| RTW INVESTMENTS, LP | 4,543,895 | $106,418 |
| Paradigm Biocapital Advisors LP | 4,473,648 | $104,773 |
| BlackRock, Inc. | 2,601,009 | $60,916 |
| MORGAN STANLEY | 2,562,901 | $60,023 |
| Jefferies Financial Group Inc. | 2,199,652 | $51,516 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,738,821 | $40,723 |
| ACORN CAPITAL ADVISORS, LLC | 1,448,420 | $33,922 |
| SG Americas Securities, LLC | 1,377,647 | $32 |
| AMERICAN CENTURY COMPANIES INC | 1,358,812 | $31,823 |
| MENORA MIVTACHIM HOLDINGS LTD. | 1,152,531 | $26,992 |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 1,125,100 | $26,350 |
| D. E. Shaw & Co., Inc. | 962,624 | $22,545 |
| MPM BioImpact LLC | 941,378 | $22,047 |
| ORBIMED ADVISORS LLC | 875,487 | $20,504 |
| STATE STREET CORP | 807,421 | $18,910 |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 781,620 | $18,306 |
| Migdal Insurance & Financial Holdings Ltd. | 770,909 | $18 |
| CITADEL ADVISORS LLC | 737,757 | $17,278 |
| SUPERSTRING CAPITAL MANAGEMENT LP | 718,354 | $16,824 |
| TCG Crossover Management, LLC | 717,347 | $16,800 |
| MILLENNIUM MANAGEMENT LLC | 618,952 | $14,496 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 616,606 | $14 |
| J. Goldman & Co LP | 513,303 | $12,022 |
| Woodline Partners LP | 500,726 | $11,727 |
| Boxer Capital Management, LLC | 500,000 | $11,710 |
| GEODE CAPITAL MANAGEMENT, LLC | 475,212 | $11,129 |
| GOLDMAN SACHS GROUP INC | 459,722 | $10,767 |
| VANGUARD GROUP INC | 439,751 | $10,299 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 435,490 | $10,199 |
| DEUTSCHE BANK AG\ | 366,680 | $8,588 |
| TANG CAPITAL MANAGEMENT LLC | 350,000 | $8,197 |
| Nuveen, LLC | 302,601 | $7,087 |
| RICE HALL JAMES & ASSOCIATES, LLC | 281,876 | $6,602 |
| Opaleye Management Inc. | 268,423 | $6,286 |
| RENAISSANCE TECHNOLOGIES LLC | 244,300 | $5,722 |
| TWO SIGMA INVESTMENTS, LP | 241,213 | $5,649 |
| NORTHERN TRUST CORP | 237,457 | $5,561 |
| UBS Group AG | 235,040 | $5,505 |
| Atom Investors LP | 234,423 | $5,490 |
| Privium Fund Management B.V. | 214,622 | $5,026 |
| Parkman Healthcare Partners LLC | 168,768 | $3,953 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 162,725 | $3,811 |
| Hennion & Walsh Asset Management, Inc. | 161,924 | $3,792 |
| EAM Investors, LLC | 160,412 | $3,757 |
| AQR CAPITAL MANAGEMENT LLC | 153,413 | $3,593 |
| Soleus Capital Management, L.P. | 150,000 | $3,513 |
| JPMORGAN CHASE & CO | 146,271 | $3,426 |
| AMERIPRISE FINANCIAL INC | 136,019 | $3,186 |
| HRT FINANCIAL LP | 130,899 | $3 |
| BANK OF AMERICA CORP /DE/ | 128,630 | $3,013 |
| WELLINGTON MANAGEMENT GROUP LLP | 126,034 | $2,952 |
| ADAR1 Capital Management, LLC | 125,375 | $2,936 |
| FMR LLC | 123,563 | $2,894 |
| ARK Investment Management LLC | 121,484 | $2,845 |
| Aisling Capital Management LP | 108,000 | $2,529 |
| Elmind Capital, LP | 100,000 | $2,342 |
| Bank of New York Mellon Corp | 98,829 | $2,315 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 90,989 | $2,131 |
| OAK RIDGE INVESTMENTS LLC | 85,230 | $1,996 |
| WELLS FARGO & COMPANY/MN | 84,158 | $1,971 |
| TD Asset Management Inc | 80,188 | $1,878 |
| Voya Investment Management LLC | 76,762 | $1,798 |
| PANAGORA ASSET MANAGEMENT INC | 74,055 | $1,734 |
| TRUIST FINANCIAL CORP | 72,286 | $1,693 |
| ALGERT GLOBAL LLC | 65,935 | $2 |
| Annandale Capital, LLC | 60,552 | $1 |
| BARCLAYS PLC | 57,744 | $1,352 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 55,686 | $1,293 |
| NEOS Investment Management LLC | 53,576 | $1,255 |
| Russell Investments Group, Ltd. | 47,257 | $1,107 |
| RHUMBLINE ADVISERS | 45,760 | $1,072 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 39,383 | $922 |
| Coastal Bridge Advisors, LLC | 37,000 | $867 |
| MEITAV INVESTMENT HOUSE LTD | 35,517 | $832 |
| ExodusPoint Capital Management, LP | 35,393 | $829 |
| Focus Partners Wealth | 35,277 | $826 |
| ALLIANCEBERNSTEIN L.P. | 35,040 | $821 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 31,569 | $627 |
| DARK FOREST CAPITAL MANAGEMENT LP | 31,516 | $738 |
| Cetera Investment Advisers | 30,096 | $705 |
| HighVista Strategies LLC | 28,005 | $656 |
| Susquehanna Portfolio Strategies, LLC | 27,380 | $641 |
| Invesco Ltd. | 27,066 | $634 |
| Toroso Investments, LLC | 26,972 | $632 |
| Palo Alto Investors LP | 24,500 | $574 |
| MML INVESTORS SERVICES, LLC | 24,363 | $571 |
| Quantinno Capital Management LP | 23,514 | $551 |
| Squarepoint Ops LLC | 22,831 | $535 |
| XTX Topco Ltd | 22,491 | $527 |
| MetLife Investment Management, LLC | 22,445 | $526 |
| INTECH INVESTMENT MANAGEMENT LLC | 22,210 | $520 |
| SIMPLEX TRADING, LLC | 22,109 | $518 |
| Allianz Asset Management GmbH | 22,000 | $515 |
| Kranot Hishtalmut Le Morim Tichoniim Havera Menahelet LTD | 21,823 | $511 |
| DIADEMA PARTNERS LP | 21,810 | $511 |
| Main Street Financial Solutions, LLC | 20,990 | $492 |
| Jump Financial, LLC | 17,900 | $419 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 17,154 | $402 |
| Cinctive Capital Management LP | 16,991 | $398 |
| OPPENHEIMER & CO INC | 16,962 | $397 |
| 66 other institutions | 266,895 | $5,869 |