GREAT POINT PARTNERS LLC Quant / Systematic

CIK: 0001281446 · Show all filings

Period: Q1 2018 (← Previous) (Next →)

Filing Date: May 14, 2018

Total Value ($000): $673,402,000 (100.0% shares, 0.0% debt)

Holdings (37)

IOVA IOVANCE BIOTHERAPEUTICS INC 8.3%

Value ($000) $56,128,000 Shares 3,321,173 Est. Cost $9.84 Unrealized +54.0%

— ARENA PHARMACEUTICALS INC 7.7%

Value ($000) $51,583,000 Shares 1,305,887 Est. Cost $3910.17 Unrealized —

KURA KURA ONCOLOGY INC 6.6%

Value ($000) $44,641,000 Shares 2,380,846 Est. Cost $11.17 Unrealized +74.3%

PTCT PTC THERAPEUTICS INC 6.2%

Value ($000) $41,668,000 Shares 1,539,822 Est. Cost $16.23 Unrealized +56.2%

— ZOGENIX INC 5.8%

Value ($000) $39,181,000 Shares 978,302 Est. Cost $14.10 Unrealized —

— SPARK THERAPEUTICS INC 5.4%

Value ($000) $36,625,000 Shares 550,000 Est. Cost $16879.86 Unrealized —

BCRX BIOCRYST PHARMACEUTICALS 5.3%

Value ($000) $35,671,000 Shares 7,478,275 Est. Cost $5.01 Unrealized +2.5%

— GLOBAL BLOOD THERAPEUTICS IN 5.3%

Value ($000) $35,579,000 Shares 736,631 Est. Cost $28.28 Unrealized —

PBYI PUMA BIOTECHNOLOGY INC 5.1%

Value ($000) $34,025,000 Shares 500,000 Est. Cost $74.88 Unrealized 0.0%

NBIX NEUROCRINE BIOSCIENCES INC 4.9%

Value ($000) $33,172,000 Shares 400,000 Est. Cost $43.70 Unrealized +93.2%

— RIGEL PHARMACEUTICALS INC 4.5%

Value ($000) $30,371,000 Shares 8,579,454 Est. Cost $288.10 Unrealized —

— AIMMUNE THERAPEUTICS INC 4.3%

Value ($000) $28,665,000 Shares 900,579 Est. Cost $11573.28 Unrealized —

— FOAMIX PHARMACEUTICALS LTD 3.6%

Value ($000) $24,530,000 Shares 4,781,708 Est. Cost $7.50 Unrealized —

EXEL EXELIXIS INC 3.0%

Value ($000) $19,933,000 Shares 899,900 Est. Cost $27.64 Unrealized 0.0%

PRTA PROTHENA CORP PLC 2.7%

Value ($000) $18,355,000 Shares 500,000 Est. Cost — Unrealized —

— ACCELERON PHARMA INC 2.7%

Value ($000) $18,074,000 Shares 462,245 Est. Cost $24466.81 Unrealized —

NVCR NOVOCURE LTD 2.4%

Value ($000) $16,426,000 Shares 753,481 Est. Cost $19.34 Unrealized +11.2%

— FIVE PRIME THERAPEUTICS INC 2.2%

Value ($000) $14,914,000 Shares 868,100 Est. Cost $17180.05 Unrealized —

— ACHILLION PHARMACEUTICALS IN 2.0%

Value ($000) $13,727,000 Shares 3,700,000 Est. Cost $3710.00 Unrealized —

— ENDOCYTE INC 2.0%

Value ($000) $13,558,000 Shares 1,491,500 Est. Cost $9090.18 Unrealized —

— CORSICANTO II DESIGNATED ACT 1.6%

Value ($000) $11,025,000 Shares 10,000,000 Est. Cost $1102.50 Unrealized —

SVRA SAVARA INC 1.2%

Value ($000) $7,932,000 Shares 862,179 Est. Cost $11.47 Unrealized +2.6%

— CTI BIOPHARMA CORP 1.0%

Value ($000) $6,579,000 Shares 1,687,020 Est. Cost $3899.78 Unrealized —

CPRX CATALYST PHARMACEUTICALS INC 1.0%

Value ($000) $6,443,000 Shares 2,695,742 Est. Cost $3.30 Unrealized +0.6%

— SIERRA ONCOLOGY INC 1.0%

Value ($000) $6,440,000 Shares 3,111,111 Est. Cost $2070.00 Unrealized —

PTCT PTC THERAPEUTICS INC 0.8%

Value ($000) $5,412,000 Shares 200,000 Est. Cost $16.23 Unrealized +56.2%

VNDA VANDA PHARMACEUTICALS INC 0.8%

Value ($000) $5,220,000 Shares 309,800 Est. Cost $12.36 Unrealized +35.4%

— ACORDA THERAPEUTICS INC 0.7%

Value ($000) $4,730,000 Shares 200,000 Est. Cost — Unrealized —

— AMARIN CORP PLC 0.5%

Value ($000) $3,300,000 Shares 1,096,200 Est. Cost $4.03 Unrealized —

— AMARIN CORP PLC 0.5%

Value ($000) $3,181,000 Shares 1,056,825 Est. Cost $4.03 Unrealized —

— MENLO THERAPEUTICS INC 0.3%

Value ($000) $1,954,000 Shares 52,008 Est. Cost $37571.14 Unrealized —

