UROGEN PHARMA LTD

Ticker: URGN CUSIP: M96088105 Class: Common Stock

Holders for Q4 2025 Position Changes for Q4 2025

Note: Option positions (PUT/CALL) are excluded.

New Positions (29)

Opaleye Management Inc.
Value ($000) $6,286 Shares 268,423
Aisling Capital Management LP
Value ($000) $2,529 Shares 108,000
EAM Investors, LLC
Value ($000) $3,757 Shares 160,412
J. Goldman & Co LP
Value ($000) $12,022 Shares 513,303
FRONTIER CAPITAL MANAGEMENT CO LLC
Value ($000) $18,306 Shares 781,620
HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND
Value ($000) $26,350 Shares 1,125,100
AMERICAN CENTURY COMPANIES INC
Value ($000) $31,823 Shares 1,358,812
DARK FOREST CAPITAL MANAGEMENT LP
Value ($000) $738 Shares 31,516
Cinctive Capital Management LP
Value ($000) $398 Shares 16,991
Susquehanna Portfolio Strategies, LLC
Value ($000) $641 Shares 27,380
WINTON GROUP Ltd
Value ($000) $309 Shares 13,188
ALGERT GLOBAL LLC
Value ($000) $2 Shares 65,935
OPPENHEIMER & CO INC
Value ($000) $397 Shares 16,962
Focus Partners Wealth
Value ($000) $826 Shares 35,277
Toroso Investments, LLC
Value ($000) $632 Shares 26,972
MML INVESTORS SERVICES, LLC
Value ($000) $571 Shares 24,363
DnB Asset Management AS
Value ($000) $397 Shares 16,961
Squarepoint Ops LLC
Value ($000) $535 Shares 22,831
SIMPLEX TRADING, LLC
Value ($000) $518 Shares 22,109
FRANKLIN RESOURCES INC
Value ($000) $392 Shares 16,745

Increased Positions (46)

SUPERSTRING CAPITAL MANAGEMENT LP
Value ($000) $16,824 (+859.3%) Shares 718,354 (+717.1%)
MPM BioImpact LLC
Value ($000) $22,047 (+718.6%) Shares 941,378 (+597.3%)
ACORN CAPITAL ADVISORS, LLC
Value ($000) $33,922 (+35.0%) Shares 1,448,420 (+15.0%)
SILVERARC CAPITAL MANAGEMENT, LLC
Value ($000) $40,723 (+29.4%) Shares 1,738,821 (+10.2%)
Paradigm Biocapital Advisors LP
Value ($000) $104,773 (+24.6%) Shares 4,473,648 (+6.1%)
Privium Fund Management B.V.
Value ($000) $5,026 (+28.1%) Shares 214,622 (+9.2%)
ADAR1 Capital Management, LLC
Value ($000) $2,936 (+320.5%) Shares 125,375 (+258.2%)
ORBIMED ADVISORS LLC
Value ($000) $20,504 (+49.2%) Shares 875,487 (+27.1%)
Hennion & Walsh Asset Management, Inc.
Value ($000) $3,792 (+191.6%) Shares 161,924 (+148.4%)
RICE HALL JAMES & ASSOCIATES, LLC
Value ($000) $6,602 (+27.7%) Shares 281,876 (+8.8%)
Woodline Partners LP
Value ($000) $11,727 (+91.9%) Shares 500,726 (+63.4%)
DEUTSCHE BANK AG\
Value ($000) $8,588 (+165.3%) Shares 366,680 (+126.0%)
ExodusPoint Capital Management, LP
Value ($000) $829 (+151.2%) Shares 35,393 (+113.9%)
CITADEL ADVISORS LLC
Value ($000) $17,278 (+43.8%) Shares 737,757 (+22.5%)
D. E. Shaw & Co., Inc.
Value ($000) $22,545 (+27.1%) Shares 962,624 (+8.3%)
AMERIPRISE FINANCIAL INC
Value ($000) $3,186 (+423.8%) Shares 136,019 (+346.2%)
VANGUARD GROUP INC
Value ($000) $10,299 (+69.9%) Shares 439,751 (+44.8%)
Russell Investments Group, Ltd.
Value ($000) $1,107 (+1570.5%) Shares 47,257 (+1323.0%)
SG Americas Securities, LLC
Value ($000) $32 (+39.7%) Shares 1,377,647 (+19.0%)
UBS Group AG
Value ($000) $5,505 (+52.9%) Shares 235,040 (+30.2%)

