New Jersey | 11,661 | $93 |
| ROYAL BANK OF CANADA | 10,884 | $87 |
| LEVIN CAPITAL STRATEGIES, L.P. | 10,000 | $80 |
| CWM, LLC | 7,783 | $0 |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,263 | $58 |
| Rockefeller Capital Management L.P. | 6,130 | $49 |
| Legal & General Group Plc | 4,276 | $34 |
| State of Alaska, Department of Revenue | 4,030 | $0 |
| Mirae Asset Global Investments Co., Ltd. | 3,911 | $31 |
| 29 other institutions | 24,584 | $182 |