— NEWLINK GENETICS CORP 0.3%

Value ($000) $1,693,000 Shares 233,500 Est. Cost $8.11 Unrealized —

— ANTARES PHARMA INC 0.2%

Value ($000) $1,100,000 Shares 500,000 Est. Cost $2200.00 Unrealized —

— ARENA PHARMACEUTICALS INC 0.1%

Value ($000) $604,000 Shares 15,300 Est. Cost $3910.17 Unrealized —

— ACORDA THERAPEUTICS INC 0.1%

Value ($000) $449,000 Shares 19,000 Est. Cost — Unrealized —

— GLOBAL BLOOD THERAPEUTICS IN 0.0%

Value ($000) $275,000 Shares 5,700 Est. Cost $28.28 Unrealized —

— STREAMLINE HEALTH SOLUTIONS 0.0%

Value ($000) $239,000 Shares 130,137 Est. Cost $6.45 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
IOVA	IOVANCE BIOTHERAPEUTICS INC	3,321,173	$56,128,000	8.3%	$9.84	+54.0%	COM	462260100
—	ARENA PHARMACEUTICALS INC	1,305,887	$51,583,000	7.7%	$3910.17	—	COM NEW	040047607
KURA	KURA ONCOLOGY INC	2,380,846	$44,641,000	6.6%	$11.17	+74.3%	COM	50127T109
PTCT	PTC THERAPEUTICS INC	1,539,822	$41,668,000	6.2%	$16.23	+56.2%	COM	69366J200
—	ZOGENIX INC	978,302	$39,181,000	5.8%	$14.10	—	COM NEW	98978L204
—	SPARK THERAPEUTICS INC	550,000	$36,625,000	5.4%	$16879.86	—	COM	84652J103
BCRX	BIOCRYST PHARMACEUTICALS	7,478,275	$35,671,000	5.3%	$5.01	+2.5%	COM	09058V103
—	GLOBAL BLOOD THERAPEUTICS IN	736,631	$35,579,000	5.3%	$28.28	—	COM	37890U108
PBYI	PUMA BIOTECHNOLOGY INC	500,000	$34,025,000	5.1%	$74.88	0.0%	COM	74587V107
NBIX	NEUROCRINE BIOSCIENCES INC	400,000	$33,172,000	4.9%	$43.70	+93.2%	COM	64125C109
—	RIGEL PHARMACEUTICALS INC	8,579,454	$30,371,000	4.5%	$288.10	—	COM NEW	766559603
—	AIMMUNE THERAPEUTICS INC	900,579	$28,665,000	4.3%	$11573.28	—	COM	00900T107
—	FOAMIX PHARMACEUTICALS LTD	4,781,708	$24,530,000	3.6%	$7.50	—	SHS	M46135105
EXEL	EXELIXIS INC	899,900	$19,933,000	3.0%	$27.64	0.0%	COM	30161Q104
PRTA	PROTHENA CORP PLC	500,000	$18,355,000	2.7%	—	—	Call	G72800108
—	ACCELERON PHARMA INC	462,245	$18,074,000	2.7%	$24466.81	—	COM	00434H108
NVCR	NOVOCURE LTD	753,481	$16,426,000	2.4%	$19.34	+11.2%	ORD SHS	G6674U108
—	FIVE PRIME THERAPEUTICS INC	868,100	$14,914,000	2.2%	$17180.05	—	COM	33830X104
—	ACHILLION PHARMACEUTICALS IN	3,700,000	$13,727,000	2.0%	$3710.00	—	COM	00448Q201
—	ENDOCYTE INC	1,491,500	$13,558,000	2.0%	$9090.18	—	COM	29269A102
—	CORSICANTO II DESIGNATED ACT	10,000,000	$11,025,000	1.6%	$1102.50	—	NOTE	220485AB2
SVRA	SAVARA INC	862,179	$7,932,000	1.2%	$11.47	+2.6%	COM	805111101
—	CTI BIOPHARMA CORP	1,687,020	$6,579,000	1.0%	$3899.78	—	COM NEW	12648L601
CPRX	CATALYST PHARMACEUTICALS INC	2,695,742	$6,443,000	1.0%	$3.30	+0.6%	COM	14888U101
—	SIERRA ONCOLOGY INC	3,111,111	$6,440,000	1.0%	$2070.00	—	COM	82640U107
PTCT	PTC THERAPEUTICS INC	200,000	$5,412,000	0.8%	$16.23	+56.2%	Call	69366J200
VNDA	VANDA PHARMACEUTICALS INC	309,800	$5,220,000	0.8%	$12.36	+35.4%	COM	921659108
—	ACORDA THERAPEUTICS INC	200,000	$4,730,000	0.7%	—	—	Put	00484M106
—	AMARIN CORP PLC	1,096,200	$3,300,000	0.5%	$4.03	—	Call	023111206
—	AMARIN CORP PLC	1,056,825	$3,181,000	0.5%	$4.03	—	SPONS ADR NEW	023111206
—	MENLO THERAPEUTICS INC	52,008	$1,954,000	0.3%	$37571.14	—	COM	586858102
—	NEWLINK GENETICS CORP	233,500	$1,693,000	0.3%	$8.11	—	COM	651511107
—	ANTARES PHARMA INC	500,000	$1,100,000	0.2%	$2200.00	—	COM	036642106
—	ARENA PHARMACEUTICALS INC	15,300	$604,000	0.1%	$3910.17	—	Call	040047607
—	ACORDA THERAPEUTICS INC	19,000	$449,000	0.1%	—	—	Call	00484M106
—	GLOBAL BLOOD THERAPEUTICS IN	5,700	$275,000	0.0%	$28.28	—	Put	37890U108
—	STREAMLINE HEALTH SOLUTIONS	130,137	$239,000	0.0%	$6.45	—	COM	86323X106