Decreased Positions (52)

Boxer Capital Management, LLC
Value ($000) $11,710 (+2.1%) Shares 500,000 (-13.0%)
TANG CAPITAL MANAGEMENT LLC
Value ($000) $8,197 (-58.9%) Shares 350,000 (-65.0%)
Parkman Healthcare Partners LLC
Value ($000) $3,953 (-50.8%) Shares 168,768 (-58.1%)
Soleus Capital Management, L.P.
Value ($000) $3,513 (-74.1%) Shares 150,000 (-77.9%)
DIADEMA PARTNERS LP
Value ($000) $511 (-71.6%) Shares 21,810 (-75.8%)
Atom Investors LP
Value ($000) $5,490 (-5.7%) Shares 234,423 (-19.7%)
Persistent Asset Partners Ltd
Value ($000) $300 (-27.5%) Shares 12,806 (-38.2%)
VOLORIDGE INVESTMENT MANAGEMENT, LLC
Value ($000) $10,199 (-25.6%) Shares 435,490 (-36.7%)
Jump Financial, LLC
Value ($000) $419 (-79.8%) Shares 17,900 (-82.8%)
HighVista Strategies LLC
Value ($000) $656 (+3.1%) Shares 28,005 (-12.2%)
MILLENNIUM MANAGEMENT LLC
Value ($000) $14,496 (-50.5%) Shares 618,952 (-57.9%)
Annandale Capital, LLC
Value ($000) $1 (-89.9%) Shares 60,552 (-14.2%)
Main Street Financial Solutions, LLC
Value ($000) $492 (-23.5%) Shares 20,990 (-34.8%)
PANAGORA ASSET MANAGEMENT INC
Value ($000) $1,734 (-52.9%) Shares 74,055 (-59.8%)
TWO SIGMA INVESTMENTS, LP
Value ($000) $5,649 (-26.7%) Shares 241,213 (-37.5%)
BNP PARIBAS ARBITRAGE, SA
Value ($000) $217 (-96.5%) Shares 9,246 (-97.0%)
JPMORGAN CHASE & CO
Value ($000) $3,426 (-67.9%) Shares 146,271 (-72.6%)
Nuveen, LLC
Value ($000) $7,087 (-30.0%) Shares 302,601 (-40.4%)
SRS Capital Advisors, Inc.
Value ($000) $0 (-99.9%) Shares 14 (-99.9%)
XTX Topco Ltd
Value ($000) $527 (-9.9%) Shares 22,491 (-23.2%)

Exited Positions (24)

Kynam Capital Management, LP
Value ($000) $6,936 Shares 282,412
TORONTO DOMINION BANK
Value ($000) $63,651 Shares 3,190,510
BENDER ROBERT & ASSOCIATES
Value ($000) $692 Shares 34,701
DAFNA Capital Management LLC
Value ($000) $549 Shares 27,515
TEMA ETFS LLC
Value ($000) $1,007 Shares 50,458
FOX RUN MANAGEMENT, L.L.C.
Value ($000) $337 Shares 16,902
Schonfeld Strategic Advisors LLC
Value ($000) $5,942 Shares 297,851
GSA CAPITAL PARTNERS LLP
Value ($000) $1 Shares 48,964
Trexquant Investment LP
Value ($000) $2,323 Shares 116,436
Walleye Capital LLC
Value ($000) $3,800 Shares 190,452
Verition Fund Management LLC
Value ($000) $1,776 Shares 89,028
Graham Capital Management, L.P.
Value ($000) $470 Shares 23,571
TWO SIGMA ADVISERS, LP
Value ($000) $2,226 Shares 111,600
JANE STREET GROUP, LLC
Value ($000) $6,552 Shares 328,419
Kovitz Investment Group Partners, LLC
Value ($000) $694 Shares 34,802
State of Wyoming
Value ($000) $66 Shares 3,301
Quadrature Capital Ltd
Value ($000) $354 Shares 17,714
Harel Insurance Investments & Financial Services Ltd.
Value ($000) $2 Shares 82,772
Man Group plc
Value ($000) $215 Shares 10,780
LPL Financial LLC
Value ($000) $231 Shares 11,561